Experts and Doctors on sirtuins in Shanghai, Shanghai Shi, China


Locale: Shanghai, Shanghai Shi, China
Topic: sirtuins

Top Publications

  1. Ying W, Xiong Z. Oxidative stress and NAD+ in ischemic brain injury: current advances and future perspectives. Curr Med Chem. 2010;17:2152-8 pubmed
  2. You D, Yin B, Li Z, Zhou Y, Yu W, Zuo P, et al. Sirtuin-dependent reversible lysine acetylation of glutamine synthetases reveals an autofeedback loop in nitrogen metabolism. Proc Natl Acad Sci U S A. 2016;113:6653-8 pubmed publisher
    ..This work presents significant new insights at the molecular level into the mechanisms underlying the regulation of protein acetylation and nitrogen metabolism in actinomycetes. ..
  3. Tan Y, Xu Z, Tao J, Ni J, Zhao W, Lu J, et al. A SIRT4-like auto ADP-ribosyltransferase is essential for the environmental growth of Mycobacterium smegmatis. Acta Biochim Biophys Sin (Shanghai). 2016;48:145-52 pubmed publisher
    ..Taken together, these results provided the characteristics of a SIRT4 homologue in prokaryotes and implicated its critical roles in the growth of environmental mycobacterial species. ..
  4. Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, et al. SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling. Cell Stem Cell. 2016;18:495-507 pubmed publisher
    ..Taken together, these findings disclose a new link between SIRT6 and Wnt signaling in the regulation of adult stem cell homeostasis and self-renewal capacity. ..
  5. Chen X, Hao B, Liu Y, Dai D, Han G, Li Y, et al. The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma. Biochem Biophys Res Commun. 2014;446:364-9 pubmed publisher
    ..In summary, our findings implicate that SIRT6 inhibits PCBP2 expression through deacetylating H3K9ac and SIRT6 acts as a tumor suppressor in human glioma. ..
  6. Cui X, Yao L, Yang X, Gao Y, Fang F, Zhang J, et al. SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK. Am J Physiol Endocrinol Metab. 2017;313:E493-E505 pubmed publisher
    ..These findings indicate that SIRT6 is a potential therapeutic target for treatment of type 2 diabetes mellitus. ..
  7. Huang N, Liu Z, Zhu J, Cui Z, Li Y, Yu Y, et al. Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells. Tumour Biol. 2017;39:1010428317708532 pubmed publisher
    ..In summary, our studies shed insights into the crucial functions of sirtuin 6 in esophageal carcinoma cells and provide evidence supporting sirtuin 6-based personalized therapies in esophageal carcinoma cell patients. ..
  8. Ye Q, Ji Q, Yan W, Yang F, Wang E. Acetylation of lysine ?-amino groups regulates aminoacyl-tRNA synthetase activity in Escherichia coli. J Biol Chem. 2017;292:10709-10722 pubmed publisher
    ..These findings imply a potential regulatory role for Lys acetylation in controlling the activity of aminoacyl-tRNA synthetases and thus protein synthesis. ..
  9. Qu N, Hu J, Liu L, Zhang T, Sun G, Shi R, et al. SIRT6 is upregulated and associated with cancer aggressiveness in papillary thyroid cancer via BRAF/ERK/Mcl‑1 pathway. Int J Oncol. 2017;50:1683-1692 pubmed publisher
    ..In conclusion, these results suggest that SIRT6 enhances cell aggressiveness in PTC via BRAF/ERK/Mcl‑1 pathway, and thus may be a promising target in the treatment of the disease. ..

More Information


  1. Huang W, Huang Y, Huang R, Huang C, Wang W, Gu J, et al. SIRT3 Expression Decreases with Reactive Oxygen Species Generation in Rat Cortical Neurons during Early Brain Injury Induced by Experimental Subarachnoid Hemorrhage. Biomed Res Int. 2016;2016:8263926 pubmed publisher
  2. Huang G, Cheng J, Yu F, Liu X, Yuan C, Liu C, et al. Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer. Oncol Rep. 2016;35:2801-10 pubmed publisher
    ..Together, these results highlight the prognostic value of SIRT4 in colorectal cancer and the potential application of SIRT4 in colorectal cancer treatment. ..
  3. Pan H, Guan D, Liu X, Li J, Wang L, Wu J, et al. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res. 2016;26:190-205 pubmed publisher
    ..Our study uncovers a novel function of SIRT6 in maintaining hMSC homeostasis by serving as a NRF2 coactivator, which represents a new layer of regulation of oxidative stress-associated stem cell decay. ..
  4. Liu B, Che W, Xue J, Zheng C, Tang K, Zhang J, et al. SIRT4 prevents hypoxia-induced apoptosis in H9c2 cardiomyoblast cells. Cell Physiol Biochem. 2013;32:655-62 pubmed publisher
    ..These results suggest that SIRT4 is a key player in hypoxia-induced cardiomyocyte apoptosis, and that strategies based on its enhancement might be of benefit in the treatment of ischaemic heart disease. ..
  5. Min L, Ji Y, Bakiri L, Qiu Z, Cen J, Chen X, et al. Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin. Nat Cell Biol. 2012;14:1203-11 pubmed publisher
    ..These results reveal a regulatory network connecting stress response and histone modification in liver tumour initiation, which could be targeted to prevent liver tumorigenesis. ..
  6. Li L, Zhao L, Yi Ming W, Yu Y, Xia C, Duan J, et al. Sirt1 hyperexpression in SHR heart related to left ventricular hypertrophy. Can J Physiol Pharmacol. 2009;87:56-62 pubmed publisher
    ..The increased sirt1 protein expression was accompanied by severe cardiac hypertrophy in older SHR. These results suggest that the increase of sirt1 gene and protein expression in the heart was associated with cardiac hypertrophy. ..
  7. Sun C, Zhang F, Ge X, Yan T, Chen X, Shi X, et al. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab. 2007;6:307-19 pubmed
    ..Taken together, the finding that SIRT1 improves insulin sensitivity has implications toward resolving insulin resistance and type 2 diabetes. ..
  8. Jin Q, Yan T, Ge X, Sun C, Shi X, Zhai Q. Cytoplasm-localized SIRT1 enhances apoptosis. J Cell Physiol. 2007;213:88-97 pubmed
    ..In summary, we found SIRT1 is able to localize in cytoplasm, and cytoplasm-localized SIRT1 enhances apoptosis. ..
  9. Liu B, Che W, Zheng C, Liu W, Wen J, Fu H, et al. SIRT5: a safeguard against oxidative stress-induced apoptosis in cardiomyocytes. Cell Physiol Biochem. 2013;32:1050-9 pubmed publisher
    ..Pharmacological interventions on SIRT5 expression may be useful in the treatment of oxidative stress-related cardiac injury. ..
  10. Zhou L, Vorhölter F, He Y, Jiang B, Tang J, Xu Y, et al. Gene discovery by genome-wide CDS re-prediction and microarray-based transcriptional analysis in phytopathogen Xanthomonas campestris. BMC Genomics. 2011;12:359 pubmed publisher
    ..Through a combined strategy involving bioinformatic, postgenomic and genetic approaches, a reliable list of 306 new CDSs was identified and a more thorough understanding of some cellular processes was gained. ..
  11. Zhou J, Zhou B, Lenzmeier B, Zhou J. Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. Nucleic Acids Res. 2009;37:3699-713 pubmed publisher
    ..Together, these data provide insight into the molecular mechanisms for the anti-silencing functions of Rpd3p during the formation of heterochromatin boundaries. ..
  12. Lin Z, Xu H, Wang J, Lin Q, Ruan Z, Liu F, et al. SIRT5 desuccinylates and activates SOD1 to eliminate ROS. Biochem Biophys Res Commun. 2013;441:191-5 pubmed publisher
    ..These results reveal a novel post-translational regulation of SOD1 by means of succinylation and SIRT5-dependent desuccinylation, which is important for the growth of lung tumor cells. ..
  13. Fu X, Meng F, Hu Y, Zhou J. Candida albicans, a distinctive fungal model for cellular aging study. Aging Cell. 2008;7:746-57 pubmed publisher
    ..cerevisiae. ..