Experts and Doctors on proteasome endopeptidase complex in Shanghai, Shanghai Shi, China


Locale: Shanghai, Shanghai Shi, China
Topic: proteasome endopeptidase complex

Top Publications

  1. Mao X, Pan X, Cheng T, Zhang X. Therapeutic potential of the proteasome inhibitor Bortezomib on titanium particle-induced inflammation in a murine model. Inflammation. 2012;35:905-12 pubmed publisher
    ..Bzb can significantly attenuate the severity of Ti-induced inflammation in air pouches. ..
  2. Xiong Y, Guan K. Mechanistic insights into the regulation of metabolic enzymes by acetylation. J Cell Biol. 2012;198:155-64 pubmed publisher
    ..Acetylation rivals other common posttranslational modifications in cell regulation not only in the number of substrates it modifies, but also the variety of regulatory mechanisms it facilitates. ..
  3. Xian L, Zhao J, Wang J, Fang Z, Peng B, Wang W, et al. p53 Promotes proteasome-dependent degradation of oncogenic protein HBx by transcription of MDM2. Mol Biol Rep. 2010;37:2935-40 pubmed publisher
    ..Our data provide a possible mechanism on how p53 regulate HBx stability and also a new clue for the study of p53 mutation and HCC development...
  4. Wu X, Wang Y, Sun Y. Molecular characterization, expression analysis and association study with immune traits of porcine PSMB6 gene. Mol Biol Rep. 2011;38:5465-70 pubmed publisher
    ..05), immunoglobin G (IgG1, P < 0.05), white blood cell count (WBC, P < 0.05). Using the pig/rodent somatic cell hybrid panel (SCHP), we mapped the porcine PSMB6 gene to SSC12, in agreement with comparative mapping data...
  5. Wen F, Guo Y, Hu Y, Liu W, Wang Q, Wang Y, et al. Distinct temporal requirements for autophagy and the proteasome in yeast meiosis. Autophagy. 2016;12:671-88 pubmed publisher
    ..Our study defines the roles of autophagy and the proteasome in meiosis: Autophagy mainly affects the initiation of meiosis, whereas the proteasome mainly affects the 2 successive meiotic divisions. ..
  6. Fan J, Zhang Y, Li P, Hou M, Tan L, Wang X, et al. Interaction of plasminogen activator inhibitor-2 and proteasome subunit, beta type 1. Acta Biochim Biophys Sin (Shanghai). 2004;36:42-6 pubmed
    ..GST-pulldown experiments confirmed the interaction between PAI-2 and PSMB1 in vitro. These data suggest that the antiapoptosis activity of PAI-2 is probably related to its interaction with PSMbeta1. ..
  7. Wang X, Li H, Chen Y, Fu J, Ren Y, Dong L, et al. p28GANK knockdown-derived reactive oxygen species induces apoptosis through mitochondrial dysfunction mediated by p38 in HepG2 cells. Int J Oncol. 2008;33:743-50 pubmed
    ..Our studies established the signaling pathway of p28GANK knockdown-induced apoptosis in HepG2 cells, namely, mitochondrial dysfunction mediated by p38 downstream of intracellular ROS generation. ..
  8. Xu H, Wang W, Li C, Yu H, Yang A, Wang B, et al. WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. Cell Res. 2009;19:561-73 pubmed publisher
    ..Our findings demonstrate that WWP2 is an important regulator of the OCT4 protein level in human ES cells. ..
  9. Hai J, Lin Q, Su S, Zhang L, Wan J, Lu Y. Chronic cerebral hypoperfusion in rats causes proteasome dysfunction and aggregation of ubiquitinated proteins. Brain Res. 2011;1374:73-81 pubmed publisher

More Information

Publications109 found, 100 shown here

  1. Gao X, Zhou C, Zhou Z, Zhang Y, Zheng X, Song A, et al. Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3. PLoS ONE. 2011;6:e19763 pubmed publisher
    ..We propose that co-chaperone HSJ1a orchestrates the balance of substrates in stressed cells in a Yin-Yang manner. ..
  2. Chen H, Ma H, Inuzuka H, Diao J, Lan F, Shi Y, et al. DNA damage regulates UHRF1 stability via the SCF(?-TrCP) E3 ligase. Mol Cell Biol. 2013;33:1139-48 pubmed publisher
    ..Taken together, our data identify SCF(?-TrCP) as a bona fide UHRF1 E3 ligase important for regulating UHRF1 steady-state levels both under normal conditions and in response to DNA damage. ..
  3. Lin R, Tao R, Gao X, Li T, Zhou X, Guan K, et al. Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol Cell. 2013;51:506-518 pubmed publisher
    ..Our study reveals a crosstalk between acetylation and ubiquitylation by competing for the same lysine residues in the regulation of fatty acid synthesis and cell growth in response to glucose. ..
  4. Wang Y, Wang Y, Zhang H, Gao Y, Huang C, Zhou A, et al. Sequential posttranslational modifications regulate PKC degradation. Mol Biol Cell. 2016;27:410-20 pubmed publisher
    ..These findings provide a molecular explanation for the activation-induced down-regulation of PKC proteins. ..
  5. Zhu J, Deng S, Lu P, Bu W, Li T, Yu L, et al. The Ccl1-Kin28 kinase complex regulates autophagy under nitrogen starvation. J Cell Sci. 2016;129:135-44 pubmed publisher
    ..The identification of this previously unknown regulatory pathway sheds new light on the complex signaling network that governs autophagy activity. ..
  6. Huang L, Yu Z, Zhang Z, Ma W, Song S, Huang G. Interaction with Pyruvate Kinase M2 Destabilizes Tristetraprolin by Proteasome Degradation and Regulates Cell Proliferation in Breast Cancer. Sci Rep. 2016;6:22449 pubmed publisher
    ..These findings demonstrate that PKM2-TTP association is crucial for regulating breast cancer cell proliferation and is therefore a potential therapeutic target in cancer. ..
  7. Guo L, Wang Y. Glutamate stimulates glutamate receptor interacting protein 1 degradation by ubiquitin-proteasome system to regulate surface expression of GluR2. Neuroscience. 2007;145:100-9 pubmed
    ..Our results suggest that glutamate induces GRIP1 degradation by proteasome through an NMDA receptor-Ca2+ pathway and that GRIP1 degradation may play an important role in regulating GluR2 surface expression. ..
  8. Mao I, Liu J, Li X, Luo H. REGgamma, a proteasome activator and beyond?. Cell Mol Life Sci. 2008;65:3971-80 pubmed publisher
    ..This review presents an overview of the function of REGgamma, a summary of the current literature, and insight into the possible biological function of REGgamma relating to cancer, viral pathogenesis, and other diseases. ..
  9. Hui B, Shi Y, Ding Z, Zhou J, Gu C, Peng Y, et al. Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma. Cancer. 2012;118:5560-71 pubmed publisher
    ..Proteasome inhibitors have been approved in clinical use against hematologic malignancies, but their application in solid tumors is uncertain. Moreover, the role of autophagy after proteasome inhibition is controversial...
  10. Shan Y, Zhou W, Fu X, Yan H, Yang W, Liu S, et al. The role of p28GANK in rat oval cells activation and proliferation. Liver Int. 2006;26:240-7 pubmed
    ..p28GANK expression was increased in oval cell-mediated liver regeneration and oval cells after mitogenic stimulation. Thus, p28GANK may play a role in oval cell-mediated liver regeneration and liver oval cell cycle progression. ..
  11. Wu X, Li K, Yerle M, Pan Y. Chromosomal assignments of the porcine COPS2, COPS4, COPS5, COPS6, USP6 and USP10 genes involved in the ubiquitin-proteasome system. Anim Genet. 2007;38:665-6 pubmed
  12. Chen Y, Li H, Fu J, Wang X, Ren Y, Dong L, et al. Oncoprotein p28 GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export. Cell Res. 2007;17:1020-9 pubmed
    ..These results suggest that overexpression of p28(GANK) prevents the nuclear localization and inhibits the activity of NF-kappaB/RelA. ..
  13. Lu S, Chen Z, Yang J, Chen L, Gong S, Zhou H, et al. Overexpression of the PSMB5 gene contributes to bortezomib resistance in T-lymphoblastic lymphoma/leukemia cells derived from Jurkat line. Exp Hematol. 2008;36:1278-84 pubmed publisher
    ..To study the mechanism of bortezomib resistance in JurkatB lines derived from T-lymphoblastic lymphoma/leukemia Jurkat line...
  14. Tan Y, Zhou H, Wang Z, Chen S. Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor. Mol Cell Biochem. 2008;318:109-15 pubmed publisher
    ..Moreover, we provide a new cell model for studying the roles of UCH-L1 in Parkinson's disease. ..
  15. Wang X, Xu H, Ju D, Xie Y. Disruption of Rpn4-induced proteasome expression in Saccharomyces cerevisiae reduces cell viability under stressed conditions. Genetics. 2008;180:1945-53 pubmed publisher
    ..This study also provides a tool for understanding the interactions between proteasome homeostasis and other cellular processes. ..
  16. Du Y, Yang D, Li L, Luo G, Li T, Fan X, et al. An insight into the mechanistic role of p53-mediated autophagy induction in response to proteasomal inhibition-induced neurotoxicity. Autophagy. 2009;5:663-75 pubmed
    ..Therefore, rapamycin may be a promising drug for protection against neuronal injury relevant to Parkinson disease (PD). Our studies thus provide a mechanistic insight into the functional link between the two protein degradation systems. ..
  17. Sun X, Meng X, Xu Z, Song R. Expression of the 26S proteasome subunit RPN10 is upregulated by salt stress in Dunaliella viridis. J Plant Physiol. 2010;167:1003-8 pubmed publisher
    ..The expression of DvRPN10 in response to the external salinity suggests that RPN10-mediated protein degradation plays a role in the salinity tolerance of D. viridis. ..
  18. Yuan Z, Luo D, Li G, Yao X, Wang H, Zeng M, et al. Characterization of the AE7 gene in Arabidopsis suggests that normal cell proliferation is essential for leaf polarity establishment. Plant J. 2010;64:331-42 pubmed publisher
    ..Possible models for how cell proliferation influences leaf adaxial-abaxial polarity establishment are discussed. ..
  19. Wang Z, Ni J, Li J, Shi B, Xu Y, Yuan Z. Inhibition of hepatitis B virus replication by cIAP2 involves accelerating the ubiquitin-proteasome-mediated destruction of polymerase. J Virol. 2011;85:11457-67 pubmed publisher
  20. Du Y, Zhang X, Tao Q, Chen S, Le W. Adeno-associated virus type 2 vector-mediated glial cell line-derived neurotrophic factor gene transfer induces neuroprotection and neuroregeneration in a ubiquitin-proteasome system impairment animal model of Parkinson's disease. Neurodegener Dis. 2013;11:113-28 pubmed publisher
  21. Xiong S, Zheng Y, Jiang P, Liu R, Liu X, Qian J, et al. PA28gamma emerges as a novel functional target of tumour suppressor microRNA-7 in non-small-cell lung cancer. Br J Cancer. 2014;110:353-62 pubmed publisher
    ..Thus, strategies targeting PA28gamma and/or miR-7 may become promising molecular therapies in NSCLC treatment. ..
  22. Li S, Song W, Jiang M, Zeng L, Zhu X, Chen J. Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation. FEBS Lett. 2014;588:1989-96 pubmed publisher
    ..Our results provide insight into autoregulation of the cyclin Y/CDK14 pair in CDK14 activation and cyclin Y turnover which is a process that is involved in membrane proximal signaling. ..
  23. Xu D, Shan B, Lee B, Zhu K, Zhang T, Sun H, et al. Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system. elife. 2015;4:e10510 pubmed publisher
  24. Xiao M, Yan M, Zhang J, Xu Q, Qi S, Wang X, et al. Cancer stem-like cell related protein CD166 degrades through E3 ubiquitin ligase CHIP in head and neck cancer. Exp Cell Res. 2017;353:46-53 pubmed publisher
    ..Our findings demonstrate that CHIP-CD166-proteasome axis participates in regulating CSC properties in HNCs, suggesting that the regulation of CD166 by CHIP could provide new options for diagnosing and treating in the patients with HNCs. ..
  25. Zhang P, Wang D, Zhao Y, Ren S, Gao K, Ye Z, et al. Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. Nat Med. 2017;23:1055-1062 pubmed publisher
  26. Shu F, Guo S, Dang Y, Qi M, Zhou G, Guo Z, et al. Human aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner. Mol Cell Biochem. 2003;254:157-62 pubmed
    ..The Aurora-B protein level increased in HeLa cells cultured with proteasome inhibitor ALLN. Our data suggest that Aurora-B might undergo degradation by binding to HC8 in a proteasome-dependent manner during mitosis. ..
  27. Zhou Y, Fang L, Du D, Zhou W, Feng X, Chen J, et al. Proteome identification of binding-partners interacting with cell polarity protein Par3 in Jurkat cells. Acta Biochim Biophys Sin (Shanghai). 2008;40:729-39 pubmed
    ..Our results have the potential to uncover novel functions of the cell polarity protein Par3 in blood cells. ..
  28. Yang J, Hong Y, Wang W, Wu W, Chi Y, Zong H, et al. HSP70 protects BCL2L12 and BCL2L12A from N-terminal ubiquitination-mediated proteasomal degradation. FEBS Lett. 2009;583:1409-14 pubmed publisher
    ..In summary, HSP70 protects BCL2L12 and BCL2L12A from N-terminal ubiquitination-mediated proteasomal degradation. ..
  29. Lu S, Yang J, Chen Z, Gong S, Zhou H, Xu X, et al. Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line. Exp Hematol. 2009;37:831-7 pubmed publisher
    ..Mutations of the PSMB5 gene resulting in substitutions of Ala49 and Ala50 of PSMB5 protein can confer varying bortezomib resistance. ..
  30. Chi Y, Hong Y, Zong H, Wang Y, Zou W, Yang J, et al. CDK11p58 represses vitamin D receptor-mediated transcriptional activation through promoting its ubiquitin-proteasome degradation. Biochem Biophys Res Commun. 2009;386:493-8 pubmed publisher
    ..Taken together, these results suggest that CDK11(p58) is involved in the negative regulation of VDR. ..
  31. Dai R, Chen Y, Fu J, Dong L, Ren Y, Yang G, et al. p28GANK inhibits endoplasmic reticulum stress-induced cell death via enhancement of the endoplasmic reticulum adaptive capacity. Cell Res. 2009;19:1243-57 pubmed publisher
    ..We propose that p28(GANK) has potential implications for HCC progression under the ER stress conditions. ..
  32. Yu B, Miao Z, Jiang Y, Li M, Yang N, Li T, et al. c-Jun protects hypoxia-inducible factor-1alpha from degradation via its oxygen-dependent degradation domain in a nontranscriptional manner. Cancer Res. 2009;69:7704-12 pubmed publisher
  33. Ruan Y, Guo L, Qiao Y, Hong Y, Zhou L, Sun L, et al. RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation. Biochem Biophys Res Commun. 2009;390:217-22 pubmed publisher
    ..Taken together, these results suggest RACK1 as a novel modulator of CLEC-2 expression. ..
  34. Chen J, Shen B, Deng X, Zhan Q, Peng C. SKP1-CULLIN1-F-box (SCF)-mediated DRG2 degradation facilitated chemotherapeutic drugs induced apoptosis in hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2012;420:651-5 pubmed publisher
    ..Taken together, these results demonstrate that regulated degradation of DRG2 has a role in chemotherapeutic drug induced hepatocellular carcinoma cells apoptosis. ..
  35. Xue J, Lv D, Jiao S, Zhao W, Li X, Sun H, et al. pVHL mediates K63-linked ubiquitination of nCLU. PLoS ONE. 2012;7:e35848 pubmed publisher
    ..In summary, our results disclose a novel function of pVHL that mediates K63-linked ubiquitination and identify nCLU as a new target of pVHL. ..
  36. Zhou J, Wan B, Li R, Gu X, Zhong Z, Wang Y, et al. Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway. Biochem Biophys Res Commun. 2012;422:647-52 pubmed publisher
    ..Consistent with this, BRSK2-mediated cell cycle arrest at the G2/M phase in mammalian cells was reversed by exogenous Jab1. Taken together, our findings provide a novel regulatory mechanism of BRSK2 through direct interaction with Jab1. ..
  37. Hai J, Lin Q, Wu Y, Huang X, Zhang G, Wang F. Effects of N-stearoyl-L-tyrosine on the hippocampal ubiquitin-proteasome system in rats with chronic cerebral hypoperfusion. Neurol Res. 2013;35:734-43 pubmed publisher
    ..These data indicate that NSTyr may exert protective effects on rat hippocampal UPS function via endogenous regulation. ..
  38. Li L, Zhao D, Wei H, Yao L, Dang Y, Amjad A, et al. REG? deficiency promotes premature aging via the casein kinase 1 pathway. Proc Natl Acad Sci U S A. 2013;110:11005-10 pubmed publisher
    ..These findings reveal a unique model that mimics acquired aging in mammals and indicates that modulating the activity of the REG?-proteasome may be an approach for intervention in aging-associated disorders. ..
  39. Sun L, Zhao H, Xu Z, Liu Q, Liang Y, Wang L, et al. Phosphatidylinositol 3-kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation. Cell Signal. 2007;19:2255-63 pubmed
    ..In conclusion, our results suggested that PKB enhanced DNMT1 stability and maintained DNA methylation and chromatin structure, which might contribute to cancer cell growth. ..
  40. Jia J, Chen Q, Zhou Y, Miao S, Zheng J, Zhang C, et al. Brain-derived neurotrophic factor-tropomyosin-related kinase B signaling contributes to activity-dependent changes in synaptic proteins. J Biol Chem. 2008;283:21242-50 pubmed publisher
    ..Our study indicates that BDNF-TrkB signaling acts upstream of the ubiquitin proteasome system, linking neuronal activity to protein turnover at the synapse. ..
  41. Zhou L, Hou J, Fu W, Wang D, Yuan Z, Jiang H. Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008;32:1674-83 pubmed publisher
    ..This will preliminarily help to optimize the new therapeutic regimens for MM treatment in the future. ..
  42. Wang K, Fang H, Xiao D, Zhu X, He M, Pan X, et al. Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells. PLoS ONE. 2009;4:e7538 pubmed publisher
  43. Dong L, Yang G, Pan Y, Chen Y, Tan Y, Dai R, et al. The oncoprotein p28GANK establishes a positive feedback loop in ?-catenin signaling. Cell Res. 2011;21:1248-61 pubmed publisher
    ..Together, these results suggest that p28(GANK) expression is regulated by a positive feedback loop involving ?-catenin, which may play a critical role in tumorigenesis and the progression of HCC. ..
  44. Yin J, Zhu J, Shen X. New insights into pre-mRNA processing factor 19: A multi-faceted protein in humans. Biol Cell. 2012;104:695-705 pubmed publisher
    ..Together, these studies add a new dimension to our understanding of hPrp19, and we have reason to believe that continuing excavation of this multi-faceted protein may shed light on its roles in human diseases, especially in cancer. ..
  45. Liu S, Yang H, Zhao J, Zhang Y, Song A, Hu H. NEDD8 ultimate buster-1 long (NUB1L) protein promotes transfer of NEDD8 to proteasome for degradation through the P97UFD1/NPL4 complex. J Biol Chem. 2013;288:31339-49 pubmed publisher
    ..This mechanism is also exemplified by the canonical neddylation of cullin 1 for SCF (SKP1-cullin1-F-box) ubiquitin E3 ligases that is exquisitely regulated by the turnover of NEDD8. ..
  46. Zhang P, Wang C, Gao K, Wang D, Mao J, An J, et al. The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. J Biol Chem. 2010;285:8869-79 pubmed publisher
    ..These findings establish a new mechanism for the negative regulation of TXNIP by Itch and shed new light on the regulation of cellular redox homeostasis. ..
  47. Yu G, Zhao Y, He J, Lonard D, Mao C, Wang G, et al. Comparative analysis of REG{gamma} expression in mouse and human tissues. J Mol Cell Biol. 2010;2:192-8 pubmed publisher
    ..Consistent with the importance of its expression in reproductive tissue, REGgamma deficiency results in dose-dependent reduction in litter size. ..
  48. Zhang Z, Wang H, Luo D, Zeng M, Huang H, Cui X. Convergence of the 26S proteasome and the REVOLUTA pathways in regulating inflorescence and floral meristem functions in Arabidopsis. J Exp Bot. 2011;62:359-69 pubmed publisher
    ..Double mutant plants combining rev with other 26S proteasome subunit mutants, rpn1a and rpn9a, resembled ae4 rev, suggesting that the 26S proteasome might act as a whole in regulating IM and FM functions. ..
  49. He J, Cui L, Zeng Y, Wang G, Zhou P, Yang Y, et al. REG? is associated with multiple oncogenic pathways in human cancers. BMC Cancer. 2012;12:75 pubmed publisher
    ..Our results indicate potentially important pathogenic roles of REG? in multiple cancer types and implicate REG? as a putative cancer marker. ..
  50. Wang C, An J, Zhang P, Xu C, Gao K, Wu D, et al. The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation. Biochem J. 2012;444:279-89 pubmed publisher
    ..Together, these observations reveal a novel post-translational regulatory mechanism of AMOT/p130. ..
  51. Graf U, Casanova E, Wyck S, Dalcher D, Gatti M, Vollenweider E, et al. Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways. Nat Cell Biol. 2017;19:763-773 pubmed publisher
    ..Our data reveal an as-yet-unappreciated dynamic nature of DNA methylation through proteasome pathways and offer insights that might help to improve ESC culture to reproduce in vitro the in vivo ground-state pluripotency. ..
  52. Wei Y, Jiang J, Liu D, Zhou J, Chen X, Zhang S, et al. Cdc34-mediated degradation of ATF5 is blocked by cisplatin. J Biol Chem. 2008;283:18773-81 pubmed publisher
    ..In summary, a down-regulation of proteasome-mediated degradation of ATF5 might contribute to cisplatin-induced apoptosis, providing a new mechanism of cisplatin-induced apoptosis. ..
  53. Zhang Q, Mao J, Liu P, Huang Q, Lu J, Xie Y, et al. A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 2009;106:3378-83 pubmed publisher
    ..Thus, these results suggest potential clinical benefits of IM/AS combination therapy for human CML. ..
  54. Fu D, Ma Y, Wu W, Zhu X, Jia C, Zhao Q, et al. Cell-cycle-dependent PC-PLC regulation by APC/C(Cdc20)-mediated ubiquitin-proteasome pathway. J Cell Biochem. 2009;107:686-96 pubmed publisher
    ..Taken together, our data indicate that PC-PLC regulation in cell cycles is controlled by APC/C(Cdc20)-mediated UPP. ..
  55. Fu J, Chen Y, Cao J, Luo T, Qian Y, Yang W, et al. p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1? pathways. Hepatology. 2011;53:181-92 pubmed publisher
    ..These results present novel mechanistic insight into a critical role of p28(GANK) in HCC progression and metastasis. ..
  56. He L, Xu H, Gu Z, Liu C, Chen G, Wang Y, et al. Ikaros is degraded by proteasome-dependent mechanism in the early phase of apoptosis induction. Biochem Biophys Res Commun. 2011;406:430-4 pubmed publisher
    ..These data might shed new insight on the role of IK1 in apoptosis and the post-translational regulation of IK1. ..
  57. Wang Y, Lu J, He L, Yu Q. Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II). PLoS ONE. 2011;6:e23993 pubmed publisher
  58. Xu J, Li R, Workeneh B, Dong Y, Wang X, Hu Z. Transcription factor FoxO1, the dominant mediator of muscle wasting in chronic kidney disease, is inhibited by microRNA-486. Kidney Int. 2012;82:401-11 pubmed
    ..Thus, FoxO1 is a dominant mediator of CKD-induced muscle wasting, and miR-486 coordinately decreases FoxO1 and PTEN to protect against this catabolic response. ..
  59. Zhang Z, Lv X, Yin W, Zhang X, Feng J, Wu W, et al. Ter94 ATPase complex targets k11-linked ubiquitinated ci to proteasomes for partial degradation. Dev Cell. 2013;25:636-44 pubmed publisher
    ..Thus, Ter94 ATPase and K11-linked ubiquitination in Ci contribute to the selectivity by proteasomes for partial degradation. ..
  60. Lv Y, Meng B, Dong H, Jing T, Wu N, Yang Y, et al. Upregulation of GSK3β Contributes to Brain Disorders in Elderly REGγ-knockout Mice. Neuropsychopharmacology. 2016;41:1340-9 pubmed publisher
    ..Dysfunction in this non-canonical proteasome degradation pathway may contribute to the sensorimotor gating deficiency and cognitive disorders in aging mice. ..
  61. Tao Y, Yang G, Yang H, Song D, Hu L, Xie B, et al. TRIP13 impairs mitotic checkpoint surveillance and is associated with poor prognosis in multiple myeloma. Oncotarget. 2017;8:26718-26731 pubmed publisher
    ..Thus, our results demonstrate that TRIP13 may serve as a biomarker for MM disease development and prognosis, making it a potential target for future therapies. ..
  62. Cheng Z, Yuan X, Qu Y, Li X, Wu G, Li C, et al. Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways. Cancer Lett. 2017;403:195-205 pubmed publisher
    ..Our findings provide important information about a novel Wnt/Notch crosstalk inhibitor that is synergistic with sorafenib for treatment of HCC, and therefore have high clinical impact. ..
  63. Yang Z, Guo J, Chen Q, Ding C, Du J, Zhu X. Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Mol Cell Biol. 2005;25:4062-74 pubmed
    ..Its depletion also prematurely triggers chromosome decondensation, a process that normally occurs from telophase for the nucleus reassembly, thus resulting in apoptosis. ..
  64. Fu Y, Fang Z, Liang Y, Zhu X, Prins P, Li Z, et al. Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing Skp2-dependent degradation of p27 via PI3K pathway. J Cell Biochem. 2007;102:704-18 pubmed
    ..Together, these results suggested that overexpression of integrin beta1 inhibited cell proliferation by preventing the Skp2-dependent degradation of p27(Kip1) via PI3K pathway. ..
  65. Wang Y, Zong H, Chi Y, Hong Y, Yang Y, Zou W, et al. Repression of estrogen receptor alpha by CDK11p58 through promoting its ubiquitin-proteasome degradation. J Biochem. 2009;145:331-43 pubmed publisher
    ..These data identified a new negative regulatory protein of ERalpha and provided a new pathway by which CDK11(p58) negatively regulated cells. ..
  66. Yan J, Zhang D, Di Y, Shi H, Rao H, Huo K. A newly identified Pirh2 substrate SCYL1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitination. FEBS Lett. 2010;584:3275-8 pubmed publisher
    ..On the other hand, while SCYL1-BP1 binds to ubiquitin E3 ligase MDM2, it promotes MDM2 self-ubiquitination and results in a reduction of MDM2 protein level. ..
  67. Wu Y, Wang L, Zhou P, Wang G, Zeng Y, Wang Y, et al. Regulation of REG? cellular distribution and function by SUMO modification. Cell Res. 2011;21:807-16 pubmed publisher
    ..This regulatory mechanism may enable REG? to function as a more potent factor in protein degradation with a broader substrate spectrum. ..
  68. Liu S, Fu Q, Zhao J, Hu H. Structural and mechanistic insights into the arginine/lysine-rich peptide motifs that interact with P97/VCP. Biochim Biophys Acta. 2013;1834:2672-8 pubmed publisher
    ..Based on biochemical features of the VBM motifs, we also identified NUB1L (NEDD8 ultimate buster-1 long) as a novel VBM-containing protein, which is involved in proteasomal degradation of NEDD8 through the P97 pathway. ..
  69. Du Y, Li X, Yang D, Zhang X, Chen S, Huang K, et al. Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo. Exp Biol Med (Maywood). 2008;233:881-90 pubmed publisher
    ..Several signaling path-ways including p38, JNK, Akt and ERK molecules seem to play an important role in this neuroprotection by GDNF. ..
  70. Lu S, Yang J, Song X, Gong S, Zhou H, Guo L, et al. Point mutation of the proteasome beta5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line. J Pharmacol Exp Ther. 2008;326:423-31 pubmed publisher
    ..The predicted structure of A108T-mutated PSMB5 shows a conformational change that suggests decreased affinity to bortezomib. In short, the G322A mutation of the PSMB5 gene is a novel mechanism for bortezomib resistance. ..
  71. Zhang Q, Wang L, Zhang Y, Jiang X, Yang F, Wu W, et al. The proteasome inhibitor bortezomib interacts synergistically with the histone deacetylase inhibitor suberoylanilide hydroxamic acid to induce T-leukemia/lymphoma cells apoptosis. Leukemia. 2009;23:1507-14 pubmed publisher
  72. Chen Y, Yuanxiang P, Knopfel T, Thomas U, Behnisch T. Hippocampal LTP triggers proteasome-mediated SPAR degradation in CA1 neurons. Synapse. 2012;66:142-50 pubmed publisher
    ..We conclude that LTP triggers a down regulation of SPAR by two complementary mechanisms, one of which has previously been described to mediate homeostatic plasticity. ..
  73. Qian Y, Chen Y, Yang W, Fu J, Cao J, Ren Y, et al. p28(GANK) prevents degradation of Oct4 and promotes expansion of tumor-initiating cells in hepatocarcinogenesis. Gastroenterology. 2012;142:1547-58.e14 pubmed publisher
    ..p28(GANK) activates and maintains liver T-ICs in HCCs by preventing degradation of Oct4. Inhibitors of p28(GANK) might therefore be developed to inactivate T-ICs and slow tumor progression. ..
  74. Huang W, Pi L, Liang W, Xu B, Wang H, Cai R, et al. The proteolytic function of the Arabidopsis 26S proteasome is required for specifying leaf adaxial identity. Plant Cell. 2006;18:2479-92 pubmed
    ..Together, our findings reveal that posttranslational regulation is essential in proper leaf patterning. ..
  75. Zhang Z, Liao B, Xu M, Jin Y. Post-translational modification of POU domain transcription factor Oct-4 by SUMO-1. FASEB J. 2007;21:3042-51 pubmed
    ..Our findings provide new evidence for the important role of post-translational modification in controlling Oct-4 function in ES cells. ..
  76. Li H, Zhang Z, Wang B, Zhang J, Zhao Y, Jin Y. Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells. Mol Cell Biol. 2007;27:5296-305 pubmed
    ..These results indicate that Wwp2 plays an important role in regulating expression of Rpb1 in normal physiological conditions. ..
  77. Wang W, Li Q, Xu J, Cao X, Li H, Tang F, et al. Interaction between CD147 and P-glycoprotein and their regulation by ubiquitination in breast cancer cells. Chemotherapy. 2008;54:291-301 pubmed publisher
    ..Our results demonstrate a mechanism underlying the linkage between multidrug resistance and tumor metastasis, and suggest for the first time that modulating the ubiquitination of P-gp and CD147 might be a novel method for tumor therapy. ..
  78. Gao B, Wang Y, Xu W, Li S, Li Q, Xiong S. Inhibition of histone deacetylase activity suppresses IFN-? induction of tripartite motif 22 via CHIP-mediated proteasomal degradation of IRF-1. J Immunol. 2013;191:464-71 pubmed publisher
    ..This study may provide novel insight into the role of HDAC activity in the transcriptional control of IFN-stimulated gene induction...
  79. Jiang L, Liu X, Xiong G, Liu H, Chen F, Wang L, et al. DWARF 53 acts as a repressor of strigolactone signalling in rice. Nature. 2013;504:401-5 pubmed publisher
    ..Moreover, D53 can interact with transcriptional co-repressors known as TOPLESS-RELATED PROTEINS. Our results suggest a model of SL signalling that involves SL-dependent degradation of the D53 repressor mediated by the D14-D3 complex. ..
  80. Xu J, Zhou L, Ji L, Chen F, Fortmann K, Zhang K, et al. The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis. Nat Commun. 2016;7:10761 pubmed publisher
    ..In sum, this study identifies REGγ-mediated control of IκBɛ as a molecular mechanism that contributes to NFκB activation and promotes bowel inflammation and associated tumour formation in response to chronic injury. ..
  81. Wang C, Qi R, Li N, Wang Z, An H, Zhang Q, et al. Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression. J Biol Chem. 2009;284:16183-90 pubmed publisher
    ..Thus, our results suggest that activation of Notch1 signaling may be a promising approach to improve the therapeutic efficacy of TRAIL-resistant HCC. ..
  82. Gao F, Wu Y, Zhao M, Liu C, Wang L, Chen G. Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction. Exp Cell Res. 2009;315:3250-8 pubmed publisher
    ..To our knowledge, this is the first demonstration that proteolytically activated PKC-delta down-regulates hnRNP K protein in a proteasome-dependent manner, which plays an important role in apoptosis induction. ..
  83. Sheng N, Xie Z, Wang C, Bai G, Zhang K, Zhu Q, et al. Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1. Proc Natl Acad Sci U S A. 2010;107:18886-91 pubmed publisher
    ..Our results reveal a mechanism by which RA suppresses BMP signaling through regulation of pSmad1 stability...
  84. Huo Z, Ye J, Chen J, Lin X, Zhou Z, Xu X, et al. Prolyl hydroxylase domain protein 2 regulates the intracellular cyclic AMP level in cardiomyocytes through its interaction with phosphodiesterase 4D. Biochem Biophys Res Commun. 2012;427:73-9 pubmed publisher
    ..In conclusion, PHD2 may directly interact with PDE4D to function as a novel regulator of the intracellular cAMP levels in cardiomyocytes. ..
  85. Zhang J, Yang Y, Zhang Z, He Y, Liu Z, Yu Y, et al. Gankyrin plays an essential role in estrogen-driven and GPR30-mediated endometrial carcinoma cell proliferation via the PTEN/PI3K/AKT signaling pathway. Cancer Lett. 2013;339:279-87 pubmed publisher
    ..This study suggests that Gankyrin is functional in endometrial cancer development. ..
  86. Jiang N, Shen Y, Fei X, Sheng K, Sun P, Qiu Y, et al. Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells. Cell Death Dis. 2013;4:e647 pubmed publisher
    ..5222, P<0.05). These findings demonstrated that VCP regulates DNA-PKcs degradation and increases the sensitivity of GBM cells to radiation. ..
  87. Liu H, Wang Q, Liu Y, Zhao X, Imaizumi T, Somers D, et al. Arabidopsis CRY2 and ZTL mediate blue-light regulation of the transcription factor CIB1 by distinct mechanisms. Proc Natl Acad Sci U S A. 2013;110:17582-7 pubmed publisher
    ..These results support the hypothesis that the evolutionarily unrelated blue-light receptors, cryptochrome and LOV-domain F-box proteins, mediate blue-light regulation of the same transcription factor by distinct mechanisms. ..
  88. Li M, Miao Z, Tan W, Yue J, Zhang C, Lin L, et al. Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation. Clin Cancer Res. 2004;10:8266-74 pubmed
    ..This study was to examine its angiogenic inhibition, impact on vascular endothelial growth factor (VEGF) secretion from tumor cells and the possible mechanism of action...
  89. Tan L, Fu X, Liu S, Li H, Hong Y, Wu M, et al. Expression of p28GANK and its correlation with RB in human hepatocellular carcinoma. Liver Int. 2005;25:667-76 pubmed
    ..Underlying nuclear translocation of p28GANK may contribute to the counteraction against RB through a feed back loop. These data provide new evidence for p28GANK to be used as a promising drug target of a therapeutic agent against HCC. ..
  90. Liu H, Qiu J, Li N, Chen T, Cao X. Human phosphatidylethanolamine-binding protein 4 promotes transactivation of estrogen receptor alpha (ERalpha) in human cancer cells by inhibiting proteasome-dependent ERalpha degradation via association with Src. J Biol Chem. 2010;285:21934-42 pubmed publisher
    ..Our data suggest that hPEBP4 inhibits proteasome-dependent ERalpha degradation through the Src pathway, thus enhancing ERalpha-mediated transactivation and promoting the proliferation of cancer cells in response to estrogen. ..
  91. Wu H, Lin Y, Shi Y, Qian W, Tian Z, Yu Y, et al. SIAH-1 interacts with mammalian polyhomeotic homologues HPH2 and affects its stability via the ubiquitin-proteasome pathway. Biochem Biophys Res Commun. 2010;397:391-6 pubmed publisher
    ..Thus, our results propose a novel role of SIAH-1 in regulating the expression level of HPH2 through the ubiquitin-proteasome pathway. ..
  92. Fan G, Zhou H, Yang H, Chen S. Heat shock proteins reduce alpha-synuclein aggregation induced by MPP+ in SK-N-SH cells. FEBS Lett. 2006;580:3091-8 pubmed
    ..These findings suggest that HSPs may inhibit the MPP+-induced alpha-synuclein expression, accelerate alpha-synuclein degradation, thereby reducing the amount of alpha-synuclein protein and accordingly preventing its aggregation. ..