Experts and Doctors on phosphoric diester hydrolases in Shanghai, Shanghai Shi, China


Locale: Shanghai, Shanghai Shi, China
Topic: phosphoric diester hydrolases

Top Publications

  1. Wu M, Ji C, Xu J, Zou X, Wang L, Zheng H, et al. A novel splice variant of human gene GDPD1 is mainly expressed in human ovary and small intestine. Int J Mol Med. 2003;12:1003-7 pubmed
    ..RT-PCR experiment revealed that our splice variant of the gene is mainly expressed in human ovary and small intestine, basically conforming to the result of serial analysis of gene expression. ..
  2. Lang Q, Zhang H, Li J, Yin H, Zhang Y, Tang W, et al. Cloning and characterization of a human GDPD domain-containing protein GDPD5. Mol Biol Rep. 2008;35:351-9 pubmed
    ..RT-PCR analysis showed that GDPD5 was widely expressed in human tissues and the expression levels in kidney and prostate were relatively low. ..
  3. Zhao T, Liu Z, Zhang D, Liu Y, Yang Y, Zhou D, et al. The ENPP1 K121Q polymorphism is not associated with type 2 diabetes or obesity in the Chinese Han population. J Hum Genet. 2011;56:12-6 pubmed publisher
    ..Our study did not replicate the positive association found previously and suggested that K121Q of ENPP1 might not have a major role in the susceptibility to T2D or obesity in the Chinese Han population. ..
  4. Cheng Y, Zhou W, El Sheery N, Peters C, Li M, Wang X, et al. Characterization of the Arabidopsis glycerophosphodiester phosphodiesterase (GDPD) family reveals a role of the plastid-localized AtGDPD1 in maintaining cellular phosphate homeostasis under phosphate starvation. Plant J. 2011;66:781-95 pubmed publisher
    ..Thus, we suggest that the GDPD-mediated lipid metabolic pathway may be involved in release of P(i) from phospholipids during P(i) starvation. ..
  5. Zhou C, Shen Q, Xue J, Ji C, Chen J. Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells. BMB Rep. 2013;46:113-8 pubmed
    ..These results may aid in clarifying the physiological functions of TTRAP, especially its roles in the regulation of cell growth and tumorigenesis. ..
  6. He Z, Zhu H, Ding L, Xiao H, Chen D, Xue F. Association of NPP1 polymorphism with postoperative progression of ossification of the posterior longitudinal ligament in Chinese patients. Genet Mol Res. 2013;12:4648-55 pubmed publisher
    ..Our findings suggest that the presence of specific genotypes of the IVS20-11delT and A533C SNPs may predict disease outcome after surgical intervention. ..
  7. Li H, Yue R, Wei B, Gao G, Du J, Pei G. Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis. EMBO J. 2014;33:1383-96 pubmed publisher
    ..Taken together, we identified LPA as an important nutrient-derived developmental cue for primitive hematopoiesis as well as a novel mechanism of hemangioblast regulation. ..
  8. Che R, Tang W, Zhang J, Wei Z, Zhang Z, Huang K, et al. No relationship between 2',3'-cyclic nucleotide 3'-phosphodiesterase and schizophrenia in the Chinese Han population: an expression study and meta-analysis. BMC Med Genet. 2009;10:31 pubmed publisher
    ..Our meta-analysis produced similar negative results. The results suggest that the CNP gene may not be involved in the etiology and pathology of schizophrenia in the Chinese population. ..
  9. Chen L, Chen D, Tang L, Ren J, Chen J, Zhen X, et al. Design and optimization of purine derivatives as in vivo active PDE10A inhibitors. Bioorg Med Chem. 2017;25:3315-3329 pubmed publisher
    ..And after further PDE enzymatic selectivity study, metabolic stability assay and in vivo pharmacological tests we identified two inhibitors as interesting lead compounds with the potential for further PDE10A lead optimizatioin. ..