Experts and Doctors on ophiopogon in Shanghai, Shanghai Shi, China

Summary

Locale: Shanghai, Shanghai Shi, China
Topic: ophiopogon

Top Publications

  1. Shen L, Xu D, Feng Y, Li X, Wu X. [Effect of intestinal bacteria on metabolism of ophiopognin saponin D' in rats]. Zhongguo Zhong Yao Za Zhi. 2005;30:618-20 pubmed
    ..To explore the metabolic transformation and the absorbed metabolites of ophiopognin saponin D' (OD') given orally in rats...
  2. Lin X, Xu D, Feng Y, Shen L. Determination of Ophiopogon japonicus polysaccharide in plasma by HPLC with modified postcolumn fluorescence derivatization. Anal Biochem. 2005;342:179-85 pubmed
    ..1 min) was quicker than that administered at 50mg/kg (28.9 min). This modified approach can also be used for microanalysis of both nonreducing oligosaccharides and other neutral polysaccharides...
  3. Xu D, Feng Y, Lin X, Deng H, Fang J, Dong Q. [Isolation, purification and structural analysis of a polysaccharide MDG-1 from Ophiopogon japonicus]. Yao Xue Xue Bao. 2005;40:636-9 pubmed
    ..To separate and purify the anti-myocardial ischemic polysaccharide fraction with a homogenous molecular weight from Ophiopogon japonicus, then study the chemical structure of the parts...
  4. Lin X, Xu D, Feng Y, Li S, Lu Z, Shen L. Release-controlling absorption enhancement of enterally administered Ophiopogon japonicus polysaccharide by sodium caprate in rats. J Pharm Sci. 2006;95:2534-42 pubmed
    ..The better the balance between the two opposite effects for drug absorption, the more effective absorption enhancement would be obtained...
  5. Lin X, Wang Z, Sun G, Shen L, Xu D, Feng Y. A sensitive and specific HPGPC-FD method for the study of pharmacokinetics and tissue distribution of Radix Ophiopogonis polysaccharide in rats. Biomed Chromatogr. 2010;24:820-5 pubmed publisher
  6. Lin X, Wang Z, Huang F, Liang S, Shen L, Feng Y, et al. Long-circulating delivery of bioactive polysaccharide from radix ophiopogonis by PEGylation. Int J Nanomedicine. 2011;6:2865-72 pubmed publisher
  7. Shen L, Feng Y, Xu D, Lin X. [Studies on using spray drying technique in preparing Ophiopogon japonicus saponin enteric microsphere by orthogonal experimental design]. Zhongguo Zhong Yao Za Zhi. 2006;31:1947-50 pubmed
    ..To explore the best technique parameters on preparing ophiopogon japonicus saponin enteric microsphere by spray drying technique...
  8. Zheng Q, Feng Y, Xu D. [Protective effect of Ophiopogonis polysaccharide MDG-1 on experimental myocardial ischemic rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27:1116-20 pubmed
    ..To investigate the protective effect of Ophiopogonis polysaccharide (MDG-1) on isolated myocardium ischemia/reperfusion injury (IRI) and subcutaneous injection of isoprenaline induced acute myocardial ischemia...
  9. Zheng Q, Feng Y, Xu D, Lin X, Chen Y. Influence of sulfation on anti-myocardial ischemic activity of Ophiopogon japonicus polysaccharide. J Asian Nat Prod Res. 2009;11:306-21 pubmed publisher
    ..05). And the obtained results from the further study also indicated that only when the degree of substitution was in a certain range, the FOJ-5-S had excellent anti-myocardial ischemic activity...

More Information

Publications14

  1. Lin X, Lu Z, Xu D, Feng Y, Shen L. [Oral absorption enhancers of Ophiopogon japonicas polysaccharides]. Zhongguo Zhong Yao Za Zhi. 2009;34:1498-502 pubmed
    ..To investigate suitable oral absorption enhancer (s) for Ophiopogon japonicas polysaccharides (OJP) and provide bases of utilizing the absorption enhancer to realize the oral administration of OJP...
  2. Lin X, Wang S, Jiang Y, Wang Z, Sun G, Xu D, et al. Poly(ethylene glycol)-radix Ophiopogonis polysaccharide conjugates: preparation, characterization, pharmacokinetics and in vitro bioactivity. Eur J Pharm Biopharm. 2010;76:230-7 pubmed publisher
    ..These findings demonstrate that PEGylation would be a promising approach for improving the clinical efficacy of ROP by prolonged retention in plasma...
  3. Xu J, Wang Y, Xu D, Ruan K, Feng Y, Wang S. Hypoglycemic effects of MDG-1, a polysaccharide derived from Ophiopogon japonicas, in the ob/ob mouse model of type 2 diabetes mellitus. Int J Biol Macromol. 2011;49:657-62 pubmed publisher
    ..MDG-1 had no significant effects on the total cholesterol and triglyceride levels, food intake and other adipose and organ tissues. These data suggest that MDG-1 exhibits hypoglycemic activity and reduces insulin resistance...
  4. Lin X, Wang Z, Wang S, Shen L, Feng Y, Ruan K, et al. Comparison of tissue distribution of a PEGylated Radix Ophiopogonis polysaccharide in mice with normal and ischemic myocardium. Eur J Pharm Biopharm. 2011;79:621-6 pubmed publisher
    ..6, and 1.3 times, respectively, whereas it was increased by approximately 1.3-fold in the liver. The results of this study are highly instructive for the further pharmaceutical development of PEGylated ROP...
  5. Wang L, Wang Y, Xu D, Ruan K, Feng Y, Wang S. MDG-1, a polysaccharide from Ophiopogon japonicus exerts hypoglycemic effects through the PI3K/Akt pathway in a diabetic KKAy mouse model. J Ethnopharmacol. 2012;143:347-54 pubmed publisher
    ..Ophiopogon japonicus is a traditional Chinese medicine that might be helpful for the treatment of type 2 diabetes. Recent studies have confirmed its beneficial properties, but not the mechanism of action...