Experts and Doctors on liver neoplasms in Shanghai, Shanghai Shi, China

Summary

Locale: Shanghai, Shanghai Shi, China
Topic: liver neoplasms

Top Publications

  1. Cui J, Zhou X, Liu Y, Tang Z, Romeih M. Wnt signaling in hepatocellular carcinoma: analysis of mutation and expression of beta-catenin, T-cell factor-4 and glycogen synthase kinase 3-beta genes. J Gastroenterol Hepatol. 2003;18:280-7 pubmed
    ..Our present findings strongly suggest that mutations of beta-catenin, as well as overexpression of beta-catenin and the Tcf-4 gene, independently activate the Wnt pathway in HCC, with the target gene most likely to be C-myc. ..
  2. Huang X, Ji G, Wu Y, Wan B, Yu L. LAMA4, highly expressed in human hepatocellular carcinoma from Chinese patients, is a novel marker of tumor invasion and metastasis. J Cancer Res Clin Oncol. 2008;134:705-14 pubmed
    ..Therefore, we hypothesize that LAMA4 is probably a novel supplementary marker for HCC diagnosis, and might be a molecular target in the future cancer therapy. ..
  3. Jia J, Zhuang P, Sun H, Zhang J, Zhang W, Zhu X, et al. Protein expression profiling of vascular endothelial growth factor and its receptors identifies subclasses of hepatocellular carcinoma and predicts survival. J Cancer Res Clin Oncol. 2009;135:847-54 pubmed publisher
    ..Seven biomarkers predicted patients' RFP, which consisted of tumoral expression of VEGF-A, VEGFR-1, and VEGF-C as well as peritumoral expression of VEGF-A, VEGFR-1, VEGFR-2, and VEGFR-3. ..
  4. Wu X, Tao R, Lei R, Han B, Cheng D, Shen B, et al. Distal pancreatectomy combined with celiac axis resection in treatment of carcinoma of the body/tail of the pancreas: a single-center experience. Ann Surg Oncol. 2010;17:1359-66 pubmed publisher
    ..DP combined with CA resection can be safely performed in certain patients with carcinoma of body/tail of the pancreas and significantly improves patient survival and quality of life. ..
  5. Xiong W, Ren Z, Qiu S, Sun H, Wang L, Liu B, et al. Residual hepatocellular carcinoma after oxaliplatin treatment has increased metastatic potential in a nude mouse model and is attenuated by Songyou Yin. BMC Cancer. 2010;10:219 pubmed publisher
    ..13/15 and 3/15 vs. 13/15, respectively). The surviving HCC after oxaliplatin treatment underwent EMT and demonstrated increased metastatic potential. Attenuation of EMT by Songyou Yin may improve the efficacy of chemotherapy in HCC. ..
  6. Li G, Ye Q, Xue Y, Sun H, Zhou H, Ren N, et al. Human mesenchymal stem cells inhibit metastasis of a hepatocellular carcinoma model using the MHCC97-H cell line. Cancer Sci. 2010;101:2546-53 pubmed publisher
    ..The MSC enhanced tumor growth but significantly inhibited the invasiveness and metastasis of HCC, possibly through downregulation of TGF?1. These findings suggest that MSC could be useful in controlling metastatic recurrence of HCC. ..
  7. Jia D, Wei L, Guo W, Zha R, Bao M, Chen Z, et al. Genome-wide copy number analyses identified novel cancer genes in hepatocellular carcinoma. Hepatology. 2011;54:1227-36 pubmed publisher
    ..These results showed that integration of genomic and transcriptional data offers powerful potential for identifying novel cancer genes in HCC pathogenesis. ..
  8. Yang Z, Zhang L, Ma A, Liu L, Li J, Gu J, et al. Transient mTOR inhibition facilitates continuous growth of liver tumors by modulating the maintenance of CD133+ cell populations. PLoS ONE. 2011;6:e28405 pubmed publisher
    ..These results may be valuable for the design of more rational strategies to control clinical malignant HCC using mTOR inhibitors. ..
  9. Guo Q, Guo B, Wang Y, Wu J, Jiang W, Zhao S, et al. Functional analysis of ?1,3/4-fucosyltransferase VI in human hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2012;417:311-7 pubmed publisher
    ..Bath application of the PI3K inhibitor blocked FUT6-induced Akt phosphorylation, p21 suppression and cell proliferation. Our results suggest that FUT6 plays an important role in HCC growth by regulating the PI3K/Akt signaling pathway. ..

More Information

Publications257 found, 100 shown here

  1. Huang C, Ding G, Gu C, Zhou J, Kuang M, Ji Y, et al. Decreased selenium-binding protein 1 enhances glutathione peroxidase 1 activity and downregulates HIF-1? to promote hepatocellular carcinoma invasiveness. Clin Cancer Res. 2012;18:3042-53 pubmed publisher
  2. Han Z. Functional genomic studies: insights into the pathogenesis of liver cancer. Annu Rev Genomics Hum Genet. 2012;13:171-205 pubmed publisher
  3. Yang S, Nie A, Zhang L, Yan G, Yao J, Xie L, et al. A novel quantitative proteomics workflow by isobaric terminal labeling. J Proteomics. 2012;75:5797-806 pubmed publisher
    ..Given its simplicity, low-cost, and accuracy, QITL can be widely applied in biological samples (cell lines, tissues, and body fluids, etc.) for quantitative proteomic research. ..
  4. Dong Q, Zhang X, Zhao Y, Jia H, Zhou H, Dai C, et al. Osteopontin promoter polymorphisms at locus -443 significantly affect the metastasis and prognosis of human hepatocellular carcinoma. Hepatology. 2013;57:1024-34 pubmed publisher
    ..05). The genetic variation at locus -443 of the OPN promoter plays important roles in the regulation of OPN expression and cancer progression of HCCs, which is a novel determinant and target for HCC metastasis and prognosis. ..
  5. Jin C, Ye Q, Yuan F, Gu Y, Li J, Shi Y, et al. Involvement of acid-sensing ion channel 1α in hepatic carcinoma cell migration and invasion. Tumour Biol. 2015;36:4309-17 pubmed publisher
    ..Suppression of ASIC1α expression by RNAi attenuated the malignant phenotype of HCC cells, suggesting a novel approach for anticancer gene therapy. ..
  6. Wang Z, Liu L, Liu X, Hu J, Wu Y, Shi J, et al. Genetic polymorphisms of the multidrug resistance 1 gene MDR1 and the risk of hepatocellular carcinoma. Tumour Biol. 2015;36:7007-15 pubmed publisher
    ..In conclusion, the present meta-analysis suggested that the presence of MDR1 mutant alleles might be a risk factor for HCC. ..
  7. Li Q, Li Y, Xu J, Wang S, Xu Y, Li X, et al. Aldolase B Overexpression is Associated with Poor Prognosis and Promotes Tumor Progression by Epithelial-Mesenchymal Transition in Colorectal Adenocarcinoma. Cell Physiol Biochem. 2017;42:397-406 pubmed publisher
    ..Upregulation of ALDOB promotes colorectal cancer metastasis by facilitating EMT and acts as a potential prognostic factor and therapeutic target in colorectal cancer. ..
  8. Shi L, Tang C, Yin C. Glycyrrhizin-modified O-carboxymethyl chitosan nanoparticles as drug vehicles targeting hepatocellular carcinoma. Biomaterials. 2012;33:7594-604 pubmed publisher
    ..0%) and PTX injection (34.5%). CMCNP-GL with different substitution degrees possessed similar targeting property and therapeutic efficacy. Furthermore, toxicity studies suggested that blank CMCNP-GL had no systemic or hepatic toxicity. ..
  9. Wang P, Dong Q, Zhang C, Kuan P, Liu Y, Jeck W, et al. Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Oncogene. 2013;32:3091-100 pubmed publisher
  10. Zhu K, Pan Q, Zhang X, Kong L, Fan J, Dai Z, et al. MiR-146a enhances angiogenic activity of endothelial cells in hepatocellular carcinoma by promoting PDGFRA expression. Carcinogenesis. 2013;34:2071-9 pubmed publisher
    ..These results suggest that miR-146a plays a key role in regulating the angiogenic activity of ECs in HCC through miR-146a-BRCA1-PDGFRA pathway. MiR-146a and PDGFRA may emerge as potential anti-angiogenic targets on ECs for HCC therapy. ..
  11. Wang Y, Huang L, Sun W, Zhang Z, Fang J, Wei B, et al. Insulin receptor tyrosine kinase substrate activates EGFR/ERK signalling pathway and promotes cell proliferation of hepatocellular carcinoma. Cancer Lett. 2013;337:96-106 pubmed publisher
    ..Taken together, these data demonstrate that IRTKS promotes the proliferation of HCC cells by enhancing EGFR-ERK signalling pathway. ..
  12. Huang P, Xu X, Wang L, Zhu B, Wang X, Xia J. The role of EGF-EGFR signalling pathway in hepatocellular carcinoma inflammatory microenvironment. J Cell Mol Med. 2014;18:218-30 pubmed publisher
    ..CXCL5 could interact with CXCL8, possibly by CXCR2 or the cross-talk between CXCR2 and EGFR. EGF-EGFR signaling pathway can be the potential target of therapies for HCC. ..
  13. Dong Y, Zhu Z, Wang W, Mao F, Ji Z. Ultrasound features of hepatocellular adenoma and the additional value of contrast-enhanced ultrasound. Hepatobiliary Pancreat Dis Int. 2016;15:48-54 pubmed
  14. Wu W, Sun H, Gao Y, Li Y, Wang L, Zhou K, et al. Reduction in p48-ISGFgamma levels confers resistance to interferon-alpha2a in MHCC97 cells. Oncology. 2004;67:428-40 pubmed
    ..Our results confirm the important role of Jak/STATS signaling in the antiproliferative effects of IFN-alpha in tumor cells and indicate that defects in ISGF3 can cause resistance to IFN-alpha(2a) treatment. ..
  15. Zhang Y, Liu W, Li Q, Chen X, Liu B, Zhu Z. [Cloning and functional analysis of the tumor metastasis related gene tropomyosin2]. Zhonghua Zhong Liu Za Zhi. 2007;29:644-8 pubmed
    ..7 +/- 3.7). The tumor volume was (241.5 +/- 95.1) mm3, significantly higher than that in blank-vector controls (100.6 +/- 85.4) mm3 and negative-controls (123.7 +/- 92.3) mm3. TM2 plays a role in growth and metastasis of hepatic tumor. ..
  16. Zhang X, Liu S, Hu T, Liu S, He Y, Sun S. Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression. Hepatology. 2009;50:490-9 pubmed publisher
    ..The present study provides a better understanding of the specificity of the biological behavior and thus may be helpful in developing an effective treatment against HBV-HCC. ..
  17. Li Y, Wang Y, Taniguchi T, Kawakami T, Baba T, Ishibashi H, et al. Identification of stemonamide synthetic intermediates as a novel potent anticancer drug with an apoptosis-inducing ability. Int J Cancer. 2010;127:474-84 pubmed publisher
    ..These observations indicate that the chemicals and its related compounds may be effective for the treatment of tumors of endoderm-derived organs, particularly the pancreas. ..
  18. Jia J, Wang W, Sun H, Liu L, Zhu X, Kong L, et al. A novel tripeptide, tyroserleutide, inhibits irradiation-induced invasiveness and metastasis of hepatocellular carcinoma in nude mice. Invest New Drugs. 2011;29:861-72 pubmed publisher
    ..YSL may have potential as a new antimetastasis agent for radiotherapy. ..
  19. Liu L, Zhu X, Wang W, Shen Y, Qin Y, Ren Z, et al. Activation of beta-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis. Clin Cancer Res. 2010;16:2740-50 pubmed publisher
    ..034), and coexpression of beta-catenin and HIF-1alpha in HCC was correlated with shorter overall survival and time to recurrence. beta-Catenin in HCC is activated by hypoxia and contributes to hypoxia-induced metastatic potential. ..
  20. Wang B, Huang G, Wang D, Li A, Xu Z, Dong R, et al. Null genotypes of GSTM1 and GSTT1 contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis. J Hepatol. 2010;53:508-18 pubmed publisher
    ..001). This meta-analysis suggests null genotypes of GSTM1 and GSTT1 are both associated with increased HCC risk in Asians, and individuals with the dual null genotype of GSTM1/GSTT1 are particularly susceptible to developing HCC. ..
  21. Guo Y, Yu W, Shen X. Tumor necrosis factor rs361525 (-238G>A) polymorphism contributes to hepatocellular carcinoma susceptibility. Saudi Med J. 2010;31:1101-5 pubmed
    ..253). Neither heterogeneity nor publication bias was detected when analyses were performed on all 4 models. This meta-analysis supports TNF rs361525 (-238G>A) polymorphism being associated with HCC in an Asian population. ..
  22. Yin J, Xie J, Liu S, Zhang H, Han L, Lu W, et al. Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma. Am J Gastroenterol. 2011;106:81-92 pubmed publisher
    ..C1673T, A1726C, A1727T, C1730G, C1766T, T1768A, C1773T, and C1799G in genotype C are specific for cirrhosis. A1846T and T1674C/G are novel factors independently associated with cirrhosis and HCC, respectively. ..
  23. Xiang Z, Zeng Z, Tang Z, Fan J, Sun H, Tan Y. Expression of cytokeratin 19 and matrix metalloproteinase 2 predicts lymph node metastasis in hepatocellular carcinoma. Mol Biol Rep. 2011;38:3531-9 pubmed publisher
    ..001), MMP-2 expression (P = 0.006), and UICC T stage (P < 0.001) were independent risk factors for developing LNM in HCC. These findings show that CK19 and MMP-2 expression may be beneficial in predicting HCC LNM and survival. ..
  24. Li L, Chen J, Wu X, Wang P, Peng Q. Plasmonic gold nanorods can carry sulfonated aluminum phthalocyanine to improve photodynamic detection and therapy of cancers. J Phys Chem B. 2010;114:17194-200 pubmed publisher
    ..In addition, the loaded AlPcS can be photothermally released from AuNRs in the cells by the irradiation with an 800 nm femtosecond laser, demonstrating the potential for controlled drug release. ..
  25. Yu Y, Shen H, Yu H, Zhong F, Zhang Y, Zhang C, et al. Systematic proteomic analysis of human hepotacellular carcinoma cells reveals molecular pathways and networks involved in metastasis. Mol Biosyst. 2011;7:1908-16 pubmed publisher
    ..This work provides a demonstration that a combination of bioinformatics and comparative proteomics can help in finding out potential biomarkers associated with HCC metastasis on the level of pathways. ..
  26. Cao L, Zhou Y, Zhai B, Liao J, Xu W, Zhang R, et al. Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines. BMC Gastroenterol. 2011;11:71 pubmed publisher
    ..Nonadherent tumor spheres from hepatoma cell lines cultured in stem cell conditioned medium possess liver CSC properties, and the CSL-independent Notch signaling pathway may play a role in liver CSCs. ..
  27. Zhou Y, Yin X, Ying J, Zhang B. Golgi protein 73 versus alpha-fetoprotein as a biomarker for hepatocellular carcinoma: a diagnostic meta-analysis. BMC Cancer. 2012;12:17 pubmed publisher
    ..0.86 (95%CI 0.84-0.87). The current evidence indicates that serum GP73 has a comparable accuracy to AFP for the diagnosis of HCC, while the value of serum GP73 in combination with AFP for HCC detection deserves further investigation. ..
  28. Guo X, Li D, Hu F, Song J, Zhang S, Deng W, et al. Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells. Cancer Lett. 2012;320:171-9 pubmed publisher
    ..This study suggests that autophagy is a potential novel target to improve therapy efficiency of conventional chemotherapeutics towards HCC. ..
  29. Ao J, Meng J, Zhu L, Nie H, Yang C, Li J, et al. Activation of androgen receptor induces ID1 and promotes hepatocellular carcinoma cell migration and invasion. Mol Oncol. 2012;6:507-15 pubmed publisher
    ..An AR antagonist was able to block this process, suggesting that AR activation in AR-positive HCC may be therapeutically inhibited as a potential intervention strategy. ..
  30. Wang L, Feng J, Da L, Li Y, Li Z, Zhao M. Adenovirus-mediated delivery of siRNA targeting TM4SF4 attenuated liver cancer cell growth in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai). 2013;45:213-9 pubmed publisher
    ..Our results indicated that targeting TM4SF4 might be a promising modality for inhibition of HCC. ..
  31. Lou X, Qi X, Zhang Y, Long H, Yang J. Decreased expression of microRNA-625 is associated with tumor metastasis and poor prognosis in patients with colorectal cancer. J Surg Oncol. 2013;108:230-5 pubmed publisher
    ..Our results suggest that miR-625 may serve as an efficient clinical biomarker and a therapeutic tool for the inhibition of metastasis in CRC. ..
  32. Lian J, Jing Y, Dong Q, Huan L, Chen D, Bao C, et al. miR-192, a prognostic indicator, targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma. Oncotarget. 2016;7:2672-83 pubmed publisher
    ..This axis provided insights into the mechanism underlying miRNA regulation of HCC metastasis and a novel therapeutic target for HCC treatment. ..
  33. Zhang L, Li Z, Sun F, Xu Y, Du Z. Effect of inserted spacer in hepatic cell-penetrating multifunctional peptide component on the DNA intracellular delivery of quaternary complexes based on modular design. Int J Nanomedicine. 2016;11:6283-6295 pubmed
    ..The present study contributed to the structural understanding of Q-complexes, and further effective modification is in progress. ..
  34. Liu H, Cui B, Xu Y, Hu C, Liu Y, Qu G, et al. Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017;277:21-32 pubmed publisher
    ..These metabolomic and transcriptomic biomarkers of EC on human cell metabolism identified in this study would facilitate further studies on the risk assessment and the mitigation of dietary EC. ..
  35. He H, Dai F, Yu L, She X, Zhao Y, Jiang J, et al. Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues. Gene Expr. 2002;10:231-42 pubmed
    ..The above findings could be valuable for understanding the vesicular transport system and elucidating the molecular basis of liver cancer carcinogenesis. ..
  36. Liang Y, Lei T, Wu H, Su J, Wang L, Lei Q, et al. S-phase delay in human hepatocellular carcinoma cells induced by overexpression of integrin beta1. World J Gastroenterol. 2003;9:1689-96 pubmed
  37. Lou B, Liao X, Wu M, Cheng P, Yin C, Fei Z. High-density lipoprotein as a potential carrier for delivery of a lipophilic antitumoral drug into hepatoma cells. World J Gastroenterol. 2005;11:954-9 pubmed
    ..HDL is a potential carrier for delivering lipophilic antitumoral drug to hepatoma cells. ..
  38. Ma D, Xu Z, Liang Y, Su J, Li Z, Zhang W, et al. Down-regulation of PTEN expression due to loss of promoter activity in human hepatocellular carcinoma cell lines. World J Gastroenterol. 2005;11:4472-7 pubmed
    ..Furthermore, the sequence analysis of 8 cells lines showed no mutation in the region of PTEN promoter and PTEN cDNA. PTEN expression is down-regulated in HCC cell lines probably due to loss of activity of PTEN promoter. ..
  39. Lian M, Liu Y, Yu S, Qian G, Wan S, Dixon K. Hepatitis B virus x gene and cyanobacterial toxins promote aflatoxin B1-induced hepatotumorigenesis in mice. World J Gastroenterol. 2006;12:3065-72 pubmed
    ..Co-exposure to AFB1 and MC-LR tends to elevate the risk of liver tumors at 24 wk relative to exposure to one of them. The combinative effect of AFB1, cyanotoxins and HBVx on hepatotumorigenesis is weak at 24 wk. ..
  40. Hu Y, Li Z, Guo L, Wang L, Zhang L, Cai X, et al. MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells. Arch Biochem Biophys. 2007;467:1-9 pubmed
    ..Finally, the molecular association between PTEN and MAGI-2 was confirmed. Our results suggested that PTEN played a critical role in MAGI-2-induced inhibition of cell migration and proliferation in HHCCs. ..
  41. Cheng H, Wang X, Zhao G, Chen D. Imaging findings and transcatheter arterial chemoembolization of hepatic malignancy with right atrial embolus in 46 patients. World J Gastroenterol. 2008;14:3563-8 pubmed
    ..Encroachment of the RA is very rare in patients with hepatic malignancies. Furthermore, a prolongation of survival time is found in those patients who underwent TACE. ..
  42. Zheng D, Zhang L, Cheng N, Xu X, Deng Q, Teng X, et al. Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A. J Hepatol. 2009;50:377-87 pubmed publisher
  43. Yang Y, Zhou F, Fang Z, Wang L, Li Z, Sun L, et al. Post-transcriptional and post-translational regulation of PTEN by transforming growth factor-beta1. J Cell Biochem. 2009;106:1102-12 pubmed publisher
  44. Huang J, Zheng D, Qin F, Cheng N, Chen H, Wan B, et al. Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. J Clin Invest. 2010;120:223-41 pubmed publisher
    ..Taken together, these data suggest that the plasma membrane protein SCARA5 can contribute to HCC tumorigenesis and metastasis via activation of the FAK signaling pathway. ..
  45. Xue Y, Zhang X, Dong Q, Sun J, Dai C, Zhou H, et al. Thrombin is a therapeutic target for metastatic osteopontin-positive hepatocellular carcinoma. Hepatology. 2010;52:2012-22 pubmed publisher
    ..Thus, thrombin may be a potential therapeutic target to inhibit HCC metastasis in OPN+ patients. ..
  46. Chen R, Xia Y, Xue T, Zhang H, Ye S. Down-regulation of osteopontin inhibits metastasis of hepatocellular carcinoma cells via a mechanism involving MMP-2 and uPA. Oncol Rep. 2011;25:803-8 pubmed publisher
    ..These findings suggest that OPN-targeted therapy may be a promising strategy for the treatment of HCC metastases. ..
  47. Wang Z, Song L, Guo L, Yin M, Sun Y. Induction of differentiation by panaxydol in human hepatocarcinoma SMMC-7721 cells via cAMP and MAP kinase dependent mechanism. Yakugaku Zasshi. 2011;131:993-1000 pubmed
    ..It suggested panaxydol might be of value for further exploration as a potential anti-cancer agent via cAMP and MAP kinase-dependent mechanism. ..
  48. Sun Y, Yang X, Zhou J, Qiu S, Fan J, Xu Y. Circulating tumor cells: advances in detection methods, biological issues, and clinical relevance. J Cancer Res Clin Oncol. 2011;137:1151-73 pubmed publisher
  49. Xu H, Huang W, Cai Y, Ding M, Gu J, Wei N, et al. HCCS1-armed, quadruple-regulated oncolytic adenovirus specific for liver cancer as a cancer targeting gene-viro-therapy strategy. Mol Cancer. 2011;10:133 pubmed publisher
    ..SPDD-HCCS1 was able to elicit reduced toxicity and enhanced efficacy both in vitro and in vivo compared to a previously constructed oncolytic adenovirus. Ad.SPDD-HCCS1 could be a promising candidate for liver cancer therapy. ..
  50. Liao J, Zhang R, Qian H, Cao L, Zhang Y, Xu W, et al. Serum profiling based on fucosylated glycoproteins for differentiating between chronic hepatitis B and hepatocellular carcinoma. Biochem Biophys Res Commun. 2012;420:308-14 pubmed publisher
    ..In conclusion, serum glycoprotein fucosylation abnormalities have diverse forms in patients with HCC. MALDI-TOF MS profiling of aberrant serum fucosylated glycoproteins distinguished HCC from controls with high accuracy. ..
  51. Chen J, Shen B, Deng X, Zhan Q, Peng C. SKP1-CULLIN1-F-box (SCF)-mediated DRG2 degradation facilitated chemotherapeutic drugs induced apoptosis in hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2012;420:651-5 pubmed publisher
    ..Taken together, these results demonstrate that regulated degradation of DRG2 has a role in chemotherapeutic drug induced hepatocellular carcinoma cells apoptosis. ..
  52. Zhang J, Lai E, Zhou W, Fu S, Pan Z, Yang Y, et al. Selective hepatic vascular exclusion versus Pringle manoeuvre in liver resection for tumours encroaching on major hepatic veins. Br J Surg. 2012;99:973-7 pubmed publisher
    ..SHVE was more efficacious than the Pringle manoeuvre in minimizing intraoperative bleeding and air embolism during partial hepatectomy for tumours encroaching on major hepatic veins, and decreased the postoperative liver failure rate. ..
  53. Qu X, Chen C, Wang J, Yan Z, Chen J, Gong G, et al. The efficacy of TACE combined sorafenib in advanced stages hepatocellullar carcinoma. BMC Cancer. 2012;12:263 pubmed publisher
    ..Of CTCAE grade IV or V toxicity was observed. TACE combined sorafenib significantly prolonged median overall survival time of patients with advanced HCC. ..
  54. Yang T, Cai S, Zhang J, Lu J, Lin C, Zhai J, et al. Krüppel-like factor 8 is a new Wnt/beta-catenin signaling target gene and regulator in hepatocellular carcinoma. PLoS ONE. 2012;7:e39668 pubmed publisher
    ..Knockdown of ?-catenin by shRNA rescues the enhanced HepG2 and Hep3B cells proliferation ability induced by overexpression of KLF8. ..
  55. Zhou Z, Dai Z, Zhou S, Fu X, Zhao Y, Shi Y, et al. Overexpression of HnRNP A1 promotes tumor invasion through regulating CD44v6 and indicates poor prognosis for hepatocellular carcinoma. Int J Cancer. 2013;132:1080-9 pubmed publisher
    ..In conclusion, overexpression of hnRNP A1 promotes HCC invasion by regulating the level of CD44v6 and indicates a poor prognosis for HCC patients after curative resection. ..
  56. Shen H, Zhu H, Yang C, Ji F. SENP2 regulates hepatocellular carcinoma cell growth by modulating the stability of ?-catenin. Asian Pac J Cancer Prev. 2012;13:3583-7 pubmed
    ..Our results suggest that SENP2 might play a role in hepatocellular carcinoma cell growth control by modulating the stability of ?-catenin. ..
  57. Yang Y, Xia T, Li N, Zhang J, Yang Y, Cong W, et al. Combined effects of p53 and MDM2 polymorphisms on susceptibility and surgical prognosis in hepatitis B virus-related hepatocellular carcinoma. Protein Cell. 2013;4:71-81 pubmed publisher
    ..05). Thus, the combined p53 Pro/Pro and MDM2 G/G genotype is associated with increased risk of developing HCC and is an independent adverse prognostic indicator in early stage HCC. ..
  58. Gui X, Li H, Li T, Pu H, Lu D. Long Noncoding RNA CUDR Regulates HULC and β-Catenin to Govern Human Liver Stem Cell Malignant Differentiation. Mol Ther. 2015;23:1843-53 pubmed publisher
  59. Jia Q, Dong Q, Qin L. CCN: core regulatory proteins in the microenvironment that affect the metastasis of hepatocellular carcinoma?. Oncotarget. 2016;7:1203-14 pubmed publisher
    ..We also propose that the CCN family proteins may play a central role in signaling the tumor microenvironment and regulating the metastasis of HCC. ..
  60. Wang X, Yuan Z, Zheng L, Yu F, Xiong W, Liu J, et al. Gene expression profiles in an hepatitis B virus transfected hepatoblastoma cell line and differentially regulated gene expression by interferon-alpha. World J Gastroenterol. 2004;10:1740-5 pubmed
    ..These down-regulated genes identified by microarray analysis could serve as new targets for anti-HBV drug development or for novel therapies. ..
  61. Lei K, Wang Y, Zhu X, Lu P, Sun B, Jia H, et al. Identification of MSRA gene on chromosome 8p as a candidate metastasis suppressor for human hepatitis B virus-positive hepatocellular carcinoma. BMC Cancer. 2007;7:172 pubmed
    ..33 +/- 2.92 vs. 9.17 +/- 3.38, p = 0.008) and invasion (7.40 +/- 1.67 vs. 17.20 +/- 2.59, p= 0.0001) of HCCLM6 cell line. MSRA gene on chromosome 8p might possess metastasis suppressor activity in HCC. ..
  62. Wang C, Qi R, Li N, Wang Z, An H, Zhang Q, et al. Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression. J Biol Chem. 2009;284:16183-90 pubmed publisher
    ..Thus, our results suggest that activation of Notch1 signaling may be a promising approach to improve the therapeutic efficacy of TRAIL-resistant HCC. ..
  63. Gan L, Guo K, Li Y, Kang X, Sun L, Shu H, et al. Up-regulated expression of stathmin may be associated with hepatocarcinogenesis. Oncol Rep. 2010;23:1037-43 pubmed
    ..Stathmin expression correlates with hepatocarcinogenesis and tumor progression. This molecule may be a promising therapeutic target in patients with hepatocellular carcinoma. ..
  64. Wang K, Liu J, Yan Z, Li J, Shi L, Cong W, et al. Overexpression of aspartyl-(asparaginyl)-beta-hydroxylase in hepatocellular carcinoma is associated with worse surgical outcome. Hepatology. 2010;52:164-73 pubmed publisher
    ..7 +/- 1.6 versus 51.9 +/- 2.8 months, and the 1- and 3- year survival rates were 97% and 52% versus 100% and 90% in AAH overexpression and underexpression patients, respectively (P < 0.001 for both)...
  65. Li J, Yang X, Sun H, Xu Y, Zhou J, Qiu S, et al. Up-regulation of Krüppel-like factor 8 promotes tumor invasion and indicates poor prognosis for hepatocellular carcinoma. Gastroenterology. 2010;139:2146-2157.e12 pubmed publisher
    ..KLF8 up-regulation might be used to indicate poor prognosis or early recurrence of cancer in patients who have had surgery for HCC. ..
  66. Zhao Q, Guo Y, Feng B, Li L, Huang C, Jiao B. Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Fitoterapia. 2011;82:735-41 pubmed publisher
    ..Based on these results, neriifolin could be considered a candidate for the treatment of hepatocellular carcinoma. ..
  67. Xu W, Cao L, Chen L, Li J, Zhang X, Qian H, et al. Isolation of circulating tumor cells in patients with hepatocellular carcinoma using a novel cell separation strategy. Clin Cancer Res. 2011;17:3783-93 pubmed publisher
    ..It is likely clinically useful in diagnosis and monitoring of HCC and may have a role in clinical decision making. ..
  68. Xing Z, Tang X, Gao Y, Da L, Song H, Wang S, et al. The human LIS1 is downregulated in hepatocellular carcinoma and plays a tumor suppressor function. Biochem Biophys Res Commun. 2011;409:193-9 pubmed publisher
    ..Our results suggest that LIS1 plays a potential tumor suppressor role in the development and progression of HCC. ..
  69. Chen L, Zheng J, Zhang Y, Yang L, Wang J, Ni J, et al. Tumor-specific expression of microRNA-26a suppresses human hepatocellular carcinoma growth via cyclin-dependent and -independent pathways. Mol Ther. 2011;19:1521-8 pubmed publisher
    ..Moreover, hAFP-TERT dual promoter-mediated miR-26a expression could specifically exert potential antitumor activity and provide a novel targeting approach for cancer therapy. ..
  70. He Y, Cui Y, Wang W, Gu J, Guo S, Ma K, et al. Hypomethylation of the hsa-miR-191 locus causes high expression of hsa-mir-191 and promotes the epithelial-to-mesenchymal transition in hepatocellular carcinoma. Neoplasia. 2011;13:841-53 pubmed
    ..Our results suggest that hsa-miR-191 locus hypomethylation causes an increase in hsa-miR-191 expression in HCC clinical tissues and that this expression induces HCC cells to transition into mesenchymal-like cells. ..
  71. Liu X, Sheng W, Wang Y. An analysis of clinicopathological features and prognosis by comparing hepatoid adenocarcinoma of the stomach with AFP-producing gastric cancer. J Surg Oncol. 2012;106:299-303 pubmed publisher
    ..01). AFP-producing gastric cancer and HAS had more aggressive behavior than that of common gastric cancer. The prognosis of HAS was poorer than that of AFPPGC, therefore it should be distinguished from the latter. ..
  72. Luo Z, Yu G, Lee H, Li L, Wang L, Yang D, et al. The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth. Cancer Res. 2012;72:3360-71 pubmed publisher
    ..Together, our findings support the clinical investigation of MLN4924 for liver cancer treatment and provide a preclinical proof-of-concept for combination therapy with an autophagy inhibitor to enhance therapeutic efficacy. ..
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    ..RAI16 could activate the phosphorylation of ERK1/2 and SMAD2/3. In conclusion, RAI16 may serve as a useful therapeutic agent for HCC gene therapy and tumor marker for HCC diagnosis. ..
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    ..Therefore, our study has revealed a novel suppressor role of TCP10L in HCC, by inhibiting proliferation of HCC cells, which may facilitate the diagnosis and molecular therapy in HCC. ..
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    ..To conclude, these findings demonstrated that DBC1 was essential in tumorigenesis and proliferation. Moreover, it was identified as a potential therapeutic target for HCC...
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    ..004, OR 95%CI:1.03-11.22). But no interaction was found between NAT2 and any environmental risk factors. The polymorphisms of NAT1 and NAT2 are not susceptible to PLC in Luoyang. Allele NAT1*10 interacts with occupational exposures. ..
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    ..Together, these results suggested that overexpression of integrin beta1 inhibited cell proliferation by preventing the Skp2-dependent degradation of p27(Kip1) via PI3K pathway. ..
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    ..31, 95% CI 1.03-1.66). These results suggested that the A/A genotype and A allele of rs231775 increased the risk of developing HBV-related HCC in a male Chinese population. ..
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    ..To investigate the effects of palliative liver resection on metastatic potential and its gene function net of residual hepatocellular carcinoma (HCC) in nude mice model...