Experts and Doctors on leptin in Shanghai, Shanghai Shi, China


Locale: Shanghai, Shanghai Shi, China
Topic: leptin

Top Publications

  1. Wu X, Yan Q, Zhang Z, Du G, Wan X. Acrp30 inhibits leptin-induced metastasis by downregulating the JAK/STAT3 pathway via AMPK activation in aggressive SPEC-2 endometrial cancer cells. Oncol Rep. 2012;27:1488-96 pubmed publisher
    ..In conclusion, we demonstrated that Acrp30 effectively reversed the invasion stimulated by leptin, and AMPK and JAK/STAT3 pathways mediated the invasive phenotype of SPEC-2 cells. ..
  2. Liu J, Zhao H, Ning G, Chen Y, Zhang L, Sun L, et al. IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women. J Bone Miner Metab. 2008;26:159-64 pubmed publisher
    ..17, P < 0.001). In conclusion, measurement of serum IGF-1 in young women may help in the early identification of those at risk for developing low bone mass and osteoporosis. ..
  3. Cai W, Yu L, Zhang Y, Feng L, Kong S, Tan H, et al. Extracts of Coreopsis tinctoria Nutt. Flower Exhibit Antidiabetic Effects via the Inhibition of ?-Glucosidase Activity. J Diabetes Res. 2016;2016:2340276 pubmed publisher
    ..The underling mechanism may be via the inhibition of ?-glucosidase activity. Our data indicate that Coreopsis tinctoria flower could be used as a beverage supplement and a potential source of drugs for treatment of diabetics. ..
  4. Li X, Wang S, Jiang L, Dai L. Stage specific effect of leptin on the expressions of estrogen receptor and extracellular matrix in a model of chondrocyte differentiation. Cytokine. 2013;61:876-84 pubmed publisher
    ..In summary, the crosstalk between leptin and estrogen receptor might be differentiation stage specific in ATDC5 cells. ..
  5. Jiang L, Zhang Z, Jiang S, Chen W, Dai L. Differential bone metabolism between postmenopausal women with osteoarthritis and osteoporosis. J Bone Miner Res. 2008;23:475-83 pubmed
    ..Differential levels of bone remodeling markers, leptin, FLI, and OPG may partly contribute to the proposed inverse relationship. Roles of leptin and its soluble receptor in bone metabolism regulation should be explored further. ..
  6. He L, Pan Y, He G, Lin B, Liao C, Zuo X, et al. Structural and functional studies of leptins from hibernating and non-hibernating bats. Gen Comp Endocrinol. 2010;168:29-35 pubmed publisher
    ..This observation provided a clue as to the differential effects of the two different leptins on 3T3-L1 cells. ..
  7. Zheng P, Ji G, Ma Z, Liu T, Xin L, Wu H, et al. Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways. Am J Chin Med. 2009;37:69-83 pubmed
    ..All the results demonstrated that puerarin can exhibit therapeutic effect on non-alcoholic fatty liver disease by improving leptin signal transduction through JAK2/STAT3 pathways. ..
  8. Jiang L, You J, Yu X, Gonzalez L, Yu Y, Wang Q, et al. Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. Proc Natl Acad Sci U S A. 2008;105:18619-24 pubmed publisher
    ..Thus, these results provide direct physiological evidence that Ob-Rb exerts crucial metabolic actions not only through tyrosine-dependent, but also tyrosine-independent mechanisms in control of energy balance and glucose homeostasis. ..
  9. Yang Y, Zhou L, Liu S, Tang J, Li F, Li R, et al. Expression of feeding-related peptide receptors mRNA in GT1-7 cell line and roles of leptin and orexins in control of GnRH secretion. Acta Pharmacol Sin. 2005;26:976-81 pubmed
    ..Feeding and reproductive function are closely linked. Many orexigenic and anorexigenic signals may control feeding behavior as well as alter GnRH secretion through their receptors on GnRH neurons. ..

More Information


  1. Cao H, Ye X, Ma J, Jiang H, Li S, Li R, et al. Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling. EBioMedicine. 2015;2:1718-24 pubmed publisher
    ..Taken together, the results suggest that mimecan is a satiety hormone in adipose tissue, and that mimecan inhibits food intake independently of leptin signaling by inducing IL-1β and IL-6 expression in the hypothalamus. ..
  2. Feng D, Wang Y, Mei Y, Xu Y, Xu H, Lu Y, et al. Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury. Lab Invest. 2009;89:222-30 pubmed publisher
    ..In conclusion, our study suggests that SCD1 deficiency protects mice from liver injury in a leptin-dependent manner. ..
  3. Yu J, Ying M, Zhuang Y, Xu T, Han M, Wu X, et al. C-terminal deletion of the atrophin-1 protein results in growth retardation but not neurodegeneration in mice. Dev Dyn. 2009;238:2471-8 pubmed publisher
    ..These results support the model that poly-Q expanded Atrophin-1 proteins cause DRPLA in a manner independent of any functional interaction with wild-type Atrophin-1 proteins. ..
  4. Shen X, Tang Q, Huang J, Cai W. Vitamin E regulates adipocytokine expression in a rat model of dietary-induced obesity. Exp Biol Med (Maywood). 2010;235:47-51 pubmed publisher
    ..422, P < 0.05). Administration of VE decreases leptin and adiponectin expression in obese rats. This finding is consistent with the view that antioxidants can play an important role in the treatment of obesity-related diseases. ..
  5. Sun L, Yu Z, Ye X, Zou S, Li H, Yu D, et al. A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese. Diabetes Care. 2010;33:1925-32 pubmed publisher
    ..These findings suggested a role of lipopolysaccharide via initiation of innate immune mechanism(s) in metabolic disorders. Prospective studies are needed to confirm these results. ..
  6. Yu D, Yu Z, Sun Q, Sun L, Li H, Song J, et al. Effects of body fat on the associations of high-molecular-weight adiponectin, leptin and soluble leptin receptor with metabolic syndrome in Chinese. PLoS ONE. 2011;6:e16818 pubmed publisher
  7. Zuo C, Huang Y, Bajis R, Sahih M, Li Y, Dai K, et al. Osteoblastogenesis regulation signals in bone remodeling. Osteoporos Int. 2012;23:1653-63 pubmed publisher
    ..Future investigations on the endogenous regulation of osteoblastogenesis will increase the current knowledge required for the development of potential drug targets in the treatment of osteoporosis. ..
  8. Zhao C, Liu D, Li H, Jiang L, Dai L. Expression of leptin and its functional receptor on disc cells: contribution to cell proliferation. Spine (Phila Pa 1976). 2008;33:E858-64 pubmed publisher
  9. Chen B, Zhou H, Zhao W, Zhou W, Yuan Q, Yang G. Effects of aqueous extract of Portulaca oleracea L. on oxidative stress and liver, spleen leptin, PAR? and FAS mRNA expression in high-fat diet induced mice. Mol Biol Rep. 2012;39:7981-8 pubmed publisher
  10. Pan Y, Shu J, Gu H, Zhou D, Liu X, Qiao Q, et al. Erythropoietin improves insulin resistance via the regulation of its receptor-mediated signaling pathways in 3T3L1 adipocytes. Mol Cell Endocrinol. 2013;367:116-23 pubmed publisher
    ..rHuEPO-induced EPOR protein expression and subsequent induction of pAKT and pSTAT5 suggest that the EPO-EPOR system may play a role in glucose metabolism within adipocytes...
  11. Jin H, Jiang B, Tang J, Lu W, Wang W, Zhou L, et al. Serum visfatin concentrations in obese adolescents and its correlation with age and high-density lipoprotein cholesterol. Diabetes Res Clin Pract. 2008;79:412-8 pubmed publisher
    ..In conclusion, visfatin levels may decrease with age and be related to the HDL metabolism in obese adolescents. ..
  12. Xiang Y, Cheng Y, Li X, Li Q, Xu J, Zhang J, et al. Up-regulated expression and aberrant DNA methylation of LEP and SH3PXD2A in pre-eclampsia. PLoS ONE. 2013;8:e59753 pubmed publisher
    ..We speculated that SH3PXD2A may take part in the pathogenesis of PE through its role in the regulation of trophoblast cell invasion in the period of placenta formation. ..
  13. Han G, Zhao W, Wang L, Yue Z, Zhao R, Li Y, et al. Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression. Brain Res. 2014;1543:1-8 pubmed publisher
  14. Wang Y, Xu Z, Wang J, Xu S. DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis. Mol Biosyst. 2016;12:721-8 pubmed publisher
    ..Moreover, the activity of JNK stimulated by leptin was suppressed by DUSP19 overexpression. The present study indicated that DUSP19, a downstream of leptin, inhibited apoptosis of chondrocytes through dephosphorylating JNK. ..
  15. Ge Y, Li J, Ni X, Guo C, Wang W, Duan T, et al. Cross talk between cAMP and p38 MAPK pathways in the induction of leptin by hCG in human placental syncytiotrophoblasts. Reproduction. 2011;142:369-75 pubmed publisher
    ..These data suggest that endogenous hCG plays a significant role in maintaining leptin production in human placental syncytiotrophoblasts, and this effect involves a cross talk between cAMP and p38 MAPK pathways. ..
  16. Wang L, Wang X, Li Z, Xia T, Zhu L, Liu B, et al. PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling. Endocrinology. 2013;154:4525-35 pubmed publisher
    ..In conclusion, this study reveals that PAQR3 has an important physiological function in modulating obesity, energy metabolism, and leptin signaling. ..
  17. Zhang Z, Shen C, Li H, Fan Q, Ding J, Jin F, et al. Leptin induces the apoptosis of chondrocytes in an in vitro model of osteoarthritis via the JAK2‑STAT3 signaling pathway. Mol Med Rep. 2016;13:3684-90 pubmed publisher
    ..These findings indicated the importance of leptin as a therapeutic target for the treatment of OA in the overweight population. ..