Experts and Doctors on hematopoiesis in Shanghai, Shanghai Shi, China


Locale: Shanghai, Shanghai Shi, China
Topic: hematopoiesis

Top Publications

  1. Wu H, Ren C, Yang F, Qin Y, Zhang Y, Liu J. Extraction and identification of collagen-derived peptides with hematopoietic activity from Colla Corii Asini. J Ethnopharmacol. 2016;182:129-36 pubmed publisher
  2. Jing C, Chen Y, Dong M, Peng X, Jia X, Gao L, et al. Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish. Dev Biol. 2013;374:24-31 pubmed publisher
    ..These results suggested that plcg1 functioned specifically in zebrafish ICM granulopoiesis for the first time. Our studies suggest that specific pathways regulate the differentiation of the hematopoietic lineages. ..
  3. Qian L, Wang Y, Jiang Q, Zhong T, Song H. Ethanol disrupts the formation of hypochord and dorsal aorta during the development of embryonic zebrafish. Sci China C Life Sci. 2005;48:608-15 pubmed
    ..These results provide important clues to the study of adverse effects of ethanol on the cardiovascular development in human fetus. ..
  4. Zhou B, Yu H, Yue R, Zhao Z, Rios J, Naveiras O, et al. Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF. Nat Cell Biol. 2017;19:891-903 pubmed publisher
    ..A-ZIP/F1 'fatless' mice exhibited delayed haematopoietic regeneration in long bones but not in tail vertebrae, where adipocytes inhibited vascularization. Adipocytes are a niche component that promotes haematopoietic regeneration. ..
  5. Ren C, Wang L, Jia X, Liu Y, Dong Z, Jin Y, et al. Activated N-Ras signaling regulates arterial-venous specification in zebrafish. J Hematol Oncol. 2013;6:34 pubmed publisher
  6. Li J, Chen X, Gong X, Liu Y, Feng H, Qiu L, et al. A transcript profiling approach reveals the zinc finger transcription factor ZNF191 is a pleiotropic factor. BMC Genomics. 2009;10:241 pubmed publisher
    ..Our analysis reveals for the first time that ZNF191 is a pleiotropic factor that has a role in hematopoiesis, brain development and cancers. ..
  7. Li H, Yue R, Wei B, Gao G, Du J, Pei G. Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis. EMBO J. 2014;33:1383-96 pubmed publisher
    ..Taken together, we identified LPA as an important nutrient-derived developmental cue for primitive hematopoiesis as well as a novel mechanism of hemangioblast regulation. ..
  8. Duan J, Ba Q, Wang Z, Hao M, Li X, Hu P, et al. Knockdown of ribosomal protein S7 causes developmental abnormalities via p53 dependent and independent pathways in zebrafish. Int J Biochem Cell Biol. 2011;43:1218-27 pubmed publisher
    ..Moreover, our data implicate that RPS7 is a regulator of matrix metalloproteinase (mmp) family in zebrafish system. These specific functions of RPS7 may provide helpful clues to study the roles of RPs in human disease. ..
  9. Wang Y, Qiao W, Zhao X, Tao M. Quantitative assessment of the influence of hematopoietically expressed homeobox variant (rs1111875) on type 2 diabetes risk. Mol Genet Metab. 2011;102:194-9 pubmed publisher
    ..This meta-analysis demonstrated that the C allele of rs1111875 of HHEX is a risk factor associated with increased T2D susceptibility, but these associations vary in different ethnic populations. ..

More Information


  1. Yue R, Li H, Liu H, Li Y, Wei B, Gao G, et al. Thrombin receptor regulates hematopoiesis and endothelial-to-hematopoietic transition. Dev Cell. 2012;22:1092-100 pubmed publisher
    ..Taken together, this study demonstrates a fundamental role of F2r-RhoA/ROCK pathway in vertebrate hematopoiesis and EHT, as well as an important molecular mechanism coordinating hematopoietic and vascular development. ..
  2. Jin W, Wu K, Li Y, Yang W, Zou B, Zhang F, et al. AML1-ETO targets and suppresses cathepsin G, a serine protease, which is able to degrade AML1-ETO in t(8;21) acute myeloid leukemia. Oncogene. 2013;32:1978-87 pubmed publisher
    ..Thus, the targeting and suppression of CTSG by AML1-ETO in t(8;21) AML may provide a mechanism for leukemia cells to escape from the intracellular surveillance system by preventing degradation of foreign proteins. ..
  3. Yang H, Liang H, Yan J, Tao R, Hao S, Ma L. Down-regulation of hematopoiesis master regulator PU.1 via aberrant methylation in chronic myeloid leukemia. Int J Hematol. 2012;96:65-73 pubmed publisher
    ..1. These data suggest that aberrant methylation of PU.1 may play a role in CML pathogenesis, and may therefore serve as a useful biomarker and potential target for demethylating drugs. ..
  4. Chuai Y, Shen J, Qian L, Wang Y, Huang Y, Gao F, et al. Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice. Med Sci Monit. 2012;18:BR89-94 pubmed
    ..This study also demonstrates that H2 could significantly increase the number of endoCFUs, BMNC and PB leukocyte. This study suggests that hydrogen-rich saline could partially protect spermatogenesis and hematopoiesis in irradiated mice. ..
  5. Shen L, Chen F, Zhang Y, Cao L, Kuang Y, Zhong M, et al. MYCN transgenic zebrafish model with the characterization of acute myeloid leukemia and altered hematopoiesis. PLoS ONE. 2013;8:e59070 pubmed publisher
    ..Therefore, this MYCN transgenic zebrafish model facilitates dissection of MYCN-mediated signaling in vivo, and enables high-throughput scale screens to identify the potential therapeutic targets. ..
  6. Shu L, Zhou Z, Zhou T, Deng M, Dong M, Chen Y, et al. Ectopic expression of Hoxb4a in hemangioblasts promotes hematopoietic development in early embryogenesis of zebrafish. Clin Exp Pharmacol Physiol. 2015;42:1275-86 pubmed publisher
    ..Taken together, these results indicate that Hoxb4a favours the development of hematopoietic progenitor cells originated from hemangioblasts in vivo. ..
  7. He H, Hua X, Yan J. Epigenetic regulations in hematopoietic Hox code. Oncogene. 2011;30:379-88 pubmed publisher
    ..This model will provide new insight into epigenetic therapy in leukemia. ..
  8. Anso E, Weinberg S, Diebold L, Thompson B, Malinge S, Schumacker P, et al. The mitochondrial respiratory chain is essential for haematopoietic stem cell function. Nat Cell Biol. 2017;19:614-625 pubmed publisher
    ..Thus, respiration is dispensable for adult or fetal HSC proliferation, but essential for fetal HSC differentiation and maintenance of adult HSC quiescence. ..
  9. Yue R, Kang J, Zhao C, Hu W, Tang Y, Liu X, et al. Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Cell. 2009;139:535-46 pubmed publisher
    ..Taken together, this study demonstrated a critical role of beta-arrestin1 during zebrafish primitive hematopoiesis, as well as an important regulator of PcG proteins and cdx4-hox pathway. ..