Experts and Doctors on cell survival in Shanghai, Shanghai Shi, China


Locale: Shanghai, Shanghai Shi, China
Topic: cell survival

Top Publications

  1. Wu H, Liu G, Li C, Zhao S. bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death. Biochem Biophys Res Commun. 2003;311:518-24 pubmed
    ..Taken together, bri3 appears to play an important role in TNF-induced cell death. Finally, we reported here that BRI3 may be localized to lysosome and function through lysosome. ..
  2. Ji W, Yang J, Wang D, Cao L, Tan W, Qian H, et al. hSulf-1 gene exhibits anticancer efficacy through negatively regulating VEGFR-2 signaling in human cancers. PLoS ONE. 2011;6:e23274 pubmed publisher
    ..Therefore, hSulf-1-mediated antiproliferation and antiangiogenesis could be a reasonable approach for cancer therapy. ..
  3. Li A, Guo H, Luo X, Sheng J, Yang S, Yin Y, et al. Apomorphine-induced activation of dopamine receptors modulates FGF-2 expression in astrocytic cultures and promotes survival of dopaminergic neurons. FASEB J. 2006;20:1263-5 pubmed
    ..These data suggest that APO can enhance biosynthesis and release of FGF-2 through activation of dopamine receptors in striatal astrocytes. Both cAMP/PKA and MEK/MAPK signaling cascades are major steps mediating this process. ..
  4. Liu B, Yi Y, Li L, Sun P, Han H, Sun G, et al. Argusides D and E, two new cytotoxic triterpene glycosides from the sea cucumber Bohadschia argus Jaeger. Chem Biodivers. 2008;5:1425-33 pubmed publisher
    ..The two glycosides exhibited significant cytotoxicities against four human tumor cell lines, A549, HCT-116, HepG2, and MCF-7. ..
  5. Su Y, He Y, Lu H, Sai L, Li Q, Li W, et al. The cytotoxicity of cadmium based, aqueous phase - synthesized, quantum dots and its modulation by surface coating. Biomaterials. 2009;30:19-25 pubmed publisher
  6. Jin Y, Song L, Su Y, Zhu L, Pang Y, Qiu F, et al. Oxime linkage: a robust tool for the design of pH-sensitive polymeric drug carriers. Biomacromolecules. 2011;12:3460-8 pubmed publisher
    ..All of these results demonstrate that these polymeric micelles self-assembled from oxime-tethered block copolymers are promising carriers for the pH-triggered intracellular delivery of hydrophobic anticancer drugs. ..
  7. Wang J, Liu H, Kurtan T, Mándi A, Antus S, Li J, et al. Protolimonoids and norlimonoids from the stem bark of Toona ciliata var. pubescens. Org Biomol Chem. 2011;9:7685-96 pubmed publisher
    ..1 ?M, while compound 8a showed significant cell protecting activity against H(2)O(2)-induced SH-SY5Y cell damage with 11.5% increase in cell viability. ..
  8. Ruan Y, Sun L, Hao Y, Wang L, Xu J, Zhang W, et al. Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma. J Clin Invest. 2012;122:2554-66 pubmed publisher
    ..Our results imply that RACK1 may function as an internal factor involved in the growth and survival of HCC and suggest that targeting RACK1 may be an efficacious strategy for HCC treatment. ..
  9. Wang Y, Xu Z, Wang J, Xu S. DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis. Mol Biosyst. 2016;12:721-8 pubmed publisher
    ..Moreover, the activity of JNK stimulated by leptin was suppressed by DUSP19 overexpression. The present study indicated that DUSP19, a downstream of leptin, inhibited apoptosis of chondrocytes through dephosphorylating JNK. ..

More Information

Publications370 found, 100 shown here

  1. Dong R, Liu X, Zhang B, Liu B, Zheng S, Dong K. Long non-coding RNA-CRNDE: a novel regulator of tumor growth and angiogenesis in hepatoblastoma. Oncotarget. 2017;8:42087-42097 pubmed publisher
    ..Taken together, this study reveals a crucial role of CRNDE in the pathology of hepatoblastoma. CRNDE may serve as a promising diagnostic marker and therapeutic target for hepatoblastoma. ..
  2. Yi J, Yang J, He R, Gao F, Sang H, Tang X, et al. Emodin enhances arsenic trioxide-induced apoptosis via generation of reactive oxygen species and inhibition of survival signaling. Cancer Res. 2004;64:108-16 pubmed
    ..This result allows us to propose a novel strategy in chemotherapy that uses mild ROS generators to facilitate apoptosis-inducing drugs whose efficacy depends on ROS. ..
  3. Wu M, Sun Q, Yang C, Chen D, Ding J, Chen Y, et al. Synthesis and activity of Combretastatin A-4 analogues: 1,2,3-thiadiazoles as potent antitumor agents. Bioorg Med Chem Lett. 2007;17:869-73 pubmed
    ..A series of 4,5-disubstitute-1,2,3-thiadiazole compounds were designed and synthesized as potent anticancer agents, some of them exhibited excellent in vitro and in vivo inhibitory activity...
  4. Shi X, Wang S, Van Antwerp M, Chen X, Baker J. Targeting and detecting cancer cells using spontaneously formed multifunctional dendrimer-stabilized gold nanoparticles. Analyst. 2009;134:1373-9 pubmed publisher
    ..This approach to functionalizing Au DSNPs may be extended to other targeting molecules, providing a unique nanoplatform for targeting and imaging of a variety of biological systems. ..
  5. Zhang K, Wang H, Huang C, Su Y, Mo X, Ikada Y. Fabrication of silk fibroin blended P(LLA-CL) nanofibrous scaffolds for tissue engineering. J Biomed Mater Res A. 2010;93:984-93 pubmed publisher
    ..These results suggested that SF/P(LLA-CL) blended nanofibrous scaffolds might be potential candidates for vascular tissue engineering...
  6. Ting L, Bo W, Li R, Chen X, Wang Y, Jun Z, et al. AMP-activated protein kinase supports the NGF-induced viability of human HeLa cells to glucose starvation. Mol Biol Rep. 2010;37:2593-8 pubmed publisher
    ..Taken together, these results indicate that AMP-activated protein kinase supports the NGF-induced viability of human HeLa cells to glucose starvation. ..
  7. Xu J, Yan C, Yang B, Xie H, Zou X, Zhong L, et al. The role of metabotropic glutamate receptor 5 in developmental lead neurotoxicity. Toxicol Lett. 2009;191:223-30 pubmed publisher
    ..These results might improve the understanding of the mechanism and potential treatments for moderate to severe lead poisoning in children...
  8. He L, Pan Y, He G, Lin B, Liao C, Zuo X, et al. Structural and functional studies of leptins from hibernating and non-hibernating bats. Gen Comp Endocrinol. 2010;168:29-35 pubmed publisher
    ..This observation provided a clue as to the differential effects of the two different leptins on 3T3-L1 cells. ..
  9. Yu W, Zhang Y, Jiang X, Zhang F. In vitro behavior of MC3T3-E1 preosteoblast with different annealing temperature titania nanotubes. Oral Dis. 2010;16:624-30 pubmed publisher
    ..Annealing can change the crystal form and composition of nanotubes. The nanotubes after annealing can promote osteoblast proliferation and mineralization in vitro. ..
  10. Shi M, Zheng M, Liu Z, Hu Z, Huang Y, Chen J, et al. DCC is specifically required for the survival of retinal ganglion and displaced amacrine cells in the developing mouse retina. Dev Biol. 2010;348:87-96 pubmed publisher
    ..Thus, our findings suggest that DCC is a key regulator for the survival of specific types of neurons during retinal development and that DCC-P3 domain is essential for this developing event. ..
  11. Cui D, Wang L, Qi A, Zhou Q, Zhang X, Jiang W. Propofol prevents autophagic cell death following oxygen and glucose deprivation in PC12 cells and cerebral ischemia-reperfusion injury in rats. PLoS ONE. 2012;7:e35324 pubmed publisher
    ..We therefore studied whether propofol could attenuate the formation of autophagosomes, and if so, whether the inhibition of autophagic cell death mediates the neuroprotective effects observed with propofol...
  12. Zou C, Xu Q, Mao F, Li D, Bian C, Liu L, et al. MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF. Cell Cycle. 2012;11:2137-45 pubmed publisher
    ..Taken together, these results demonstrate that miR-145 plays important inhibitory role in breast cancer malignancy by targeting N-RAS and VEGF-A, which may be potential therapeutic and diagnostic targets. ..
  13. Rong X, Yang S, Miao H, Guo T, Wang Z, Shi W, et al. Effects of erythropoietin-dextran microparticle-based PLGA/PLA microspheres on RGCs. Invest Ophthalmol Vis Sci. 2012;53:6025-34 pubmed publisher
    ..The PLGA/PLA microspheres may be a feasible protein delivery system, such as EPO, to intravitreal injection for retinal degeneration diseases. ..
  14. Lian S, Xiao Y, Bian Q, Xia Y, Guo C, Wang S, et al. Injectable hydrogel as stem cell scaffolds from the thermosensitive terpolymer of NIPAAm/AAc/HEMAPCL. Int J Nanomedicine. 2012;7:4893-905 pubmed publisher
    ..The copolymer with NIPAAm/AAc/HEMAPCL ratio of 88:9.6:2.4 was bioconjugated with type I collagen for the purpose of biocompatibility enhancement. In-vitro cytotoxicity of the hydrogels both with and without collagen was also addressed. ..
  15. Liu C, Zhang C, Mitchel R, Cui J, Lin J, Yang Y, et al. A critical role of toll-like receptor 4 (TLR4) and its' in vivo ligands in basal radio-resistance. Cell Death Dis. 2013;4:e649 pubmed publisher
    ..Further, these data also suggest that management of gut flora through antibiotic or possibly probiotic therapy may alter the innate response to the total body irradiation. ..
  16. Huang M, Lou D, Wang Y, Cai Q, Li H. Paraquat inhibited differentiation in human neural progenitor cells (hNPCs) and down regulated miR-200a expression by targeting CTNNB1. Environ Toxicol Pharmacol. 2016;42:205-11 pubmed publisher
  17. Pan L, Xu P, Luo X, Wang L, Liu S, Zhu Y, et al. Shizukaol B, an active sesquiterpene from Chloranthus henryi, attenuates LPS-induced inflammatory responses in BV2 microglial cells. Biomed Pharmacother. 2017;88:878-884 pubmed publisher
    ..Taken together, our findings suggest that shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway. ..
  18. Yanqing Z, Yu Min L, Jian Q, Bao Guo X, Chuan Zhen L. Fibronectin and neuroprotective effect of granulocyte colony-stimulating factor in focal cerebral ischemia. Brain Res. 2006;1098:161-9 pubmed
  19. Zhao J, Chen G, Cao D, Li Y, Diao F, Cai H, et al. Expression of Gli1 correlates with the transition of breast cancer cells to estrogen-independent growth. Breast Cancer Res Treat. 2010;119:39-51 pubmed publisher
  20. Mai J, Song S, Rui M, Liu D, Ding Q, Peng J, et al. A synthetic peptide mediated active targeting of cisplatin liposomes to Tie2 expressing cells. J Control Release. 2009;139:174-81 pubmed publisher
    ..Such liposome formulation may be developed into a very useful agent for metronomic chemotherapy. ..
  21. Weng R, Li Q, Li H, Yang M, Sheng L. Mimic hypoxia improves angiogenesis in ischaemic random flaps. J Plast Reconstr Aesthet Surg. 2010;63:2152-9 pubmed publisher
    ..DFO-induced VEGF autocrine secretion also protects endothelial cells from severe hypoxia injury. ..
  22. Xiong W, Ren Z, Qiu S, Sun H, Wang L, Liu B, et al. Residual hepatocellular carcinoma after oxaliplatin treatment has increased metastatic potential in a nude mouse model and is attenuated by Songyou Yin. BMC Cancer. 2010;10:219 pubmed publisher
    ..13/15 and 3/15 vs. 13/15, respectively). The surviving HCC after oxaliplatin treatment underwent EMT and demonstrated increased metastatic potential. Attenuation of EMT by Songyou Yin may improve the efficacy of chemotherapy in HCC. ..
  23. Xia A, Chen M, Gao Y, Wu D, Feng W, Li F. Gd3+ complex-modified NaLuF4-based upconversion nanophosphors for trimodality imaging of NIR-to-NIR upconversion luminescence, X-Ray computed tomography and magnetic resonance. Biomaterials. 2012;33:5394-405 pubmed publisher
    ..In addition, the biological toxicity of UCNP@SiO(2)-GdDTPA is evaluated by the methyl thiazolyl tetrazolium (MTT) assay and histological analysis of viscera sections. ..
  24. Ni X, Suhail M, Yang Q, Cao A, Fung K, Postier R, et al. Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human pancreatic cancer cell death in cultures and in a xenograft murine model. BMC Complement Altern Med. 2012;12:253 pubmed publisher
  25. Chu M, Shao Y, Peng J, Dai X, Li H, Wu Q, et al. Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles. Biomaterials. 2013;34:4078-4088 pubmed publisher
    ..A morphological examination revealed that after a photothermal therapy, the tumor tissue structure exhibited discontinuation, the cells were significantly shriveled and some cells have finally disintegrated. ..
  26. Chen M, Xiang Z, Cai J. The anti-apoptotic and neuro-protective effects of human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) on acute optic nerve injury is transient. Brain Res. 2013;1532:63-75 pubmed publisher
    ..Thus, our results imply that hUCB-MSCs take anti-apoptotic, pro-neuroregenerative and anti-inflammatory effects in the early time for acute optic nerve injury in adult rats but could not prevent RGCs from death eventually. ..
  27. Pan Y, Zhang L, Zeng L, Ren W, Xiao X, Zhang J, et al. Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer. Nanoscale. 2016;8:878-88 pubmed publisher
    ..Therefore, we developed a multifunctional yolk-shell delivery system, which could have potential applications as a visualized theranostic nanoprobe to overcome MDR in breast cancer. ..
  28. Sun Z, Luo B, Liu Z, Huang L, Liu B, Ma T, et al. Effect of perfluorotributylamine-enriched alginate on nucleus pulposus cell: Implications for intervertebral disc regeneration. Biomaterials. 2016;82:34-47 pubmed publisher
    ..These findings highlight the promising application of PFTBA in further intervertebral disc regeneration. ..
  29. Jin Z, Qing K, Ouyang Y, Liu Z, Wang W, Li X, et al. Low dose of lenalidmide and PI3K/mTOR inhibitor trigger synergistic cytoxicity in activated B cell-like subtype of diffuse large B cell lymphoma. J Exp Clin Cancer Res. 2016;35:52 pubmed publisher
    ..Cotreatment was also effective in vivo. These data pave the way for potential treatment of ABC-DLBCL with combination of NVP-Bez235 and lenalidomide. ..
  30. Li X, Wu H, Mao X, Jiang L, Wang Y. USP5 promotes tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 protein. Biochem Biophys Res Commun. 2017;492:48-54 pubmed publisher
  31. Liu X, Bai C, Xu Z, Huang S, Yuan Y, Gong D, et al. Therapeutic potential of angiogenin modified mesenchymal stem cells: angiogenin improves mesenchymal stem cells survival under hypoxia and enhances vasculogenesis in myocardial infarction. Microvasc Res. 2008;76:23-30 pubmed publisher
  32. Zhou J, Xu Z, Jiang C. Neuropeptide Y promotes TGF-beta1 production in RAW264.7 cells by activating PI3K pathway via Y1 receptor. Neurosci Bull. 2008;24:155-9 pubmed
    ..The elevated TGF-beta1 production induced by NPY could be abolished by wortmannin pretreatment. NPY may elicit TGF-beta1 production in RAW264.7 cells via Y1 receptor, and the activated PI3K pathway may account for this effect. ..
  33. Zhang X, Hu X, Hou A, Wang H. Inhibitory effect of 2,4,2',4'-tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone on tyrosinase activity and melanin biosynthesis. Biol Pharm Bull. 2009;32:86-90 pubmed
    ..These results indicated that TMBC may be a new promising pigmentation-altering agent for cosmetic or therapeutic applications. ..
  34. Dong C, Wang Y, Zhu Y. Asymmetric synthesis and biological evaluation of Danshensu derivatives as anti-myocardial ischemia drug candidates. Bioorg Med Chem. 2009;17:3499-507 pubmed publisher
    ..Therefore, these Danshensu derivatives may be good drug candidates for anti-myocardial ischemia therapy and merit further investigation. ..
  35. Li S, Dong P, Wang J, Zhang J, Gu J, Wu X, et al. Icariin, a natural flavonol glycoside, induces apoptosis in human hepatoma SMMC-7721 cells via a ROS/JNK-dependent mitochondrial pathway. Cancer Lett. 2010;298:222-30 pubmed publisher
    ..Taken together, these findings suggest that icariin induces apoptosis through a ROS/JNK-dependent mitochondrial pathway...
  36. Shi X, Hong Z, Liu H, Zhang Y, Zhu Y. Neuroprotective effects of SCM198 on 6-hydroxydopamine-induced behavioral deficit in rats and cytotoxicity in neuronal SH-SY5Y cells. Neurochem Int. 2011;58:851-60 pubmed publisher
    ..Therefore we suggest that SCM198 might provide a useful therapeutic strategy for neurodegenerative diseases such as Parkinson's disease. ..
  37. Yan S, Zhu J, Wang Z, Yin J, Zheng Y, Chen X. Layer-by-layer assembly of poly(L-glutamic acid)/chitosan microcapsules for high loading and sustained release of 5-fluorouracil. Eur J Pharm Biopharm. 2011;78:336-45 pubmed publisher
    ..Therefore, the novel PLGA/CS microcapsules are expected to find application in drug delivery systems because of the properties of biodegradability, high loading, sustained release and cell compatibility. ..
  38. Wang S, Lin X, Wang L, Ruan K, Feng Y, Li X. A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression. Int J Biol Macromol. 2012;50:734-40 pubmed publisher
  39. Feng B, Dong T, Wang L, Zhou H, Zhao H, Dong F, et al. Colorectal cancer migration and invasion initiated by microRNA-106a. PLoS ONE. 2012;7:e43452 pubmed publisher
    ..These observations indicate that miR-106a inhibits the anti-metastatic target directly and results in CRC cell migration and invasion. ..
  40. Peng J, Zhao L, Zhu X, Sun Y, Feng W, Gao Y, et al. Hollow silica nanoparticles loaded with hydrophobic phthalocyanine for near-infrared photodynamic and photothermal combination therapy. Biomaterials. 2013;34:7905-12 pubmed publisher
    ..This multifunctional nanomedicine may be useful for PTT/PDT treatment of cancer. ..
  41. Ren L, Zhang D, Jiang X, Gai Y, Wang W, Reed B, et al. Peroxidation due to cryoprotectant treatment is a vital factor for cell survival in Arabidopsis cryopreservation. Plant Sci. 2013;212:37-47 pubmed publisher
  42. Ding W, Tong Y, Zhang X, Pan M, Chen S. Study of Arsenic Sulfide in Solid Tumor Cells Reveals Regulation of Nuclear Factors of Activated T-cells by PML and p53. Sci Rep. 2016;6:19793 pubmed publisher
    ..These results indicate that AS differentially regulates NFAT pathway through PML and p53 and reveal an intricate reciprocal regulatory relationship between NFAT proteins and p53 pathway. ..
  43. Zhang Y, Wen S, Zhao L, Li D, Liu C, Jiang W, et al. Ultrastable polyethyleneimine-stabilized gold nanoparticles modified with polyethylene glycol for blood pool, lymph node and tumor CT imaging. Nanoscale. 2016;8:5567-77 pubmed publisher
    ..These findings suggest that the formed PEGylated Au PSNPs may be used as a promising contrast agent for CT imaging of different biological systems. ..
  44. Wang S, Jeffries E, Gao J, Sun L, You Z, Wang Y. Polyester with Pendent Acetylcholine-Mimicking Functionalities Promotes Neurite Growth. ACS Appl Mater Interfaces. 2016;8:9590-9 pubmed publisher
    ..Overall, this simple and versatile synthesis provides a useful tool to produce biomaterials for creating the appropriate stimulatory environment for nerve regeneration. ..
  45. Pan L, Wang X, Zhang Q, Luo X, Xu P, Liu S, et al. Boehmenan, a lignan from the Chinese medicinal plant Clematis armandii, induces apoptosis in lung cancer cells through modulation of EGF-dependent pathways. Phytomedicine. 2016;23:468-76 pubmed publisher
    ..Taken together, our results suggested that boehmenan-mediated anti-tumor property was mediated by modulation of mitochondria and EGFR signaling pathway in A549 NSCLC cells. ..
  46. Li S, Dai W, Mo W, Li J, Feng J, Wu L, et al. By inhibiting PFKFB3, aspirin overcomes sorafenib resistance in hepatocellular carcinoma. Int J Cancer. 2017;141:2571-2584 pubmed publisher
    ..Our results suggest that aspirin overcomes sorafenib resistance and their combination may be an effective treatment approach for HCC. ..
  47. Che W, Bao Y, Tang F. Down-regulation of C35 decreased the cell viability and migration of breast ductal carcinoma cells. PLoS ONE. 2017;12:e0183941 pubmed publisher
    ..In addition, the migration of breast ductal carcinoma cells decreased when C35 expression was interfered by siRNA1 for 24 h, and interfered by siRNA1 and siRNA2 for 48 h. ..
  48. Wang H, Bai L, Shen B, Yan Z, Jiang Z. Coculture with endothelial cells enhances vascular smooth muscle cell adhesion and spreading via activation of beta1-integrin and phosphatidylinositol 3-kinase/Akt. Eur J Cell Biol. 2007;86:51-62 pubmed
  49. Cao Y, Li H, Liu H, Zheng C, Ji H, Liu X. The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression. Cell Res. 2010;20:99-108 pubmed publisher
    ..These findings identify LKB1 as a critical factor for the survival of DP thymocytes through regulation of AMPK activation and Bcl-XL expression. ..
  50. Shi B, Wang Y, Zhuang Y, Chu J, Zhang S, Shi X, et al. Expansion of mouse sertoli cells on microcarriers. Cell Prolif. 2010;43:275-86 pubmed publisher
  51. Liu X, Pan L, Zhuo Y, Gong Q, Rose P, Zhu Y. Hypoxia-inducible factor-1? is involved in the pro-angiogenic effect of hydrogen sulfide under hypoxic stress. Biol Pharm Bull. 2010;33:1550-4 pubmed
    ..Our findings suggest that HIF-1/VEGF is involved in H2S promotes proliferation and migration of ECs. ..
  52. Wang Y, Zhang C, Zhang Q, Li P. Composite electrospun nanomembranes of fish scale collagen peptides/chito-oligosaccharides: antibacterial properties and potential for wound dressing. Int J Nanomedicine. 2011;6:667-76 pubmed publisher
    ..FSCP/COS NFMs had good anti-bactericidal activity that improved with increased COS, and showed good biocompatibility in vitro and supported the proliferation of fibroblasts. ..
  53. Kaikai S, Yuchen S, Lili J, Zhengtao W. Critical role of c-Jun N-terminal kinase in regulating bFGF-induced angiogenesis in vitro. J Biochem. 2011;150:189-97 pubmed publisher
  54. Chen H, Bao Y, Yu L, Jia R, Cheng W, Shao C. Comparison of cellular damage response to low-dose-rate 125I seed irradiation and high-dose-rate gamma irradiation in human lung cancer cells. Brachytherapy. 2012;11:149-56 pubmed publisher
    ..Ku as molecular markers together with cell proliferation rate can be used to predict the radiosensitivity of tumor cells to LDR 125I seed irradiation. ..
  55. Yan Z, Yang R, Jiang Y, Yang Z, Yang J, Zhao Q, et al. Induction of apoptosis in human promyelocytic leukemia HL60 cells by panaxynol and panaxydol. Molecules. 2011;16:5561-73 pubmed publisher
    ..In conclusion, panaxynol and panaxydol have profound effects on growth and apoptosis of HL60 cells, suggesting those substances are worthy of further exploration as potential anti-cancer agents. ..
  56. Dong P, Zhang Y, Gu J, Wu W, Li M, Yang J, et al. Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin. J Ethnopharmacol. 2011;137:1373-80 pubmed publisher
    ..However, the detailed mechanism of anti-metastasis effect of wogonin, a main active ingredient of Scutellaria baicalensis, remains elusive...
  57. Zhai X, Huang W, Liu J, Pang Y, Zhu X, Zhou Y, et al. Micelles from amphiphilic block copolyphosphates for drug delivery. Macromol Biosci. 2011;11:1603-10 pubmed publisher
    ..8 µg mL(-1). It is demonstrated that PEP-b-PIPP micelles can be used as a safe and promising drug delivery system. ..
  58. Zhu X, Zhou J, Chen M, Shi M, Feng W, Li F. Core-shell Fe3O4@NaLuF4:Yb,Er/Tm nanostructure for MRI, CT and upconversion luminescence tri-modality imaging. Biomaterials. 2012;33:4618-27 pubmed publisher
    ..In vitro tests reveal that the MUCNP is non-cytotoxic. These results suggest that the developed MUCNP could be served as an MR, CT and UCL probe for tri-modality imaging...
  59. Tong N, Zhang Z, Gong Y, Yin L, Wu X. Diosmin protects rat retina from ischemia/reperfusion injury. J Ocul Pharmacol Ther. 2012;28:459-66 pubmed
    ..Diosmin also attenuated the I/R-induced loss of RGCs of the rat retina (P<0.05). Diosmin protected the retina from I/R injury, possibly via a mechanism involving the regulation of oxidative parameters. ..
  60. Qian Y, Zha Y, Feng B, Pang Z, Zhang B, Sun X, et al. PEGylated poly(2-(dimethylamino) ethyl methacrylate)/DNA polyplex micelles decorated with phage-displayed TGN peptide for brain-targeted gene delivery. Biomaterials. 2013;34:2117-29 pubmed publisher
    ..Therefore, the results demonstrate that the TGN-decorated PEG-PDMAEMA developed in this study could be utilized as a potential vehicle for gene delivery to the brain. ..
  61. Qin J, Li K, Peng C, Li X, Lin J, Ye K, et al. MRI of iron oxide nanoparticle-labeled ADSCs in a model of hindlimb ischemia. Biomaterials. 2013;34:4914-25 pubmed publisher
    ..Developed DMSA-NPs were shown to exhibit a considerable potential for use as nanoprobes for MRI of stem cells, which will enhance our understanding of cell-based therapeutic strategies for ischemic diseases...
  62. Zheng J, Tian X, Sun Y, Lu D, Yang W. pH-sensitive poly(glutamic acid) grafted mesoporous silica nanoparticles for drug delivery. Int J Pharm. 2013;450:296-303 pubmed publisher
    ..Overall, these results demonstrate that MSN-PLGA is a promising platform to build pH controlled drug delivery systems for cancer therapy. ..
  63. Zhu J, Liao L, Zhu L, Zhang P, Guo K, Kong J, et al. Size-dependent cellular uptake efficiency, mechanism, and cytotoxicity of silica nanoparticles toward HeLa cells. Talanta. 2013;107:408-15 pubmed publisher
    ..6>167.8>307.6 nm. This knowledge is fundamentally important and will facilitate more development of size-defined SNPs as the transporters for various purposes. ..
  64. Liu D, Mao S, Zhang H, Yu X, Feng M, Wang B, et al. Racemosins A and B, two novel bisindole alkaloids from the green alga Caulerpa racemosa. Fitoterapia. 2013;91:15-20 pubmed publisher
    ..6% increase in cell viability at the concentration of 10?M when compared to epigallocatechin gallate (EGCG, 16.57% increase at 10 ?M) as the positive control. ..
  65. Cheng M, Gao X, Wang Y, Chen H, He B, Li Y, et al. Synthesis of liver-targeting dual-ligand modified GCGA/5-FU nanoparticles and their characteristics in vitro and in vivo. Int J Nanomedicine. 2013;8:4265-76 pubmed publisher
    ..GCGA/5-FU nanoparticles significantly suppressed tumor growth in orthotopic liver transplantation mouse model, and improved mouse survival. ..
  66. Feng J, Chong M, Chan J, Zhang Z, Teoh S, Thian E. A scalable approach to obtain mesenchymal stem cells with osteogenic potency on apatite microcarriers. J Biomater Appl. 2014;29:93-103 pubmed publisher
    ..001). Additionally, type I collagen and osteocalcin expression were 1.8- and 1.5-fold higher than that of adherent monolayer culture on day 12, respectively (p < 0.001). ..
  67. Cheng P, Han P, Zhao C, Zhang S, Wu H, Ni J, et al. High-purity magnesium interference screws promote fibrocartilaginous entheses regeneration in the anterior cruciate ligament reconstruction rabbit model via accumulation of BMP-2 and VEGF. Biomaterials. 2016;81:14-26 pubmed publisher
    ..HP Mg was promising as a biodegradable interference screw with the potential to promote fibrocartilaginous entheses regeneration in ACL reconstruction. ..
  68. Zhou Z, Ma J, Xiao C, Han X, Qiu R, Wang Y, et al. Phenotypic and functional alterations of pDCs in lupus-prone mice. Sci Rep. 2016;6:20373 pubmed publisher
    ..In conclusion, pDC are activated alone with disease development and its phenotype and function differ among lupus-prone strains, and these differences may contribute to the development of lupus in these mice. ..
  69. Wo F, Xu R, Shao Y, Zhang Z, Chu M, Shi D, et al. A Multimodal System with Synergistic Effects of Magneto-Mechanical, Photothermal, Photodynamic and Chemo Therapies of Cancer in Graphene-Quantum Dot-Coated Hollow Magnetic Nanospheres. Theranostics. 2016;6:485-500 pubmed publisher
    ..The unique nanocomposites with combined mechanical, chemo, and physical effects will provide an alternative strategy for highly improved cancer therapy efficiency. ..
  70. Yang Y, Zong M, Xu W, Zhang Y, Wang B, Yang M, et al. Natural pyrethrins induces apoptosis in human hepatocyte cells via Bax- and Bcl-2-mediated mitochondrial pathway. Chem Biol Interact. 2017;262:38-45 pubmed publisher
    ..Taken together, the results indicate that natural pyrethrins has potentially exert adverse effects on human health by inducing caspase-dependent apoptosis in hepatocytes through Bax- and Bcl-2-mediated mitochondrial pathway. ..
  71. Zhou W, Song F, Wu Q, Liu R, Wang L, Liu C, et al. miR-217 inhibits triple-negative breast cancer cell growth, migration, and invasion through targeting KLF5. PLoS ONE. 2017;12:e0176395 pubmed publisher
    ..MiR-217 suppresses TNBC, at least partially, through down-regulating the KLF5 expression. These results suggest that the miR-217-KLF5 axis might serve as a potential target for treatment of TNBC. ..
  72. Chen G, Li H, Chen Y, Gu X, Duan S. Decreased estradiol release from astrocytes contributes to the neurodegeneration in a mouse model of Niemann-Pick disease type C. Glia. 2007;55:1509-18 pubmed
    ..Our findings suggest that astrocyte dysfunction contributes to the neurodegeneration of NPC and estradiol treatment may be useful in ameliorating progression of the disease. ..
  73. Tian D, Zhu M, Li J, Ma Y, Wu R. Cigarette smoke extract induces activation of beta-catenin/TCF signaling through inhibiting GSK3beta in human alveolar epithelial cell line. Toxicol Lett. 2009;187:58-62 pubmed publisher
  74. Ji L, Liu T, Wang Z. Pyrrolizidine alkaloid clivorine induced oxidative injury on primary cultured rat hepatocytes. Hum Exp Toxicol. 2010;29:303-9 pubmed publisher
    ..Taken together, our results demonstrated that clivorine induced toxicity on primary cultured rat hepatocytes by causing the damage on cellular redox balance. ..
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