Experts and Doctors on cullin proteins in Jinan, Shandong Sheng, China
Locale: Jinan, Shandong Sheng, China
Topic: cullin proteins
Zou Y, Mi J, Cui J, Lu D, Zhang X, Guo C, et al
. Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression. J Biol Chem. 2009;284:33320-32 pubmed publisher
..NLS-deleted CUL4B was distributed in cytoplasm and failed to promote cell proliferation. Therefore, the nuclear localization of CUL4B mediated by NLS is critical for its normal function in cell proliferation. ..
Li X, Lu D, He F, Zhou H, Liu Q, Wang Y, et al
. Cullin 4B protein ubiquitin ligase targets peroxiredoxin III for degradation. J Biol Chem. 2011;286:32344-54 pubmed publisher
..Together, our study has identified a specific target substrate of CUL4B ubiquitin ligase that may have significant implications for the pathogenesis observed in patients with mutations in CUL4B. ..
Jiang B, Zhao W, Yuan J, Qian Y, Sun W, Zou Y, et al
. Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development. PLoS ONE. 2012;7:e37070 pubmed publisher
..Together, our results showed that CUL4B is indispensable for embryonic development in the mouse. ..
Hu H, Yang Y, Ji Q, Zhao W, Jiang B, Liu R, et al
. CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis. Cancer Cell. 2012;22:781-95 pubmed publisher
..Our data indicate that CUL4B promotes tumorigenesis, supporting the pursuit of CUL4B as a target for cancer therapy. ..
He F, Lu D, Jiang B, Wang Y, Liu Q, Liu Q, et al
. X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling. Biochim Biophys Acta. 2013;1832:595-605 pubmed publisher
..This observation may provide novel insights into the molecular mechanisms underlying CUL4B-associated XLID pathogenesis. ..
Zou Y, Mi J, Wang W, Lu J, Zhao W, Liu Z, et al
. CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. J Cell Biol. 2013;200:743-56 pubmed publisher
..Interestingly, the up-regulation of CDK2 by CUL4B is achieved via the repression of miR-372 and miR-373, which target CDK2. Our findings thus establish a CUL4B-CDK2-CDC6 cascade in the regulation of DNA replication licensing. ..
Wang Y, Ma G, Wang Q, Wen M, Xu Y, He X, et al
. Involvement of CUL4A in regulation of multidrug resistance to P-gp substrate drugs in breast cancer cells. Molecules. 2013;19:159-76 pubmed publisher
..Thus, these results implied that CUL4A and ERK1/2 participated in multi-drug resistance in breast cancer through regulation of MDR1/P-gp expression. ..
Mi J, Zou Y, Lin X, Lu J, Liu X, Zhao H, et al
. Dysregulation of the miR-194-CUL4B negative feedback loop drives tumorigenesis in non-small-cell lung carcinoma. Mol Oncol. 2017;11:305-319 pubmed publisher
..The function of miR-194 as a negative regulator of CUL4B has therapeutic implications in lung cancer. ..
Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, et al
. A cullin 4B-RING E3 ligase complex fine-tunes pancreatic ? cell paracrine interactions. J Clin Invest. 2017;127:2631-2646 pubmed publisher
..Our results reveal an epigenetic regulatory mechanism of ? cell paracrine interactions in which CRL4B-PRC2 complexes, Cav1.2, and AC6 expression fine-tune somatostatin secretion and facilitate glucose homeostasis in pancreatic islets. ..