Experts and Doctors on phenotype in Shenyang, Liaoning, China


Locale: Shenyang, Liaoning, China
Topic: phenotype

Top Publications

  1. Mao Z, Huang Y, Sun M, Ruan Q, Qi Y, He R, et al. Genetic polymorphism of UL144 open reading frame of human cytomegalovirus DNA detected in colon samples from infants with Hirschsprung's disease. World J Gastroenterol. 2007;13:4350-4 pubmed
    ..There are genetic diversities of UL144 ORF in colon tissue of infants with HD. However, cytomegalovirus UL144 genotypes are not associated with clinical manifestations of HD. ..
  2. Wang J, Liu Y, Wei M, Mi X, Wang E. Clinical correlations and prognostic relevance of Fn14 expression in breast carcinoma. Histol Histopathol. 2013;28:859-64 pubmed publisher
    ..Our results suggest that Fn14 protein is a valuable marker of breast carcinoma progression. Fn14 might be used as a valuable prognostic marker for breast carcinoma patients. ..
  3. Zhao L, Di Z, Zhang L, Wang L, Ma L, Lv Y, et al. Association of SPINK5 gene polymorphisms with atopic dermatitis in Northeast China. J Eur Acad Dermatol Venereol. 2012;26:572-7 pubmed publisher
    ..However, the SPINK5 gene polymorphisms was found not to be associated with AD in regard to either serum IgE levels, concurrent allergic asthma or early onset of AD. Our study confirms the association between SPINK5 and AD. ..
  4. Zhang J, Lu G. Effect of 17??estradiol in rat bone marrow?derived endothelial progenitor cells. Mol Med Rep. 2013;8:178-82 pubmed publisher
    ..Proliferation levels were contrary to these observations, with levels decreasing as the concentration of 17??estradiol increased. ..
  5. Zhao J, Wang D, Yao H, Sun D, Li H. CTLA-4 and MDR1 polymorphisms increase the risk for ulcerative colitis: A meta-analysis. World J Gastroenterol. 2015;21:10025-40 pubmed publisher
    ..389, 95%CI: 1.214-1.590, P < 0.001; dominant model: OR = 1.518, 95%CI: 1.222-1.886, P < 0.001). CTLA-4 gene rs3087243 G > A and rs231775 G > A, and MDR1 gene rs1045642 C > T might confer an increase for UC risk. ..
  6. Chen S, Wang J, Gou W, Xiu Y, Zheng H, Zong Z, et al. The involvement of RhoA and Wnt-5a in the tumorigenesis and progression of ovarian epithelial carcinoma. Int J Mol Sci. 2013;14:24187-99 pubmed publisher
    ..RhoA is a potential tumorigenesis, differentiation, and progression biomarker in ovarian carcinoma. ..
  7. Chen S, Zhao Y, Gou W, Zhao S, Takano Y, Zheng H. The anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid (SAHA) on the aggressive phenotypes of ovarian carcinoma cells. PLoS ONE. 2013;8:e79781 pubmed publisher
    ..As such, aberrant acetylation of histone H3 and H4 may play an important role in the carcinogenesis and differentiation of ovarian carcinoma. ..
  8. Hua H, Liang Z, Li W, Meng Y, Li X, Zhang Z, et al. Phenotypic and functional maturation of murine dendritic cells (DCs) induced by purified Glycyrrhizin (GL). Int Immunopharmacol. 2012;12:518-25 pubmed publisher
    ..These data indicated that GL could promote maturation of DCs and this adjuvant-like activity may have potential therapeutic value. It is therefore concluded that GL could exert positive modulation on murine DCs. ..
  9. Zhang J, Wang Y, Zhang D, Yang Z, Dong X, Jiang G, et al. delta-Catenin promotes malignant phenotype of non-small cell lung cancer by non-competitive binding to E-cadherin with p120ctn in cytoplasm. J Pathol. 2010;222:76-88 pubmed publisher
    ..We conclude that delta-catenin is an oncoprotein overexpressed in NSCLC and that increased delta-catenin expression is critical for maintenance of the malignant phenotype of lung cancer. ..

More Information


  1. Xu Z, Yu L, Zhang X. Association between the hOGG1 Ser326Cys polymorphism and lung cancer susceptibility: a meta-analysis based on 22,475 subjects. Diagn Pathol. 2013;8:144 pubmed publisher
    ..000). Our data showed that the hOGG1 Ser326Cys polymorphism contributed to the risk of lung cancer. The virtual slides for this article can be found here: ..
  2. Zheng H, Nakamura T, Zheng Y, Nakanishi Y, Tabuchi Y, Uchiyama A, et al. SV40 T antigen disrupted the cell metabolism and the balance between proliferation and apoptosis in lens tumors of transgenic mice. J Cancer Res Clin Oncol. 2009;135:1521-32 pubmed publisher
    ..05), but lower than the others (P < 0.05). SV40 T antigen remarkably targeted the cell metabolism and disrupted the balance between proliferation and apoptosis during the lens carcinogenesis and following progression. ..
  3. Dongya M, Wencheng X, Xiaobo M, Lu W. Transition mutations in 23S rRNA account for acquired resistance to macrolides in Ureaplasma urealyticum. Microb Drug Resist. 2008;14:183-6 pubmed publisher
    ..No mutation was found in the ATCC 27618. The mechanisms of Uu resistance to ROM and AZM may be associated with the C2243N (T or C) mutation in 23S rRNA. Further studies are necessary to confirm this hypothesis. ..
  4. Dai H, Han G, Yan Y, Zhang F, Liu Z, Li X, et al. Transcript assembly and quantification by RNA-Seq reveals differentially expressed genes between soft-endocarp and hard-endocarp hawthorns. PLoS ONE. 2013;8:e72910 pubmed publisher
    ..The high quality ESTs generated in this study will aid future gene cloning from hawthorn. Our study provides important insights into the molecular mechanisms underlying soft endocarp formation in hawthorn. ..
  5. Wang H, Zhu J, Li L, Li Y, Lv H, Xu Y, et al. Effects of Nrf2 deficiency on arsenic metabolism in mice. Toxicol Appl Pharmacol. 2017;337:111-119 pubmed publisher
    ..These results suggest that the Nrf2-KO mice are more sensitive to arsenic than Nrf2-WT mainly because of differences in adaptive antioxidant detoxification capacity rather than arsenic methylation capacity. ..
  6. Zhan Z, Nwafor C, Hou Z, Gong J, Zhu B, Jiang Y, et al. Cytological and morphological analysis of hybrids between Brassicoraphanus, and Brassica napus for introgression of clubroot resistant trait into Brassica napus L. PLoS ONE. 2017;12:e0177470 pubmed publisher
    ..napus clubroot resistant cultivars. ..
  7. Choi S, Yu X, Dhandapani V, Li X, Wang Z, Lee S, et al. Integrated analysis of leaf morphological and color traits in different populations of Chinese cabbage (Brassica rapa ssp. pekinensis). Theor Appl Genet. 2017;130:1617-1634 pubmed publisher
    ..These robust QTLs and their candidate genes provide useful information for further research into leaf architecture with crop breeding. ..
  8. Wang N, Ma H, Li Z, Gao Y, Cao X, Jiang Y, et al. Chronic unpredictable stress exacerbates surgery-induced sickness behavior and neuroinflammatory responses via glucocorticoids secretion in adult rats. PLoS ONE. 2017;12:e0183077 pubmed publisher
    ..Stress-induced GCs played a pivotal role in enhancing surgery-induced neuroinflammatory processes by modulation of microglia functions. ..
  9. Liu Y, Wang Y, Zhang Y, Miao Y, Zhao Y, Zhang P, et al. Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer. Lung Cancer. 2009;63:375-82 pubmed publisher
    ..Based on our results, we conclude that abnormal p120-catenin expression correlates with abnormal E-cadherin expression and specific small GTPase overexpression, which contribute to the malignancy-related to NSCLC. ..
  10. Deng S, Zhu G, Liu F, Zhang H, Qin X, Li L, et al. CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:664-8 pubmed publisher
    ..No difference was found in all participants and females. The GG genotype and G allele were associated with ischemic stroke in the male Northern Chinese Han population. ..
  11. Hou X, Li Y, Li J, Wang W, Fan C, Wang H, et al. Development of thyroid dysfunction and autoantibodies in Graves' multiplex families: an eight-year follow-up study in Chinese Han pedigrees. Thyroid. 2011;21:1353-8 pubmed publisher
    ..Although smoking was negatively associated with the presence of thyroid antibodies (TPOAb/TgAb), smoking may induce or aggravate GD. ..
  12. Sun Z, Wang X, Lu J, Ding Q, Dong L, Zhao Y. [Correlation analysis between WNK4 gene and essential hypertension]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003;25:145-8 pubmed
    ..WNK4 gene were expressed in the tissues of kidney, brain, lung, heart, spleen and intestine of fetus. WNK4 gene is well correlated with essential hypertension. ..
  13. Han Y, Deng J, Guo L, Yan C, Liang M, Kang J, et al. CREG promotes a mature smooth muscle cell phenotype and reduces neointimal formation in balloon-injured rat carotid artery. Cardiovasc Res. 2008;78:597-604 pubmed publisher
  14. Liu Y, Dong Q, Wang S, Fang C, Miao Y, Wang L, et al. Abnormal expression of Pygopus 2 correlates with a malignant phenotype in human lung cancer. BMC Cancer. 2013;13:346 pubmed publisher
    ..We therefore conclude that abnormal Pygo2 protein expression may be a marker for advanced NSCLC. Furthermore, Pygo2 knockdown suppresses cell growth. ..
  15. Wang T, Zhang M, Han Y, Zhang X, Yan C, Liang Z, et al. Lack of association between cellular repressor of E1A-stimulated genes (CREG) [corrected] polymorphisms and coronary artery disease in the Han population of North China. Clin Chim Acta. 2011;412:249-52 pubmed publisher
    ..05). This study did not show an association between common variants of CREG and CAD in the northern Chinese Han population. ..
  16. Yao D, Dai C, Peng S. Mechanism of the mesenchymal-epithelial transition and its relationship with metastatic tumor formation. Mol Cancer Res. 2011;9:1608-20 pubmed publisher
    ..Given the critical role of MET in metastatic tumor formation, the potential to effectively target the MET process at sites of metastasis offers new hope for inhibiting metastatic tumor formation. ..
  17. Xu Z, Wu R. Alteration in metastasis potential and gene expression in human lung cancer cell lines by ITGB8 silencing. Anat Rec (Hoboken). 2012;295:1446-54 pubmed publisher
    ..The ITGB8 silencing may change the lung cancer cells to a less invasive phenotype through alteration in the expression of metastasis-related genes. ..
  18. Tian X, Yan C, Liu M, Zhang Q, Liu D, Liu Y, et al. CREG1 heterozygous mice are susceptible to high fat diet-induced obesity and insulin resistance. PLoS ONE. 2017;12:e0176873 pubmed publisher
    ..This study uncovered a novel function of CREG1 in metabolic disorders. ..
  19. Tang S, Wang X, Li W, Yang X, Li Z, Liu W, et al. Biallelic Mutations in CFAP43 and CFAP44 Cause Male Infertility with Multiple Morphological Abnormalities of the Sperm Flagella. Am J Hum Genet. 2017;100:854-864 pubmed publisher
    ..Further investigations on other CFAP-encoding genes in more genetically unexplained MMAF-affected individuals could uncover novel mechanisms underlying sperm flagellar formation. ..
  20. van Triest H, Chen D, Ji X, Qi S, Li Ling J. PhenOMIM: an OMIM-based secondary database purported for phenotypic comparison. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:3589-92 pubmed publisher
    ..The data is freely available online for reviewing and commenting purposes and can be found at ..
  21. Du Y, Dai D, Yang Z. Role of RECK methylation in gastric cancer and its clinical significance. World J Gastroenterol. 2010;16:904-8 pubmed
    ..5% (26/40), with a sensitivity of 66.7% (6/9) and a specificity of 74.2% (23/31). Aberrant methylation of RECK gene may provide useful information for the early diagnosis and treatment of peritoneal metastasis of gastric cancer. ..
  22. Pei F, Han Y, Zhang X, Yan C, Huang M, Deng J, et al. Association analysis of the IL-17F His161Arg polymorphism in myocardial infarction. Coron Artery Dis. 2009;20:513-7 pubmed publisher
    ..This study indicates for the first time that, unlike other chronic inflammatory diseases, the IL-17F His161Arg polymorphism is unlikely to be a major contributor to the pathogenesis of MI. ..
  23. Wang J, Nakazaki T, Chen S, Chen W, Saito H, Tsukiyama T, et al. Identification and characterization of the erect-pose panicle gene EP conferring high grain yield in rice (Oryza sativa L.). Theor Appl Genet. 2009;119:85-91 pubmed publisher
    ..Experimental results showed that EP gene markedly enhanced grain yield, chiefly by increasing number of secondary branches and number of grains on the secondary branch. EP gene also produced a remarkable increase in grain density. ..
  24. Gu S, Xing C, Han J, Tso M, Hong J. Differentiation of rabbit bone marrow mesenchymal stem cells into corneal epithelial cells in vivo and ex vivo. Mol Vis. 2009;15:99-107 pubmed
    ..To examine whether bone marrow mesenchymal stem cells (MSCs) could be differentiated into corneal epithelial cells in vivo and ex vivo...
  25. Wang J, Su K, Guo Y, Xing H, Zhao Y, Liu Z, et al. Construction of a high-density genetic map for grape using specific length amplified fragment (SLAF) sequencing. PLoS ONE. 2017;12:e0181728 pubmed publisher
  26. Geng L, Wang Y, Zhai N, Lu Y, Song F, Chen H. Association between pemphigus vulgaris and human leukocyte antigen in Han nation of northeast China. Chin Med Sci J. 2005;20:166-70 pubmed
    ..09%, 7.74%, and 1.89%). After P value correction, the difference was still significant between the two groups. PV significantly relates with HLA in PV patients of Han nation of northeast China. ..
  27. Li M, Yang J, Zhou W, Ren Y, Wang X, Chen H, et al. Activation of an AKT/FOXM1/STMN1 pathway drives resistance to tyrosine kinase inhibitors in lung cancer. Br J Cancer. 2017;117:974-983 pubmed publisher
    ..Our findings elucidate an additional common mechanism for TKI resistance and provide a promising therapeutic target for reversing TKI resistance in NSCLC. ..