Experts and Doctors on rats in Nanjing, Jiangsu, China

Summary

Locale: Nanjing, Jiangsu, China
Topic: rats

Top Publications

  1. Wang S, Hu L, Zhang Y, Sun T, Sun Y, Liu S, et al. Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats. Neuropsychopharmacology. 2006;31:933-40 pubmed
    ..ii) KATP channels regulate extracellular neurotransmitter levels in the striatum of unilateral 6-OHDA-lesioned rats and may play neuroprotective roles due to their effects on glutamate transporters. ..
  2. Lu Y, Li J, Wang G. In vitro and in vivo evaluation of mPEG-PLA modified liposomes loaded glycyrrhetinic acid. Int J Pharm. 2008;356:274-81 pubmed publisher
    ..7-fold longer residence time (MRT), a 2.75-fold larger AUC and a 0.4-fold lower clearance compared with conventional injection, respectively. These results combined suggested that the LC-CP had a well-improved residence in rats. ..
  3. Wang H, Jiang X, Xu J, Xu J, Tong J, Wang Y. The profile of gene expression and role of nuclear factor kappa B on glomerular injury in rats with Thy-1 nephritis. Clin Exp Immunol. 2008;152:559-67 pubmed publisher
  4. Chen L, Lu Y, Wu J, Xu B, Zhang L, Gao M, et al. Ligustrazine inhibits B16F10 melanoma metastasis and suppresses angiogenesis induced by Vascular Endothelial Growth Factor. Biochem Biophys Res Commun. 2009;386:374-9 pubmed publisher
    ..Our data suggests that Ligustrazine may inhibit tumor metastasis, at least in part, through its anti-angiogenic activity. ..
  5. Tian H, Huang B, Zhao J, Hu X, Guo J, Li L. Non-receptor tyrosine kinase Src is required for ischemia-stimulated neuronal cell proliferation via Raf/ERK/CREB activation in the dentate gyrus. BMC Neurosci. 2009;10:139 pubmed publisher
    ..Src kinase increase numbers of newborn neuronal cells in the DG via the activation of Raf/ERK/CREB signaling cascade after cerebral ischemia. ..
  6. Chen J, Zhang T, Cai B, Chen M, Fang Y. [Pharmaceutical properties of novel liposomes containing total alkaloids from seed of Strychnos nux-vomica]. Zhongguo Zhong Yao Za Zhi. 2010;35:35-9 pubmed
  7. Guan X, Wang L, Chen C, Guan Y, Li S. Roles of two subtypes of corticotrophin-releasing factor receptor in the corticostriatal long-term potentiation under cocaine withdrawal condition. J Neurochem. 2010;115:795-803 pubmed publisher
  8. Ning Y, Zhang W, Cheng J, Li X, Wang M, Lin L. [Insulin-like growth factor 1 regulates expression of stem cell factor through ERKMAPK signaling pathway in gastric smooth muscle cell]. Zhonghua Yi Xue Za Zhi. 2010;90:2402-6 pubmed
    ..05). The SCF expression in gastric SMC is stimulated by IGF-1 in both dose- and time-dependent manners through IGF-1R in which ERKMAPK signal transduction may play an important role. ..
  9. Chang J, Zhang W, Shen B, Wei Y, Zhang L, Wang Y, et al. [Proteomic analysis of the testis and differential expression of Annexin A3 in hypospadiac rats]. Zhonghua Nan Ke Xue. 2010;16:877-82 pubmed
    ..The differential expression of Annexin A3 may play an important role in the development of hypospadia. ..

More Information

Publications522 found, 100 shown here

  1. Xu N, Qiu C, Wang W, Wang Y, Chai C, Yan Y, et al. HPLC/MS/MS for quantification of two types of neurotransmitters in rat brain and application: myocardial ischemia and protection of Sheng-Mai-San. J Pharm Biomed Anal. 2011;55:101-8 pubmed publisher
    ..These findings demonstrate that myocardial ischemia reduces the concentrations of 5-HT, NE, M-ENK and L-ENK in rat brains, while SMS shows protective effects on MI associated with reversing these four neurotransmitters to sham levels. ..
  2. Yan L, Lu Y, Zheng S, Wang A, Li M, Ruan J, et al. Injectable caltrop fruit saponin protects against ischemia-reperfusion injury in rat brain. Am J Chin Med. 2011;39:325-33 pubmed
  3. Wu Y, Chen R, Zhao X, Li A, Li G, Zhou J. JWA regulates chronic morphine dependence via the delta opioid receptor. Biochem Biophys Res Commun. 2011;409:520-5 pubmed publisher
    ..These observations suggest that JWA is directly involved in the regulation of chronic morphine dependence...
  4. Ma S, Kou J, Yu B. Safety evaluation of steroidal saponin DT-13 isolated from the tuber of Liriope muscari (Decne.) Baily. Food Chem Toxicol. 2011;49:2243-51 pubmed publisher
    ..Necropsy, hematological and biochemical analysis, and histopathological examination did not reveal any remarkable and treatment related changes. In conclusion, DT-13 is of low toxicity at the tested doses...
  5. Huang M, Qian Y, Guan T, Huang L, Tang X, Li Y. Different neuroprotective responses of Ginkgolide B and bilobalide, the two Ginkgo components, in ischemic rats with hyperglycemia. Eur J Pharmacol. 2012;677:71-6 pubmed publisher
    ..These results suggested that CBF plays crucial roles during early stage of reperfusion in the presence of hyperglycemia. Administration of compound that improves CBF may have little effect in hyperglycemic stroke. ..
  6. Wang Y, Zhu Y, Gao L, Yin H, Xie Z, Wang D, et al. Formononetin attenuates IL-1?-induced apoptosis and NF-?B activation in INS-1 cells. Molecules. 2012;17:10052-64 pubmed publisher
    ..Our observations indicated that formononetin could protect against pancreatic ?-cell apoptosis caused by IL-1? and therefore could be used in the future as a new drug improving diabetes mellitus. ..
  7. Tang J, Li W, Xie Y, Guo H, Cheng P, Chen H, et al. Morphological and functional deterioration of the rat thyroid following chronic exposure to low-dose PCB118. Exp Toxicol Pathol. 2013;65:989-94 pubmed publisher
    ..Exposure to PCB118 also caused significant decreases in NIS and TG mRNA expression levels. Chronic exposure to low-dose PCB118 and other PCB congeners may be a significant risk factor for thyroid diseases. ..
  8. Zhang W, Miao J, Wang S, Zhang Y. The protective effects of beta-casomorphin-7 against glucose -induced renal oxidative stress in vivo and vitro. PLoS ONE. 2013;8:e63472 pubmed publisher
    ..Our results suggest that administration of BCM7 would alleviate high glucose-induced renal oxidative stress in vivo and in vitro, which may be associated with down regulation of the concentration of Ang II partly. ..
  9. Tian J, Wang Y, Xu Y, Yu Z, Wei A, Zhang W, et al. Characterization of isobutylhydroxyamides with NGF-potentiating activity from Zanthoxylum bungeanum. Bioorg Med Chem Lett. 2016;26:338-342 pubmed publisher
  10. Tian J, Lin X, Guan R, Xu J. The effects of hydroxyethyl starch on lung capillary permeability in endotoxic rats and possible mechanisms. Anesth Analg. 2004;98:768-74, table of contents pubmed
    ..A randomized, controlled laboratory experiment indicated that hydroxyethyl starch (HES) could reduce increased lung capillary permeability in endotoxemia. This effect may be due to an antiinflammatory effect of HES. ..
  11. Li L, Ding J, Ren Z, Han Q, Hu G, Xiao M. Expression and colocalization of NADPH-diaphorase and Fos in the subnuclei of the parabrachial nucleus in rats following visceral noxious stimulation. Brain Res. 2006;1114:41-52 pubmed
    ..These results suggest that neurons in the el of the PB that project to the CeA are activated by visceral noxious stimulation and could be indirectly influenced by nitric oxide in the PB. ..
  12. Chai Y, Niu L, Sun X, Ding J, Hu G. Iptakalim protects PC12 cell against H2O2-induced oxidative injury via opening mitochondrial ATP-sensitive potassium channel. Biochem Biophys Res Commun. 2006;350:307-14 pubmed
    ..These protective effects of IPT were abolished by selective mitoK(ATP) channel blocker 5-hydroxydecanoate. Therefore, IPT can protect PC12 cells against H(2)O(2)-induced oxidative injury via activating mitoK(ATP) channel. ..
  13. Xu X, Chen X, Ji H, Li P, Bian Y, Yang D, et al. Astragaloside IV improved intracellular calcium handling in hypoxia-reoxygenated cardiomyocytes via the sarcoplasmic reticulum Ca-ATPase. Pharmacology. 2008;81:325-32 pubmed publisher
    ..These results suggest that the beneficial effect of astragaloside IV in H/R-induced injury may be related to normalization of SR Ca2+ pump expression and, thus, may prevent the depression in SR Ca2+ handling. ..
  14. Sun Z, Jiang H, Ye Z, Jia B, Zhang X, Zhang K. Expression of Rho GDIalpha in rat osteoblasts intermittently exposed to parathyroid hormone in vitro and in vivo. Acta Pharmacol Sin. 2009;30:1001-7 pubmed publisher
    ..This up-regulation of RhoGDIalpha may be one of the mechanisms underlying the synergistic bone-forming effect of PTH and estrogen.Acta Pharmacologica Sinica (2009) 30: 1001-1007; doi: 10.1038/aps.2009.60. ..
  15. Xu G, Dou J, Zhang L, Guo Q, Zhou C. Inhibitory effects of baicalein on the influenza virus in vivo is determined by baicalin in the serum. Biol Pharm Bull. 2010;33:238-43 pubmed
    ..2 microg/ml in the cytopathic effect assay. Our results showed that baicalein warrants further research as a potential antiinfluenza viral agent. ..
  16. Zhou X, Sheng Y, Yang R, Kong X. Nicotine promotes cardiomyocyte apoptosis via oxidative stress and altered apoptosis-related gene expression. Cardiology. 2010;115:243-50 pubmed publisher
    ..Nicotine promotes cardiomyocyte apoptosis by inducing oxidative stress and disrupting apoptosis-related gene expression. ..
  17. Shu T, Zhu Y, Wang H, Lin Y, Ma Z, Han X. AGEs decrease insulin synthesis in pancreatic ?-cell by repressing Pdx-1 protein expression at the post-translational level. PLoS ONE. 2011;6:e18782 pubmed publisher
    ..In summary, AGEs induced nuclear accumulation of Foxo1; this in turn reduced Pdx-1 expression by decreasing its protein stability, ultimately affecting insulin synthesis. ..
  18. Lei Z, Jiang Y, Li T, Zhu J, Zeng S. Signaling of glial cell line-derived neurotrophic factor and its receptor GFR?1 induce Nurr1 and Pitx3 to promote survival of grafted midbrain-derived neural stem cells in a rat model of Parkinson disease. J Neuropathol Exp Neurol. 2011;70:736-47 pubmed publisher
    ..Our data demonstrate the contribution of GDNF to DA neuron development and may also elucidate pathogenetic mechanisms in Parkinson disease and contribute to the development of novel therapies for the disorder. ..
  19. Luo B, Zhang S, Ma S, Zhou J, Wang B. Effects of cold air on cardiovascular disease risk factors in rat. Int J Environ Res Public Health. 2012;9:2312-25 pubmed publisher
  20. Wang C, Yang F, Xu Z, Shi D, Chen D, Dai J, et al. Intravenous release of NO from lipidic microbubbles accelerates deep vein thrombosis resolution in a rat model. Thromb Res. 2013;131:e31-8 pubmed publisher
    ..The antithrombotic properties of NO microbubbles may be associated with reduced platelets and inflammatory cells aggregation, enhanced collagen turnover and stimulus to an anticoagulant condition of endothelium. ..
  21. Yang B, Sun H, Li W, Zhu C, Jian B, Hou W, et al. Expression of Rap1 during germ cell development in the rat and its functional implications in 2-methoxyacetic acid-induced spermatocyte apoptosis. Urology. 2013;81:696.e1-8 pubmed publisher
    ..Additional characterization of this small guanosine triphosphatase in the apoptotic dynamics should provide information on the early diagnosis of MAA-induced male infertility. ..
  22. Ren S, Yan J, Zhang X, Bu Y, Pan W, Yao W, et al. PKC? is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP. EMBO J. 2013;32:1365-80 pubmed publisher
    ..Thus, we conclude that PKC? is the critical signalling molecule responsible for GluA1-containing AMPAR phosphorylation and synaptic incorporation at activated synapses during LTP expression. ..
  23. Liu X, Zhang T, Xia W, Wang Y, Ma K. Recombinant human erythropoietin pretreatment alleviates renal glomerular injury induced by cardiopulmonary bypass by reducing transient receptor potential channel 6-nuclear factor of activated T-cells pathway activation. J Thorac Cardiovasc Surg. 2013;146:681-7 pubmed publisher
    ..Pretreatment of 5000 U/kg recombinant human erythropoietin elicited potent glomerular protection against cardiopulmonary bypass. This protection may be partly due to downregulation of glomerular TRPC6-NFATc1 pathway. ..
  24. Sun Z, Gong X, Zhu H, Wang C, Xu X, Cui D, et al. Inhibition of Wnt/?-catenin signaling promotes engraftment of mesenchymal stem cells to repair lung injury. J Cell Physiol. 2014;229:213-24 pubmed publisher
    ..Our study suggested that inhibition of abnormal activated Wnt/?-catenin signaling would promote MSCs epithelial differentiation to repair lung injury and reduce pulmonary fibrosis. ..
  25. Tang S, Buriro R, Liu Z, Zhang M, Ali I, Adam A, et al. Localization and expression of Hsp27 and ?B-crystallin in rat primary myocardial cells during heat stress in vitro. PLoS ONE. 2013;8:e69066 pubmed publisher
    ..Our findings indicate that Hsp27 and ?B-crystallin do play a role in the response of cardiac cells to heat stress, but the details of their function remain to be investigated. ..
  26. Ma Y, Zhang X, Shen B, Lu Y, Chen W, Ma J, et al. Generating rats with conditional alleles using CRISPR/Cas9. Cell Res. 2014;24:122-5 pubmed publisher
  27. Li F, Wu J, Wang J, Yang X, Cai P, Liu Q, et al. Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease. Bioorg Med Chem. 2017;25:3815-3826 pubmed publisher
    ..62). In addition, s19 could reduce PC12 cells death induced by oxidative stress and penetrate the blood-brain barrier (BBB). Taken together, these results suggested that s19 might be a promising multitargeted compound for AD treatment. ..
  28. Chen G, Shi J, Ding Y, Yin H, Hang C. Progesterone prevents traumatic brain injury-induced intestinal nuclear factor kappa B activation and proinflammatory cytokines expression in male rats. Mediators Inflamm. 2007;2007:93431 pubmed publisher
    ..The results of the present study suggest that the therapeutic benefit of post-TBI progesterone injections might be due to its inhibitory effects on intestinal NF-kappaB activation and proinflammatory cytokines expression. ..
  29. Lai Y, Ma L, Huang W, Yu X, Zhang Y, Ji H, et al. Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors. Bioorg Med Chem Lett. 2010;20:7349-53 pubmed publisher
    ..Therefore, our findings may aid in the design of new and safe anti-inflammatory reagents for the intervention of painful inflammatory diseases, such as rheumatoid arthritis at clinic. ..
  30. Zhou W, Di L, Shan J, Bi X, Chen L, Wang L, et al. In vitro metabolism in Sprague-Dawley rat liver microsomes of forsythoside A in different compositions of Shuang-Huang-Lian. Fitoterapia. 2011;82:1222-30 pubmed publisher
  31. Zhuang L, Jin R, Zhu L, Xu H, Li Y, Gao S, et al. Promoter characterization and role of cAMP/PKA/CREB in the basal transcription of the mouse ORMDL3 gene. PLoS ONE. 2013;8:e60630 pubmed publisher
  32. Li H, Wu W, Sun Q, Liu M, Li W, Zhang X, et al. Expression and cell distribution of receptor for advanced glycation end-products in the rat cortex following experimental subarachnoid hemorrhage. Brain Res. 2014;1543:315-23 pubmed publisher
  33. Chen G, Shi J, Jin W, Wang L, Xie W, Sun J, et al. Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion. Ann Clin Lab Sci. 2008;38:65-74 pubmed
    ..In summary, post-TBI progesterone administration attenuates the TLRs/NF-kappaB signaling pathway in injured rat brain, and this may be a mechanism whereby progesterone improves the outcome following TBI. ..
  34. Yin R, Huang H, Zhang J, Zhu J, Jing H, Li Z. Dietary n-3 fatty acids attenuate cardiac allograft vasculopathy via activating peroxisome proliferator-activated receptor-gamma. Pediatr Transplant. 2008;12:550-6 pubmed publisher
    ..Our results demonstrated that fish oil might attenuate CAV development, possibly through activating PPAR gamma and subsequently inhibiting the NF-kappaB activation, the chemokines secretion, as well as the CCR2 expression. ..
  35. Liu Y, Zha B, Zhang H, Zhu X, Li Y, Zhu J, et al. Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model. J Exp Clin Cancer Res. 2009;28:107 pubmed publisher
  36. Qi J, Sun M, Ping Q, Zhuang J, Li J, Peddie F, et al. The mechanisms for enhanced oral absorption of hydroxysafflor yellow A by chuanxiong volatile oil. Planta Med. 2010;76:786-92 pubmed publisher
    ..91-fold when 100 and 25 mg/kg of CVO were co-administrated, respectively. CVO was an effective absorption enhancer for oral delivery of BCS III drugs. It can cause redistribution of claudin-1 proteins and open the tight junctions. ..
  37. Guo J, Zhu J, Deng X, Hu X, Zhao J, Sun Y, et al. Palmitate-induced inhibition of insulin gene expression in rat islet β-cells involves the ceramide transport protein. Cell Physiol Biochem. 2010;26:717-28 pubmed publisher
  38. Zhang L, Lu L, Jin S, Jing X, Yao D, Hu N, et al. Tissue-specific alterations in expression and function of P-glycoprotein in streptozotocin-induced diabetic rats. Acta Pharmacol Sin. 2011;32:956-66 pubmed publisher
    ..Alterations in the expression and function of Abcb1/P-GP under diabetic conditions are tissue specific, Abcb1 specific and diabetic duration-dependent. ..
  39. Li H, Wang Y. Effect of auricular acupuncture on gastrointestinal motility and its relationship with vagal activity. Acupunct Med. 2013;31:57-64 pubmed publisher
    ..However, HRV did not reflect the acupuncture-induced changes in vagal nerve function. ..
  40. Huang Y, Tian Y, Li G, Li Y, Yin X, Peng C, et al. Discovery of safety biomarkers for realgar in rat urine using UFLC-IT-TOF/MS and 1H NMR based metabolomics. Anal Bioanal Chem. 2013;405:4811-22 pubmed publisher
    ..The LC/MS and NMR based metabolomics approach established provided a systematic and holistic view of the biochemical effects of realgar on rats, and might be employed to investigate other drugs or xenobiotics in the future. ..
  41. Liu L, Guo J, Yuan L, Cheng M, Cao L, Shi H, et al. Alpha-fetoprotein is dynamically expressed in rat pancreas during development. Dev Growth Differ. 2007;49:669-81 pubmed
    ..5, and declined after birth to a nearly undetectable level in adults. The dynamic expression of AFP in rat pancreas from different stages indicates that AFP might be involved in some aspects of pancreatic development. ..
  42. Yang Y, Zhang S, Ding J, Zhou F, Hu G. Iptakalim protects against MPP+-induced degeneration of dopaminergic neurons in association with astrocyte activation. Int J Neuropsychopharmacol. 2009;12:317-27 pubmed publisher
    ..Together, these findings suggest that Ipt may protect against MPP+-induced degeneration of dopaminergic neurons by inhibiting astrocyte activation and subsequent release of pro-inflammatory factors...
  43. Zhu R, Zhou M, He J, Ding F, Yu S, Xu G. [Protective effect of curcumin on oleic-induced acute lung injury in rats]. Zhongguo Zhong Yao Za Zhi. 2008;33:2141-5 pubmed
    ..The mediation of both proinflammatory factor and anti-inflammatory factor by curcumine may be involved in mechanism of action of curcumine effects. ..
  44. Fang W, Deng Y, Li Y, Shang E, Fang F, Lv P, et al. Blood brain barrier permeability and therapeutic time window of Ginkgolide B in ischemia-reperfusion injury. Eur J Pharm Sci. 2010;39:8-14 pubmed publisher
    ..In conclusion, Ginkgolide B could pass through BBB, especially after ischemia-reperfusion injury of brain, and might be therapeutically effective for ischemia/reperfusion injury of human brain...
  45. Hu Y, Chen X, Duan H, Hu Y, Mu X. Chinese herbal medicinal ingredients inhibit secretion of IL-6, IL-8, E-selectin and TXB2 in LPS-induced rat intestinal microvascular endothelial cells. Immunopharmacol Immunotoxicol. 2009;31:550-5 pubmed publisher
    ..All these changes were significant. Taken together, the data suggest that all seven active ingredients of PD can effectively reduce inflammatory response, thus relieving intestinal dysfunction via multiple pathways. ..
  46. Zhu J, Jia R, Xu L, Wu J, Wang Z, Wang S, et al. Reduced expression of SK3 and IK1 channel proteins in the cavernous tissue of diabetic rats. Asian J Androl. 2010;12:599-604 pubmed publisher
    ..05). Diabetes inhibits mRNA and protein expression of both SK3 and IK1 in the cavernous tissue of diabetic rats. This could play a key role in the development of erectile dysfunction in diabetic rats. ..
  47. Zhang J, Li B, Yu L, He Y, Li H, Zhu J, et al. A role for orexin in central vestibular motor control. Neuron. 2011;69:793-804 pubmed publisher
    ..These findings may account for why the absence of orexin results in narcolepsy-cataplexy. ..
  48. Zhou H, Dou J, Wang J, Chen L, Wang H, Zhou W, et al. The antibacterial activity of BF-30 in vitro and in infected burned rats is through interference with cytoplasmic membrane integrity. Peptides. 2011;32:1131-8 pubmed publisher
    ..Taken together, our data demonstrate that antibacterial activity of BF-30 has potential therapeutic value for the prevention and treatment of burn and wound infections. ..
  49. Xu F, Peng D, Tao C, Yin D, Kou J, Zhu D, et al. Anti-depression effects of Danggui-Shaoyao-San, a fixed combination of Traditional Chinese Medicine, on depression model in mice and rats. Phytomedicine. 2011;18:1130-6 pubmed publisher
    ..These results demonstrated for the first time DSS has anti-depression effect and it may be influencing the central AVP system. ..
  50. Hou M, Liu Y, Zhu L, Sun B, Guo M, Burén J, et al. Neonatal overfeeding induced by small litter rearing causes altered glucocorticoid metabolism in rats. PLoS ONE. 2011;6:e25726 pubmed publisher
  51. He Y, Wu G, Li D, Tang B, Li B, Ding Y, et al. Histamine promotes rat motor performances by activation of H(2) receptors in the cerebellar fastigial nucleus. Behav Brain Res. 2012;228:44-52 pubmed publisher
  52. Wang Q, Lin Y, Zhang Q, Sun S, Ling X. [Changes of BDNF expression in hippocampus and serum of rats with artificial chronic obstructive pulmonary disease]. Sheng Li Xue Bao. 2011;63:505-10 pubmed
    ..In conclusion, the expression of BDNF in the hippocampus and serum is highly increased in the COPD group. Smoking and intratracheal instillation of LPS induce the increase of BDNF level in the hippocampus and serum. ..
  53. Zheng J, Gong J, Zhang A, Li S, Zeng Z, Han Y, et al. Attenuation of glomerular filtration barrier damage in adriamycin-induced nephropathic rats with bufalin: an antiproteinuric agent. J Steroid Biochem Mol Biol. 2012;129:107-14 pubmed publisher
    ..These results suggest that bufalin could alleviate ADR-induced proteinuria by protecting the glomerular filtration barrier and may be a novel potential therapeutic agent for proteinuria-associated kidney disease. ..
  54. Liu J, Zhao H, Liu Y, Liu Y, Wang X. Effect of two selenium sources on hepatocarcinogenesis and several angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats. J Trace Elem Med Biol. 2012;26:255-61 pubmed publisher
    ..SS at the same therapeutic dosage had less effect on the hepatocarcinogenesis by inhibiting angiogenesis and relative cytokines to some extent. ..
  55. Sun Y, Peng L, Sun X, Bo J, Yang D, Zheng Y, et al. Intrathecal injection of spironolactone attenuates radicular pain by inhibition of spinal microglia activation in a rat model. PLoS ONE. 2012;7:e39897 pubmed publisher
  56. Zhu F, Yu H, Wu H, Shi R, Tao W, Qiu Y. [Correlation of Pinellia ternata agglutinin and Pinellia ternata raphides' toxicity]. Zhongguo Zhong Yao Za Zhi. 2012;37:1007-11 pubmed
    ..PTA had obvious effect of pro-inflammation. The toxic mechanism of P. ternata was PTA induced inflammation only when the raphides pierce into the organization. ..
  57. Xiong X, Chen W, Han Y, Zhou Y, Zhang F, Gao X, et al. Enhanced adipose afferent reflex contributes to sympathetic activation in diet-induced obesity hypertension. Hypertension. 2012;60:1280-6 pubmed publisher
    ..The results indicate that enhanced AAR contributes to sympathetic activation in OH, and paraventricular nucleus plays an important role in the enhanced AAR and sympathetic activation in OH. ..
  58. Zhou L, Zhang K, Li J, Cui X, Wang A, Huang S, et al. Inhibition of vascular endothelial growth factor-mediated angiogenesis involved in reproductive toxicity induced by sesquiterpenoids of Curcuma zedoaria in rats. Reprod Toxicol. 2013;37:62-9 pubmed publisher
    ..Our results suggest that the reproductive toxicity of C. zedoaria may be caused by sesquiterpenoids in the essential oil blocking VEGF-mediated angiogenesis. ..
  59. Liu G, Zhang Y, Dai D, Ding M, Cong X, Dai Y. Male hypogonadism induced by high fat diet and low dose streptozotocin is mediated by activated endoplasmic reticulum stress and I?B? and attenuated by argirein and valsartan. Eur J Pharmacol. 2013;713:78-88 pubmed publisher
    ..In conclusion, diabetic testopathy induced by a HFD and low STZ is characterized by an entity of inflammation and is alleviated by argirein and valsartan through normalizing activated I?B? and ER stress. ..
  60. Jiang L, Zhou Y, Xiong M, Fang L, Wen P, Cao H, et al. Sp1 mediates microRNA-29c-regulated type I collagen production in renal tubular epithelial cells. Exp Cell Res. 2013;319:2254-65 pubmed publisher
  61. Chen Y, Guo J, Qian Y, Guo S, Ma C, Duan J. Toxicity of daphnane-type diterpenoids from Genkwa Flos and their pharmacokinetic profile in rat. Phytomedicine. 2013;21:82-9 pubmed publisher
  62. Wang Q, Wang D, Yan G, Sun L, Tang C. TRPC6 is required for hypoxia-induced basal intracellular calcium concentration elevation, and for the proliferation and migration of rat distal pulmonary venous smooth muscle cells. Mol Med Rep. 2016;13:1577-85 pubmed publisher
    ..Results from the present study suggest that TRPC6 expression is increased during chronic hypoxia, which contributes to Ca2+ entry into the cell, thus promoting proliferation and migration of PVSMCs. ..
  63. Qian Y, Peng Y, Shang E, Zhao M, Yan L, Zhu Z, et al. Metabolic profiling of the hepatotoxicity and nephrotoxicity of Ginkgolic acids in rats using ultra-performance liquid chromatography-high-definition mass spectrometry. Chem Biol Interact. 2017;273:11-17 pubmed publisher
    ..The results suggested that exposure to GAs could cause disturbances in liver and kidney function associated with the metabolisms of lipids, glucose and the enzyme activity. ..
  64. Qi X, Qin Z, Tang J, Han P, Xing Q, Wang K, et al. Omega-3 polyunsaturated fatty acids ameliorates testicular ischemia-reperfusion injury through the induction of Nrf2 and inhibition of NF-?B in rats. Exp Mol Pathol. 2017;103:44-50 pubmed publisher
    ..These results provided evidences that n-3 PUFAs ameliorated testes damage caused by testicular I/R injury through its antioxidative capacity and anti-inflammatory effects, involving the activation of Nrf2 and the inhibition of NF-?B. ..
  65. Zhang H, Wu W, Feng C, Liu Z, Bai E, Wang X, et al. Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants. Eur J Med Chem. 2017;135:12-23 pubmed publisher
  66. Yao B, Fan J, Wang Y, Cui Y, Huang Y. [The distribution of androgen receptor and its coexistence with gonadotropin releasing hormone receptor in rat submaxillary]. Zhonghua Nan Ke Xue. 2002;8:32-4 pubmed
    ..It suggests that submaxillary is a target organ of androgen, responsible for modulating biological function of submaxillary. ..
  67. Lai X, Zhang L, Li J, Liu H, Liu X, Di L, et al. Comparative pharmacokinetic and bioavailability studies of three salvianolic acids after the administration of Salviae miltiorrhizae alone or with synthetical borneol in rats. Fitoterapia. 2011;82:883-8 pubmed publisher
    ..These results indicated that borneol could enhance the intestinal absorption, decrease the distribution and inhibit the metabolism of salvianolic acids. ..
  68. Lu T, Jiang Y, Zhou Z, Yue X, Wei N, Chen Z, et al. Intranasal ginsenoside Rb1 targets the brain and ameliorates cerebral ischemia/reperfusion injury in rats. Biol Pharm Bull. 2011;34:1319-24 pubmed
    ..Our work suggests that intranasal GRb1 exerts brain-targeting effects and that a single dose of intranasal GRb1 immediately after MCAO ameliorates ischemia/reperfusion insult. Autophagy is involved in these beneficial effects. ..
  69. Tian M, Zhu D, Xie W, Shi J. Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains. FEBS Lett. 2012;586:3737-45 pubmed publisher
    ..These findings implicate Ang II as a crucial mediator of AD pathology and a link between cardiovascular events and AD. ..
  70. Tu Y, Sun W, Wan Y, Che X, Pu H, Yin X, et al. Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, ameliorates adriamycin-induced renal inflammation and glomerular injury via inhibiting p38MAPK signaling pathway activity in rats. J Ethnopharmacol. 2013;147:311-20 pubmed publisher
  71. Tao Y, Du Y, Li W, Cai B, Di L, Shi L, et al. Integrating UHPLC-MS/MS quantification and DAS analysis to investigate the effects of wine-processing on the tissue distributions of bioactive constituents of herbs in rats: Exemplarily shown for Dipsacus asper. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1055-1056:135-143 pubmed publisher
    ..The accumulation of bioactive constituents in liver and kidney tissues after wine-processing will contribute to the enhancement of liver and kidney nourishing effects. ..
  72. Li Q, Chou G, Dou C, Wang Z, Huang F. [Studies on the analgesic and antiinflammatory action of radix Linderae extract]. Zhong Yao Cai. 1997;20:629-31 pubmed
    ..The component further isolated from the plant could antagonize the swelling of rat toes induced by carrageenin...
  73. Guo J, Ping Q, Jiang G, Dong J, Qi S, Feng L, et al. Transport of leuprolide across rat intestine, rabbit intestine and Caco-2 cell monolayer. Int J Pharm. 2004;278:415-22 pubmed
    ..At low drug concentration, reduction of enzyme degradation is the most important factor. ..
  74. Zhou F, Wu J, Sun X, Yao H, Ding J, Hu G. Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation. Neuropsychopharmacology. 2007;32:2570-80 pubmed
    ..These data strongly suggest that the K(ATP) opener IPT may be a novel and promising neuroprotective drug via inhibiting microglia-mediated neuroinflammation. ..
  75. Liu H, Liu Z, Guan Q. Oral sildenafil prevents and reverses the development of pulmonary hypertension in monocrotaline-treated rats. Interact Cardiovasc Thorac Surg. 2007;6:608-13 pubmed
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