Experts and Doctors on mice in Nanjing, Jiangsu, China

Summary

Locale: Nanjing, Jiangsu, China
Topic: mice

Top Publications

  1. Zhao Y, Liu J, Wang J, Wang L, Yin H, Tan R, et al. Fumigaclavine C improves concanavalin A-induced liver injury in mice mainly via inhibiting TNF-alpha production and lymphocyte adhesion to extracellular matrices. J Pharm Pharmacol. 2004;56:775-82 pubmed
  2. Zhang H, Sun S, Guo Y, Chen Z, Huang L, Gao Y, et al. Tissue distribution of a plasmid DNA containing epitopes of foot-and-mouth disease virus in mice. Vaccine. 2005;23:5632-40 pubmed
    ..Collective results suggested that 'nude' DNA, as water injection, was characterized as quick absorbent, extensive distribution, but low utilization rate. Finally, the immune mechanism for the DNA vaccine was discussed. ..
  3. Nai Y, Jiang Z, Wang Z, Li N, Li J. Prevention of cancer cachexia by pyrrolidine dithiocarbamate (PDTC) in colon 26 tumor-bearing mice. JPEN J Parenter Enteral Nutr. 2007;31:18-25 pubmed
    ..This study was aimed to assess the effect of pyrrolidine dithiocarbamate (PDTC, an inhibitor of NFkappaB) on interleukin (IL)-6 synthesis and cachexia in colon 26 tumor-bearing mice...
  4. Kong X, Fang M, Li P, Fang F, Xu Y. HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells. J Mol Cell Cardiol. 2009;46:292-9 pubmed publisher
    ..Therefore, modulating CIITA activity by targeting HDAC2 may provide potential anti-atherogenic strategies. ..
  5. Wang X, Zhou S, Chi Y, Wen X, Hoellwarth J, He L, et al. CD4+CD25+ Treg induction by an HSP60-derived peptide SJMHE1 from Schistosoma japonicum is TLR2 dependent. Eur J Immunol. 2009;39:3052-65 pubmed publisher
    ..These findings provide the basis for a more complete understanding of the S. japonicum-host interactions that contribute to host homeostatic mechanisms, preventing an excessive immune response...
  6. Liang J, Aihua Z, Yu W, Yong L, Jingjing L. HSP65 serves as an immunogenic carrier for a diabetogenic peptide P277 inducing anti-inflammatory immune response in NOD mice by nasal administration. Vaccine. 2010;28:3312-7 pubmed publisher
    ..Our results demonstrate that HSP65 may serve as a particularly advantageous carrier for P277-based vaccines and mucosal administration may be a therapeutic approach for treatment of type 1 diabetes. ..
  7. Dou J, Chen L, Xu G, Zhang L, Zhou H, Wang H, et al. Effects of baicalein on Sendai virus in vivo are linked to serum baicalin and its inhibition of hemagglutinin-neuraminidase. Arch Virol. 2011;156:793-801 pubmed publisher
    ..70 μg/ml, and significant inhibition was observed in a plaque assay at a concentration of 1.6 μg/ml baicalin in overlay medium, which suggests that baicalein is a potential anti-parainfluenzaviral agent in vivo. ..
  8. Zhang Q, Zhang Y, Feng H, Guo R, Jin L, Wan R, et al. High density lipoprotein (HDL) promotes glucose uptake in adipocytes and glycogen synthesis in muscle cells. PLoS ONE. 2011;6:e23556 pubmed publisher
    ..This investigation was designed to determine the effects and mechanisms of HDL on glucose uptake in adipocytes and glycogen synthesis in muscle cells...
  9. Xu Q, Liu L, Qian X, Chen Q, Jiang Y, Li D, et al. MiR-145 directly targets p70S6K1 in cancer cells to inhibit tumor growth and angiogenesis. Nucleic Acids Res. 2012;40:761-74 pubmed publisher
    ..The miR-145 rescue could be a rationale for therapeutic applications in colon cancer in the future. ..

More Information

Publications655 found, 100 shown here

  1. Wu W, Flannery B, Sugita Konishi Y, Watanabe M, Zhang H, Pestka J. Comparison of murine anorectic responses to the 8-ketotrichothecenes 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, fusarenon X and nivalenol. Food Chem Toxicol. 2012;50:2056-61 pubmed publisher
    ..Toxic potency data such as is described here will be applicable to future comparative risk assessments for this important group of trichothecene mycotoxins. ..
  2. Lu G, Zheng M, Zhu Y, Sha M, Wu Y, Han X. Selection of peptide inhibitor to matrix metalloproteinase-2 using phage display and its effects on pancreatic cancer cell lines PANC-1 and CFPAC-1. Int J Biol Sci. 2012;8:650-62 pubmed publisher
    ..Furthermore, these two peptides could suppress tumor growth in vivo. Our results indicated that two peptides selected by phase display technology may be used as anticancer drugs in the future. ..
  3. Zhang Y, Fang L, Zhang Q, Zheng Q, Tong J, Fu X, et al. An oncolytic adenovirus regulated by a radiation-inducible promoter selectively mediates hSulf-1 gene expression and mutually reinforces antitumor activity of I131-metuximab in hepatocellular carcinoma. Mol Oncol. 2013;7:346-58 pubmed publisher
  4. Li Y, Huang Y, Piao Y, Nagaoka K, Watanabe G, Taya K, et al. Protective effects of nuclear factor erythroid 2-related factor 2 on whole body heat stress-induced oxidative damage in the mouse testis. Reprod Biol Endocrinol. 2013;11:23 pubmed publisher
    ..However, it's still unclear about the exactly effects of Nrf2 on the testis. Here, we investigate the protective effect of Nrf2 on whole body heat stress-induced oxidative damage in mouse testis...
  5. Feng M, Wang Q, Wang H, Guan W. Tumor necrosis factor-alpha preconditioning attenuates liver ischemia/reperfusion injury through preserving sarco/endoplasmic reticulum calcium-ATPase function. J Surg Res. 2013;184:1109-13 pubmed publisher
    ..In this study, we demonstrated that IRI reduced SERCA-3 expression in liver. Low dose of TNF-α preconditioning protected against SERCA-3 reducing, promoted intercellular calcium storage, and attenuated liver IRI. ..
  6. Fang M, Xia J, Wu X, Kong H, Wang H, Xie W, et al. Adenosine signaling inhibits CIITA-mediated MHC class II transactivation in lung fibroblast cells. Eur J Immunol. 2013;43:2162-73 pubmed publisher
  7. Huang Z, Ruan H, Zhang Z, Chen W, Lin Z, Zeng H, et al. Mutation in the first Ig-like domain of Kit leads to JAK2 activation and myeloproliferation in mice. Am J Pathol. 2014;184:122-32 pubmed publisher
    ..Our data suggest that overactivation of JAK2 leads to myeloproliferation in Kit mutant mice and provide mechanistic insights for the diagnosis and treatment of myeloproliferative neoplasms in humans. ..
  8. Feng X, Lv C, Wang F, Gan K, Zhang M, Tan W. Modulatory effect of 1,25-dihydroxyvitamin D 3 on IL1 ? -induced RANKL, OPG, TNF ? , and IL-6 expression in human rheumatoid synoviocyte MH7A. Clin Dev Immunol. 2013;2013:160123 pubmed publisher
  9. Yan B, Tao Z, Li X, Zhang H, Yao J, Jiang Q. Aberrant expression of long noncoding RNAs in early diabetic retinopathy. Invest Ophthalmol Vis Sci. 2014;55:941-51 pubmed publisher
    ..lncRNAs are involved in the pathogenesis of DR through the modulation of multiple pathogenetic pathways. MALAT1, a conserved lncRNA, may become a potential therapeutic target for the prognosis, diagnosis, and treatment of DR. ..
  10. Zhang C, Ding Z, Lv G, Li J, Zhou P, Zhang J. Lower irisin level in patients with type 2 diabetes mellitus: A case-control study and meta-analysis. J Diabetes. 2016;8:56-62 pubmed publisher
    ..46 ng/mL (95% confidence interval [CI] 9.31, 39.60; P = 0.002) lower in T2DM patients than healthy controls. This study confirmed that circulating irisin concentrations were significantly lower in patients with T2DM. ..
  11. Wang L, Dong J, Wei M, Wen W, Gao J, Zhang Z, et al. Selective and augmented β-glucuronidase expression combined with DOX-GA3 application elicits the potent suppression of prostate cancer. Oncol Rep. 2016;35:1417-24 pubmed publisher
    ..Selective and amplified βG expression together with the prodrug DOX‑GA3 had an increased antitumor effect, showing great potential for prostate cancer therapy. ..
  12. Fan Y, Kong H, Shi X, Sun X, Ding J, Wu J, et al. Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine and astrocytic modulation. Neurobiol Aging. 2008;29:1226-36 pubmed
  13. Zhang H, Sun S, Guo Y, Zhu W, Shi K, Xu G, et al. Optimization strategy for plasmid DNAs containing multiple-epitopes of foot-and-mouth disease virus by cis-expression with IL-2. Vaccine. 2008;26:769-77 pubmed publisher
    ..In conclusion, cis-expression strategy with IL-2 up-regulated specific immunological response and provide protection against homologous virus. ..
  14. Yang X, Lin L, Zhang X, Ji Y, Lv J, Zhu Y, et al. Identification of a novel repressor element in the cyclo-oxygenase-2 promoter and its nuclear binding protein. Clin Exp Pharmacol Physiol. 2008;35:1204-8 pubmed publisher
    ..This provides additional data on COX-2 gene regulation and may provide an insight into the clinical treatment of diseases where COX-2 is highly expressed. ..
  15. Zhang W, Lu Y, Xu B, Wu J, Zhang L, Gao M, et al. Acidic mucopolysaccharide from Holothuria leucospilota has antitumor effect by inhibiting angiogenesis and tumor cell invasion in vivo and in vitro. Cancer Biol Ther. 2009;8:1489-99 pubmed
  16. Chen J, Lin A, Chen Z, Wang W, Zhang T, Cai H, et al. Ammonium sulfate gradient loading of brucine into liposomes: effect of phospholipid composition on entrapment efficiency and physicochemical properties in vitro. Drug Dev Ind Pharm. 2010;36:245-53 pubmed publisher
    ..We developed a novel liposome-based brucine formulation that was composed of soybean phosphatidylcholine (SPC) and hydrogenated soybean phosphatidylcholine (HSPC)...
  17. Cong R, Sun Q, Yang L, Gu H, Zeng Y, Wang B. Effect of Genistein on vasculogenic mimicry formation by human uveal melanoma cells. J Exp Clin Cancer Res. 2009;28:124 pubmed publisher
    ..05). Genistein inhibits VM formation of uveal melanoma cells in vivo and in vitro. One possible underlying molecular mechanism by which Genistein could inhibit VM formation of uveal melanoma is related to down-regulation of VE-cadherin. ..
  18. Guo X, Shen J, Xia Z, Zhang R, Zhang P, Zhao C, et al. Proteomic analysis of proteins involved in spermiogenesis in mouse. J Proteome Res. 2010;9:1246-56 pubmed publisher
  19. Cao R, Hu Y, Wang Y, Gurley E, Studer E, Wang X, et al. Prevention of HIV protease inhibitor-induced dysregulation of hepatic lipid metabolism by raltegravir via endoplasmic reticulum stress signaling pathways. J Pharmacol Exp Ther. 2010;334:530-9 pubmed publisher
    ..These results suggest that incorporation of this HIV integrase inhibitor may reduce the side effects associated with current HAART. ..
  20. Yin H, Luo J, Kong L. Tetracyclic diterpenoids with isomerized isospongian skeleton and labdane diterpenoids from the fruits of Amomum kravanh. J Nat Prod. 2013;76:237-42 pubmed publisher
    ..Compound 2 showed inhibitory activity on nitric oxide production in lipopolysaccharide-induced RAW264.7 macrophages with an IC(50) value of 36.2 ?M...
  21. Yao W, Peng Y, Du M, Luo J, Zong L. Preventative vaccine-loaded mannosylated chitosan nanoparticles intended for nasal mucosal delivery enhance immune responses and potent tumor immunity. Mol Pharm. 2013;10:2904-14 pubmed publisher
    ..05). Cell binding and cellular uptake results indicated that MCS/pGRP nanoparticles bound with C-type lectin receptors on macrophages. MCS was an efficient targeting gene delivery carrier and could be used in antitumor immunotherapy. ..
  22. Wang X, Ying P, Diao F, Wang Q, Ye D, Jiang C, et al. Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection. J Exp Med. 2013;210:1559-74 pubmed publisher
    ..Notably, this defect could be rescued by GGPP administration in EMCV-challenged mice. Our results suggest a novel mechanism by which mumps infection during childhood results in adult sterility. ..
  23. Shi J, Wang B, Tian Y, Xu J, Gao L, Zhao S, et al. Antiepileptics topiramate and levetiracetam alleviate behavioral deficits and reduce neuropathology in APPswe/PS1dE9 transgenic mice. CNS Neurosci Ther. 2013;19:871-81 pubmed publisher
    ..Further, TPM and LEV inhibited histone deacetylase activity in vivo. Therefore, TPM and LEV might have the potential to treat AD effectively in patient care. ..
  24. He M, Li J, Tan S, Wang R, Zhang Y. Photodegradable supramolecular hydrogels with fluorescence turn-on reporter for photomodulation of cellular microenvironments. J Am Chem Soc. 2013;135:18718-21 pubmed publisher
    ..Photomodulation of cellular microenvironments was demonstrated not only for the cells grown on top of the gel but also for stem cells encapsulated inside the hydrogels. ..
  25. Tian J, Wang Y, Xu Y, Yu Z, Wei A, Zhang W, et al. Characterization of isobutylhydroxyamides with NGF-potentiating activity from Zanthoxylum bungeanum. Bioorg Med Chem Lett. 2016;26:338-342 pubmed publisher
  26. Zhang B, Xie S, Su Z, Song S, Xu H, Chen G, et al. Heme oxygenase-1 induction attenuates imiquimod-induced psoriasiform inflammation by negative regulation of Stat3 signaling. Sci Rep. 2016;6:21132 pubmed publisher
    ..SHP-1-mediated suppression of Stat3 activation after HO-1 activation is a unique molecular mechanism for the regulation of Stat3 activation. ..
  27. Han Z, Gao L, Lin Y, Chang L, Wu H, Luo C, et al. Neuroprotection of taurine against reactive oxygen species is associated with inhibiting NADPH oxidases. Eur J Pharmacol. 2016;777:129-35 pubmed publisher
    ..So, we suppose that protection of taurine against reactive oxygen species during NMDA-induced neuron injury is associated with Nox inhibition, probably in a calcium-dependent manner. ..
  28. Qian X, Ma X, Zhou H, Yu C, Zhang Y, Yang X, et al. Expression and prognostic value of E-cadherin in laryngeal cancer. Acta Otolaryngol. 2016;136:722-8 pubmed publisher
    ..Tumor growth was significantly inhibited in the Ad-ECD group. Except the tumor tissue, no positive ECD expression or significant tumor cells were found in the brain, liver, and lung tissues. ..
  29. Ma F, Liu F, Ding L, You M, Yue H, Zhou Y, et al. Anti-inflammatory effects of curcumin are associated with down regulating microRNA-155 in LPS-treated macrophages and mice. Pharm Biol. 2017;55:1263-1273 pubmed publisher
    ..1% vs 13.5%). MicroRNA-155 level and cytokines were also reduced in curcumin-treated mice (p?<?0.05). Curcumin's ability to suppress LPS-induced inflammatory response may be due to the inhibition of miR-155. ..
  30. Jin H, Chen L, Wang S, Chao D. Portulaca oleracea extract can inhibit nodule formation of colon cancer stem cells by regulating gene expression of the Notch signal transduction pathway. Tumour Biol. 2017;39:1010428317708699 pubmed publisher
    ..Furthermore, it inhibits the expression of the Notch1 and ?-catenin genes. Taken together, this suggests that it may elicit its effects through regulatory and target genes that mediate the Notch signal transduction pathway. ..
  31. Zhang N, Xu X, Zhang X, Qu D, Xue L, Mo R, et al. Nanocomposite hydrogel incorporating gold nanorods and paclitaxel-loaded chitosan micelles for combination photothermal-chemotherapy. Int J Pharm. 2016;497:210-21 pubmed publisher
    ..This combination photothermal-chemotherapy presents superior effects on suppressing the tumor recurrence and prolonging the survival in the Heps-bearing mice, compared to the photothermal therapy alone. ..
  32. Cao P, Xia Z, Song W, Zhang S. Neutralizing human anti-B-cell-activating factor of the TNF family (BAFF) scFv selected from phage antibody library. Immunol Lett. 2005;101:87-94 pubmed
    ..Together with its fully human mature, F8 scFv may have therapeutic implications in therapy of autoimmune disorders mediated by BAFF. ..
  33. Guo T, Cao G, Yu Q, Xiao M, Zhao S, Ji L. [The effect of core binding factor alpha1 on transcriptional regulation of mouse dentin sialophosphoprotein]. Shanghai Kou Qiang Yi Xue. 2006;15:657-9 pubmed
    ..This suggests that cbfalpha1 can transcriptionally regulate the expression of DSPP. Supported by National Natural Science Foundation of China (Grant No.30271418). ..
  34. Gu N, Guo X, Ni Y, Liu F, Fei L, Chen R. [Overexpression of resistin affect 3T3-L1 adipocyte lipid metabolism]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007;24:251-5 pubmed
    ..05). Overexpression of resistin can affect 3T3-L1 adipocyte lipid metabolism and thereby result in obesity and insulin resistance, but have no effect on GLUT4 gene expression. ..
  35. Fang X, Gao J, Zhu D. Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity. Life Sci. 2008;82:615-22 pubmed publisher
    ..These observations suggest that kaempferol and quercetin potentially act at multiple targets to ameliorate hyperglycemia, including by acting as partial agonists of PPARgamma...
  36. Jiang X, Wang Z, Zhu Y, Zhang X, Cui X, Yao K, et al. Inhibition of CD8+ T lymphocytes attenuates respiratory syncytial virus-enhanced allergic inflammation. Respiration. 2009;77:76-84 pubmed publisher
    ..These findings suggest that CD8+ T lymphocytes play a critical role for the development of respiratory syncytial virus-induced airway inflammation and airway hyperresponsiveness. ..
  37. Guo X, Zhang P, Qi Y, Chen W, Chen X, Zhou Z, et al. Proteomic analysis of male 4C germ cell proteins involved in mouse meiosis. Proteomics. 2011;11:298-308 pubmed publisher
    ..Characterization of the proteome of 4C germ cells from mouse testis provides an inventory of proteins, which is useful for understanding meiosis and the mechanisms of male infertility. ..
  38. Liu G, Yao K, Wang B, Zhou F, Chen Y, Li L, et al. Reconstituted complexes of mycobacterial HSP70 and EBV LMP2A-derived peptides elicit peptide-specific cytotoxic T lymphocyte responses and anti-tumor immunity. Vaccine. 2011;29:7414-23 pubmed publisher
    ..These studies provide new insights for the development of novel LMP2A-based vaccines against EBV-associated malignancies. ..
  39. Zhang Y, Wu L, Wang Y, Zhang M, Li L, Zhu D, et al. Protective role of estrogen-induced miRNA-29 expression in carbon tetrachloride-induced mouse liver injury. J Biol Chem. 2012;287:14851-62 pubmed publisher
    ..In conclusion, our results collectively demonstrate that estrogen can inhibit CCl(4)-induced hepatic injury through the induction of hepatic miR-29. ..
  40. Ji C, Yang Y, He L, Gu B, Xia J, Sun W, et al. Increasing ceramides sensitizes genistein-induced melanoma cell apoptosis and growth inhibition. Biochem Biophys Res Commun. 2012;421:462-7 pubmed publisher
    ..Our study suggests that increasing cellular level of ceramides may sensitize genistein-induced anti-melanoma effects. ..
  41. Zhang C, Li Y, Zhao W, Lifshitz L, Li H, Harfe B, et al. The transmembrane protein 16A Ca(2+)-activated Cl- channel in airway smooth muscle contributes to airway hyperresponsiveness. Am J Respir Crit Care Med. 2013;187:374-81 pubmed publisher
    ..In addition, up-regulation of TMEM16A and its augmented activation contribute to AHR in an ovalbumin-sensitized mouse model of chronic asthma. TMEM16A may represent a potential therapeutic target for asthma. ..
  42. Shi X, Shang E, Tang Y, Zhu H, Guo J, Huang M, et al. [Interaction of nourishing and tonifying blood effects of the combination of Angelicae sinensis Radix and Astragali Radix studied by response surface method]. Yao Xue Xue Bao. 2012;47:1375-83 pubmed
    ..And the response surface method was firstly applied to quantitatively evaluate the bio-activity change of herb combination, which provided a novel way for modern basic research on the interaction of herbs. ..
  43. Wu G, Wu P, Xue X, Yan X, Liu S, Zhang C, et al. Application of S-thanatin, an antimicrobial peptide derived from thanatin, in mouse model of Klebsiella pneumoniae infection. Peptides. 2013;45:73-7 pubmed publisher
    ..The plasma endotoxin level was improved as well. All above implied that S-thanatin, as an alternative, may provide a novel strategy for treating K. pneumoniae infection and other infections due to multidrug-resistant bacteria. ..
  44. Zhang Y, Yang L, Gao Y, Fan Z, Cai X, Liu M, et al. MicroRNA-106b induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting mitofusin-2. Mol Cell Endocrinol. 2013;381:230-40 pubmed publisher
    ..MiR-106b targeted Mfn2 and regulated skeletal muscle mitochondrial function and insulin sensitivity. Therefor, Inhibition of miR-106b may be a potential new strategy for treating insulin resistance and type 2 diabetes. ..
  45. Iyer V, Shen B, Zhang W, Hodgkins A, Keane T, Huang X, et al. Off-target mutations are rare in Cas9-modified mice. Nat Methods. 2015;12:479 pubmed publisher
  46. Tian J, Luo Y, Huang L, Feng Y, Ju H, Yu B. Pegylated folate and peptide-decorated graphene oxide nanovehicle for in vivo targeted delivery of anticancer drugs and therapeutic self-monitoring. Biosens Bioelectron. 2016;80:519-524 pubmed publisher
  47. Cao G, Chen H, Zhang Y, Li F, Liu C, Xiang X, et al. YiQiFuMai Powder Injection ameliorates the oxygen-glucose deprivation-induced brain microvascular endothelial barrier dysfunction associated with the NF-κB and ROCK1/MLC signaling pathways. J Ethnopharmacol. 2016;183:18-28 pubmed publisher
    ..These data provide new insights into the use of this preparation for treating cerebrovascular diseases. ..
  48. Jin Z, Li R, Zhou C, Shi L, Zhang X, Yang Z, et al. Efficient Gene Knockdown in Mouse Oocytes through Peptide Nanoparticle-Mediated SiRNA Transfection. PLoS ONE. 2016;11:e0150462 pubmed publisher
    ..We propose that peptide nanoparticles may be superior for preliminary functional studies of unknown genes in mouse oocytes. ..
  49. Hu Z, Li J, Kuang Z, Wang M, Azhar S, Guo Z. Cell-Specific Polymorphism and Hormonal Regulation of DNA Methylation in Scavenger Receptor Class B, Type I. DNA Cell Biol. 2016;35:280-9 pubmed publisher
    ..We further suggest that the cell-specific DNA methylation in SR-BI intronic regions may be associated with specific biological function(s) of these regions, including regulation of gene expression. ..
  50. Tang J, Qin Z, Han P, Wang W, Yang C, Xu Z, et al. High Annexin A5 expression promotes tumor progression and poor prognosis in renal cell carcinoma. Int J Oncol. 2017;50:1839-1847 pubmed publisher
    ..Annexin A5 may be a potential prognostic biomarker in RCC and promotes proliferation, migration and invasion of RCC cells via activating PI3K/Akt/mTOR signaling pathway and regulating EMT process and MMP expression. ..
  51. Huang W, Wei X, Ni W, Cao M, Meng L, Yang H. The expression of RNA-binding protein RBM38 decreased in renal cell carcinoma and represses renal cancer cell proliferation, migration, and invasion. Tumour Biol. 2017;39:1010428317701635 pubmed publisher
    ..028). All these suggested that RBM38 acts as a tumor suppressor in renal cell carcinoma, which has the potential value for the prediction of renal cell carcinoma prognosis. ..
  52. Xu X, Yang Y, Mo X, Wei J, Zhang X, You Q. Design, synthesis, and evaluation of benzofuran derivatives as novel anti-pancreatic carcinoma agents via interfering the hypoxia environment by targeting HIF-1? pathway. Eur J Med Chem. 2017;137:45-62 pubmed publisher
    ..These studies indicated that compound 9o was a promising candidate for the treatment of PDAC, deserving further studies. ..
  53. Zhu J, Yong W, Wu X, Yu Y, Lv J, Liu C, et al. Anti-inflammatory effect of resveratrol on TNF-alpha-induced MCP-1 expression in adipocytes. Biochem Biophys Res Commun. 2008;369:471-7 pubmed publisher
    ..Finally, the inhibition of MCP-1 may represent a novel mechanism of resveratrol in preventing obesity-related pathologies. ..
  54. Hong Jie F, Fu yu T, Ying M, Cheng ping L. Virulence and antigenicity of the szp-gene deleted Streptococcus equi ssp. zooepidemicus mutant in mice. Vaccine. 2009;27:56-61 pubmed publisher
    ..Semi-quantitative RT-PCR analysis showed a marked increased in levels of IL-4 and IFN-gamma mRNA in immunized mice. These data demonstrate that szp-knockout strain is a better candidate for vaccine development. ..
  55. Jin W, Wang H, Ji Y, Zhu L, Yan W, Qiao L, et al. Genetic ablation of Nrf2 enhances susceptibility to acute lung injury after traumatic brain injury in mice. Exp Biol Med (Maywood). 2009;234:181-9 pubmed publisher
    ..The results of the present study suggest that Nrf2 reduces TBI-induced acute lung injury, possibly by decreasing pulmonary inflammation and inducing antioxidant and detoxifying enzymes. ..
  56. Chen S, Yin D, Yao W, Wang Y, Zhang Y, Gao X. Macrophage receptors of polysaccharide isolated from a marine filamentous fungus Phoma herbarum YS4108. Acta Pharmacol Sin. 2009;30:1008-14 pubmed publisher
    ..We have demonstrated that YCP-induced NO production occurs through the TLR4 and CR3 membrane receptors in a p38 kinase-dependent manner in macrophages.Acta Pharmacologica Sinica (2009) 30: 1008-1014; doi: 10.1038/aps.2009.93. ..
  57. Chen P, Kakan X, Zhang J. Altered circadian rhythm of the clock genes in fibrotic livers induced by carbon tetrachloride. FEBS Lett. 2010;584:1597-601 pubmed publisher
  58. Liang Z, Kong Y, Luo C, Shen Y, Zhang S. Molecular cloning, functional characterization and phylogenetic analysis of B-cell activating factor in zebrafish (Danio rerio). Fish Shellfish Immunol. 2010;29:233-40 pubmed publisher
    ..Thus, the fusion protein represents a readily obtainable source of biologically active zsBAFF that may prove useful in further studies on zebrafish BAFF and its receptors. ..
  59. Yang S, Wang C, Fang X, Zhai L, Dong C, Ding L, et al. Fusion of C3d molecule with neutralization epitope(s) of hepatitis E virus enhances antibody avidity maturation and neutralizing activity following DNA immunization. Virus Res. 2010;151:162-9 pubmed publisher
  60. Chen J, Zhang X, Jiang Y, Yan L, Tang L, Yin Y, et al. Bioactivity and pharmacokinetics of two human serum albumin-thymosin alpha1-fusion proteins, rHSA-Talpha1 and rHSA-L-Talpha1, expressed in recombinant Pichia pastoris. Cancer Immunol Immunother. 2010;59:1335-45 pubmed publisher
    ..The analysis of bioactivity and pharmacokinetics suggested that fusion proteins rHSA-L-Talpha1 and rHSA-Talpha1 were new drug candidates...
  61. Chen L, Zheng S, Sun Z, Wang A, Huang C, Punchard N, et al. Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity. Cancer Chemother Pharmacol. 2011;68:17-27 pubmed publisher
    ..This property might offer an opportunity to study underlying mechanisms for the different antitumor effects of administered Cryptotanshinone in B16 and B16BL6 cells. ..
  62. Zhou Q, Zhu L, Chen C, Wu H, Luo C, Chang L, et al. Hippocampal neuronal nitric oxide synthase mediates the stress-related depressive behaviors of glucocorticoids by downregulating glucocorticoid receptor. J Neurosci. 2011;31:7579-90 pubmed publisher
    ..In addition, directly delivering ONOO(-) donor into hippocampus caused depressive-like behaviors. Our findings reveal a role of hippocampal nNOS in regulating the behavioral effects of glucocorticoids. ..
  63. Feng B, Wang R, Song H, Chen L. MicroRNA-200b reverses chemoresistance of docetaxel-resistant human lung adenocarcinoma cells by targeting E2F3. Cancer. 2012;118:3365-76 pubmed publisher
    ..Our results suggest that down-regulation of miR-200b could lead to E2F3 overexpression and in turn contribute to chemoresistance of lung adenocarcinoma cells to docetaxel. ..
  64. Yao Y, Wang Y, Zhang Y, Li Y, Sheng Z, Wen S, et al. In vivo imaging of macrophages during the early-stages of abdominal aortic aneurysm using high resolution MRI in ApoE mice. PLoS ONE. 2012;7:e33523 pubmed publisher
    ..This alters the MRI signaling properties and can be used in imaging inflammation associated with AAA. It is important to compare images of the aorta before and after SPIO injection. ..
  65. Wang D, Ren B, Liu C, Zhu J, Zhang J, Zhang W, et al. [Role of cannabinoid 2 receptor in the development of bone cancer pain]. Zhonghua Yi Xue Za Zhi. 2012;92:440-3 pubmed publisher
    ..006 in group D at 12 h after an intrathecal injection of JWH015, the ratio of CB2/?-actin 0.510 ± 0.010 significantly decreased (P < 0.05). The cannabinoid 2 receptor plays an important role in the formation of bone cancer pain. ..
  66. Yan G, Zhang L, Fang T, Zhang Q, Wu S, Jiang Y, et al. MicroRNA-145 suppresses mouse granulosa cell proliferation by targeting activin receptor IB. FEBS Lett. 2012;586:3263-70 pubmed publisher
    ..Altogether, this study revealed that miR-145 suppresses mGC proliferation by targeting ACVRIB. ..
  67. Qin Z, Zhang M, Guo X, Wang Y, Zhu G, Ni Y, et al. ?-Lipoic acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1/Akt signaling pathway. J Bioenerg Biomembr. 2012;44:579-86 pubmed publisher
    ..These results indicated that ?-LA protects 3T3-L1 adipocytes from LYRM1-induced insulin resistance partially via its capacity to restore mitochondrial function and/or increase phosphorylation of IRS-1 and Akt. ..
  68. Chen H, Zheng C, Gao Q, Ge Y, Liu Z. Heart-type fatty acid binding protein is associated with proteinuria in obesity. PLoS ONE. 2012;7:e45691 pubmed publisher
    ..643, P = 0.036). This study confirmed an association of H-FABP with the pathogenesis of clinical and experimental ORG, and suggests that such a process might be related to podocytes and lipid dysmetabolism. ..
  69. Fan H, Zhao G, Liu L, Liu F, Gong W, Liu X, et al. Pre-treatment with IL-1? enhances the efficacy of MSC transplantation in DSS-induced colitis. Cell Mol Immunol. 2012;9:473-81 pubmed publisher
    ..In summary, IL-1?-primed MSCs have improved efficacy in treating DSS-induced colitis, which at least partly depends on their increased immunosuppressive capacities and enhanced migration ability. ..
  70. Wang M, Jiang C, Ma L, Zhang Z, Cao L, Liu J, et al. Preparation, preliminary characterization and immunostimulatory activity of polysaccharide fractions from the peduncles of Hovenia dulcis. Food Chem. 2013;138:41-7 pubmed publisher
  71. Sun J, Tu M, Han B, Xue X, Zhang Y, Wei J, et al. Generation and characterization of rabbit polyclonal antibodies against Vasohibin-2 for determination of its intracellular localization. Int J Oncol. 2013;43:255-61 pubmed publisher
    ..This is the first study to report differences in the intracellular localization of the VASH2 protein and, hence, a new research direction on the study of VASH2. ..
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