Experts and Doctors on adipocytes in Changsha, Hunan, China


Locale: Changsha, Hunan, China
Topic: adipocytes

Top Publications

  1. Qiu N, Cao L, David V, Quarles L, Xiao Z. Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesis. PLoS ONE. 2010;5:e15240 pubmed publisher
    ..Our findings suggest a role for Pkd1 and Kif3a to counterbalance the regulation of osteogenesis and adipogenesis through differential regulation of Runx2 and PPAR? by Gli2. ..
  2. Yi W, Xu X. [Effects of LPS-induced inflammation on differentiation of orbital pre-adipocytes in thyroid-associated ophthalmopathy]. Zhonghua Yan Ke Za Zhi. 2011;47:156-61 pubmed
    ..The expression of PPAR? is enhanced significantly while the expression of COX2 and PGE(2) is attenuated markedly when the orbital pre-adipocytes differentiated into adipocytes. ..
  3. Yu B, Wu C, Zhao S. Plasma apolipoprotein O level increased in the patients with acute coronary syndrome. J Lipid Res. 2012;53:1952-7 pubmed publisher
    ..61, 95% CI 2.16-14.60, P < 0.001). In conclusion, apoO increased in ACS patients, and may be regarded as an independent inflammatory predictor of ACS patients. ..
  4. Chen Y, Chen M, Wu Z, Zhao S. Ox-LDL induces ER stress and promotes the adipokines secretion in 3T3-L1 adipocytes. PLoS ONE. 2013;8:e81379 pubmed publisher
    ..In conclusion, ox-LDL promoted the expression and secretion of visfatin and resistin through its activation of ER stress, which may be related to the increase of cholesterol load in adipocytes. ..
  5. Meng W, Liang X, Chen H, Luo H, Bai J, Li G, et al. Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway. Diabetes. 2017;66:1198-1213 pubmed publisher
    ..Taken together, our findings reveal Rheb as an important negative regulator of beige fat development and thermogenesis. In addition, Rheb is able to suppress the beiging effect through an mTORC1-independent mechanism. ..
  6. Zhao S, Dong S. Effect of tumor necrosis factor alpha on cholesterol efflux in adipocytes. Clin Chim Acta. 2008;389:67-71 pubmed
    ..It is not known whether TNF-alpha has effect on cholesterol efflux in adipocyte...
  7. Yang J, Zhao S, Li J, Dong S. Effect of niacin on adipocyte leptin in hypercholesterolemic rabbits. Cardiovasc Pathol. 2008;17:219-25 pubmed publisher
    ..69 and r=-.63, respectively, P<.01). Niacin can reduce serum level and adipose mRNA expression of leptin and up-regulate PPARgamma and CD36 mRNA expression in hypercholesterolemic rabbits. ..
  8. Ling H, Ou H, Feng S, Zhang X, Tuo Q, Chen L, et al. CHANGES IN microRNA (miR) profile and effects of miR-320 in insulin-resistant 3T3-L1 adipocytes. Clin Exp Pharmacol Physiol. 2009;36:e32-9 pubmed publisher
    ..Anti-miR-320 oligo was found to regulate insulin resistance in adipocytes by improving insulin–PI3-K signalling pathways. The findings provide information regarding a potentially new therapeutic strategy to control insulin resistance. ..
  9. Xie N, Cui Y, Yin Y, Zhao X, Yang J, Wang Z, et al. Effects of two Lactobacillus strains on lipid metabolism and intestinal microflora in rats fed a high-cholesterol diet. BMC Complement Altern Med. 2011;11:53 pubmed publisher
    ..Our strains might be able to improve the intestinal microbial balance and potentially improve intestinal transit time. Although the mechanism is largely unknown, L. plantarum 9-41-A may play a role in fat metabolism. ..

More Information


  1. Dong S, Zhao S, Wu Z, Yang J, Xie X, Yu B, et al. Curcumin promotes cholesterol efflux from adipocytes related to PPARgamma-LXRalpha-ABCA1 passway. Mol Cell Biochem. 2011;358:281-5 pubmed publisher
    ..Curcumin can affect the cholesterol efflux from adipocytes by regulating the PPAR?-LXR-ABCA1 passway...
  2. Zheng X, Zhao S, Yu B, Wu C, Liu L. Apolipoprotein A5 internalized by human adipocytes modulates cellular triglyceride content. Biol Chem. 2012;393:161-7 pubmed publisher
    ..Importantly, treatment of adipocytes with apoA5 significantly decreased cellular TG storage. In conclusion, apoA5 can be internalized by human adipocytes and may act as a novel regulator to control TG storage in human adipocytes. ..
  3. Zhang R, Wang D, Xia Z, Chen C, Cheng P, Xie H, et al. The role of microRNAs in adipocyte differentiation. Front Med. 2013;7:223-30 pubmed publisher
    ..In this review, we summarize the biology and functional mechanisms of miRNAs in adipocyte differentiation. In addition, we further discuss the miRNAs profiling, the miRNAs function and miRNAs target prediction in the adipogenesis. ..
  4. Ming G, Xiao D, Gong W, Liu H, Liu J, Zhou H, et al. JAZF1 can regulate the expression of lipid metabolic genes and inhibit lipid accumulation in adipocytes. Biochem Biophys Res Commun. 2014;445:673-80 pubmed publisher
    ..This result suggests that JAZF1 may be a potential target for the treatment of diseases, such as obesity and lipid metabolism disorders. ..