Experts and Doctors on testosterone in Wuhan, Hubei, China


Locale: Wuhan, Hubei, China
Topic: testosterone

Top Publications

  1. Liu C, Deng J, Yu L, Ramesh M, Zhou B. Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol. Aquat Toxicol. 2010;96:70-6 pubmed publisher
    ..The results demonstrated that waterborne exposure to 8:2 FTOH caused disruption of sex hormone biosynthesis and impaired reproduction in adult zebrafish, ultimately resulting in decreased hatching rates in the offspring. ..
  2. Su Y, Li L, Hou J, Wu N, Lin W, Li G. Life-cycle exposure to microcystin-LR interferes with the reproductive endocrine system of male zebrafish. Aquat Toxicol. 2016;175:205-12 pubmed publisher
  3. Liu C, Zhang X, Deng J, Hecker M, Al Khedhairy A, Giesy J, et al. Effects of prochloraz or propylthiouracil on the cross-talk between the HPG, HPA, and HPT axes in zebrafish. Environ Sci Technol. 2011;45:769-75 pubmed publisher
    ..These results are consistent with the hypothesis that increased steroidogenic gene expression after PTU exposure resulted from a reduction in T4 and T3 concentrations, which resulted in greater secretion of FSH and LH...
  4. Ma Y, Liu C, Lam P, Wu R, Giesy J, Hecker M, et al. Modulation of steroidogenic gene expression and hormone synthesis in H295R cells exposed to PCP and TCP. Toxicology. 2011;282:146-53 pubmed publisher
    ..The research indicates that H295R cells can be used as an in vitro model for endocrine disruption assay for chlorophenols and the mechanism involvement of disturbing cAMP signaling. ..
  5. Zhai X, Lu Y. Development and validation of a simple LC method for the determination of phenacetin, coumarin, tolbutamide, chlorzoxazone, testosterone and their metabolites as markers of cytochromes 1A2, 2A6, 2C11, 2E1 and 3A2 in rat microsomal medium. Pharmazie. 2013;68:19-26 pubmed
    ..The method is applicable for the modeling and description of pharmacological interactions on rat cytochromes P450 or can be used for in vitro evaluation of cytochromes 1A2, 2A6, 2C11, 2E1 and 3A2. ..
  6. Zeng Q, Li M, Xie S, Gu L, Yue J, Cao W, et al. Baseline blood trihalomethanes, semen parameters and serum total testosterone: a cross-sectional study in China. Environ Int. 2013;54:134-40 pubmed publisher
    ..07). Our results indicate that elevated THM exposure may lead to decreased sperm concentration and serum total testosterone. However, the effects of THM exposure on male reproductive health still warrant further studies in humans...
  7. Zhang W, Zang N, Jiang Y, Chen P, Wang X, Zhang X. Upregulation of Phosphodiesterase type 5 in the Hyperplastic Prostate. Sci Rep. 2015;5:17888 pubmed publisher
    ..The upregulation of PDE5 in the hyperplastic prostate could explain the mechanism and contribute to the high effectiveness of PDE5-Is for treating LUTS/BPH. Fibromuscular stroma could be the main target for PDE5-Is within prostate. ..
  8. Ren X, Fu X, Zhang X, Chen S, Huang S, Yao L, et al. Testosterone regulates 3T3-L1 pre-adipocyte differentiation and epididymal fat accumulation in mice through modulating macrophage polarization. Biochem Pharmacol. 2017;140:73-88 pubmed publisher
    ..Testosterone supplementation reverses this effect. Therefore, our findings indicate that testosterone inhibits pre-adipocyte differentiation by switching macrophages to M2 polarization through the G?i and Akt signaling pathways. ..
  9. Liu C, Yu L, Deng J, Lam P, Wu R, Zhou B. Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic-pituitary-gonadal (HPG) axis of zebrafish. Aquat Toxicol. 2009;93:131-7 pubmed publisher
    ..The results suggested that FTOHs may disturb fish reproduction through endocrine disrupted activity. ..

More Information


  1. Deng J, Liu C, Yu L, Zhou B. Chronic exposure to environmental levels of tribromophenol impairs zebrafish reproduction. Toxicol Appl Pharmacol. 2010;243:87-95 pubmed publisher
    ..The F(1)-generation larvae exhibited increased malformation, reduced survival, and retarded growth, suggesting that TBP in the aquatic environment has significant adverse effects on fish population. ..
  2. Wu H, Hao Y, Yu X, Xian Y, Zhao Q, Chen D, et al. Variation in sexual behaviors in a group of captive male Yangtze finless porpoises (Neophocaena phocaenoides asiaeorientalis): motivated by physiological changes?. Theriogenology. 2010;74:1467-75 pubmed publisher
    ..However, its oversexed behavior neither quantitatively correlated with its smaller testicular volume (P = 0.61) nor with its testicular pixel intensity (P = 0.69)...
  3. Chen L, Zhang X, Zhou W, Qiao Q, Liang H, Li G, et al. The interactive effects of cytoskeleton disruption and mitochondria dysfunction lead to reproductive toxicity induced by microcystin-LR. PLoS ONE. 2013;8:e53949 pubmed publisher
  4. Hua J, Han J, Wang X, Guo Y, Zhou B. The binary mixtures of megestrol acetate and 17?-ethynylestradiol adversely affect zebrafish reproduction. Environ Pollut. 2016;213:776-784 pubmed publisher
    ..This study has important implications for environmental risk assessment of synthetic hormones that are concurrently present in aquatic systems. ..
  5. Qian Y, Zeng F. Re-establishment of spermatogenesis by diethylstilbestrol after 2,5-hexanedione-induced irreversible testicular atrophy in rats. J Huazhong Univ Sci Technolog Med Sci. 2008;28:179-81 pubmed publisher
    ..Estrogen plays an important part in spermatogenesis, and the role of estrogen in spermatogenesis is more than suppressing the hypothalamo-pituitary-testis axis. ..
  6. Yao M, Dai M, Liu Z, Huang L, Chen D, Wang Y, et al. Comparison of the substrate kinetics of pig CYP3A29 with pig liver microsomes and human CYP3A4. Biosci Rep. 2011;31:211-20 pubmed publisher
    ..These findings indicate that pig CYP3A29 is similar to human CYP3A4 in both extent of expression and activity. The results reported in this paper provide a basis for future in vitro toxicity and metabolism studies...
  7. Ma Y, Han J, Guo Y, Lam P, Wu R, Giesy J, et al. Disruption of endocrine function in in vitro H295R cell-based and in in vivo assay in zebrafish by 2,4-dichlorophenol. Aquat Toxicol. 2012;106-107:173-81 pubmed publisher
    ..The results demonstrated that 2,4-DCP modulates transcription of steroidogenetic genes in both H295R cells and in the zebrafish HPG-axis and disrupts steroidogenesis, which in turn, can cause adverse effects on reproduction in fish. ..