Experts and Doctors on male in Wuhan, Hubei, China


Locale: Wuhan, Hubei, China
Topic: male

Top Publications

  1. Che J, Shen W, Deng Y, Dai Y, Liao Y, Yuan X, et al. Effects of lentivirus-mediated silencing of Periostin on tumor microenvironment and bone metastasis via the integrin-signaling pathway in lung cancer. Life Sci. 2017;182:10-21 pubmed publisher
    ..The study demonstrated that down-regulation of Periostin expression modulated tumor microenvironment and inhibited bone metastasis by blocking integrin-signaling pathway in LC. ..
  2. Lian H, Cheng Y, Wu X. TMEM16A exacerbates renal injury by activating P38/JNK signaling pathway to promote podocyte apoptosis in diabetic nephropathy mice. Biochem Biophys Res Commun. 2017;487:201-208 pubmed publisher
    ..Phosphorylation levels of P38 and JNK in siRNA-TMEM16A group were lower than that of the Model group. Thus, TMEM16A is one of the critical components of a signal transduction pathway that links renal injury to podocyte apoptosis in DN. ..
  3. Li W, Tu J, Liu X, Yang W. Farnesyltransferase inhibitor FTI-277 inhibits PD-L1 expression on septic spleen lymphocytes and promotes spleen lymphocyte activation. Clin Exp Immunol. 2017;190:8-18 pubmed publisher
    ..Farnesyltransferase represents a valuable therapeutic target for the treatment of sepsis. ..
  4. Guo H, Chu Y, Wang L, Chen X, Chen Y, Cheng H, et al. PBX3 is essential for leukemia stem cell maintenance in MLL-rearranged leukemia. Int J Cancer. 2017;141:324-335 pubmed publisher
    ..Significantly, the differential expression of PBX3 in normal and malignant hematopoietic cells suggests PBX3 as a potential prognostic marker and therapeutic target for MLL-r leukemia. ..
  5. Liu F, Zhao S, Chen Q, Chang Z, Zhang J, Zheng Y, et al. [Surveillance data on typhoid fever and paratyphoid fever in 2015, China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2017;38:754-758 pubmed publisher
    ..68%?????15.89%?????12.01%????<5????????????1.57/10??0.69/10?????????????????5??????????????????????????????????????????????????????? ??? 2015????????????????????????????????????????????????????????????. ..
  6. Feng B, Shang J, Wu S, Chen H, Han Y, Li Y, et al. [Efficacy and safety of pegylated interferon ?-2b injection (Y shape, 40 kD) in treatment of patients with genotype 1/6 chronic hepatitis C]. Zhonghua Gan Zang Bing Za Zhi. 2017;25:187-194 pubmed publisher
    ..9%?????????????????????????????93.8%?????????????????????96.30%?94.94%??????????????5.13%?5.06%? ??? peg-ifn???????????1/6?chc???????????peg-ifn?-2b?y??40 kd????????peg-ifn?-2a??????????. ..
  7. Gao W, Zhao B, Liu L, Yuan Q, Wu X, Xia Z. Myocardial ischemic post-conditioning protects the lung against myocardial ischemia/reperfusion-induced damage by activating GSK-3?. Acta Cir Bras. 2017;32:376-387 pubmed publisher
    ..Myocardial ischemia reperfusion injury induces acute lung injury by induction of inflammation and cell apoptosis. Ischemic post-conditioning protects the lung from ALI following MIRI by increasing p-GSK-3?. ..
  8. Gu Q, Han Y, Lan Y, Li Y, Kou W, Zhou Y, et al. Association between polymorphisms in the APOB gene and hyperlipidemia in the Chinese Yugur population. Braz J Med Biol Res. 2017;50:e6613 pubmed publisher
  9. Wang B, Ao J, Yu D, Rao T, Ruan Y, Yao X. Inhibition of mitochondrial translation effectively sensitizes renal cell carcinoma to chemotherapy. Biochem Biophys Res Commun. 2017;490:767-773 pubmed publisher
    ..Our work used pharmacological and genetic strategies to demonstrate the important roles of mitochondrial translation in RCC and emphasize the therapeutic value of sensitizing RCC to chemotherapy. ..

More Information

Publications187 found, 100 shown here

  1. Fang X, Li S, Han Q, Zhao Y, Gao J, Yan J, et al. Overexpression cdc42 attenuates isoflurane-induced neurotoxicity in developmental brain of rats. Biochem Biophys Res Commun. 2017;490:719-725 pubmed publisher
    ..Cdc42 over-expression could reverse neurotoxicity and improve cognitive impairment induced by isoflurane. ..
  2. Chen Q, Xing X, Wu Y, Liao Q, Liu G, Jiang X, et al. [Hand, foot and mouth disease in Hubei province, 2009-2015: an epidemiological and etiological study]. Zhonghua Liu Xing Bing Xue Za Zhi. 2017;38:441-445 pubmed publisher
    ..5~5????????????????????6~11???????2009?2015???????????ev71?cox a16?cox a16?cox a16?ev71?cox a16??????????????????4?6??11?12??????????????? ??? 2009?2015???????????????0.5~5??????????????????6~11?????????????????????????????????. ..
  3. Hou J, Sun H, Huang X, Zhou Y, Zhang Y, Yin W, et al. Exposure to polycyclic aromatic hydrocarbons and central obesity enhanced risk for diabetes among individuals with poor lung function. Chemosphere. 2017;185:1136-1143 pubmed publisher
    ..383 (95% CI: -0.07, 0.80, p = 0.086) or 0.465 (95% CI: 0.019, 0.912, p = 0.04). The results indicated that central obesity may enhance the effect of exposure to background PAHs on diabetes in individuals with poor lung function. ..
  4. Xu R, Li Q, Liu R, Shen J, Li M, Zhao M, et al. Association Analysis of the MHC in Lupus Nephritis. J Am Soc Nephrol. 2017;28:3383-3394 pubmed publisher
    ..001; odds ratio, 0.38; 95% confidence interval, 0.30 to 0.49) at genome-wide significance. These data implicate aberrant peptide presentation by MHC classes 1 and 2 molecules and sex hormone modulation in the development of LN. ..
  5. Pan M, Li W, Yang J, Li Z, Zhao J, Xiao Y, et al. Plumbagin-loaded aptamer-targeted poly D,L-lactic-co-glycolic acid-b-polyethylene glycol nanoparticles for prostate cancer therapy. Medicine (Baltimore). 2017;96:e7405 pubmed publisher
    ..5?hours for targeted and nontargeted NPs. The IC50 of targeted NPs and nontargeted NPs was 32.59?±?8.03??M and 39.02?±?7.64??M, respectively.Plumbagin-loaded PSMA aptamer-targeted NPs can be used in targeted chemotherapy against PCa...
  6. Zhang C, Zhang S, He W, Lu J, Xu Y, Yang J, et al. Baicalin may alleviate inflammatory infiltration in dextran sodium sulfate-induced chronic ulcerative colitis via inhibiting IL-33 expression. Life Sci. 2017;186:125-132 pubmed publisher
    ..Baicalin treatment effectively alleviated DSS-induced chronic UC, and the protective mechanisms may involve inhibition of IL-33 expression and subsequent NF-?B activation. ..
  7. Song J, Zhang X, Zhao Y, Yang H, Zhang J, Zhang X, et al. (R)- and (S)-18F-labeled 2-arylbenzofurans with improved pharmacokinetics as ?-amyloid imaging probes. Eur J Med Chem. 2017;134:271-280 pubmed publisher
    ..All in all, (S)-[18F]17 (Ki = 14.6 nM) with excellent pharmacokinetics (brain2 min = 8.60% ID/g, brain2 min/brain60 min = 14.1) deserves further evaluation. ..
  8. Zhang C, Yin A, Li H, Wang R, Wu G, Shen J, et al. Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children. EBioMedicine. 2015;2:968-84 pubmed publisher
  9. Guo Y, Ding S, Guo H, Li S, Lu X, Chen Z, et al. Graft-versus-host-disease after kidney transplantation: A case report and literature review. Medicine (Baltimore). 2017;96:e7333 pubmed publisher
    ..MP bolus, IVIG, and decreased immunosuppression could be beneficial to the clinical outcome. Kidney recipients have a prognosis superior to recipients of organs bearing large numbers of lymphocytes. ..
  10. Jiang R, Dong X, Zhu W, Duan Q, Xue Y, Shen Y, et al. Combining PET/CT with serum tumor markers to improve the evaluation of histological type of suspicious lung cancers. PLoS ONE. 2017;12:e0184338 pubmed publisher
    ..05 for all). SUVmax and serum tumor markers show values in evaluating the histological types of suspicious lung cancers. When properly combined, the diagnostic efficiency can increase significantly. ..
  11. Sang Y, Zhang F, Wang H, Yao J, Chen R, Zhou Z, et al. Apigenin exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway. Food Funct. 2017;8:2331-2340 pubmed publisher
    ..In conclusion, focusing on the Nrf2 pathway is a suitable strategy to delay the aging process, and apigenin may exert an anti-senescent effect process via activating the Nrf2 pathway. ..
  12. Zhao J, Zhou Y, Li X, Cai W, Hua H. Silencing of juvenile hormone epoxide hydrolase gene (Nljheh) enhances short wing formation in a macropterous strain of the brown planthopper, Nilaparvata lugens. J Insect Physiol. 2017;102:18-26 pubmed publisher
    ..Compared to the dsgfp injection control, silencing Nljhe had no brachypterizing effect. Our results indicated that NlJHEH plays an important role in the wing morph determination of N. lugens. ..
  13. Luo X, Hou L, Liang L, Dong G, Shen S, Zhao Z, et al. Long-acting PEGylated recombinant human growth hormone (Jintrolong) for children with growth hormone deficiency: phase II and phase III multicenter, randomized studies. Eur J Endocrinol. 2017;177:195-205 pubmed publisher
    ..05). Adverse event rates and treatment compliance were comparable between the two groups. Jintrolong PEG-rhGH at a dose of 0.2?mg/kg/week for 25 weeks is effective and safe for GHD treatment and is non-inferior to daily rhGH. ..
  14. Chai J, Xiong Q, Wang D, Wan X, Niu H, Xiang H, et al. Identification of novel regulatory GRE-binding elements in the porcine IP3R1 gene promoter and their transcriptional activation under glucocorticoid stimulation. Gen Comp Endocrinol. 2017;249:71-81 pubmed publisher
    ..This process can lead to an imbalance in intracellular calcium concentration, which may subsequently activate the apoptosis signal and decrease cell activity, and cause deterioration of meat quality. ..
  15. Wang J, Li C, Wan F, Li Z, Zhang J, Zhang J, et al. The rs1550117 A>G variant in DNMT3A gene promoter significantly increases non-small cell lung cancer susceptibility in a Han Chinese population. Oncotarget. 2017;8:23470-23478 pubmed publisher
    ..Collectively, our results propose a suppression role of DNMT3A in NSCLC development and emphasize the dual roles of DNMT3A in tumorigenesis. ..
  16. Yi L, Wen H, Huang X, Qiu M, Cao X. [Cardiac autonomic nerve function in obese school-age children]. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:524-528 pubmed
    ..The more obese the children, the lower the vagal tone, which may increase the risks of cardiovascular diseases. ..
  17. Zeng X, Li X, Zhang Q, Liu Q, Li L, Xiong Y, et al. Tert-Butylhydroquinone Protects Liver Against Ischemia/Reperfusion Injury in Rats Through Nrf2-Activating Anti-Oxidative Activity. Transplant Proc. 2017;49:366-372 pubmed publisher
    ..t-BHQ exerted potent anti-inflammatory effects in I/R-induced liver injury, and tBHQ would be a new effectively therapeutic measure for preventing hepatic I/R injury during liver surgery. ..
  18. Liu Y, Xie S, Yu Q, Huo X, Ming X, Wang J, et al. Short-term effects of ambient air pollution on pediatric outpatient visits for respiratory diseases in Yichang city, China. Environ Pollut. 2017;227:116-124 pubmed publisher
    ..5, PM10, NO2, CO, and O3 may account for increased risk of pediatric outpatient visits for respiratory diseases, and emphasize the needs for reduction of air pollutant exposures for children. ..
  19. Xu M, Zuo D, Liu X, Fan H, Chen Q, Deng S, et al. MiR-155 contributes to Th17 cells differentiation in dextran sulfate sodium (DSS)-induced colitis mice via Jarid2. Biochem Biophys Res Commun. 2017;488:6-14 pubmed publisher
    ..This study suggests that miR-155 plays a host-damaging role during DSS-induced colitis mice and induces Th17 differentiation by targeting Jarid2. ..
  20. Liu P, Ji Y, Yuen T, Rendina Ruedy E, DeMambro V, Dhawan S, et al. Blocking FSH induces thermogenic adipose tissue and reduces body fat. Nature. 2017;546:107-112 pubmed publisher
    ..These actions result from the specific binding of the antibody to the β-subunit of Fsh to block its action. Our studies uncover opportunities for simultaneously treating obesity and osteoporosis. ..
  21. Zhu Q, Yan J, Gao Y, Zhang J, Yuan B, Feng Y. Highly sensitive determination of fatty acid esters of hydroxyl fatty acids by liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1061-1062:34-40 pubmed publisher
    ..The proposed method could be successfully applied for the detection of FAHFAs in various biological samples, which will facilitate the understanding of the physiological functions of FAHFAs. ..
  22. Jin N, Zhu H, Liang X, Huang W, Xie Q, Xiao P, et al. Sodium selenate activated Wnt/β-catenin signaling and repressed amyloid-β formation in a triple transgenic mouse model of Alzheimer's disease. Exp Neurol. 2017;297:36-49 pubmed publisher
    ..These findings reveal that the Wnt/β-catenin signaling is a potential target for prevention of AD and sodium selenate may be developed as a new drug for AD treatment. ..
  23. Peng T, Wang Y, Bao X. [Preliminary report on the application of femtosecond laser-assisted anterior capsulotomy in intumescent white cataract surgery]. Zhonghua Yan Ke Za Zhi. 2017;53:281-287 pubmed publisher
    ..31?1.10?2.78?2.90?????2?f????2.50?2.32?2.56?2.18??????????p<0.05?? ??? ????????????????????????????????????iol???????????????????????????????2017?53?281-287?. ..
  24. Shi H, Zhang C, Pasupuleti V, Hu X, Prosdocimo D, Wu W, et al. CCN3 Regulates Macrophage Foam Cell Formation and Atherosclerosis. Am J Pathol. 2017;187:1230-1237 pubmed publisher
    ..These results suggest that bone marrow-derived CCN3 is an essential regulator of atherosclerosis and point to a novel role of CCN3 in modulating lipid accumulation within macrophages. ..
  25. He J, Feng J. Two-incision laparoscopic appendectomy for a severe hemophilia A child patient with coagulation factor VII deficiency: Case report and review of literature. Medicine (Baltimore). 2017;96:e8197 pubmed publisher
    ..However, only several cases reported about the appendectomy for hemophilia A. We report a case of acute appendicitis treated by two-incision laparoscopy in a boy with hemophilia A and coagulation factor VII deficiency for the first time...
  26. Ma Z, Yuan Y, Zhang X, Xu S, Wang S, Tang Q. Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-?/AKT Pathways. EBioMedicine. 2017;18:179-187 pubmed publisher
    ..In conclusion, piperine attenuated cardiac fibrosis via the activation of PPAR-? and the resultant inhibition of AKT/GSK3?. ..
  27. Zhou Z, Xiong W, Li L, Li F. Adjacent segmental degeneration following Wallis interspinous stabilization implantation: Biomechanical explanations and the value of magnetic resonance imaging. Medicine (Baltimore). 2017;96:e7056 pubmed publisher
    ..015).ASD of the facet joint in the cranial segment occurred after Wallis system implantation, suggesting that the Wallis system cannot prevent ASD of the facet joint, but could have some other benefits for the discs. ..
  28. Sun T, Chen S, Huang H, Li T, Yang W, Liu L. Metabolic profile study of 7, 8-dihydroxyflavone in monkey plasma using high performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1061-1062:97-102 pubmed publisher
    ..We further demonstrated that methylated 7, 8-DHF can be also conjugated with glucuronidation/sulfation, and the methylation occurs mainly in the 8 position. ..
  29. Liu B, Tang Y, Yi M, Liu Q, Xiong H, Hu G, et al. Genetic variants in the plasminogen activator inhibitor-1 gene are associated with an increased risk of radiation pneumonitis in lung cancer patients. Cancer Med. 2017;6:681-688 pubmed publisher
    ..331; 95% confidence interval, 1.168-9.497; P = 0.024). Our results indicated that PAI-1:rs7242 in the 3'-untranslated region of PAI-1 can be a predictor of grade ≥3 RP before radiotherapy. ..
  30. Li N, Yuan Q, Cao X, Zhang Y, Min Z, Xu S, et al. Opposite effects of HDAC5 and p300 on MRTF-A-related neuronal apoptosis during ischemia/reperfusion injury in rats. Cell Death Dis. 2017;8:e2624 pubmed publisher
    ..The results suggest that both HDAC5 and p300 are involved in MRTF-A-mediated effect on neuronal apoptosis during ischemia/reperfusion injury, but with opposite effects. ..
  31. Cao Y, Li J, Shen L, Wang J, Xia Z, Tao K, et al. Gastric cancer in a situs inversus totalis patient with multiple intestinal and vessel variations related to gastrectomy surgery: A case report and literature review. Medicine (Baltimore). 2017;96:e8209 pubmed publisher
    ..As exemplified by our case, SIT might be accompanied by multiple anatomic variations. Detailed preoperative detailed imaging of the blood vessels and gastrointestinal tract is useful in these patients. ..
  32. Xia S, He C, Zhu Y, Wang S, Li H, Zhang Z, et al. GABABR-Induced EGFR Transactivation Promotes Migration of Human Prostate Cancer Cells. Mol Pharmacol. 2017;92:265-277 pubmed publisher
  33. Luo D, Chen L, Yu B. Inhibition of the high affinity choline transporter enhances hyperalgesia in a rat model of chronic pancreatitis. Biochem Biophys Res Commun. 2017;488:204-210 pubmed publisher
    ..Increased CHT1 activity or the up-regulation of its expression may be used to treat pain in patients with CP. ..
  34. Fang C, Guo Z, Chen X, Liu T, Zeng X, Wang X. Relationship between SRD5A2 rs9282858 polymorphism and the susceptibility of prostate cancer: A meta-analysis based on 20 publications. Medicine (Baltimore). 2017;96:e6791 pubmed publisher
    ..Our findings indicate that SRD5A2 rs9282858 polymorphism may be a susceptible factor to PCa. ..
  35. Zhang Q, Zhao L, Tian X, Yan C, Li Y, Liu Y, et al. The novel intracellular protein CREG inhibits hepatic steatosis, obesity, and insulin resistance. Hepatology. 2017;66:834-854 pubmed publisher
    ..This study offers insights into NAFLD pathogenesis and its complicated pathologies, such as obesity and insulin resistance, and paves the way for disease treatment through targeting CREG. (Hepatology 2017;66:834-854). ..
  36. Liu C, Tang Y, Wang D, Zhang X. The effect of public reporting presentation on patients' decision making: An experimental survey in Yunan Province, China. Medicine (Baltimore). 2017;96:e7203 pubmed publisher
    ..The present study demonstrated that numerical and ranked PRCPI, combined with sufficient patient education, could be most effective to facilitate patient use. ..
  37. Wang S, Wang X, Zheng K, Liu K, Wang S, Xie C. Simultaneous targeting PI3K and PERK pathways promotes cell death and improves the clinical prognosis in esophageal squamous carcinoma. Biochem Biophys Res Commun. 2017;493:534-541 pubmed publisher
    ..These results indicated that dual targeting of PI3K and PERK pathways might improve clinical prognosis and enhance the treatment of ESCC patients. ..
  38. Wang M, Zhang H, Zhu F, Peng F, Wang X, Shen M, et al. Pancreaticoduodenectomy for borderline resectable pancreatic head cancer with a modified artery-first approach technique. Hepatobiliary Pancreat Dis Int. 2017;16:215-221 pubmed
  39. Liu S, Sun Y, Jiang M, Li Y, Tian Y, Xue W, et al. Glyceraldehyde-3-phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase. Hepatology. 2017;66:631-645 pubmed publisher
    ..GAPDH increases histone methylation levels by up-regulating PHGDH, promoting diversion from glycolysis to serine biosynthesis, and consequently accelerating HCC development. (Hepatology 2017;66:631-645). ..
  40. Yuan L, Hua C, Gao S, Yin Y, Dai M, Meng H, et al. Astragalus Polysaccharides Attenuate Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats. Am J Chin Med. 2017;45:773-789 pubmed publisher
    ..In couclusion, APS ameliorates MCT-induced pulmonary artery hypertension by inhibiting pulmonary arterial remodeling partially via eNOS/NO and NF-[Formula: see text]B signaling pathways. ..
  41. Xu Y, Qin S, An T, Tang Y, Huang Y, Zheng L. MiR-145 detection in urinary extracellular vesicles increase diagnostic efficiency of prostate cancer based on hydrostatic filtration dialysis method. Prostate. 2017;77:1167-1175 pubmed publisher
    ..miR-145 in UEVs is upregulated from PCa patients compared BPH patients and healthy controls. We suggest the potential use of UEVs miR-145 as a biomarker of PCa. ..
  42. Liao W, Fan M, Yang Y, Yang W, Li L, Liu M. [Effects of Angelica sinensis injection on the neuronal metabolites and blood flow speed within reperfusion following the ischemic cerebral injury in rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2003;19:209-12 pubmed
    ..The length of brain surface vessels in group C increased. The Angelica sinensis injection enhanced the blood circulation in the ischemic brain, improved the neuronal metabolisms. ..
  43. Wei C, Wu K, Gao Y, Zhang L, Li D, Luo Z. Magnesium Reduces Hepatic Lipid Accumulation in Yellow Catfish (Pelteobagrus fulvidraco) and Modulates Lipogenesis and Lipolysis via PPARA, JAK-STAT, and AMPK Pathways in Hepatocytes. J Nutr. 2017;147:1070-1078 pubmed publisher
    ..PPARA, JAK-STAT, and AMPK pathways mediated the magnesium-induced changes in lipid deposition and metabolism. These results offer new insight into magnesium nutrition in vertebrates. ..
  44. Chen B, Hu N. Rimonabant improves metabolic parameters partially attributed to restoration of high voltage-activated Ca2+ channels in skeletal muscle in HFD-fed mice. Braz J Med Biol Res. 2017;50:e6141 pubmed publisher
    ..1 in the SM as potential targets for obesity treatment. ..
  45. Fan L, Tong Q, Dong W, Yang G, Hou X, Xiong W, et al. Tissue Distribution, Excretion, and Metabolic Profile of Dihydromyricetin, a Flavonoid from Vine Tea (Ampelopsis grossedentata) after Oral Administration in Rats. J Agric Food Chem. 2017;65:4597-4604 pubmed publisher
    ..The present findings may provide the theoretical basis for evaluating the biological activities of DMY and will be helpful for its future development and application...
  46. Sotos Prieto M, Bhupathiraju S, Mattei J, Fung T, Li Y, Pan A, et al. Association of Changes in Diet Quality with Total and Cause-Specific Mortality. N Engl J Med. 2017;377:143-153 pubmed publisher
    ..Improved diet quality over 12 years was consistently associated with a decreased risk of death. (Funded by the National Institutes of Health.). ..
  47. Shen Y, Huang G, McCormick B, Song T, Xu X. Effects of high-intensity interval versus mild-intensity endurance training on metabolic phenotype and corticosterone response in rats fed a high-fat or control diet. PLoS ONE. 2017;12:e0181684 pubmed publisher
    ..Compared with ME training, HI training contributes to greater improvements in metabolic and corticosterone responses, leading to a greater reduction in susceptibility to HFD-induced disorders. ..
  48. Shang X, Lu R, Liu M, Xiao S, Dong N. Heart rate and outcomes in patients with heart failure with preserved ejection fraction: A dose-response meta-analysis. Medicine (Baltimore). 2017;96:e8431 pubmed publisher
    ..05).Higher heart rate in sinus rhythm is a risk factor for adverse outcomes in patients with HFpEF. Future trials are required to determine whether heart rate reduction may improve the prognosis of HFpEF...
  49. Zheng C, Liao W, Fan M, Yang W, Meng L. [Effects of Angelica sinensis treatment on the expression of flt-1 and flk-1 mRNA after the ischemic brain injury in rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2006;22:385-9 pubmed
    ..957). The increasing amount of Flt-1, Flk-1 expression was enhanced by Angelica sinensis following transient interruption of cerebral blood flow in rats. ..
  50. Xia H, Zhu J, Wang J, Ren J, Cai Y, Wang F, et al. Association of ATF4 Expression With Tissue Hypoxia and M2 Macrophage Infiltration in Infantile Hemangioma. J Histochem Cytochem. 2017;65:285-294 pubmed publisher
    ..All those results and established evidence indicated that hypoxia-induced ATF4 expression may promote progression of proliferating IH through M-CSF-induced M2-polarized macrophages infiltration. ..
  51. Miao N, Wang X, Feng Y, Gong Y. Male-biased miR-92 from early chicken embryonic gonads directly targets ATRX and DDX3X. Gene. 2017;626:326-336 pubmed publisher
    ..The overall results indicate that miR-92 may perform roles in early chicken gonadogenesis by regulating the expressions of ATRX and DDX3X, respectively. ..
  52. Luo A, Yan H, Liang J, Du C, Zhao X, Sun L, et al. MicroRNA-21 regulates hepatic glucose metabolism by targeting FOXO1. Gene. 2017;627:194-201 pubmed publisher
    ..These results suggest that miR-21 is a critical regulator in hepatic gluconeogenesis and may provide a novel therapeutic target for treating insulin resistance and type 2 diabetes. ..
  53. Liu X, Chen X, Wang H, Yang Q, Ur Rehman K, Li W, et al. Dynamic changes of nutrient composition throughout the entire life cycle of black soldier fly. PLoS ONE. 2017;12:e0182601 pubmed publisher
    ..Moreover it contributes to advance exploring for developmental and metabolic biology of this edible insect. ..
  54. Lan X, Lan X, Chang Y, Zhang X, Liu J, Vikash V, et al. Identification of Two Additional Susceptibility Loci for Inflammatory Bowel Disease in a Chinese Population. Cell Physiol Biochem. 2017;41:2077-2090 pubmed publisher
    ..Most importantly, we found that ZMIZ1 expression was markedly higher in both IBD patients and mice with experimentally induced colitis, suggesting that ZMIZ1 plays important roles in the pathogenesis of IBD. ..
  55. Xu G, Lou N, Xu Y, Shi H, Ruan H, Xiao W, et al. Diagnostic and prognostic value of scavenger receptor class B type 1 in clear cell renal cell carcinoma. Tumour Biol. 2017;39:1010428317699110 pubmed publisher
    ..In conclusion, our findings implied that scavenger receptor class B type 1 might serve as a diagnostic and independent prognostic biomarker in clear cell renal cell carcinoma. ..
  56. Luo X, Chen L, Liu W, Dong S, Luo H, Zhang B, et al. A propensity score analysis of two methods of hepatic vascular occlusion in hepatectomy. J Surg Res. 2017;213:184-190 pubmed publisher
    ..In terms of postoperative morbidity and mortality, duration of hospital stay after surgery, IPVBO was also equal to HIO. Thus, IPVBO could be an alternative method of hepatic inflow occlusion. ..
  57. Tian G, Liu X, Zeng X, Su X, Wei W, Wang X. [Bibliometric analysis on relations between cardiovascular disease and erectile dysfunction]. Zhonghua Liu Xing Bing Xue Za Zhi. 2017;38:810-813 pubmed publisher
  58. Zhang N, Wei W, Yang Z, Che Y, Jin Y, Liao H, et al. Nobiletin, a Polymethoxy Flavonoid, Protects Against Cardiac Hypertrophy Induced by Pressure-Overload via Inhibition of NAPDH Oxidases and Endoplasmic Reticulum Stress. Cell Physiol Biochem. 2017;42:1313-1325 pubmed publisher
    ..Inhibition of oxidative and ER stress by NOB in the myocardium may represent a potential therapy for cardiac hypertrophy. Moreover, there is a direct role of NOX2 in regulating ER stress stimulated by PE. ..
  59. Gong J, Han J, He J, Liu J, Han P, Wang Y, et al. Paired related homeobox protein 1 regulates PDGF-induced chemotaxis of hepatic stellate cells in liver fibrosis. Lab Invest. 2017;97:1020-1032 pubmed publisher
    ..These studies reveal a role of Prrx1 as a modulator of PDGF-dependent signaling in HSCs, and inhibiting its expression may offer a therapeutic approach for hepatic fibrosis. ..
  60. Fu H, Dong D, Feng D, He Z, Tang S, Fu Q, et al. To Share or Not to Share: A Cross-Sectional Study on Health Information Sharing and Its Determinants Among Chinese Rural Chronic Patients. J Health Commun. 2017;22:800-807 pubmed publisher
    ..A more sophisticated model needs to be established to reveal the complex processes of health information communication. ..
  61. Liang T, Zhao C, Wu G, Tang B, Luo X, Lu S, et al. Multi-tract percutaneous nephrolithotomy combined with EMS lithotripsy for bilateral complex renal stones: our experience. BMC Urol. 2017;17:15 pubmed publisher
    ..Ultrasonography-guided multi-tract PCNL using EMS is an efficient method for the treatment of complex renal calculi. According to our experience, it is safe to make multiple tracts on both sides simultaneously. ..
  62. Cheng X, Wang Y, Chen H, Xu Y, Xiong W, Wang T. Claudin-1 regulates pulmonary artery smooth muscle cell proliferation through the activation of ERK1/2. Biomed Pharmacother. 2017;89:983-990 pubmed publisher
    ..Together, our findings indicate that up-regulation of CLDN1 promotes PASMC proliferation contributing to pulmonary arterial remodeling in PAH. ..
  63. Zhao G, Zhang P, Gong J, Zhang X, Wang P, Yin M, et al. Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4. Nat Med. 2017;23:742-752 pubmed publisher
    ..Taken together, these findings could lead to the development of promising strategies to treat NASH by targeting MVB regulators to properly orchestrate the lysosome-mediated protein degradation of key mediators of the disease. ..
  64. Wang Z, Han Q, Guo Y, Liu X, Qiu T. Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation. Acta Cir Bras. 2018;33:238-249 pubmed publisher
    ..Ozone oxidative preconditioning could attenuate the inflammatory reaction and oxidative stress injury in renal allograft, which might be related with the enhancement of anti-oxidative system and suppression of inflammatory reaction. ..
  65. Kassebaum N, Kyu H, Zoeckler L, Olsen H, Thomas K, Pinho C, et al. Child and Adolescent Health From 1990 to 2015: Findings From the Global Burden of Diseases, Injuries, and Risk Factors 2015 Study. JAMA Pediatr. 2017;171:573-592 pubmed publisher
  66. Qin M, Li L, Liu X, Liu T, Shi S. Neural substrate of posterior left atrium: A novel modulation for inducibility and remodeling of atrial fibrillation in canine. PLoS ONE. 2017;12:e0176626 pubmed publisher
    ..Local denervation of PLA, as predominant atrial autonomic profile, greatly inhibits AF inducibility and atrial remodeling. ..
  67. Liu L, Li Y, Liu S, Duan Q, Chen L, Wu T, et al. Downregulation of miR-193a-3p inhibits cell growth and migration in renal cell carcinoma by targeting PTEN. Tumour Biol. 2017;39:1010428317711951 pubmed publisher
    ..Taken together, the findings indicated for the first time that miR-193a-3p functions as a tumor-promoting microRNA by directly targeting PTEN in renal cell carcinoma. ..
  68. Guo K, Yao J, Yu Q, Li Z, Huang H, Cheng J, et al. The expression pattern of long non-coding RNA PVT1 in tumor tissues and in extracellular vesicles of colorectal cancer correlates with cancer progression. Tumour Biol. 2017;39:1010428317699122 pubmed publisher
  69. Zhuo M, Pan Y, Wu K, Xu Y, Luo Z. Characterization and mechanism of phosphoinositide 3-kinases (PI3Ks) members in insulin-induced changes of protein metabolism in yellow catfish Pelteobagrus fulvidraco. Gen Comp Endocrinol. 2017;247:34-45 pubmed publisher
    ..Thus, our study demonstrated that among seven PI3K members, PI3KCb and PI3KC2a were more sensitive to the insulin signaling pathway, and insulin stimulated hepatic protein synthesis in yellow catfish through PI3K signaling pathway. ..
  70. Li L, Yuan Y, Chen L, Li M, Ji P, Gong J, et al. Gadolinium-enhanced 7.0 T magnetic resonance imaging assessment of the aqueous inflow in rat eyes in vivo. Exp Eye Res. 2017;162:18-26 pubmed publisher
    ..The aqueous inflow calculation via non-invasive local application of 234.5 mg/ml Gd-DTPA can be assessed by the variability of relative concentration of Gd-DTPA in anterior chamber and ACV in vivo, under anesthetic condition. ..
  71. Zhao K, Wu C, Yao Y, Cao L, Zhang Z, Yuan Y, et al. Ceruloplasmin inhibits the production of extracellular hepatitis B virions by targeting its middle surface protein. J Gen Virol. 2017;98:1410-1421 pubmed publisher
    ..Taken together, our results suggest that CP may be an important host factor that targets MHBs during the envelopment and/or release of virions. ..
  72. Gao Y, Zhang Q, Yan J, Niu X, Han P, Yuan H, et al. Sudden onset of static equilibrium dysfunction in patients receiving a cochlear implant. Medicine (Baltimore). 2017;96:e8465 pubmed publisher
    ..We investigated the sudden onset of static equilibrium dysfunction caused by cochlear implantation (CI) in congenital hearing loss patients...
  73. Hu L, Bai Y, Gu Y, Yu D, Peng S, Liu X, et al. Establishment of an experimental angiographic slow coronary flow model by microsphere embolism in swines. Int J Cardiol. 2014;176:1123-5 pubmed publisher
  74. Lan T, Yan X, Li Z, Xu X, Mao Q, Ma W, et al. Long non-coding RNA PVT1 serves as a competing endogenous RNA for miR-186-5p to promote the tumorigenesis and metastasis of hepatocellular carcinoma. Tumour Biol. 2017;39:1010428317705338 pubmed publisher
    ..Taken together, plasmacytoma variant translocation 1 served as an endogenous sponge for miR-186-5p to reduce its inhibiting effect on yes-associated protein 1 and thus promoted the tumorigenesis of hepatocellular carcinoma. ..
  75. Xie W, Ren M, Li L, Zhu Y, Chu Z, Zhu Z, et al. Perinatal testosterone exposure potentiates vascular dysfunction by ER? suppression in endothelial progenitor cells. PLoS ONE. 2017;12:e0182945 pubmed publisher
    ..We conclude that perinatal testosterone exposure potentiates vascular dysfunction through ER? suppression in EPCs. ..
  76. Fan C, Yu S, Zhang S, Ding X, Su J, Cheng Z. Association between folate intake and risk of head and neck squamous cell carcinoma: An overall and dose-response PRISMA meta-analysis. Medicine (Baltimore). 2017;96:e8182 pubmed publisher
    ..3% degree (OR 0.957, 95% CI 0.935-0.980).These results indicate that folate is a protective nutrient against HNSCC carcinogenesis...
  77. Zhang Y, Li H, Wu H, Zong X, Zhu Z, Pan Y, et al. The 5th national survey on the physical growth and development of children in the nine cities of China: Anthropometric measurements of Chinese children under 7 years in 2015. Am J Phys Anthropol. 2017;163:497-509 pubmed publisher
    ..Urban-suburban difference of those measurements became smaller, while their regional difference persistently exist. Chinese healthy children under 7 years in nine cities was taller and heavier than WHO standards. ..
  78. Li H, Yang S, Gu L, Zhang Y, Yan X, Liang Z, et al. Effect of low-to-moderate-dose corticosteroids on mortality of hospitalized adolescents and adults with influenza A(H1N1)pdm09 viral pneumonia. Influenza Other Respir Viruses. 2017;11:345-354 pubmed publisher
    ..The effect of corticosteroids on influenza A(H1N1)pdm09 viral pneumonia patients remains controversial, and the impact of dosage has never been studied...
  79. Wu M, Wang Y, Wang Y, Zhang M, Luo Y, Tang J, et al. Paclitaxel-loaded and A10-3.2 aptamer-targeted poly(lactide-co-glycolic acid) nanobubbles for ultrasound imaging and therapy of prostate cancer. Int J Nanomedicine. 2017;12:5313-5330 pubmed publisher
  80. Li M, Yang J, Zhou W, Ren Y, Wang X, Chen H, et al. Activation of an AKT/FOXM1/STMN1 pathway drives resistance to tyrosine kinase inhibitors in lung cancer. Br J Cancer. 2017;117:974-983 pubmed publisher
    ..Our findings elucidate an additional common mechanism for TKI resistance and provide a promising therapeutic target for reversing TKI resistance in NSCLC. ..
  81. Wang X, Ma Q, Ding A, Zeng B, Wang F. [Effects of intermittent hypoxia on long-term potentiation in hippocampal dentate gyrus of rat]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2001;17:18-20 pubmed
    ..The present results suggest that the hippocampal synaptic plasticity could be decreased by the treated of intermittent hypoxia. ..
  82. Huang Z, Song Y, Pang Z, Zhang B, Yang H, Shi H, et al. Targeted delivery of thymosin beta 4 to the injured myocardium using CREKA-conjugated nanoparticles. Int J Nanomedicine. 2017;12:3023-3036 pubmed publisher
    ..CRKEA modification favored T?4 accumulation and retention in the infarcted region, leading to augmented functional benefits. Fibrin-targeting delivery system represents a generalizable platform technology for regenerative medicine. ..
  83. Li H, Chen L, Wang T, Wang S, Liu J. The effect of cavernous nerve traction on erectile function in rats. PLoS ONE. 2017;12:e0186077 pubmed publisher
    ..05). The findings indicate that CN traction is an effective CN injury model and the injury it caused is relatively mild compared with the CN crush model...
  84. Wang D, Zhang L, Zeng Q, Xie M. Assessment of left ventricular performance in heart transplant recipients by three-dimensional speckle tracking imaging. Medicine (Baltimore). 2017;96:e8129 pubmed publisher
  85. Li X, Zhou J, Huang K. Inhibition of the lncRNA Mirt1 Attenuates Acute Myocardial Infarction by Suppressing NF-κB Activation. Cell Physiol Biochem. 2017;42:1153-1164 pubmed publisher
    ..These effects could be attributed, at least partly, to inhibition of the NF-κB pathway, resulting in decreased expression of inflammatory factors. ..
  86. Tian D, Peng J, Murugan M, Feng L, Liu J, Eyo U, et al. Chemokine CCL2-CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus. J Neurosci. 2017;37:7878-7892 pubmed publisher
    ..The current study provides a novel insight on the function and mechanisms of CCL2-CCR2 signaling in KA-induced neurodegeneration and behavioral deficits. ..
  87. Wu B, SÅ‚abicki M, Sellner L, Dietrich S, Liu X, Jethwa A, et al. MED12 mutations and NOTCH signalling in chronic lymphocytic leukaemia. Br J Haematol. 2017;179:421-429 pubmed publisher
    ..Our results suggest that MED12 mutations may contribute to CLL pathogenesis by activating NOTCH signalling. ..
  88. Deng C, Wu C, Lyu N, Huang Z. Driving style recognition method using braking characteristics based on hidden Markov model. PLoS ONE. 2017;12:e0182419 pubmed publisher
    ..The results showed that the driving style discrimination based on hidden Markov model algorithm could realize effective discriminant of driving style. ..
  89. Chen W, Cui X, Xing J, Wu T. Response to: Hsp27 and Hsp70 in chronic obstructive pulmonary disease. Cell Stress Chaperones. 2015;20:725-6 pubmed publisher
  90. Shou K, Niu Y, Zheng X, Ma Z, Jian C, Qi B, et al. Enhancement of Bone-Marrow-Derived Mesenchymal Stem Cell Angiogenic Capacity by NPWT for a Combinatorial Therapy to Promote Wound Healing with Large Defect. Biomed Res Int. 2017;2017:7920265 pubmed publisher
    ..Our data suggest that NPWT may act as an inductive role to enhance BMSCs angiogenic capacity and this combinatorial therapy may serve as a simple but efficient clinical solution for complex wounds with large defects. ..
  91. Zhang H, Xu Y, Zhu J, Zhong B. Poor sleep quality is significantly associated with low sexual satisfaction in Chinese methadone-maintained patients. Medicine (Baltimore). 2017;96:e8214 pubmed publisher
    ..58, P?=?.009).Poor sleep quality is significantly associated with low sexual satisfaction of methadone-maintained patients. Improving sleep quality might improve sexual satisfaction of patients receiving MMT. ..
  92. Chen Z, Bao L, Chen C, Zou T, Xue Y, Li F, et al. Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset. J Infect Dis. 2017;215:1807-1815 pubmed publisher
    ..Monotherapy with MCA1 represents a potential alternative treatment for human infections with MERS-CoV worthy of evaluation in clinical settings. ..