Experts and Doctors on intervertebral disc degeneration in Wuhan, Hubei, China
Locale: Wuhan, Hubei, China
Topic: intervertebral disc degeneration
Wang K, Liu W, Song Y, Wu X, Zhang Y, Li S, et al
. The role of angiopoietin-2 in nucleus pulposus cells during human intervertebral disc degeneration. Lab Invest. 2017;97:971-982 pubmed publisher
..The present study therefore provides new insights into the role of the angiopoietin-Tie system in the pathogenesis of IVD degeneration. ..
Hua W, Wu X, Zhang Y, Song Y, Tu J, Kang L, et al
. Dysregulated miR-127-5p contributes to type II collagen degradation by targeting matrix metalloproteinase-13 in human intervertebral disc degeneration. Biochimie. 2017;139:74-80 pubmed publisher
..Dysregulated miR-127-5p contributed to the degradation of type II collagen by targeting MMP-13 in human IDD. Our findings highlight that miR-127-5p may serve as a new therapeutic target in IDD. ..
Zhao K, Zhang Y, Kang L, Song Y, Wang K, Li S, et al
. Epigenetic silencing of miRNA-143 regulates apoptosis by targeting BCL2 in human intervertebral disc degeneration. Gene. 2017;628:259-266 pubmed publisher
..Our results suggest that miRNA-143 promotes the progression of nucleus pulposus apoptosis by directly targeting BCL2, providing a potential therapeutic target for the treatment of intervertebral disc degeneration disease. ..
Zhou Z, Xiong W, Li L, Li F. Adjacent segmental degeneration following Wallis interspinous stabilization implantation: Biomechanical explanations and the value of magnetic resonance imaging. Medicine (Baltimore). 2017;96:e7056 pubmed publisher
..015).ASD of the facet joint in the cranial segment occurred after Wallis system implantation, suggesting that the Wallis system cannot prevent ASD of the facet joint, but could have some other benefits for the discs. ..
Liu W, Xia P, Feng J, Kang L, Huang M, Wang K, et al
. MicroRNA-132 upregulation promotes matrix degradation in intervertebral disc degeneration. Exp Cell Res. 2017;359:39-49 pubmed publisher
..Our findings demonstrated that miR-132 promotes ECM degradation by human NP cells by direct targeting of GDF5. Hence, miR-132 represents a potential therapeutic target in the treatment of IDD. ..