Experts and Doctors on flame retardants in Wuhan, Hubei, China
Locale: Wuhan, Hubei, China
Topic: flame retardants
Deng J, Yu L, Liu C, Yu K, Shi X, Yeung L, et al
. Hexabromocyclododecane-induced developmental toxicity and apoptosis in zebrafish embryos. Aquat Toxicol. 2009;93:29-36 pubmed publisher
..The results also indicate that zebrafish embryos can serve as a reliable model for the developmental toxicity of HBCD. ..
Yu L, Deng J, Shi X, Liu C, Yu K, Zhou B. Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis of zebrafish larvae. Aquat Toxicol. 2010;97:226-33 pubmed publisher
Wang J, Shi X, Du Y, Zhou B. Effects of xenoestrogens on the expression of vitellogenin (vtg) and cytochrome P450 aromatase (cyp19a and b) genes in zebrafish (Danio rerio) larvae. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2011;46:960-7 pubmed publisher
..These results indicate that analysis of vtg and cyp19b gene expression in zebrafish during early embryogenesis and organogenesis represents the basis of a sensitive and fast bioassay for the routine assessment of xenoestrogen effects. ..
Chen L, Yu K, Huang C, Yu L, Zhu B, Lam P, et al
. Prenatal transfer of polybrominated diphenyl ethers (PBDEs) results in developmental neurotoxicity in zebrafish larvae. Environ Sci Technol. 2012;46:9727-34 pubmed publisher
..This study provides the first evidence that parental exposure to environmentally relevant concentrations of PBDEs could cause adverse effects on neurodevelopment in zebrafish offspring. ..
Yu K, He Y, Yeung L, Lam P, Wu R, Zhou B. DE-71-induced apoptosis involving intracellular calcium and the Bax-mitochondria-caspase protease pathway in human neuroblastoma cells in vitro. Toxicol Sci. 2008;104:341-51 pubmed publisher
..Overall, our results indicate that DE-71 induces the apoptosis of [Ca(2+)](i) in SK-N-SH cells via Bax insertion, Cyt c release in the mitochondria, and the caspase activation pathway. ..
Li J, Liang Y, Zhang X, Lu J, Zhang J, Ruan T, et al
. Impaired gas bladder inflation in zebrafish exposed to a novel heterocyclic brominated flame retardant tris(2,3-dibromopropyl) isocyanurate. Environ Sci Technol. 2011;45:9750-7 pubmed publisher
..For the first time, we report that the gas bladder could be a primary target organ for TBC, and assessment of the gas bladder should be included in toxicity testing protocols of zebrafish embryos. ..
Yu L, Lam J, Guo Y, Wu R, Lam P, Zhou B. Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish. Environ Sci Technol. 2011;45:10652-9 pubmed publisher
..For the first time, we demonstrated that parental exposure to low concentrations of PBDEs could affect THs in the offspring and the transgenerational PBDE-induced toxicity in subsequent nonexposed generations. ..
Xu T, Chen L, Hu C, Zhou B. Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae. Environ Toxicol Pharmacol. 2013;35:13-20 pubmed publisher
..Overall, the results indicated that acute exposure to PBDEs could disturb retinoid signaling and may impact on eye development of zebrafish larvae. ..
Liu C, Su G, Giesy J, Letcher R, Li G, Agrawal I, et al
. Acute Exposure to Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Causes Hepatic Inflammation and Leads to Hepatotoxicity in Zebrafish. Sci Rep. 2016;6:19045 pubmed publisher
..Collectively, our results suggest that exposure to TDCIPP induces hepatic inflammation and leads to hepatotoxicity in zebrafish. ..