Experts and Doctors on endocrine disruptors in Wuhan, Hubei, China


Locale: Wuhan, Hubei, China
Topic: endocrine disruptors

Top Publications

  1. Yu L, Lam J, Guo Y, Wu R, Lam P, Zhou B. Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish. Environ Sci Technol. 2011;45:10652-9 pubmed publisher
    ..For the first time, we demonstrated that parental exposure to low concentrations of PBDEs could affect THs in the offspring and the transgenerational PBDE-induced toxicity in subsequent nonexposed generations. ..
  2. Liu C, Yu L, Deng J, Lam P, Wu R, Zhou B. Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic-pituitary-gonadal (HPG) axis of zebrafish. Aquat Toxicol. 2009;93:131-7 pubmed publisher
    ..The results suggested that FTOHs may disturb fish reproduction through endocrine disrupted activity. ..
  3. Liu C, Deng J, Yu L, Ramesh M, Zhou B. Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol. Aquat Toxicol. 2010;96:70-6 pubmed publisher
    ..The results demonstrated that waterborne exposure to 8:2 FTOH caused disruption of sex hormone biosynthesis and impaired reproduction in adult zebrafish, ultimately resulting in decreased hatching rates in the offspring. ..
  4. Ma Y, Liu C, Lam P, Wu R, Giesy J, Hecker M, et al. Modulation of steroidogenic gene expression and hormone synthesis in H295R cells exposed to PCP and TCP. Toxicology. 2011;282:146-53 pubmed publisher
    ..The research indicates that H295R cells can be used as an in vitro model for endocrine disruption assay for chlorophenols and the mechanism involvement of disturbing cAMP signaling. ..
  5. Lin Y, Wei J, Li Y, Chen J, Zhou Z, Song L, et al. Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat. Am J Physiol Endocrinol Metab. 2011;301:E527-38 pubmed publisher
    ..DEHP exposure in critical periods of development can be a potential risk factor, at least in part, for developing diabetes. ..
  6. Wang J, Shi X, Du Y, Zhou B. Effects of xenoestrogens on the expression of vitellogenin (vtg) and cytochrome P450 aromatase (cyp19a and b) genes in zebrafish (Danio rerio) larvae. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2011;46:960-7 pubmed publisher
    ..These results indicate that analysis of vtg and cyp19b gene expression in zebrafish during early embryogenesis and organogenesis represents the basis of a sensitive and fast bioassay for the routine assessment of xenoestrogen effects. ..
  7. Ma Y, Han J, Guo Y, Lam P, Wu R, Giesy J, et al. Disruption of endocrine function in in vitro H295R cell-based and in in vivo assay in zebrafish by 2,4-dichlorophenol. Aquat Toxicol. 2012;106-107:173-81 pubmed publisher
    ..The results demonstrated that 2,4-DCP modulates transcription of steroidogenetic genes in both H295R cells and in the zebrafish HPG-axis and disrupts steroidogenesis, which in turn, can cause adverse effects on reproduction in fish. ..
  8. Chen Q, Yu L, Yang L, Zhou B. Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae. Aquat Toxicol. 2012;110-111:141-8 pubmed publisher
    ..These results suggest that the hypothalamic-pituitary-thyroid axis can be evaluated to determine thyroid endocrine disruption by BDE-209 in developing zebrafish larvae. ..
  9. Huang X, Zhou Y, Ma J, Wang N, Zhang Z, Ji J, et al. Nitric oxide mediated effects on reproductive toxicity caused by carbon disulfide in male rats. Environ Toxicol Pharmacol. 2012;34:679-87 pubmed publisher
    ..SNP reduced some of the toxic effects of CS(2), while L-NMMA treatment showed no effect. The results suggests that NO mediates compromised reproductive system function caused by CS(2) exposure...

More Information


  1. Guo Y, Zhou B. Thyroid endocrine system disruption by pentachlorophenol: an in vitro and in vivo assay. Aquat Toxicol. 2013;142-143:138-45 pubmed publisher
    ..PCP exposure did not influence the transcription of the transthyretin (TTR) gene. The results indicate that PCP potentially disrupts the thyroid endocrine system both in vitro and in vivo. ..
  2. Liang X, Martyniuk C, Cheng G, Zha J, Wang Z. Pyruvate carboxylase as a sensitive protein biomarker for exogenous steroid chemicals. Environ Pollut. 2014;189:184-93 pubmed publisher
    ..05). Our results suggest that endocrine disruptors interfere with genes and proteins of the TCA cycle and PC may be a sensitive biomarker of exposure to exogenous steroid chemicals in the liver of fish. ..
  3. Cheng X, Chen X, Jin X, He J, Yin Z. Generation and characterization of gsu?:EGFP transgenic zebrafish for evaluating endocrine-disrupting effects. Toxicol Appl Pharmacol. 2014;278:78-84 pubmed publisher
    ..These reporter fish can serve as a novel platform to perform screenings of endocrine-disrupting chemicals (EDCs) in vivo as well. ..
  4. Dang Y, Wang J, Giesy J, Liu C. Responses of the zebrafish hypothalamic-pituitary-gonadal-liver axis PCR array to prochloraz are dependent on timing of sampling. Aquat Toxicol. 2016;175:154-9 pubmed publisher
    ..Correlations among parameters in samples collected at the two times indicated the effects might be due to different concentrations of E2 in plasma due to exposure to PCZ. ..
  5. Zhang L, Wei C, Zhang H, Song M. Criteria for assessing the ecological risk of nonylphenol for aquatic life in Chinese surface fresh water. Chemosphere. 2017;184:569-574 pubmed publisher
    ..008% to 24.600%. The analysis provides a theoretical basis for both short- and long-term risk assessments with respect to nonylphenol, and also a means to quantify the risk to aquatic ecosystems. ..
  6. Song Y, Yang K. [Effect of p, p'-DDE on DNA damage and expression of FasL gene of rat Sertoli cell in vitro]. Wei Sheng Yan Jiu. 2006;35:261-3 pubmed
    ..p, p'-DDE might induce the Sertoli cell damage and destroy the dynamic process of spermatogenesis through the Fas/FasL pathway, which might lead to oligozoospermatism. ..