Experts and Doctors on cysteine endopeptidases in Wuhan, Hubei, China


Locale: Wuhan, Hubei, China
Topic: cysteine endopeptidases

Top Publications

  1. Wang L, Lin Y, Yang J, Guo W. Insufficient increment of CD4+CD25+ regulatory T cells after stimulation in vitro with allergen in allergic asthma. Int Arch Allergy Immunol. 2009;148:199-210 pubmed publisher
    ..The high levels of T(reg) cell response and IL-10 and IFN- gamma responses to specific allergen can partly explain the immunological characteristics associated with sensitized asymptomatic subjects. ..
  2. Zhang K, Huang J, Wang Q, He Y, Xu Z, Xiang M, et al. Recombinant pseudorabies virus expressing P12A and 3C of FMDV can partially protect piglets against FMDV challenge. Res Vet Sci. 2011;91:90-4 pubmed publisher
    ..PRV-P12A3C induced 60% protection, compared with piglets that were vaccinated with TK(-)/gE(-)/gI(-). The severity of clinical signs for the remaining two piglets was lighter and the appearance of vesicles was delayed. ..
  3. Yue M, Mo S, Song P, Gong Y. Identification of Z-OTU protein during zebrafish oogenesis and early embryogenesis. Dongwuxue Yanjiu. 2011;32:386-90 pubmed publisher
    ..We inferred that Z-OTU protein, like other OTU-related protease with DUB activity, was required for germinal vesicle breakdown of oocytes during meiosis, germinal vesicle migration, and embryo cleavage maintenance. ..
  4. Mo S, Song P, Lv D, Chen Y, Zhou W, Gong W, et al. Zebrafish z-otu, a novel Otu and Tudor domain-containing gene, is expressed in early stages of oogenesis and embryogenesis. Biochim Biophys Acta. 2005;1732:1-7 pubmed
    ..Therefore, z-otu might link the ubiquitin signaling pathway to early oogenesis and maintaining the totipotency of embryonic cell. ..
  5. Xu X, Yuan G, Liu W, Zhang Y, Chen W. Expression of cathepsin L in nasopharyngeal carcinoma and its clinical significance. Exp Oncol. 2009;31:102-5 pubmed
    ..Multivariate survival analysis showed that cathepsin L protein expression level had a marginal significant correlation with prognosis of NPC. Cathepsin L is a potential biomarker for prognosis of NPC and contributes to NPC metastasis. ..
  6. Li S, Zheng H, Mao A, Zhong B, Li Y, Liu Y, et al. Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. J Biol Chem. 2010;285:4291-7 pubmed publisher
    ..These findings suggest that OTUB1 and OTUB2 negatively regulate virus-triggered type I IFN induction and cellular antiviral response by deubiquitinating TRAF3 and -6. ..
  7. Li H, Zheng Z, Zhou P, Zhang B, Shi Z, Hu Q, et al. The cysteine protease domain of porcine reproductive and respiratory syndrome virus non-structural protein 2 antagonizes interferon regulatory factor 3 activation. J Gen Virol. 2010;91:2947-58 pubmed publisher
    ..These findings suggest that Nsp2 is likely to play an important role in subversion of IRF-3-dependent innate antiviral defences, providing a basis for elucidating the mechanisms underlying PRRSV pathogenesis...
  8. Zheng H, Yan F, Lu Y, Sun L, Lin L, Cai L, et al. Mapping the self-interacting domains of TuMV HC-Pro and the subcellular localization of the protein. Virus Genes. 2011;42:110-6 pubmed publisher
    ..It was also shown that the central and C-terminal regions of the HC-Pro participated in these self-interactions. Fluorescence microscopy showed that TuMV HC-Pro was present in the cytoplasm and formed aggregates along the ER. ..
  9. Ye S, Xia H, Dong C, Cheng Z, Xia X, Zhang J, et al. Identification and characterization of Iflavirus 3C-like protease processing activities. Virology. 2012;428:136-45 pubmed publisher
    ..Our work is the first study to identify an iflaviral 3CL protease and further characterize it in detail and should foster our understanding of EoV and other iflaviruses. ..

More Information


  1. Wang D, Fang L, Li K, Zhong H, Fan J, Ouyang C, et al. Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signaling. J Virol. 2012;86:9311-22 pubmed publisher
    ..Collectively, our data identify NEMO as a substrate for FMDV 3C(pro) and reveal a novel mechanism evolved by a picornavirus to counteract innate immune signaling...
  2. Qian S, Fan W, Liu T, Wu M, Zhang H, Cui X, et al. Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage. J Virol. 2017;91: pubmed publisher
    ..We also found that SVV is sensitive to IFN-β. These findings increase our understanding of the interaction between SVV and host innate immunity. ..
  3. Lin X, Sun R, Zhang F, Gao Y, Bin L, Lan K. The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Expression of SUMO/Sentrin-Specific Peptidase 6 To Facilitate Establishment of Latency. J Virol. 2017;91: pubmed publisher
    ..This delicate regulation may provide important insights to explain the abundance of LANA during KSHV latency. ..
  4. Hu P, Huang P, Chen M. Curcumin reduces Streptococcus mutans biofilm formation by inhibiting sortase A activity. Arch Oral Biol. 2013;58:1343-8 pubmed publisher
    ..The aim of this study was to investigate the inhibitory ability of curcumin against S. mutans sortase A and the effect of curcumin for biofilm formation...
  5. Hu M, Liao C, Yang Q, Xie X, Shu H. Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5. J Exp Med. 2017;214:973-989 pubmed publisher
    ..These findings suggest that dynamic sumoylation and desumoylation of MDA5 and RIG-I modulate efficient innate immunity to RNA virus and its timely termination. ..
  6. Zhou J, Wang D, Xi Y, Zhu X, Yang Y, Lv M, et al. Assessing activity of Hepatitis A virus 3C protease using a cyclized luciferase-based biosensor. Biochem Biophys Res Commun. 2017;488:621-627 pubmed publisher
  7. Zhang Z, Kang S, Liu X, Ahn E, Zhang Z, He L, et al. Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease. Nat Struct Mol Biol. 2017;24:632-642 pubmed publisher
    ..Together, these findings support AEP's role as a key mediator of α-synuclein-related etiopathological effects in PD. ..