Experts and Doctors on animals in Shijiazhuang, Hebei, China


Locale: Shijiazhuang, Hebei, China
Topic: animals

Top Publications

  1. Xu S, Gao W, Cong B, Ma C, Li S, Ling Y, et al. Effect of cholecystokinin octapeptide on diacylglycerol-PKC signaling pathway in rat pulmonary interstitial macrophages stimulated by lipopolysaccharide. Acta Pharmacol Sin. 2005;26:1497-504 pubmed
    ..It significantly inhibited LPS-induced DAG content, PKC activity and PKCzeta translocation in a concentration-dependent manner. The CCK receptor, especially the CCK-A receptor, might play a major role in this process. ..
  2. Xiao L, Wu Y, Zhang H, Liu Y, He R. Hydrogen sulfide facilitates carotid sinus baroreflex in anesthetized rats. Acta Pharmacol Sin. 2006;27:294-8 pubmed
    ..To study effects of hydrogen sulfide (H2S) on the carotid sinus baroreflex (CSB)...
  3. Wang Y, Wang P, Takashi K. Chronic effects of different non-esterified fatty acids on pancreatic islets of rats. Endocrine. 2006;29:169-73 pubmed
    ..05). Elevation of palmitate, stearate, oleate or linoleate decreases the beta-cell secretory response to glucose, through inhibiting PDH activity. Linoleate exerts more negative effect on GSIS than other NEFA. ..
  4. Wang W, Shi Z, Yu J, Guo L, Wang L, Han D, et al. [Effect of recombinant human erythropoietin on hippocampal p-Akt and caspase-9 expressions in rats with status epilepticus and the mechanism]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:64-9 pubmed
  5. Zhang R, Lu H, Tian S, Yin J, Chen Q, Ma L, et al. Protective effects of pre-germinated brown rice diet on low levels of Pb-induced learning and memory deficits in developing rat. Chem Biol Interact. 2010;184:484-91 pubmed publisher
    ..The mechanisms might be related to the anti-oxidative effects and large amount of GABA in PR. Our study provides a regimen to reduce Pb-induced toxicity, especially future learning and memory deficits in the developing brain. ..
  6. Du X, Zhang X, Qi J, An H, Li J, Wan Y, et al. Characteristics and molecular basis of celecoxib modulation on K(v)7 potassium channels. Br J Pharmacol. 2011;164:1722-37 pubmed publisher
    ..They also provide a new approach to developing K(v)7 modulators and for studying the structure-function relationship of K(v)7 channels. ..
  7. Ding H, Yan C, Shi H, Zhao Y, Chang S, Yu P, et al. Hepcidin is involved in iron regulation in the ischemic brain. PLoS ONE. 2011;6:e25324 pubmed publisher
  8. Chen B, Wang C, Chen W, Ma J. Altered TGF-?2 and bFGF expression in scleral desmocytes from an experimentally-induced myopia guinea pig model. Graefes Arch Clin Exp Ophthalmol. 2013;251:1133-44 pubmed publisher
    ..To determine changes in expression of transforming growth factor ?-2 (TGF-?2) and basic fibroblast growth factor (bFGF) in scleral desmocytes from anterior and posterior portions of experimentally-induced myopic eyes of guinea pigs...
  9. Wang X, Yao M, Liu S, Hao J, Liu Q, Gao F. Interplay between the Notch and PI3K/Akt pathways in high glucose-induced podocyte apoptosis. Am J Physiol Renal Physiol. 2014;306:F205-13 pubmed publisher
    ..The inhibition of the Notch pathway or the activation of the PI3K/Akt pathway prevented cell apoptosis in HG-treated podocytes. These findings suggest that the Notch and PI3K/Akt pathways may mediate HG-induced podocyte apoptosis. ..

More Information

Publications288 found, 100 shown here

  1. Zhu L, Zhao S, Liu S, Liu Q, Li F, Hao J. PTEN Regulates Renal Extracellular Matrix Deposit via Increased CTGF in Diabetes Mellitus. J Cell Biochem. 2016;117:1187-98 pubmed publisher
    ..In the end our study suggests that PTEN regulates renal extracellular matrix production via activated Akt and increased CTGF in diabetes mellitus. ..
  2. Li Y, Zhang X, Cui L, Chen R, Zhang Y, Zhang C, et al. Salvianolic acids enhance cerebral angiogenesis and neurological recovery by activating JAK2/STAT3 signaling pathway after ischemic stroke in mice. J Neurochem. 2017;143:87-99 pubmed publisher
    ..In summary, these data suggest that Sals administration enhances cerebral angiogenesis and promotes neurological recovery after ischemic stroke, mediated by the activation of JAK2/STAT3 signaling pathway. ..
  3. Liu D, Zhu B, Wang X, Yan H, Ding Y. [Screening of stage-specific expression genes of Spirometra erinacei-europaei plerocercoid by mRNA differential display technique]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2002;20:14-7 pubmed
    ..To screen stage-specific expression genes of plerocercoid of Spirometra erinacei-europaei...
  4. Zheng B, Han M, Bernier M, Zhang X, Meng F, Miao S, et al. Krüppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor beta-mediated, not by retinoic acid receptor alpha-mediated, phosphatidylinositol 3-kinase and ERK signaling in vascular smooth muscle cells. J Biol Chem. 2009;284:22773-85 pubmed publisher
    ..These findings provide a novel mechanism for signal suppression and growth inhibitory effects of Klf4 in VSMCs. Moreover, the results of this study suggest that Klf4 is one of the key mediators of retinoid actions in VSMCs. ..
  5. Xu L, Guo Y, Liu Y, Wu S, Yang C, Wu D, et al. Oxidative stress in immune-mediated motoneuron destruction. Brain Res. 2009;1302:225-32 pubmed publisher
    ..The activation of p38MAPK signal pathway was involved in the development of the motor neuron degeneration of the spinal cord. ..
  6. Dong L, Wen J, Liu G, McNutt M, Miao S, Gao R, et al. Blockade of the Ras-extracellular signal-regulated kinase 1/2 pathway is involved in smooth muscle 22 alpha-mediated suppression of vascular smooth muscle cell proliferation and neointima hyperplasia. Arterioscler Thromb Vasc Biol. 2010;30:683-91 pubmed publisher
  7. Guo F, Liu B, Tang F, Lane S, Souslova E, Chudakov D, et al. Astroglia are a possible cellular substrate of angiotensin(1-7) effects in the rostral ventrolateral medulla. Cardiovasc Res. 2010;87:578-84 pubmed publisher
    ..We hypothesise that Ang1-7 modulates astrocytic signalling which in vivo may affect local metabolism and microcirculation, resulting in changes in activity of RVLM pre-sympathetic neurones and hence blood pressure. ..
  8. Li Y, Qi J, Liu K, Li B, Wang H, Jia J. Peroxynitrite-induced nitration of cyclooxygenase-2 and inducible nitric oxide synthase promotes their binding in diabetic angiopathy. Mol Med. 2010;16:335-42 pubmed publisher
    ..The results provide in vivo evidence that COX-2 and iNOS can bind in diabetic angiopathy and that peroxynitrite-induced nitration of COX-2 and iNOS promotes their binding, contributing to diabetic angiopathy. ..
  9. Ma Z, Zhang J, Du R, Ji E, Chu L. Rho kinase inhibition by fasudil has anti-inflammatory effects in hypercholesterolemic rats. Biol Pharm Bull. 2011;34:1684-9 pubmed
  10. Gan K, Wang C, Chen J, Zhu C, Song G. Mitofusin-2 ameliorates high-fat diet-induced insulin resistance in liver of rats. World J Gastroenterol. 2013;19:1572-81 pubmed publisher
    ..01), compared with the Ad group. HFDs induce insulin resistance, and this can be reversed by MFN2 over-expression targeting the insulin signaling pathway. ..
  11. Tang N, Zhang Y, Ying W, Yao X. Interleukin-1? upregulates matrix metalloproteinase-13 gene expression via c-Jun N-terminal kinase and p38 MAPK pathways in rat hepatic stellate cells. Mol Med Rep. 2013;8:1861-5 pubmed publisher
    ..Thus, the JNK and p38 MAPK pathway co-operatively mediate MMP-13 mRNA expression in rat HSCs. ..
  12. Hou Y, Lin H, Zhu L, Liu Z, Hu F, Shi J, et al. The inhibitory effect of IFN-? on protease HTRA1 expression in rheumatoid arthritis. J Immunol. 2014;193:130-8 pubmed publisher
  13. Luo Y, Zhang L, Lin Z, Ma J, Jia J, Namgoong S, et al. Distinct subcellular localization and potential role of LINE1-ORF1P in meiotic oocytes. Histochem Cell Biol. 2016;145:93-104 pubmed publisher
    ..We also found that ORF1P could form DCP1A body-like foci structure in both cytoplasm and nucleus after heat shock. Taken together, accurate regulation of ORF1P plays an essential role in mouse oocyte meiotic maturation. ..
  14. Jiang Y, Wang L, Lao J, Zhao X. Comparative study of intercostal nerve transfer to lower trunk and contralateral C7 root transfer in repair of total brachial plexus injury in rats. J Plast Reconstr Aesthet Surg. 2016;69:623-8 pubmed publisher
    ..Therefore, at present, the more important implication of the comparative study is that traditional cC7 root transfer remains the mainstay strategy to repair forearm flexor muscle function. ..
  15. You L, Yan C, Zheng B, Ci Y, Chang S, Yu P, et al. Astrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis. Cell Death Dis. 2017;8:e2676 pubmed publisher
    ..Such a pathway is relevant to NDs in that it links inflammation, microglia and astrocytes to neuronal damage. ..
  16. Kang Y, Yan W, Fang H, Zhang G, Du Y, Wang L, et al. Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline. Oxid Med Cell Longev. 2017;2017:7908072 pubmed publisher
    ..Intranasal administration of Ptx may hopefully become a noninvasive, painless, and easily administered option for epileptic patients. ..
  17. Li Y, Zhou J. Roles of silent information regulator 1-serine/arginine-rich splicing factor 10-lipin 1 axis in the pathogenesis of alcohol fatty liver disease. Exp Biol Med (Maywood). 2017;242:1117-1125 pubmed publisher
    ..It seems a new signaling axis, SIRT1-SFRS10-LIPIN1 axis, acting in the pathogenesis of AFLD exists. Further study aimed at SIRT1-SFRS10-LIPIN1 signaling system will possibly offer a more effective therapeutic target for AFLD. ..
  18. Zhao Y, Li M, Sun Y, Wu W, Kou G, Guo L, et al. Life-history dependent relationships between body condition and immunity, between immunity indices in male Eurasian tree sparrows. Comp Biochem Physiol A Mol Integr Physiol. 2017;210:7-13 pubmed publisher
  19. Cong B, Li S, Ling Y, Yao Y, Gu Z, Wang J, et al. Expression and cell-specific localization of cholecystokinin receptors in rat lung. World J Gastroenterol. 2003;9:1273-7 pubmed
  20. Zhang Y, Guo Y, Jia Q, Wang Y, Zhang H. Mechanism of anti-apoptotic action of dipfluzine on neuronal damage of the rat hippocampal CA1 region subjected to transient forebrain ischemia. Yao Xue Xue Bao. 2005;40:97-104 pubmed
  21. Zheng B, Wen J, Han M. hhLIM is a novel F-actin binding protein involved in actin cytoskeleton remodeling. FEBS J. 2008;275:1568-78 pubmed publisher
    ..Taken together, these data identify hhLIM as an actin-binding protein that increases actin cytoskeleton stability by promoting bundling of actin filaments. ..
  22. Wang Y, Shi C, Dong F, Sheng J, Xu Y. Inhibition of the rapid component of the delayed rectifier potassium current in ventricular myocytes by angiotensin II via the AT1 receptor. Br J Pharmacol. 2008;154:429-39 pubmed publisher
    ..This is a potential mechanism by which elevated levels of Ang II are involved in the occurrence of arrhythmias in cardiac hypertrophy and failure. ..
  23. Zeng R, Zhang Z, Mei X, Gong W, Wei L. Protective effect of a RSV subunit vaccine candidate G1F/M2 was enhanced by a HSP70-Like protein in mice. Biochem Biophys Res Commun. 2008;377:495-499 pubmed publisher
    ..Interestingly, the protective effect of HSP-G1F/M2 against RSV was significantly stronger than that of G1F/M2+Alum. The results suggest that HSP70L1 is a potent adjuvant of G1F/M2. ..
  24. Feng X, Zhang L, Zhu H. Comparative anticancer and antioxidant activities of different ingredients of Ginkgo biloba extract (EGb 761). Planta Med. 2009;75:792-6 pubmed publisher
    ..Terpene trilactones cannot exert the anticancer effects of flavonoids in vivo. Raising the levels of the free radical scavenger enzymes GST, SOD and CAT may be one of the involved anticancer mechanisms. ..
  25. Cui R, Duan X, Anderson G, Qiao Y, Yu P, Qian Z, et al. Age-dependent expression of hephaestin in the brain of ceruloplasmin-deficient mice. J Trace Elem Med Biol. 2009;23:290-9 pubmed publisher
    ..These data suggest that Heph may compensate for the loss of CP in a region-specific manner. ..
  26. Zhao C, Yan L, Wang Y, Wang W, Zhou J, Zhen Z. [Role of resistin in inflammation of hepatocytes in nonalcoholic steatohepatitis]. Zhonghua Gan Zang Bing Za Zhi. 2009;17:683-7 pubmed
    ..Resistin can induce the production of TNF alpha, IL-6 and other inflammatory factors by hepatocytes, and therefore is an important inflammatory factor in NASH. ..
  27. Yuan G, Jia Z, Yang H, Wu S, Gao H, Wei C, et al. Comfortable lifestyle-induced imbalance of neuro-endocrine-immunity network: a possible mechanism of vascular endothelial dysfunction. Chin J Integr Med. 2010;16:54-60 pubmed publisher
  28. Du X, Wang C, Zhang H. Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats. Mol Pain. 2011;7:35 pubmed publisher
    ..KATP activators can be evaluated clinically for the treatment of pain symptoms. ..
  29. He H, Ren L, Tian H, Lu H, Zhao D. Effects of imidazolines on neurogenic contraction in isolated urinary bladder detrusor strips from rabbit. Can J Physiol Pharmacol. 2012;90:219-27 pubmed publisher
  30. Xie T, Wang W, Mao Z, Qu Z, Luan S, Jia L, et al. Effects of epigallocatechin-3-gallate on pentylenetetrazole-induced kindling, cognitive impairment and oxidative stress in rats. Neurosci Lett. 2012;516:237-41 pubmed publisher
    ..These observations suggest that EGCG may be a potential agent for the treatment of epilepsy as well as a preventive agent against cognitive impairment induced by seizure. ..
  31. Shi H, Wen J, Miao S, Liu Y, Zheng B. KLF5 and hhLIM cooperatively promote proliferation of vascular smooth muscle cells. Mol Cell Biochem. 2012;367:185-94 pubmed publisher
    ..These data suggest that KLF5 reverses hhLIM function from anti-proliferation to pro-proliferation through its interaction with hhLIM on the cyclin E promoter. ..
  32. Li C, Cao J, Wang Y, Zhao X, Deng C, Wei N, et al. Accelerated blood clearance of pegylated liposomal topotecan: influence of polyethylene glycol grafting density and animal species. J Pharm Sci. 2012;101:3864-76 pubmed publisher
  33. Song S, Gao J, Wang K, Li R, Tian Y, Wei J, et al. Attenuation of brain edema and spatial learning de?cits by the inhibition of NADPH oxidase activity using apocynin following diffuse traumatic brain injury in rats. Mol Med Rep. 2013;7:327-31 pubmed publisher
    ..These results reveal that treatment with apocynin may provide a new neuroprotective therapeutic strategy against DBI by diminishing the upregulation of NOX2 protein and NOX activity. ..
  34. Shi C, Wang X, Dong F, Wang Y, Hui J, Lin Z, et al. Temporal alterations and cellular mechanisms of transmural repolarization during progression of mouse cardiac hypertrophy and failure. Acta Physiol (Oxf). 2013;208:95-110 pubmed publisher
    ..The two distinct TDR modes were revealed during the progression of mouse cardiac hypertrophy and failure, indicating that the remodelling of TDR depends on the stage of the disease. ..
  35. Zhang J, Zhen Y, Pu Bu Ci Ren -, Song L, Kong W, Shao T, et al. Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus. Behav Brain Res. 2013;244:70-81 pubmed publisher
    ..However, salidroside (50 and 75 mg/kg p.o.) reversed all the former alterations. Thus, the study indicates that salidroside may have a protective effect against AD via modulating oxidative stress and inflammatory mediators. ..
  36. Li Q, Guo H, Maslov L, Qiao X, Zhou J, Zhang Y. Mitochondrial permeability transition pore plays a role in the cardioprotection of CB2 receptor against ischemia-reperfusion injury. Can J Physiol Pharmacol. 2014;92:205-14 pubmed publisher
    ..Furthermore, JWH133 reversed the MPTP opening induced by atractyloside. The protective effect of JWH133 on the heart against I-R injury may be through increased ERK1/2 phosphorylation, inhibiting MPTP opening. ..
  37. Qi T, Xu F, Yan X, Li S, Li H. Sulforaphane exerts anti-inflammatory effects against lipopolysaccharide-induced acute lung injury in mice through the Nrf2/ARE pathway. Int J Mol Med. 2016;37:182-8 pubmed publisher
    ..These findings demonstrate that sulforaphane exerts protective effects against LPS-induced ALI through the Nrf2/ARE pathway. Thus, sulforaphane may be a potential a candidate for use in the treatment of ALI. ..
  38. Zhao J, Liu J, Wei T, Ma X, Cheng Q, Huo S, et al. Quercetin-loaded nanomicelles to circumvent human castration-resistant prostate cancer in vitro and in vivo. Nanoscale. 2016;8:5126-38 pubmed publisher
    ..Thus, our nanomicelle-based drug delivery system constitutes a promising and effective therapeutic strategy for clinical treatment. ..
  39. Shen W, Chen J, Yin J, Wang S. Selenium protects reproductive system and foetus development in a rat model of gestational lead exposure. Eur Rev Med Pharmacol Sci. 2016;20:773-80 pubmed
    ..These adverse effects are rectified or attenuated by selenium supplementation. ..
  40. Duan W, Zhang R, Guo Y, Jiang Y, Huang Y, Jiang H, et al. Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice. In Vitro Cell Dev Biol Anim. 2009;45:388-97 pubmed publisher
    ..Total nuclear factor E2-related factor 2, which governs basal and inducible expression of HO1 and NQO1, decreased significantly. Significantly, epigallocatechin gallate restored the Nrf2 activity. ..
  41. Hu Y, Li W, Lu L, Cai J, Xian X, Zhang M, et al. An anti-nociceptive role for ceftriaxone in chronic neuropathic pain in rats. Pain. 2010;148:284-301 pubmed publisher
    ..These results indicate that Cef plays an anti-nociceptive role by up-regulating spinal GLT-1 expression and its function. ..
  42. Ren Y, Shi Y, Wang Y, Li Y, Wu S, Li H, et al. p38 MAPK pathway is involved in high glucose-induced thioredoxin interacting protein induction in mouse mesangial cells. FEBS Lett. 2010;584:3480-5 pubmed publisher
    ..These data suggest that HG-induced overexpression of TXNIP in MMCs, which may be via the p38 MAPK pathway. ..
  43. Wu B, Zheng Y, Sang X, Jin M, Wang W, Zhang Q, et al. [Role of the IGF-1/PI3K pathway and the molecular mechanism of Fuzhenghuayu therapy in a spontaneous recovery rat model of liver fibrosis]. Zhonghua Gan Zang Bing Za Zhi. 2013;21:674-8 pubmed publisher
    ..The IGF-1/PI3K pathway may contribute to progression of liver fibrosis. The mechanism by which FZHY prevents liver fibrosis in a rat model may involve blocking of the IGF/PI3K pathway and inhibiting HSC activation. ..
  44. Sun W, Zhuang C, Li X, Zhang B, Lu X, Zheng Z, et al. Varic acid analogues from fungus as PTP1B inhibitors: Biological evaluation and structure-activity relationships. Bioorg Med Chem Lett. 2017;27:3382-3385 pubmed publisher
    ..Trivaric acid showed insulin-sensitizing effect not only in vitro but also in vivo, representing a promising lead compound for further optimization. ..
  45. Liu J, Xu Y, Kang Y, Cao S, Shi G, Cui H, et al. The aberrantly expressed long non-coding RNA in the substantia nigra and corpus striatum of Nrf2-knockout mice. J Neurochem. 2017;143:65-75 pubmed publisher
    ..The dysregulated DELs and DEMs in the substantia nigra and corpus striatum of Nrf2 (-/-) mice were identified. Our results might provide useful information for further exploring the pathogenesis mechanism of PD. ..
  46. Shi R, Zhao C, Zhu H, Yang Y, Wang S, Jiang L. [Relationship between the increase of hepatic D-bifunctional protein activity and bile acid biosynthesis in rats]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005;27:321-4 pubmed
    ..95, P < 0.01). The up-regulation of DBP mRNA and activity in liver can result in the increase in CYP7A1 mRNA expression and bile acid biosynthesis, suggesting that DBP may be involved in bile acid biosynthesis together with CYP7A1. ..
  47. Sun X, Li W, Li Q, Zhang M, Xian X, Qi J, et al. Limb ischemic preconditioning induces brain ischemic tolerance via p38 MAPK. Brain Res. 2006;1084:165-74 pubmed
  48. Zhao C, Wang Y, Zhou J, Jia B, Cui J. [An experimental study on the reverse mechanism of PPAR-gamma agonist rosiglitazone in rats with non-alcoholic steatohepatitis]. Zhonghua Gan Zang Bing Za Zhi. 2007;15:450-5 pubmed
    ..This may help to provide a new idea for treating NASH effectively. ..
  49. Liu B, Han M, Wen J. Acetylbritannilactone Inhibits Neointimal Hyperplasia after Balloon Injury of Rat Artery by Suppressing Nuclear Factor-{kappa}B Activation. J Pharmacol Exp Ther. 2008;324:292-8 pubmed
    ..These findings suggest that ABL is a potential inhibitor of neointimal formation because it blocks injury-induced NF-kappaB activation and may have beneficial effects in reducing the risk of restenosis after angioplasty. ..
  50. Zhang Q, Li Y, Shi Y, Zhang Y. HVJ envelope vector, a versatile delivery system: its development, application, and perspectives. Biochem Biophys Res Commun. 2008;373:345-9 pubmed publisher
    ..In this review, the development, application, and perspectives of the HVJ envelope vector will be discussed. ..
  51. Wang P, Wang W, Sun Zhang -, Wang H, Yan Lou -, Fan Y. Impaired spatial learning related with decreased expression of calcium/calmodulin-dependent protein kinase IIalpha and cAMP-response element binding protein in the pentylenetetrazol-kindled rats. Brain Res. 2008;1238:108-17 pubmed publisher
    ..We concluded that Ca(2+) influx, CaMKII(alpha) and CREB expression levels in hippocampus of chronic epileptic rats may be related with their impaired spatial learning and memory. ..
  52. Liu J, Sun Z, Ma Y. [Change of JNK and c-Jun in lung injury associated with paraquat poisoning of rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008;26:406-9 pubmed
    ..The increase of CO of lung tissue in rats at the lung injury associated with paraquat poisoning reduces the acute lung injury of rats. The level of JNK and c-Jun phosphorylation increases obviously, especially after Hemin is utilized. ..
  53. Meng F, Han M, Zheng B, Wang C, Zhang R, Zhang X, et al. All-trans retinoic acid increases KLF4 acetylation by inducing HDAC2 phosphorylation and its dissociation from KLF4 in vascular smooth muscle cells. Biochem Biophys Res Commun. 2009;387:13-8 pubmed publisher
    ..Collectively, our results indicate that ATRA induces HDAC2 phosphorylation mediated by JNK signaling, and thus causes HDAC2 dissociation from KLF4, subsequently leading to the increase in KLF4 acetylation. ..
  54. Zhang R, Han M, Zheng B, Li Y, Shu Y, Wen J. Krüppel-like factor 4 interacts with p300 to activate mitofusin 2 gene expression induced by all-trans retinoic acid in VSMCs. Acta Pharmacol Sin. 2010;31:1293-302 pubmed publisher
    ..KLF4 acetylation by p300 increased its activity to transactivate the mfn-2 promoter. ATRA induces KLF4 acetylation by p300 and increases the ability of KLF4 to transactivate the mfn-2 promoter in VSMCs. ..
  55. Ji H, Miao J, Zhang X, Du Y, Liu H, Li S, et al. Inhibition of sonic hedgehog signaling aggravates brain damage associated with the down-regulation of Gli1, Ptch1 and SOD1 expression in acute ischemic stroke. Neurosci Lett. 2012;506:1-6 pubmed publisher
    ..05). Collectively, the present results suggest that inhibition of Shh signaling pathway exacerbated rat ischemic damage caused by pMCAO, which may be correlated with down-regulated expression of Gli1, Ptch1 and SOD1. ..
  56. Chen L, Li Z, Ping M, Li R, Liu J, Xie X, et al. Regulation of Olig2 during astroglial differentiation in the subventricular zone of a cuprizone-induced demyelination mouse model. Neuroscience. 2012;221:96-107 pubmed publisher
    ..The BMP signaling pathway may contribute to the cytoplasmic translocation and altered expression of Olig2 during the remyelination process. These findings provide a better understanding of the mechanisms involved in remyelination. ..
  57. Wu B, Song B, Yang H, Huang B, Chi B, Guo Y, et al. Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model. Neurotoxicology. 2013;35:62-70 pubmed publisher
    ..Further studies will be needed with non-lethal dose of PQ to confirm these results and demonstrate the direct CNS toxicity of PQ. ..
  58. Shi L, Shi L, Zhang H, Hu Z, Wang C, Zhang D, et al. Oxymatrine ameliorates non-alcoholic fatty liver disease in rats through peroxisome proliferator-activated receptor-? activation. Mol Med Rep. 2013;8:439-45 pubmed publisher
    ..The beneficial effects of OMT were further confirmed by the observation of a decrease in lipid accumulation in the histology of the liver. Our results indicate that OMT may be used to treat NAFLD. ..
  59. Zhang L, Zhang X, Zhang C, Bai X, Zhang J, Zhao X, et al. Nobiletin promotes antioxidant and anti-inflammatory responses and elicits protection against ischemic stroke in vivo. Brain Res. 2016;1636:130-141 pubmed publisher
    ..05). NOB may have a neuroprotective effect on cerebral ischemia, and this protection may be through upregulating Nrf2, HO-1 and downregulating NF-κB expression. ..
  60. Ma Y, Kong L, Qi S, Wang D. Atorvastatin blocks increased l-type Ca2+ current and cell injury elicited by angiotensin II via inhibiting oxide stress. Acta Biochim Biophys Sin (Shanghai). 2016;48:378-84 pubmed publisher
    ..These results suggested that atorvastatin mediates cardioprotection against arrhythmias and cell injury by controlling the AngII-ROS cascade. ..
  61. Ge N, Liu C, Li G, Xie L, Zhang Q, Li L, et al. Hydrosulfide attenuates acute myocardial ischemic injury through the glycogen synthase kinase-3?/?-catenin signaling pathway. Int J Mol Med. 2016;37:1281-9 pubmed publisher
    ..These findings suggest that hydrosulfide exerts cardioprotective effects against AMI-induced apoptosis through the GSK-3?/?-catenin signaling pathway. ..
  62. Cui C, Hao S, Li X, Bai X, Cheng J, Shan B. [Effects of IL-18 gene transfection on the proliferation in vitro and tumorigenesis in vivo of mouse ovarian cancer cell line OVHM]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008;24:577-80 pubmed
    ..To investigate the effects of IL-18 gene transfection on proliferation, apoptosis and tumorigenesis of mouse ovarian cancer cell line OVHM...
  63. Fu L, Ma C, Cong B, Li S, Chen H, Zhang J. Hypomethylation of proximal CpG motif of interleukin-10 promoter regulates its expression in human rheumatoid arthritis. Acta Pharmacol Sin. 2011;32:1373-80 pubmed publisher
    ..CHIP assays revealed increased phospho-CREB binding to the IL10 promoter. The methylation of the proximal CpGs in the IL10 promoter may regulate gene transcription in RA. ..
  64. Gao Z, Zhang L, Hu J, Sun Y. Mesenchymal stem cells: a potential targeted-delivery vehicle for anti-cancer drug, loaded nanoparticles. Nanomedicine. 2013;9:174-84 pubmed publisher
    ..In this review, the feasibility of mesenchymal stem cell-based targeted delivery of anticancer agents is discussed. ..
  65. Yu H, Yang H, Ma D, Lv Y, Liu T, Zhang K, et al. Vespid chemotactic peptide precursor from the wasp, Vespa magnifica (Smith). Toxicon. 2007;50:377-82 pubmed
    ..The current results suggested that the biosynthesis mode of VCP was different from that of temporin AMP, even though the two mature peptides were similar in many ways. It is also the first report about VCP precursor from wasp venom. ..
  66. Xu S, Gao W, Cong B, Yao Y, Gu Z. Effect of lipopolysaccharide on expression and characterization of cholecystokinin receptors in rat pulmonary interstitial macrophages. Acta Pharmacol Sin. 2004;25:1347-53 pubmed
    ..19 +/- 0.06 micromol/L) and CCK-BR specific antagonist CR2945 (IC50 = 3.2 +/- 0.1 nmol/L). Two types of functional CCK-AR and CCK-BR existed in rat PIMs and their expression could be upregulated by LPS. ..
  67. Hao L, Ling Y, Mao Q, Ling Y, He S. The antagonism of cholecystokinin octapeptide-8 to the peroxynitrite oxidation on a diabetic cataractal rat model. Chin Med J (Engl). 2006;119:1451-7 pubmed
    ..The antagonizing mechanism of CCK-8 may be related to direct antagonism of ONOO- as well as its inhibition of the expression of iNOS mRNA for production of NO and therefore decrease in the formation of ONOO-. ..
  68. Zhao D, Ren L, Lu H, Zhang X. Potentiation by yohimbine of alpha-adrenoceptor-mediated vasoconstriction in response to clonidine in the rabbit ear vein. Eur J Pharmacol. 2008;589:201-5 pubmed publisher
  69. Yin J, Niu Y, Zhang R, Song B, Cheng J. [Effects of prenatal exposure to low level lead on expression of GAP-43 in hippocampus of rat's offspring]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008;26:208-11 pubmed
    ..Exposure to low level lead during pregnancy could inhibit the GAP-43 protein and mRNA expression in hippocampus of rat's offspring, which may be one of the molecular mechanisms of lead on learning and memory. ..
  70. Dong M, Liu R, Guo L, Li C, Tan G. Pathological findings in rats with experimental allergic encephalomyelitis. APMIS. 2008;116:972-84 pubmed publisher
    ..Elevated expression of MMP-2 and MMP-9 may play a role in some aspects of pathological changes in EAE, for example, destroying the blood-brain barrier, degrading the myelin sheath, and damaging axons. ..
  71. Yang J, Liu H, Li Y. Effect of endoplasmic reticulum stress in VEGF-induced neuroprotection. J Invest Surg. 2009;22:29-34 pubmed publisher
    ..VEGF inhibited the cell apoptosis and the expressions of caspase-12 and caspase-3. These results suggest that VEGF may protect neurons from apoptosis by inhibiting ER stress pathway. ..
  72. He M, Han M, Zheng B, Shu Y, Wen J. Angiotensin II stimulates KLF5 phosphorylation and its interaction with c-Jun leading to suppression of p21 expression in vascular smooth muscle cells. J Biochem. 2009;146:683-91 pubmed publisher
    ..These results suggest that Ang II induces KLF5 phosphorylation mediated by the ERK signalling in VSMCs, which in turn stimulates the interaction of KLF5 with c-Jun, subsequently leads to the suppression of p21 expression. ..
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