Experts and Doctors on antiviral agents in Guiyang, Guizhou Sheng, China

Summary

Locale: Guiyang, Guizhou Sheng, China
Topic: antiviral agents

Top Publications

  1. Hu D, Wan Q, Yang S, Song B, Bhadury P, Jin L, et al. Synthesis and antiviral activities of amide derivatives containing the alpha-aminophosphonate moiety. J Agric Food Chem. 2008;56:998-1001 pubmed publisher
    ..6 microg/mL). To the best of our knowledge, this is the first report on the synthesis and antiviral activity of amide derivatives containing an alpha-aminophosphonate moiety. ..
  2. Long N, Cai X, Song B, Yang S, Chen Z, Bhadury P, et al. Synthesis and antiviral activities of cyanoacrylate derivatives containing an alpha-aminophosphonate moiety. J Agric Food Chem. 2008;56:5242-6 pubmed publisher
    ..9 microg/mL). To the best of our knowledge, this is the first report on the synthesis and antiviral activity of cyanoacrylate derivatives containing an alpha-aminophosphonate moiety. ..
  3. Chen Z, Wang X, Song B, Wang H, Bhadury P, Yan K, et al. Synthesis and antiviral activities of novel chiral cyanoacrylate derivatives with (E) configuration. Bioorg Med Chem. 2008;16:3076-83 pubmed publisher
    ..These compounds exhibited weak to good anti-TMV bioactivity with (R)-4p showing significant enhancement of disease resistance in tobacco leaves. ..
  4. Chen M, Chen Z, Song B, Bhadury P, Yang S, Cai X, et al. Synthesis and antiviral activities of chiral thiourea derivatives containing an alpha-aminophosphonate moiety. J Agric Food Chem. 2009;57:1383-8 pubmed publisher
    ..4, and 50.4%, respectively) as the commercial product Ningnanmycin (56.2%). This would appear to be the first report of the synthesis and antiviral activity of chiral thiourea derivatives containing an alpha-aminophosphonate moiety. ..
  5. Li X, Chen Z, Jin L, Hu D, Yang S. New Strategies and Methods to Study Interactions between Tobacco Mosaic Virus Coat Protein and Its Inhibitors. Int J Mol Sci. 2016;17:252 pubmed publisher
    ..The four-layer aggregate disk of TMV CP was little inhibited by ATF, DFL and BQX. Our results provide original data, as well as new strategies and methods, for research on the mechanism of action of anti-viral drugs. ..
  6. Xiao H, Zheng P, Tang C, Xie Y, Wu F, Song J, et al. Synthesis and anti-TMV activity of dialkyl/dibenzyl 2-((6-substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) malonates. Molecules. 2013;18:13623-35 pubmed publisher
    ..The compounds 5i and 5m have good antiviral activity against TMV with a curative rate of 52.23% and 54.41%, respectively, at a concentration of 0.5 mg/mL. ..
  7. Zhou W, Zhang X. Research progress of Chinese herbal medicine Radix isatidis (banlangen). Am J Chin Med. 2013;41:743-64 pubmed publisher
    ..This article aims to expand understanding of R. isatidis in the following aspects including medicinal resources, chemical constituents, pharmacological activities, clinical applications, and separation and analytical technologies. ..
  8. Lan X, Xie D, Yin L, Wang Z, Chen J, Zhang A, et al. Novel ?,?-unsaturated amide derivatives bearing ?-amino phosphonate moiety as potential antiviral agents. Bioorg Med Chem Lett. 2017;27:4270-4273 pubmed publisher
    ..Present work provides a promising template for development of potential inhibitor of plant virus. ..
  9. Chen Z, Zeng M, Song B, Hou C, Hu D, Li X, et al. Dufulin activates HrBP1 to produce antiviral responses in tobacco. PLoS ONE. 2012;7:e37944 pubmed publisher
    ..This study identified HrBP1 as a target protein of Dufulin and that Dufulin can activate the SA signaling pathway to induce host plants to generate antiviral responses. ..

More Information

Publications18

  1. Yang J, Song B, Bhadury P, Chen Z, Yang S, Cai X, et al. Synthesis and antiviral bioactivities of 2-cyano-3-substituted-amino(phenyl) methylphosphonylacrylates (acrylamides) containing alkoxyethyl moieties. J Agric Food Chem. 2010;58:2730-5 pubmed publisher
    ..8, 60.2, 78.9% and 60.0, 58.9, 85.5%, respectively, at 500 mg/L against TMV). To the best of the authors' knowledge, this is the first report on the synthesis and antiviral activity of the title compounds II...
  2. Wu J, Shi Q, Chen Z, He M, Jin L, Hu D. Synthesis and bioactivity of pyrazole acyl thiourea derivatives. Molecules. 2012;17:5139-50 pubmed publisher
  3. Ge Y, Liu K, Zhang J, Mu S, Hao X. The limonoids and their antitobacco mosaic virus (TMV) activities from Munronia unifoliolata Oliv. J Agric Food Chem. 2012;60:4289-95 pubmed publisher
    ..Six compounds (1-5 and 8) exhibited infection inhibition activities against TMV...
  4. Chen Z, Xu W, Liu K, Yang S, Fan H, Bhadury P, et al. Synthesis and antiviral activity of 5?(4?chlorophenyl)-1,3,4-thiadiazole sulfonamides. Molecules. 2010;15:9046-56 pubmed publisher
    ..The bioassay tests showed that compounds 7b and 7i possessed certain anti-tobacco mosaic virus activity. ..
  5. Yu L, Gan X, Zhou D, He F, Zeng S, Hu D. Synthesis and Antiviral Activity of Novel 1,4-Pentadien-3-one Derivatives Containing a 1,3,4-Thiadiazole Moiety. Molecules. 2017;22: pubmed publisher
    ..This finding suggests that 1,4-pentadien-3-one derivatives containing a 1,3,4-thiadiazole moiety may be considered as potential lead structures for discovering new antiviral agents. ..
  6. Wang Z, Xie D, Gan X, Zeng S, Zhang A, Yin L, et al. Synthesis, antiviral activity, and molecular docking study of trans-ferulic acid derivatives containing acylhydrazone moiety. Bioorg Med Chem Lett. 2017;27:4096-4100 pubmed publisher
    ..Docking results were consistent with the inactivating activity of target compounds against TMV. ..
  7. Gan X, Hu D, Chen Z, Wang Y, Song B. Synthesis and antiviral evaluation of novel 1,3,4-oxadiazole/thiadiazole-chalcone conjugates. Bioorg Med Chem Lett. 2017;27:4298-4301 pubmed publisher
    ..57µg/mL, respectively, which were comparable to that of Ningnanmycin (36.85µg/mL) and superior to that of Ribavirin (88.52µg/mL). Interestingly, the trend of antiviral activity in vivo was consistent with the in vitro results. ..
  8. Ouyang G, Cai X, Chen Z, Song B, Bhadury P, Yang S, et al. Synthesis and antiviral activities of pyrazole derivatives containing an oxime moiety. J Agric Food Chem. 2008;56:10160-7 pubmed publisher
    ..7 and 65.3 microg/mL) as the commercial product Ningnanmycin (EC 50 = 52.7 microg/mL). To the best of our knowledge, this is the first report on the antiviral activity of pyrazole derivatives containing an oxime moiety...
  9. Fan D, Zhou X, Zhao C, Chen H, Zhao Y, Gong X. Anti-inflammatory, antiviral and quantitative study of quercetin-3-O-?-D-glucuronide in Polygonum perfoliatum L. Fitoterapia. 2011;82:805-10 pubmed publisher
    ..The contents of quercetin-3-O-?-D-glucuronide in 28 samples from different regions of China were between 0.06% and 2.09%. The developed analytical method was applied to investigate P. perfoliatum L. and for quality control of the herb...