Experts and Doctors on sodium channels in Guangzhou, Guangdong, China
Locale: Guangzhou, Guangdong, China
Topic: sodium channels
Chen Z, Chen S, Chen L, Zhou J, Dai Q, Yang L, et al
. Long-term increasing co-localization of SCN8A and ankyrin-G in rat hippocampal cornu ammonis 1 after pilocarpine induced status epilepticus. Brain Res. 2009;1270:112-20 pubmed publisher
..310, P<0.001). The data revealed that both SCN8A and ankyrin-G increased significantly in the CA1 subfield of the rat hippocampus 60 days following pilocarpine induced status epilepticus and co-localized with each other. ..
Yang W, Wu M, Liu J, Peng X, Li H. Reporter gene assay for detection of shellfish toxins. Biomed Environ Sci. 2009;22:419-22 pubmed publisher
..pEGFP-c-fos-T24 can be applied in detecting HAB toxins, and cell-based assay can be used as an alternative for screening sodium channel-specific HAB toxins. ..
Jiang Q, Tu W. [Protective effects of sufentanil pretreatment against acute gastric mucosal lesion in rats and its relationship with acid-sensing ion channels]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:1099-102 pubmed
..ASIC3 is involved in the development of acute gastric mucosal lesion, and sufentanil pretreatment offers protection of gastric mucosa by inhibiting the expression of ASIC3. ..
He X, Zang Y, Chen X, Pang R, Xu J, Zhou X, et al
. TNF-? contributes to up-regulation of Nav1.3 and Nav1.8 in DRG neurons following motor fiber injury. Pain. 2010;151:266-79 pubmed publisher
..These data suggest that increased TNF-? may be responsible for up-regulation of Nav1.3 and Nav1.8 in uninjured DRG neurons following nerve injury. ..
Zang Y, He X, Xin W, Pang R, Wei X, Zhou L, et al
. Inhibition of NF-kappaB prevents mechanical allodynia induced by spinal ventral root transection and suppresses the re-expression of Nav1.3 in DRG neurons in vivo and in vitro. Brain Res. 2010;1363:151-8 pubmed publisher
..The data suggested that injury to ventral root might lead to neuropathic pain and the re-expression of Nav1.3 in primary sensory neurons by activation of NF-?B. ..
Cheng J, Makielski J, Yuan P, Shi N, Zhou F, Ye B, et al
. Sudden unexplained nocturnal death syndrome in Southern China: an epidemiological survey and SCN5A gene screening. Am J Forensic Med Pathol. 2011;32:359-63 pubmed publisher
..This is the first report of an epidemiological survey and SCN5A gene screening in SUNDS in the Han population of China. The genotypes of 5457CC and 3666+69CC in SCN5A gene may be Chinese SUNDS susceptible polymorphisms. ..
Yu M, Shi Y, Gao M, Deng W, Liu X, Chen L, et al
. Milder phenotype with SCN1A truncation mutation other than SMEI. Seizure. 2010;19:443-5 pubmed publisher
..Further work is needed to optimize the protocol for specific genetic testing in children with epilepsy. ..
Chen X, Pang R, Shen K, Zimmermann M, Xin W, Li Y, et al
. TNF-? enhances the currents of voltage gated sodium channels in uninjured dorsal root ganglion neurons following motor nerve injury. Exp Neurol. 2011;227:279-86 pubmed publisher
..These data suggest that the increase in sodium currents in uninjured DRG neurons following nerve injury might be mediated by over-production of TNF-?. ..
Deng G, Qin J, Sun X, Kuang Z, Su T, Zhao Q, et al
. Promoter analysis of mouse Scn3a gene and regulation of the promoter activity by GC box and CpG methylation. J Mol Neurosci. 2011;44:115-21 pubmed publisher
..These results suggest that the GC box and CpG methylation might play important roles in regulating mouse Scn3a gene expression. ..