Experts and Doctors on middle aged in Guangzhou, Guangdong, China


Locale: Guangzhou, Guangdong, China
Topic: middle aged

Top Publications

  1. Xiu L, Weng J, Sui Y, Wang J, Yan J, Huang Z. [Common variants in beta 3-adrenergic-receptor and uncoupling protein-2 genes are associated with type 2 diabetes and obesity]. Zhonghua Yi Xue Za Zhi. 2004;84:375-9 pubmed
    ..The homozygote of beta(3)-AR gene Trp64Arg mutation is related with diabetes. The accumulation of the effects of two micro-genes creates obvious phenotypic effects. ..
  2. Xie D, Yang G, Chen Y, Jiang L, Xiao L. [Significance and mechanisms of overexpression of PAK1 gene in epithelial ovarian neoplasms]. Zhonghua Zhong Liu Za Zhi. 2006;28:911-4 pubmed
    ..Mechanism other than gene amplification of PAK1 may play a more important role in the regulation of protein expression of PAK1 in ovarian tumors. ..
  3. Li Y, Zhuang L, Lai X, Jiang G. [Effects of electroacupuncture on plasma vasoactive intestinal peptide and substance P in perennial allergic rhinitis patients]. Zhen Ci Yan Jiu. 2007;32:136-8 pubmed
    ..05). EA can effectively relieve perennial allergic rhinitis patients' clinical symptoms, which is closely related to its functions in lowering plasma VIP and SP levels. ..
  4. Xiang G, Wen X, Wang H, Chen K, Liu H. Expression of X-linked inhibitor of apoptosis protein in human colorectal cancer and its correlation with prognosis. J Surg Oncol. 2009;100:708-12 pubmed publisher
    ..0206; HR: 2.730; 95% CI: 1.226-5.445). The status of XIAP expression might become an independent prognostic marker for CRC. ..
  5. Yang Z, Wang L, Kang L, Xiang J, Peng J, Cui J, et al. Clinicopathologic characteristics and outcomes of patients with obstructive colorectal cancer. J Gastrointest Surg. 2011;15:1213-22 pubmed publisher
    ..Patients in the COC group have worse overall survival with high postoperative recurrence rate compared to those in the NOC group. ..
  6. Huang D, Deng W, Li C, Chen S. Craniocervical necrotizing fasciitis of odontogenic origin with thoracic extension. J Craniofac Surg. 2011;22:1109-11 pubmed publisher
  7. Li L, Qiao D, Fu X, Lao S, Zhang X, Wu C. Identification of Mycobacterium tuberculosis-specific Th1, Th17 and Th22 cells using the expression of CD40L in tuberculous pleurisy. PLoS ONE. 2011;6:e20165 pubmed publisher
    ..Taken together, our data indicate that the expression of CD40L on MTB-specific CD4(+) T cells could be a good marker for the evaluation and isolation of MTB-specific Th cells and might also be useful in the diagnosis of TB. ..
  8. Zhu Y, Huang J, Xia Y, Zhao W, Jiang W, Lin T, et al. Primary mediastinal large B-cell lymphoma (PMLBCL) in Chinese patients: clinical characteristics and prognostic factors. Int J Hematol. 2011;94:178-184 pubmed publisher
    ..84%, P = 0.287; PFS: 53 vs. 73%, P = 0.371). Our data additionally suggest that low serum albumin is a novel prognostic predictor for PMLBCL, and could be useful in determining treatment options in the clinic. ..
  9. Song J, Socheat D, Tan B, Seila S, Xu Y, Ou F, et al. Randomized trials of artemisinin-piperaquine, dihydroartemisinin-piperaquine phosphate and artemether-lumefantrine for the treatment of multi-drug resistant falciparum malaria in Cambodia-Thailand border area. Malar J. 2011;10:231 pubmed publisher
    ..The trial was registered at Chinese Clinical Trial Register under identifier 2005L01041. ..

More Information

Publications739 found, 100 shown here

  1. Zhang Q, Lin S, He F, Kang D, Chen G, Luo W. Water-filled balloon in the postoperative resection cavity improves dose distribution to target volumes in radiotherapy of maxillary sinus carcinoma. Chin J Cancer. 2011;30:786-93 pubmed publisher
  2. Fu B, Zhang T, Li H, Yi S, Wang G, Xu C, et al. The role of liver transplantation for intrahepatic cholangiocarcinoma: a single-center experience. Eur Surg Res. 2011;47:218-21 pubmed publisher
    ..5, 50.5, 50.5 and 50.5%, respectively. With better and strict patient selection, the prognosis of LT for ICC could be improved. ICC patients with lymph node involvement, vascular or bile duct invasion are contraindicated for LT. ..
  3. Liu J, Hu Y, Xie X, Fu J. Subcarinal node metastasis in thoracic esophageal squamous cell carcinoma. Ann Thorac Surg. 2012;93:423-7 pubmed publisher
    ..Subcarinal node metastasis indicates worse prognosis of patients with thoracic esophageal squamous cell carcinoma compared with paraesophageal node metastasis. ..
  4. Chen L, Liu L, Chen M, Li W, Yin W, Lin A, et al. Prognostic value of subclassification using MRI in the t4 classification nasopharyngeal carcinoma intensity-modulated radiotherapy treatment. Int J Radiat Oncol Biol Phys. 2012;84:196-202 pubmed publisher
  5. Wu Y, Kuang D, Pan W, Wan Y, Lao X, Wang D, et al. Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions. Hepatology. 2013;57:1107-16 pubmed publisher
  6. Li K, Chen M, Situ J, Huang W, Su Z, He D, et al. Role of co-expression of c-Myc, EZH2 and p27 in prognosis of prostate cancer patients after surgery. Chin Med J (Engl). 2013;126:82-7 pubmed
    ..Composite index of c-Myc, EZH2, and p27 can be valued as powerful prognosis parameter for intermediate-risk prostate cancer patients after the surgery, and postoperative adjuvant therapy can be adopted accordingly. ..
  7. Dong J, Li J, Liu S, Feng X, Chen S, Chen Y, et al. CD33?/p-STAT1? double-positive cell as a prognostic factor for stage IIIa gastric cancer. Med Oncol. 2013;30:442 pubmed publisher
  8. Kong Y, Wang J, Liu W, Chen Q, Yang J, Wei W, et al. Cytokeratin19-2g2, a novel fragment of cytokeratin19 in serum, indicating a more invasive behavior and worse prognosis in breast cancer patients. PLoS ONE. 2013;8:e57092 pubmed publisher
    ..029) and death (P?=?0.040) in breast cancer patients. Serum CK19-2G2 may be an independent indicator for prognosis and a candidate marker for monitoring metastasis in breast cancer. ..
  9. Chen Y, Sun Y, Liang S, Zong J, Li W, Chen M, et al. Progress report of a randomized trial comparing long-term survival and late toxicity of concurrent chemoradiotherapy with adjuvant chemotherapy versus radiotherapy alone in patients with stage III to IVB nasopharyngeal carcinoma from endemic regions . Cancer. 2013;119:2230-8 pubmed publisher
  10. Tao C, Liu X, Tang L, Mao Y, Chen L, Li W, et al. Prognostic scoring system for locoregional control among the patients with nasopharyngeal carcinoma treated by intensity-modulated radiotherapy. Chin J Cancer. 2013;32:494-501 pubmed publisher
    ..4%, 93.6%, 85.2%, and 78.6%, respectively (P < 0.001). We have developed a PSS that can help identify NPC patients who are at high risk for locoregional relapse and can guide individualized treatments for NPC patients. ..
  11. Sun J, Xie Q, Tan D, Ning Q, Niu J, Bai X, et al. The 104-week efficacy and safety of telbivudine-based optimization strategy in chronic hepatitis B patients: a randomized, controlled study. Hepatology. 2014;59:1283-92 pubmed publisher
    ..Adding adefovir can benefit these patients with additive antiviral potency and low resistance without increased side effects. ..
  12. Liu R, Wang Y, Xiong W, Zhang Z, Deng H, Li G. [Efficacy analysis of suprapubic single-incision laparoscopy in the treatment of rectosigmoid cancer]. Zhonghua Wei Chang Wai Ke Za Zhi. 2016;19:647-53 pubmed
    ..In experienced laparoscopic treatment centers, SSILS for rectosigmoid cancer is feasible and safe with quite good oncological efficacy and certain advantages, such as fast recovery, less pain and better cosmetic result. ..
  13. Zou J, Li H, Huang Q, Liu X, Qi X, Wang Y, et al. Dopamine-induced SULT1A3/4 promotes EMT and cancer stemness in hepatocellular carcinoma. Tumour Biol. 2017;39:1010428317719272 pubmed publisher
    ..In addition, SULT1A3/4 re-expression could serve as a biomarker for hepatocellular carcinoma prognosis...
  14. Li L, Lao S, Wu C. Increased frequency of CD4(+)CD25(high) Treg cells inhibit BCG-specific induction of IFN-gamma by CD4(+) T cells from TB patients. Tuberculosis (Edinb). 2007;87:526-34 pubmed
  15. Liu M, Xie D, Mai S, Tong Z, Shao J, Fu Y, et al. Overexpression of AIB1 in nasopharyngeal carcinomas correlates closely with advanced tumor stage. Am J Clin Pathol. 2008;129:728-34 pubmed publisher
    ..05). These findings suggest that overexpression of AIB1 in NPCs may be important in the acquisition of an invasive and/or metastatic phenotype. ..
  16. An K, Shu H, Huang W, Huang X, Xu M, Yang L, et al. Effects of propofol on pulmonary inflammatory response and dysfunction induced by cardiopulmonary bypass. Anaesthesia. 2008;63:1187-92 pubmed publisher
    ..01). These findings suggest that propofol administered during bypass could reduce the severity of pulmonary dysfunction. ..
  17. Ahmed C, Wang Z, Bin Z, Chen J, Kamal M, Hou J. Hepatitis B virus genotypes, subgenotypes, precore, and basal core promoter mutations in the two largest provinces of Pakistan. J Gastroenterol Hepatol. 2009;24:569-73 pubmed publisher
    ..96%), T1762 (39.13%), and A1764 (30.43%), which were also detected in the genotype D samples. Genotype D subtype D1 is the most prevalent HBV strain in Pakistan with 8-bp deletion mutants the most common in HBV carriers. ..
  18. Chen J, Hu C, Hou J, Shao Q, Yan L, Zhu X, et al. Epstein-Barr virus encoded latent membrane protein 1 regulates mTOR signaling pathway genes which predict poor prognosis of nasopharyngeal carcinoma. J Transl Med. 2010;8:30 pubmed publisher
    ..These results suggest that the mTOR signaling pathway is regulated by LMP1 expression in NPC. LMP1 and the genes in the mTOR pathway such as p-P70S6K and p-4EBP1 may be potential prognostic biomarkers. ..
  19. Du Y, Yang J, Li J, Zhou R, He J. Unilateral optic neuritis in a Chinese population in three centers. J Clin Neurosci. 2011;18:902-4 pubmed publisher
    ..It seems that visual recovery in our patients is relatively good. ..
  20. Liu Y, Tan N, Zhou Y, Chen Y, Chen J, Chen J, et al. High-sensitivity C-reactive protein predicts contrast-induced nephropathy after primary percutaneous coronary intervention. J Nephrol. 2012;25:332-40 pubmed publisher
    ..10 mg/L remained significantly associated with CIN (odds ratio = 6.51; 95% confidence interval, 1.26-33.61). An hs-CRP >16.10 was a significant and independent predictor of CIN after primary PCI in patients with STEMI. ..
  21. Tan Y, Hu Z, Zhao Y, Cai X, Luo C, Zou C, et al. The beginning of the rpoB gene in addition to the rifampin resistance determination region might be needed for identifying rifampin/rifabutin cross-resistance in multidrug-resistant Mycobacterium tuberculosis isolates from Southern China. J Clin Microbiol. 2012;50:81-5 pubmed publisher
    ..tuberculosis. Molecular assays for identifying RIF/Rfb cross-resistance in M. tuberculosis might be improved in terms of accuracy by including this region, in addition to the rifampin resistance determination region. ..
  22. Chen Z, Wang T, Cai L, Su C, Zhong B, Lei Y, et al. Clinicopathological significance of non-small cell lung cancer with high prevalence of Oct-4 tumor cells. J Exp Clin Cancer Res. 2012;31:10 pubmed publisher
    ..Oct-4 may maintain NSCLC cells in a poorly differentiated state through a mechanism that depends on promoting cell proliferation. ..
  23. Cao Y, Liu X, Xu H. Utility of serum tartrate-resistant acid phosphatase isoform 5b, bone alkaline phosphatase and osteocalcin in osteoporotic fractures in Chinese patients. Clin Lab. 2012;58:845-50 pubmed
    ..Elevated serum TRACP 5b and BAP, combined with or without increased osteocalcin, are valuable tools for the assessment of osteoporotic fracture risk in Chinese patients. ..
  24. Wei Q, Fu B, Liu J, Zhang Z, Zhao T. Candida albicans and bacterial vaginosis can coexist on Pap smears. Acta Cytol. 2012;56:515-9 pubmed publisher
    ..The aim of our study was to study the relationship of blastospores and pseudohyphae in Papanicolaou (Pap) smears and Nugent scores for bacterial vaginosis (BV)...
  25. Huang W, Zheng Y, Wang L, Huang S, Liu B, Jin L, et al. Five-year incidence and postoperative visual outcome of cataract surgery in urban southern China: the Liwan Eye Study. Invest Ophthalmol Vis Sci. 2012;53:7936-42 pubmed publisher
    ..To determine the 5-year incidence and visual outcome of cataract surgery in an adult urban Chinese population...
  26. Chen J, Zhang N, Jiang Y, Hui D, Wen Z, Li H, et al. Variations of Epstein-Barr virus nuclear antigen 1 in Epstein-Barr virus-associated gastric carcinomas from Guangzhou, southern China. PLoS ONE. 2012;7:e50084 pubmed publisher
    ..This, to our best knowledge, is the first investigation of EBNA1 polymorphisms in EBVaGC from endemic area of NPC. ..
  27. Li Z, Peng L, Han S, Huang Z, Shi F, Cai Z, et al. [Screening molecular markers in early breast cancer of the same pathological types but with different prognoses using Agilent gene chip]. Nan Fang Yi Ke Da Xue Xue Bao. 2013;33:1483-8 pubmed
  28. Pan Y, Liu Z, Feng Z, Hui D, Huang X, Tong D, et al. The overexpression of Rabl3 is associated with pathogenesis and clinicopathologic variables in hepatocellular carcinoma. Tumour Biol. 2017;39:1010428317696230 pubmed publisher
    ..Our studies suggest that the Rabl3 is a valuable marker of hepatocellular carcinoma progression and that the overexpression of Rabl3 plays an important role in the development and pathogenesis of hepatocellular carcinoma. ..
  29. Fang C, Wang W, Feng X, Sun J, Zhang Y, Zeng Y, et al. Nomogram individually predicts the overall survival of patients with gastroenteropancreatic neuroendocrine neoplasms. Br J Cancer. 2017;117:1544-1550 pubmed publisher
  30. Zhou F, Hu L, Wang R, Huang Z, Luo Q. Study on clinical effect and mechanism of jianpi qingre huayu recipe. Chin J Integr Med. 2007;13:22-6 pubmed
    ..IL-8 level in gastric mucosa was improved in both groups but the improvement in the treated group was better. JQH could effectively treat gastric ulcer and partly reduce its recurrence through improving patients' immune function. ..
  31. Qiu M, Yuan Z, Luo H, Ruan D, Wang Z, Wang F, et al. Impact of pretreatment hematologic profile on survival of colorectal cancer patients. Tumour Biol. 2010;31:255-60 pubmed publisher
    ..The cumulative effect of anemia and thrombocytosis yielded shorter survival. Anemia and thrombocytosis can be considered as useful prognostic markers in patients with colorectal cancer. ..
  32. Rao B, Gao Y, Huang J, Gao X, Fu X, Huang M, et al. Mutations of p53 and K-ras correlate TF expression in human colorectal carcinomas: TF downregulation as a marker of poor prognosis. Int J Colorectal Dis. 2011;26:593-601 pubmed publisher
    ..TF may participate in both K-ras and p53 mutations involved in colorectal carcinogenesis and could be considered as a prognostic indicator for patients CRC. ..
  33. Huang P, Cao K, Guo X, Mo H, Guo L, Xiang Y, et al. A randomized trial of induction chemotherapy plus concurrent chemoradiotherapy versus induction chemotherapy plus radiotherapy for locoregionally advanced nasopharyngeal carcinoma. Oral Oncol. 2012;48:1038-1044 pubmed publisher
    ..Using carboplatin in the concurrent chemoradiotherapy was not suitable for nasopharyngeal carcinoma. ..
  34. Guo Y, Wang X, Tian X, Li Y, Li B, Huang Q, et al. Tumor-derived hepatocyte growth factor is associated with poor prognosis of patients with glioma and influences the chemosensitivity of glioma cell line to cisplatin in vitro. World J Surg Oncol. 2012;10:128 pubmed
    ..HGF might influence tumor progression by modulating the cell growth, migration and chemoresistance to drugs. Increased expression of HGF may be a valuable predictor for prognostic evaluation of glioma patients. ..
  35. Zhao H, Huang Y, Xue C, Chen Y, Hou X, Guo Y, et al. Prognostic significance of the combined score of endothelial expression of nucleolin and CD31 in surgically resected non-small cell lung cancer. PLoS ONE. 2013;8:e54674 pubmed publisher
    ..Thus, the expression levels of nucleolin may provide a new prognostic marker to identify patients at higher risk for treatment failure, especially in some subgroups. ..
  36. Feng W, Wang G, Zhang G, Li W, Li M, He X, et al. [Expression of matrix metalloproteinase-9 in the arachnoid membrane around posterior communicating artery aneurysms]. Nan Fang Yi Ke Da Xue Xue Bao. 2013;33:1189-93 pubmed
    ..MMP-9 is closely related with the formation of posterior communicating artery aneurysms by causing degradation of extracellular matrix of the vascular wall and the arachnoid membrane. ..
  37. Zong Z, Zhou T, Rao L, Jiang Z, Li Y, Hou Z, et al. Musashi2 as a novel predictive biomarker for liver metastasis and poor prognosis in colorectal cancer. Cancer Med. 2016;5:623-30 pubmed publisher
    ..Conclusively, our study indicates that MSI-2 overexpression is associated with an unfavorable prognosis and may be a potential biomarker for liver metastasis in colorectal cancer patients. ..
  38. Tan G, Liu Q, Tang X, Kang T, Li Y, Lu J, et al. Diagnostic values of serum cathepsin B and D in patients with nasopharyngeal carcinoma. BMC Cancer. 2016;16:241 pubmed publisher
    ..5% specificity (AUC = 0.552; 95% CI, 42.3-68.1; p = 0.42). Serum CTSB and CTSD concentrations were found to have a diagnostic value in NPC. However, the CTSB and CTSD serum levels had no prognostic role for the outcome in NPC patients. ..
  39. Tan S, Ma W, Hu S, Dong N. [Clinical observation and nursing of direct cyclopexy]. Yan Ke Xue Bao. 2005;21:173-5 pubmed
    ..Ultrasound biomicroscopy (UBM) before surgery, careful observation of the IOP with correct directions, better psychological nursing and instructions for discharging are the important measures to successful surgery. ..
  40. Huo Y, Wang X, Li J, Zhu C, Sun X, Zhao X, et al. [Analysis of clinical manifestations of subheath status in a medical college of Guangdong Province]. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27:448-9 pubmed
    ..The clinical manifestations of sub-health status complex. ..
  41. He J, Ying W, Yang H, Xu X, Shao W, Guan Y, et al. Gemcitabine plus cisplatin chemotherapy with concurrent para-toluenesulfonamide local injection therapy for peripherally advanced nonsmall cell lung cancer larger than 3 cm in the greatest dimension. Anticancer Drugs. 2009;20:838-44 pubmed publisher
    ..GEM/CIS chemotherapy with concurrent PTS local injection therapy is a well-tolerated modality with potential activity in previously untreated peripheral advanced nonsmall cell lung cancer patients. ..
  42. Huang X, Shen J, Huang Y, Zheng Z, Fei H, Hou Y, et al. En face view of atrial septal defect by two-dimensional transthoracic echocardiography: comparison to real-time three-dimensional transesophageal echocardiography. J Am Soc Echocardiogr. 2010;23:714-21 pubmed publisher
    ..Two-dimensional TTE can provide en face views of ASDs and their spatial orientations with respect to neighboring structures. This method may provide incremental information to 3D echocardiography in patients with ASDs. ..
  43. Di B, Xu X, Li T, Lu E, Wu J, Liu Y, et al. Immunogenicity associated with the routine use of an influenza A H1N1 vaccine in health care personnel in Guangzhou, China. Clin Vaccine Immunol. 2010;17:1478-80 pubmed publisher
    ..2% at 30 days postvaccination, lower than those obtained in previously published controlled trials. Low baseline antibody levels and an increase in seroprotection in a negative-control cohort suggest that the virus remains prevalent. ..
  44. Xu B, Shi P, Wu H, Guo X, Wang Q, Zhou S. Utility of FDG PET/CT in guiding antifungal therapy in acute leukemia patients with chronic disseminated candidiasis. Clin Nucl Med. 2010;35:567-70 pubmed publisher
    ..FDG PET/CT appeared to be a valuable modality in designing proper antifungal therapy against chronic disseminated candidiasis in patients with acute leukemia. ..
  45. Zhang F, Meng F, Li H, Dong Y, Yang W, Han A. Suppression of retinoid X receptor alpha and aberrant ?-catenin expression significantly associates with progression of colorectal carcinoma. Eur J Cancer. 2011;47:2060-7 pubmed publisher
    ..032). Taken together with our previous study, aberrant ?-catenin expression upregulated by suppression of RXR? may play a crucial role in pathogenesis and progression of CRC. ..
  46. Feng L, Li L, Liu Y, Qiao D, Li Q, Fu X, et al. B lymphocytes that migrate to tuberculous pleural fluid via the SDF-1/CXCR4 axis actively respond to antigens specific for Mycobacterium tuberculosis. Eur J Immunol. 2011;41:3261-9 pubmed publisher
    ..Collectively, these data demonstrate that Mycobacterium tuberculosis-specific B cells exist at local sites of infection in TP patients and this localization might influence the immune response to M. tuberculosis. ..
  47. Du Z, Kou C, Wang H, Huang M, Liao D, Hu C, et al. Clinical significance of elevated spleen tyrosine kinase expression in nasopharyngeal carcinoma. Head Neck. 2012;34:1456-64 pubmed publisher
    ..High expression of Syk, which results partly from LMP2A expression in NPC, is associated with tumor recurrence and poor prognosis of patients with NPC. ..
  48. Wei X, Xu R, Yang Z, Li Z, Liao Y, Johnson R, et al. Novel uromodulin mutation in familial juvenile hyperuricemic nephropathy. Am J Nephrol. 2012;36:114-20 pubmed publisher
    ..Mutations in the uromodulin (UMOD) gene encoding uromodulin/Tamm-Horsfall, a glycosylphosphatidylinositol (GPI)-anchored protein, cause this disease...
  49. Wang X, Xia B, Liang Y, Peng L, Wang Z, Zhuo J, et al. Membranous ABCG2 expression in colorectal cancer independently correlates with shortened patient survival. Cancer Biomark. 2013;13:81-8 pubmed publisher
    ..But the expression of ABCG2 is controversial in many kinds of tumors including colorectal cancer (CRC)...
  50. Xue Q, Sun K, Deng H, Lei S, Dong J, Li G. MicroRNA-338-3p inhibits colorectal carcinoma cell invasion and migration by targeting smoothened. Jpn J Clin Oncol. 2014;44:13-21 pubmed publisher
    ..Additionally, smoothened was identified as a direct target of microRNA-338-3p by luciferase assay. MicroRNA-338-3p could inhibit colorectal carcinoma cell invasion and migration by inhibiting smoothened expression. ..
  51. Duan F, Qian F, Fang K, Lin K, Wang W, Chen Y. miR-133b, a muscle-specific microRNA, is a novel prognostic marker that participates in the progression of human colorectal cancer via regulation of CXCR4 expression. Mol Cancer. 2013;12:164 pubmed publisher
    ..Our study demonstrated that downregulated miR-133b contributed to increased cell invasion and migration in CRC by negatively regulating CXCR4. These findings may be significant for the development of therapy target for CRC. ..
  52. Xie C, Chen X, Qiu F, Zhang L, Wu D, Chen J, et al. The role of WWOX polymorphisms on COPD susceptibility and pulmonary function traits in Chinese: a case-control study and family-based analysis. Sci Rep. 2016;6:21716 pubmed publisher
    ..For other SNPs, no significant association was observed for COPD and pulmonary function. Taken together, our data demonstrated that the SNP rs383362G >T of WWOX plays a role in COPD inheritance. ..
  53. Schnell O, Weng J, Sheu W, Watada H, Kalra S, Soegondo S, et al. Acarbose reduces body weight irrespective of glycemic control in patients with diabetes: results of a worldwide, non-interventional, observational study data pool. J Diabetes Complications. 2016;30:628-37 pubmed publisher
    ..This post-hoc analysis showed that acarbose treatment reduces body weight independent of glycemic control status but dependent on baseline body weight. ..
  54. Wang D, Liang S, Zhang Z, Zhao G, Hu Y, Liang S, et al. A novel pathogenic splice acceptor site germline mutation in intron 14 of the APC gene in a Chinese family with familial adenomatous polyposis. Oncotarget. 2017;8:21327-21335 pubmed publisher
    ..This novel splice-acceptor site mutation causing FAP in this Chinese family expands the germline mutation spectrum of the APC gene in the Chinese population. ..
  55. Lin C, Zeng Y, Xiao M, Mei X, Shen L, Guo M, et al. The Relationship Between MMP-2 -1306C>T and MMP-9 -1562C>T Polymorphisms and the Risk and Prognosis of T-Cell Acute Lymphoblastic Leukemia in a Chinese Population: A Case-Control Study. Cell Physiol Biochem. 2017;42:1458-1468 pubmed publisher
    ..These results indicated that MMP-2 -1306C/T and MMP-9 -1562C/T polymorphisms might be associated with an increased risk of T-ALL. The MMP-9 -1562C>T polymorphism may also be related to the prognosis of T-ALL patients. ..
  56. Song L, Yan W, Zhao T, Deng M, Song S, Zhang J, et al. Mycobacterium tuberculosis infection and FHIT gene alterations in lung cancer. Cancer Lett. 2005;219:155-62 pubmed
    ..025, logistic regression analysis P=0.012). These results indicate that M-TB infection is associated with FHIT gene LOH in lung cancer. ..
  57. Luo J, Peng B, Quan W, Cao Z, Xiao G, Lu J, et al. [Therapeutic effects of aspiration with a directional soft tube and conservative treatment on mild hemorrhage in the basal ganglion]. Nan Fang Yi Ke Da Xue Xue Bao. 2008;28:1352-3 pubmed
    ..To compare the therapeutic effects of aspiration via a directional soft tube and conservative treatment in patients with mild hemorrhage in the basal ganglion...
  58. Songtao Q, Lei Y, Si G, Yanqing D, Huixia H, Xuelin Z, et al. IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma. Cancer Sci. 2012;103:269-73 pubmed publisher
    ..Use of IDH status combined with MGMT promoter status as a stratification factor seems appropriate in future clinical trials involving temozolomide for the treatment of patients with secondary glioblastoma. ..
  59. Yu F. A novel technique for reconstruction of the posterior wall of the external auditory canal and tympanum using pedicled temporalis myofascia. Acta Otolaryngol. 2013;133:699-707 pubmed publisher
    ..74% and the 2-year healing rate of tympanic membrane perforation was 95.65%. The 46 ears included in the 2-year follow-up showed significant improvement between preoperative and postoperative AC and ABG values. ..
  60. Zhou G, Yu X, Chen M, Guo R, Lei Y, Sun Y, et al. Radiation-induced temporal lobe injury for nasopharyngeal carcinoma: a comparison of intensity-modulated radiotherapy and conventional two-dimensional radiotherapy. PLoS ONE. 2013;8:e67488 pubmed publisher
    ..006, 0.042, <0.001 when compared with T1, T2 and T3, respectively). IMRT is superior to 2DRT for the management of T1-T3 NPC in terms of sparing the temporal lobe. The high incidence of TLI in T4 disease needs to be addressed. ..
  61. He M, Abdou A, Ellwein L, Naidoo K, Sapkota Y, Thulasiraj R, et al. Age-related prevalence and met need for correctable and uncorrectable near vision impairment in a multi-country study. Ophthalmology. 2014;121:417-422 pubmed publisher
    ..Prevalence of correctable NVI is greatest among persons of working age, and rates of correction are low in many settings, suggesting that strategies targeting the workplace may be needed. ..
  62. Zhu Y, Liu H, Zhang L, Zeng T, Song Y, Qin Y, et al. Downregulation of LGI1 promotes tumor metastasis in esophageal squamous cell carcinoma. Carcinogenesis. 2014;35:1154-61 pubmed publisher
    ..Taken together, our study revealed that LGI1 plays an important tumor suppressive role in the development and progression of ESCC, with possible application in clinics as a biomarker and a potential new therapeutic target. ..
  63. Feng C. [The causes of blindness by corneal diseases in 3,499 cases]. Zhonghua Yan Ke Za Zhi. 1990;26:151-3 pubmed
    ..4%), corneal injuries (15.7%), keratomalacia (10.0%), and trachoma (3.8%). Patients of the latter two diseases were mostly old cases. The authors discussed the incidence of corneal diseases and their prevention and treatment...
  64. Fu Y, Fan C, Deng H, Hu S, Lv D, Li L, et al. Association of CYP2D6 and CYP1A2 gene polymorphism with tardive dyskinesia in Chinese schizophrenic patients. Acta Pharmacol Sin. 2006;27:328-32 pubmed
    ..However, genetic factors have a weaker association with susceptibility to TD compared with mean age and duration of illness. ..
  65. Huang X. Images in cardiovascular medicine. Partially unroofed coronary sinus. Circulation. 2007;116:e373 pubmed
  66. Peng X, Wan Y, Chen Y, Chen L, He A, Liao W, et al. Primary non-Hodgkin's lymphoma of the spine with neurologic compression treated by radiotherapy and chemotherapy alone or combined with surgical decompression. Oncol Rep. 2009;21:1269-75 pubmed
    ..The authors emphasize the importance of chemotherapy and radiotherapy followed by surgical decompression depending on individual priorities in the indications for operation on primary NHL of spine with neurologic compression. ..
  67. Wan T, Liu J, Zheng L, Cai M, Ding T. [Prognostic significance of tumor-associated macrophage infiltration in advanced epithelial ovarian carcinoma]. Ai Zheng. 2009;28:323-7 pubmed
    ..Multivariate analysis revealed that histological grade and TAM infiltration status are independent predictors for overall survival. TAM infiltration is obvious in advanced ovarian cancer, which indicates poor prognosis. ..
  68. Xiong Y, Zhang Z, Li Y, Liu Z, Hou G, Liu Q, et al. Benign pathological findings in 303 Chinese patients undergoing surgery for presumed localized renal cell carcinoma. Int J Urol. 2010;17:517-21 pubmed publisher
    ..To analyze the incidence of benign lesions in Chinese patients undergoing nephrectomies for renal masses identified as localized renal cell carcinoma (RCC) in preoperative imaging...
  69. Huang G, Li B, Zhang M, Zhang H, Wei R, Yuan Y, et al. LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma. World J Gastroenterol. 2010;16:2046-54 pubmed
    ..006 and P = 0.026, respectively). LOH in genes around D4S2964 may play an important role in HCC development and progression. LOH in ARD1B and SEPT11 could serve as novel prognostic predictors in HCC patients. ..
  70. Dai J, Tu W, Yang Z, Lin R. Case report: intraoperative management of extreme hemodilution in a patient with a severed axillary artery. Anesth Analg. 2010;111:1204-6 pubmed publisher
    ..No evidence of cardiac ischemia was noted and he was discharged in good condition. Extreme hemodilution can be successfully managed by maintaining a normal blood volume, 100% oxygen, and the use of plasma substitutes...
  71. Liu H, Liu Y, Wang L, Xu D, Lin B, Zhong R, et al. Prevalence of primary biliary cirrhosis in adults referring hospital for annual health check-up in Southern China. BMC Gastroenterol. 2010;10:100 pubmed publisher
  72. Li M, Luo R, Chen J, Cao Y, Lu J, He J, et al. High expression of transcriptional coactivator p300 correlates with aggressive features and poor prognosis of hepatocellular carcinoma. J Transl Med. 2011;9:5 pubmed publisher
    ..The combined clinicopathologic prognostic model may become a useful tool for identifying HCC patients with different clinical outcomes. ..
  73. Huang H, Lin Z, Lin X, Cai Q, Xia Z, Jiang W. Long-term outcomes of patients with newly diagnosed extranodal natural killer/T-cell lymphoma treated by etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin regimen: a single-institution experience. Leuk Lymphoma. 2011;52:1041-8 pubmed publisher
    ..0%. However, patients with disseminated and extranasal disease responded poorly. These results indicate that EPOCH followed by IFRT yields promising outcomes for patients with localized nasal ENKL. ..
  74. Wang Y, Cai R, HAN Y, Wang W, Yang X, Liu S. [Quality of life in patients with esophageal carcinoma undergoing thoracoscopic and laparoscopic esophagectomy and circular stapled cervical esophagogastric anastomosis via retrosternal route]. Zhonghua Wei Chang Wai Ke Za Zhi. 2011;14:428-31 pubmed
    ..Stapled anastomosis is associated with lower rate of anastomotic leak. QOL is better in patients following thoracoscopic and laparoscopic esophagectomy as compared to those following three-incision open surgery. ..
  75. Wang H, Chen X, Geng Q, Liu P, Lin G, Xia Z, et al. Induction therapy using the MRC UKALLXII/ECOG E2993 protocol in Chinese adults with acute lymphoblastic leukemia. Int J Hematol. 2011;94:163-168 pubmed publisher
    ..Risk stratification at diagnosis based on age and WBC count is suitable for adults with ALL, and it is necessary to adopt different strategies as determined by diagnostic results. Lastly, Ph+ patients have an extremely poor prognosis. ..
  76. Liu Z, Luo W, Zhou Y, Zhen Y, Yang H, Yu X, et al. Potential tumor suppressor NESG1 as an unfavorable prognosis factor in nasopharyngeal carcinoma. PLoS ONE. 2011;6:e27887 pubmed publisher
    ..Our studies are the first to demonstrate that decreased NESG1 expression is an unfavorable prognostic factor for NPC. ..
  77. An S, Chen Z, Su J, Zhang X, Zhong W, Yang J, et al. Identification of enriched driver gene alterations in subgroups of non-small cell lung cancer patients based on histology and smoking status. PLoS ONE. 2012;7:e40109 pubmed publisher
    ..This study also suggests that we may consider patients with infrequent alterations of driver genes as having rare or orphan diseases that should be managed with special molecularly targeted therapies. ..
  78. Guo R, Zheng H, Huang L, Zhou Y, Zhang X, Liang C, et al. Epidemiologic and economic burden of influenza in the outpatient setting: a prospective study in a subtropical area of China. PLoS ONE. 2012;7:e41403 pubmed publisher
    ..Direct costs (mostly medical costs) impose an enormous burden on the patient family. Vaccination strategies for high-risk groups need to be further strengthened. ..
  79. Zhang J, Cai M, Wang X, Duan L, Shao Q, Tong Z, et al. Elevated DLL4 expression is correlated with VEGF and predicts poor prognosis of nasopharyngeal carcinoma. Med Oncol. 2013;30:390 pubmed publisher
    ..05). These findings provide evidence that high expression of DLL4 serves as an independent predictor of poor prognosis in NPC patients. ..
  80. Fu X, Jiang J, Gu X, Li Z. Malignant perivascular epithelioid cell tumor of mesentery with lymph node involvement: a case report and review of literature. Diagn Pathol. 2013;8:60 pubmed publisher
    ..To our knowledge, this is the first case of malignant PEComa in mesentery accompanied with regional lymph node involvement. The literature on this rare tumor is reviewed and diagnostic criteria of malignant PEComa are discussed...
  81. Liu L, Dai Y, Chen J, Zeng T, Chen L, Zhu Y, et al. Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3?/Snail signaling. Hepatology. 2014;59:531-43 pubmed publisher
    ..MAEL is an oncogene that plays an important role in the development and progression of HCC by inducing EMT and enhancing the stemness of HCC. ..
  82. Li H, Huang S, He Y, Liu Y, Liu Y, Chen J, et al. Impact of an Early Decrease in Systolic Blood Pressure on The Risk of Contrast-Induced Nephropathy after Percutaneous Coronary Intervention. Heart Lung Circ. 2016;25:118-23 pubmed publisher
    ..368, 95%CI: 1.043-5.379, P=0.039), after adjustment for other risk factors. An early moderate postprocedural decrease in SBP may increase the risk of CIN in patients undergoing PCI. ..
  83. Zhong J, Huang W, Deng Q, Wu M, Jiang H, Lin X, et al. Inhibition of TREM-1 and Dectin-1 Alleviates the Severity of Fungal Keratitis by Modulating Innate Immune Responses. PLoS ONE. 2016;11:e0150114 pubmed publisher
    ..Inhibition of TREM-1 and Dectin-1 can alleviate the severity of corneal damage by downregulating the excessive inflammatory response. ..
  84. Lv D, Lin W, Xue Z, Pu W, Yang Q, Huang X, et al. Decreased functional connectivity in the language regions in bipolar patients during depressive episodes but not remission. J Affect Disord. 2016;197:116-24 pubmed publisher
    ..Our results illustrated that connectivity disturbances in the language regions may change depending on the disease phase of bipolar disorder. ..
  85. Zhu R, Lin W, Zhang W, Ren J, Su Y, He J, et al. Modification effects of genetic polymorphisms in FTO, IL-6, and HSPD1 on the associations of diabetes with breast cancer risk and survival. PLoS ONE. 2017;12:e0178850 pubmed publisher
    ..70 (0.49, 0.99)]. Our results suggest that the contribution of diabetes to breast cancer risk might be modified by IL-6 rs1800796 and HSPD1 rs2605039. Diabetes and HSPD1 rs2605039 might also influence breast cancer prognosis. ..
  86. Xu H, Sun Q, Lu L, Luo F, Zhou L, Liu J, et al. MicroRNA-218 acts by repressing TNFR1-mediated activation of NF-?B, which is involved in MUC5AC hyper-production and inflammation in smoking-induced bronchiolitis of COPD. Toxicol Lett. 2017;280:171-180 pubmed publisher
  87. Li F, Wang F, Nie F, Li Z, Huang Y, Zhang J, et al. [The effects of glucose fluctuation on resistin]. Zhonghua Nei Ke Za Zhi. 2010;49:484-7 pubmed
    ..23, P=0.02). Glucose fluctuation induced monocyte/macrophage to secrete resistin, greater the glucose fluctuation, greater the change of amplitude of serum resistin. ..
  88. Ou Yang K, Liang J, Huang Z. Association of clinicopathologic parameters with the expression of inducible nitric oxide synthase and vascular endothelial growth factor in mucoepidermoid carcinoma. Oral Dis. 2011;17:590-6 pubmed publisher
    ..05) but were not correlated lymph node metastasis and metastasis. Inducible nitric oxide synthase can stimulate the expression of VEGF, and their expression status may help assess tumor malignancy and patient prognosis. ..
  89. Zeng Z, Wu W, Yang J, Tang Z, Chen D, Qiu M, et al. Prognostic relevance of melanoma antigen D1 expression in colorectal carcinoma. J Transl Med. 2012;10:181 pubmed publisher
    ..Univariate and multivariate analyses indicated that MAGED1 expression was an independent prognostic factors (p?<?0.001). MAGED1 may serve as a novel prognostic biomarker of human colorectal cancer. ..
  90. Jia Y, Guan R, Li L. [Relationship between fissured tongue with flow and components of saliva]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1994;14:31-2, 5 pubmed
    ..It was also showed that the formation of FT has to a certain extent something to do with the electrolyte disturbance in aqueous solution, malnutrition, as well as immunity and endocrinic function of patients. ..
  91. Li J, Zhang X, Xie D, Deng H, Gao Y, Chen Q, et al. Expression of immune-related molecules in primary EBV-positive Chinese nasopharyngeal carcinoma: associated with latent membrane protein 1 (LMP1) expression. Cancer Biol Ther. 2007;6:1997-2004 pubmed
    ..It has been reported that the expression pattern of immune related-molecules on tumor cells will affect the outcome of T-cell-based adoptive immunotherapy for NPC. ..
  92. Guo X, Zhang G, Wang J, Liu W, Wang F, Dong J, et al. Prognostic relevance of Centromere protein H expression in esophageal carcinoma. BMC Cancer. 2008;8:233 pubmed publisher
    ..Our results suggest that CENP-H protein is a valuable marker of esophageal carcinoma progression. CENP-H might be used as a valuable prognostic marker for esophageal carcinoma patients. ..