Experts and Doctors on micrornas in Guangzhou, Guangdong, China

Summary

Locale: Guangzhou, Guangdong, China
Topic: micrornas

Top Publications

  1. Li B, Sun H. MiR-26a promotes neurite outgrowth by repressing PTEN expression. Mol Med Rep. 2013;8:676-80 pubmed publisher
    ..miR-26a has the potential to serve as a therapeutic target for patients with Alzheimer's disease (AD). ..
  2. Zhu M, Wang J, Deng R, Xiong P, Liang H, Wang X. A microRNA encoded by Autographa californica nucleopolyhedrovirus regulates expression of viral gene ODV-E25. J Virol. 2013;87:13029-34 pubmed publisher
  3. Li L, Zhang C, Liu L, Yi C, Lu S, Zhou X, et al. miR-720 inhibits tumor invasion and migration in breast cancer by targeting TWIST1. Carcinogenesis. 2014;35:469-78 pubmed publisher
    ..Collectively, our data indicate that miR-720 is frequently decreased in breast cancer and manifests antimetastatic activity by downregulating TWIST1, presenting a novel mechanism of miRNA-mediated regulation of tumor metastasis. ..
  4. Liao A, Tan G, Chen L, Zhou W, Hu H. RASSF1A inhibits gastric cancer cell proliferation by miR-711- mediated downregulation of CDK4 expression. Oncotarget. 2016;7:5842-51 pubmed publisher
    ..This finding might provide us with a novel therapeutic target for gastric cancer by increasing RASSF1A expression via miR-711 regulation. ..
  5. Gong C, Yao Y, Wang Y, Liu B, Wu W, Chen J, et al. Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer. J Biol Chem. 2011;286:19127-37 pubmed publisher
    ..Therefore, miR-21 overexpression contributes to trastuzumab resistance in HER2(+) breast cancers and antagonizing miR-21 demonstrates therapeutic potential by sensitizing the malignancy to anti-HER2 treatment. ..
  6. Li C, Li C, Yue J, Huang X, Chen M, Gao J, et al. miR-21 and miR-101 regulate PLAP-1 expression in periodontal ligament cells. Mol Med Rep. 2012;5:1340-6 pubmed publisher
    ..Our results indicated that mir-101 and mir-21 target PLAP-1 to regulate its expression during osteogenic differentiation of PDLCs. ..
  7. Zhang Y, Wang Z, Chen M, Peng L, Wang X, Ma Q, et al. MicroRNA-143 targets MACC1 to inhibit cell invasion and migration in colorectal cancer. Mol Cancer. 2012;11:23 pubmed publisher
    ..Our findings newly described miR-143/MACC1 link and provided a potential mechanism for MACC1 dysregulation and contribution to CRC cell invasion. It may help to estimate the therapeutic utility of miR-143 in CRC. ..
  8. Liu Y, Cai H, Liu J, Fan H, Wang Z, Wang Q, et al. A miR-151 binding site polymorphism in the 3'-untranslated region of the cyclin E1 gene associated with nasopharyngeal carcinoma. Biochem Biophys Res Commun. 2013;432:660-5 pubmed publisher
    ..These results suggest that CCNE1 rs3218073 polymorphism can be exploited as a novel biomarker for future NPC diagnosis and prognosis. ..
  9. Deng M, Liu J, Gu Y, Zheng G, He Z. [miR-216b suppresses cell proliferation and invasion by targeting PKC? in nasopharyngeal carcinoma cells]. Zhonghua Zhong Liu Za Zhi. 2013;35:645-50 pubmed
    ..Moreover, the overexpressed PKC? may partially reverse the inhibitory effect of miR-216b on proliferation of CNE2 cells. miR-216b suppresses cell proliferation and invasion by targeting PKC? in NPC cells. ..

More Information

Publications433 found, 100 shown here

  1. Zhou J, Ma W, Yu H, Xiao W, Zheng W. [Time course of let-7a expression in the cell cycle of human cervical carcinoma HeLa cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29:442-5 pubmed
    ..Cell cycle can significantly influence the expression level of let-7a, which may provide new clues to the understanding of the cell cycle control mechanisms. ..
  2. Zhao Y, Liu H, Li Y, Wu J, Greenlee A, Yang C, et al. The role of miR-506 in transformed 16HBE cells induced by anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide. Toxicol Lett. 2011;205:320-6 pubmed publisher
    ..The identification of tumor suppressive miRNAs could provide new insight into the molecular mechanisms of chemical carcinogenesis. ..
  3. Lv L, Huang F, Mao H, Li M, Li X, Yang M, et al. MicroRNA-21 is overexpressed in renal cell carcinoma. Int J Biol Markers. 2013;28:201-7 pubmed publisher
    ..To identify microRNAs (miRNAs) that are overexpressed in renal cell carcinoma (RCC) and characterize the functional role of miR-21...
  4. Duan H, Jiang Y, Zhang H, Wu Y. MiR-320 and miR-494 affect cell cycles of primary murine bronchial epithelial cells exposed to benzo[a]pyrene. Toxicol In Vitro. 2010;24:928-35 pubmed publisher
  5. Zhou Q, Fan J, Ding X, Peng W, Yu X, Chen Y, et al. TGF-{beta}-induced MiR-491-5p expression promotes Par-3 degradation in rat proximal tubular epithelial cells. J Biol Chem. 2010;285:40019-27 pubmed publisher
    ..Taken together, we conclude that up-regulation of miR-491-5p contributes to TGF-?-regulated Par-3 expression. Our study uncovered a novel mechanism by which TGF-? disrupts cell junction. ..
  6. Yang R, Zheng T, Cai X, Yu Y, Yu C, Guo L, et al. Genome-wide analyses of amphioxus microRNAs reveal an immune regulation via miR-92d targeting C3. J Immunol. 2013;190:1491-500 pubmed publisher
    ..This study provides evidence for the complex immune regulation of miRNAs in the acute-phase response in basal chordates. ..
  7. Peng B, Hu S, Jun Q, Luo D, Zhang X, Zhao H, et al. MicroRNA-200b targets CREB1 and suppresses cell growth in human malignant glioma. Mol Cell Biochem. 2013;379:51-8 pubmed publisher
    ..These results indicate that miR-200b targets the CREB1 gene and suppresses glioma cell growth, suggesting that miR-200b shows tumor-suppressive activity in human malignant glioma. ..
  8. Meng X, Wu J, Pan C, Wang H, Ying X, Zhou Y, et al. Genetic and epigenetic down-regulation of microRNA-212 promotes colorectal tumor metastasis via dysregulation of MnSOD. Gastroenterology. 2013;145:426-36.e1-6 pubmed publisher
    ..miR-212 is transcribed from a stable intron of a non-protein coding gene, and is reportedly down-regulated in different tumor types. We investigated the role of miR-212 in colorectal carcinogenesis and progression...
  9. Zhang J, Lu Y, Yue X, Li H, Luo X, Wang Y, et al. MiR-124 suppresses growth of human colorectal cancer by inhibiting STAT3. PLoS ONE. 2013;8:e70300 pubmed publisher
    ..These data suggest that miR-124 serves as a tumor suppressor by targeting STAT3, and call for the use of miR-124 as a potential therapeutic tool for CRC, where STAT3 is often hyper-activated. ..
  10. Wang R, Ma J, Wang M, Cui J, Wu W, Liu R, et al. A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway. Cell Physiol Biochem. 2017;43:1152-1167 pubmed publisher
    ..The results suggested the human long non-coding RNA ALT1 is a novel regulator for cell cycle of HUVECs via ACE2 and cyclin D1 pathway. ..
  11. Hu H, Li Y, Gu J, Zhu X, Dong D, Yao J, et al. Antisense oligonucleotide against miR-21 inhibits migration and induces apoptosis in leukemic K562 cells. Leuk Lymphoma. 2010;51:694-701 pubmed publisher
    ..Our data suggest that miR-21 may play an oncogenic role in the cellular processes of CML, and antisense inhibition of miR-21 may therefore be useful as CML therapy. ..
  12. Wang X, Zhang X, Zhen J, Zhang P, Xu G, Jiang H. MicroRNA expression in the embryonic mouse inner ear. Neuroreport. 2010;21:611-7 pubmed publisher
    ..Our results indicate that miRNAs are widely expressed in the developing inner ear, with more species recruited as hair cells differentiate, suggesting an important developmental role. ..
  13. Sun K, Zeng J, Wang W, Wu C, Lei S, Li G. [MicroRNA-221 controls CDKN1C/P57 expression in human colorectal carcinoma]. Zhonghua Wei Chang Wai Ke Za Zhi. 2011;14:279-83 pubmed
    ..miR-221-specific inhibitor potentially inhibits the growth of CRC cells. Therefore, it may be a new target for the biologic therapy for CRC. ..
  14. Sun L, Yao Y, Liu B, Lin Z, Lin L, Yang M, et al. MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. Oncogene. 2012;31:432-45 pubmed publisher
    ..Our data suggest that reduced expression of miR-200b and miR-15b underscores the mechanisms of chemotherapy-induced EMT in TSCC, and may serve as therapeutic targets to reverse chemotherapy resistance in tongue cancers...
  15. Yu S, Liu Y, Wang J, Guo Z, Zhang Q, Yu F, et al. Circulating microRNA profiles as potential biomarkers for diagnosis of papillary thyroid carcinoma. J Clin Endocrinol Metab. 2012;97:2084-92 pubmed publisher
    ..Increased expression of miR-151-5p and miR-222 was also found in the tissue of PTC patients. Our study demonstrates that serum miRNA profiles may be used as novel and minimally invasive diagnostic markers for PTC. ..
  16. Zhou J, Ju W, Wang D, Wu L, Zhu X, Guo Z, et al. Down-regulation of microRNA-26a promotes mouse hepatocyte proliferation during liver regeneration. PLoS ONE. 2012;7:e33577 pubmed publisher
    ..The current study reveals a novel miRNA-mediated regulation pattern during the proliferative phase of LR. ..
  17. Zhu J, Chen R, Fu Y, Lin Q, Huang S, Guo L, et al. Smad3 inactivation and MiR-29b upregulation mediate the effect of carvedilol on attenuating the acute myocardium infarction-induced myocardial fibrosis in rat. PLoS ONE. 2013;8:e75557 pubmed publisher
    ..Taken together, we found that smad3 inactivation and miR-29b upregulation contributed to the cardioprotective activity of carvedilol against AMI-induced myocardial fibrosis. ..
  18. Cai S, Wang Z, Chen C, Wu W, He Y, Zhan W, et al. Role of silencing phosphatase of regenerationg liver-3 expression by microRNA interference in the growth of gastric cancer. Chin Med J (Engl). 2008;121:2534-8 pubmed
    ..001). Knockdown of PRL-3 significantly suppressed the proliferation of SGC7901 cells in vitro and tumor growth in vivo. PRL-3 plays a key role in the growth of gastric cancer. PRL-3 should be considered as a potential therapeutic target. ..
  19. Xu F, Liu Q, Chen L, Kuang J, Walk T, Wang J, et al. Genome-wide identification of soybean microRNAs and their targets reveals their organ-specificity and responses to phosphate starvation. BMC Genomics. 2013;14:66 pubmed publisher
    ..The targets of miR399, miR2111, and miR159e-3p were confirmed. Taken together, our study implies the important roles of miRNAs in P signaling and provides clues for deciphering the functions for microRNA/target modules in soybean. ..
  20. Huang Y, Gong W, Ren H, Xiong J, Gao X, Sun X. Identification of the conserved and novel microRNAs by deep sequencing and prediction of their targets in Topmouth culter. Gene. 2017;626:298-304 pubmed publisher
  21. Hong X, Cao H, Zhao F, Pan X, Zhang K, Xu Q, et al. [MiR-196a-2 gene polymorphism and the antiviral therapy of chronic hepatitis C]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010;24:470-2 pubmed
  22. Huang X, Xu S, Gao J, Liu F, Yue J, Chen T, et al. miRNA expression profiling identifies DSPP regulators in cultured dental pulp cells. Int J Mol Med. 2011;28:659-67 pubmed publisher
    ..The results presented here suggest that DSPP is regulated post-transcriptionally by mir32, mir885-5p and mir586 during odontoblast differentiation. ..
  23. Yue J, Wu B, Gao J, Huang X, Li C, Ma D, et al. DMP1 is a target of let-7 in dental pulp cells. Int J Mol Med. 2012;30:295-301 pubmed publisher
    ..Gene expression levels of let-7 and DMP1 were validated by qRT-PCR of dental pulp cells cultured in a mineralizing medium. Our results suggest that DMP1 is regulated post-transcriptionally by let-7 during odontoblast differentiation. ..
  24. Wang W, Zhao Y, Han B, Hong S, Chen Y. Circulating microRNAs identified in a genome-wide serum microRNA expression analysis as noninvasive biomarkers for endometriosis. J Clin Endocrinol Metab. 2013;98:281-9 pubmed publisher
    ..miR-199a may also play an important role in the progression of the disease. This is the first report that circulating miRNAs serve as biomarkers of endometriosis. ..
  25. Wu J, Yang T, Li X, Yang Q, Liu R, Huang J, et al. Alteration of serum miR-206 and miR-133b is associated with lung carcinogenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Toxicol Appl Pharmacol. 2013;267:238-46 pubmed publisher
    ..Our results demonstrate that lung carcinogen NNK exposure changes the expression of serum miRNAs. Serum miR-206 and miR-133b could be associated with lung carcinogenesis induced by NNK. ..
  26. Liao W, Ye Y, Zhang N, Li T, Wang S, Cui Y, et al. MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2. J Pathol. 2014;232:415-27 pubmed publisher
    ..Restoration of miR-30b expression may represent a promising therapeutic approach for targeting malignant CRC. ..
  27. Zeng L, Chen Y, Wang Y, Yu L, Knox B, Chen J, et al. MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation. Biochem Pharmacol. 2017;140:139-149 pubmed publisher
  28. Li Z, Zhan W, Wang Z, Zhu B, He Y, Peng J, et al. Inhibition of PRL-3 gene expression in gastric cancer cell line SGC7901 via microRNA suppressed reduces peritoneal metastasis. Biochem Biophys Res Commun. 2006;348:229-37 pubmed
    ..Therefore, we concluded that artificial miRNA can depress the expression of PRL-3, and that PRL-3 might be a potential therapeutic target for gastric cancer peritoneal metastasis. ..
  29. Liu Q, Zhang Y, Wang C, Luo Y, Huang Q, Chen S, et al. Expression analysis of phytohormone-regulated microRNAs in rice, implying their regulation roles in plant hormone signaling. FEBS Lett. 2009;583:723-8 pubmed publisher
    ..These findings enable us to further investigate the role of miRNAs in phytohormone signaling. ..
  30. Du Z, Hu L, Wang H, Yan L, Zeng Y, Shao J, et al. Upregulation of MiR-155 in nasopharyngeal carcinoma is partly driven by LMP1 and LMP2A and downregulates a negative prognostic marker JMJD1A. PLoS ONE. 2011;6:e19137 pubmed publisher
    ..The potential of miR-155 and JMJD1A as therapeutic targets in NPC should be further investigated. ..
  31. Wu Z, Sun H, Zeng W, He J, Mao X. Upregulation of MircoRNA-370 induces proliferation in human prostate cancer cells by downregulating the transcription factor FOXO1. PLoS ONE. 2012;7:e45825 pubmed publisher
    ..Taken together, our results suggest that miR-370 plays an important role in the proliferation of human prostate cancer cells, by directly suppressing the tumor suppressor FOXO1. ..
  32. Li Y, Zhang M, Wen H, Hu C, Liu R, Wei H, et al. Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction. Clinics (Sao Paulo). 2013;68:75-80 pubmed
  33. Shan Z, Yao C, Li Z, Teng Y, Li W, Wang J, et al. Differentially expressed microRNAs at different stages of atherosclerosis in ApoE-deficient mice. Chin Med J (Engl). 2013;126:515-20 pubmed
  34. Mai Z, Peng Z, Zhang J, Chen L, Liang H, Cai B, et al. miRNA expression profile during fluid shear stress-induced osteogenic differentiation in MC3T3-E1 cells. Chin Med J (Engl). 2013;126:1544-50 pubmed
    ..The short-term and appropriate FSS is sufficient to promote terminal differentiation of pre-osteoblasts and a group of miRNAs may be involved in FSS-induced pre-osteoblast differentiation. ..
  35. Zhou C, Liu G, Wang L, Lu Y, Yuan L, Zheng L, et al. MiR-339-5p regulates the growth, colony formation and metastasis of colorectal cancer cells by targeting PRL-1. PLoS ONE. 2013;8:e63142 pubmed publisher
    ..These findings suggest that miR-339-5p may be useful as a new potential therapeutic target for CRC. ..
  36. Xiao F, Bai Y, Chen Z, Li Y, Luo L, Huang J, et al. Downregulation of HOXA1 gene affects small cell lung cancer cell survival and chemoresistance under the regulation of miR-100. Eur J Cancer. 2014;50:1541-54 pubmed publisher
    ..Our data suggested that HOXA1-mediated SCLC chemoresistance is under the regulation of miR-100. HOXA1 may be a prognostic predictor and potential therapeutic target in human SCLC. ..
  37. Wang Q, She Y, Bi X, Zhao B, Ruan X, Tan Y. Dexmedetomidine Protects PC12 Cells from Lidocaine-Induced Cytotoxicity Through Downregulation of COL3A1 Mediated by miR-let-7b. DNA Cell Biol. 2017;36:518-528 pubmed publisher
    ..Therefore, miR-let-7b and COL3A1 might play critical roles in neuronal injury, and they are potential therapeutic targets. ..
  38. Ma Q, Wang X, Li Z, Li B, Ma F, Peng L, et al. microRNA-16 represses colorectal cancer cell growth in vitro by regulating the p53/survivin signaling pathway. Oncol Rep. 2013;29:1652-8 pubmed publisher
    ..Our findings provide further evidence for the involvement of dysregulated miRNAs in CRC, and miR-16 could serve as a molecular target for CRC therapy. ..
  39. Zhou W, Song F, Wu Q, Liu R, Wang L, Liu C, et al. miR-217 inhibits triple-negative breast cancer cell growth, migration, and invasion through targeting KLF5. PLoS ONE. 2017;12:e0176395 pubmed publisher
    ..MiR-217 suppresses TNBC, at least partially, through down-regulating the KLF5 expression. These results suggest that the miR-217-KLF5 axis might serve as a potential target for treatment of TNBC. ..
  40. Lin K, Zhang X, Feng D, Zhang H, Zeng C, Han B, et al. miR-125b, a target of CDX2, regulates cell differentiation through repression of the core binding factor in hematopoietic malignancies. J Biol Chem. 2011;286:38253-63 pubmed publisher
  41. Li H, Dai S, Zhen T, Shi H, Zhang F, Yang Y, et al. Clinical and biological significance of miR-378a-3p and miR-378a-5p in colorectal cancer. Eur J Cancer. 2014;50:1207-21 pubmed publisher
    ..In conclusion, miR-378a-3p and miR-378a-5p expression might play an important role as tumour suppressor gene in the initial stage of carcinogenesis of CRC. ..
  42. Wan D, Shen S, Fu S, Preston B, Brandon C, He S, et al. miR-203 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting oncogene ADAM9 and oncogenic long non-coding RNA HULC. Anticancer Agents Med Chem. 2016;16:414-23 pubmed
    ..These results suggested that miR-203 played tumor suppressive roles by downregulating ADAM9 and HULC and indicated its potential application in cancer treatment. ..
  43. Xu J, Liao X, Wong C. Downregulations of B-cell lymphoma 2 and myeloid cell leukemia sequence 1 by microRNA 153 induce apoptosis in a glioblastoma cell line DBTRG-05MG. Int J Cancer. 2010;126:1029-35 pubmed publisher
    ..By luciferase reporter assays, we further showed that miR-153 inhibited Bcl-2 and Mcl-1 expressions by directly targeting the 3'UTR regions of their respective mRNAs. ..
  44. Yang Q, Jie Z, Cao H, Greenlee A, Yang C, Zou F, et al. Low-level expression of let-7a in gastric cancer and its involvement in tumorigenesis by targeting RAB40C. Carcinogenesis. 2011;32:713-22 pubmed publisher
    ..The results of this study suggest that let-7a and RAB40C are potentially useful targets for gastric cancer diagnosis and therapy. ..
  45. Zhang J, Xiao Z, Lai D, Sun J, He C, Chu Z, et al. miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer. Br J Cancer. 2012;107:352-9 pubmed publisher
    ..miR-21, miR-17 and miR-19a induced by PRL-3 contribute to the proliferation and invasion of colon cancer. ..
  46. Fang R, Li L, Li J. Spatial and temporal expression modes of MicroRNAs in an elite rice hybrid and its parental lines. Planta. 2013;238:259-69 pubmed publisher
    ..Together, our results reveal that miRNAs, especially those from QTL intervals, play roles in heterotic performance in this elite rice hybrid, our results also shade new light on understanding the molecular mechanisms of heterosis. ..
  47. Guan H, Wei G, Wu J, Fang D, Liao Z, Xiao H, et al. Down-regulation of miR-218-2 and its host gene SLIT3 cooperate to promote invasion and progression of thyroid cancer. J Clin Endocrinol Metab. 2013;98:E1334-44 pubmed publisher
    ..Our findings highlight the functional associations of intronic miRNAs and their host genes in thyroid carcinogenesis. ..
  48. Liu Y, Zheng W, Song Y, Ma W, Yin H. Low expression of miR-196b enhances the expression of BCR-ABL1 and HOXA9 oncogenes in chronic myeloid leukemogenesis. PLoS ONE. 2013;8:e68442 pubmed publisher
    ..MiR-196b may represent an effective target for chronic myeloid leukemia therapy. ..
  49. Chen L, Tang Y, Wang J, Yan Z, Xu R. miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4. Biochem Biophys Res Commun. 2013;435:745-50 pubmed publisher
    ..Taken together, our findings not only suggest that miR-421 promotes nasopharyngeal carcinoma cell proliferation and anti-apoptosis, but also uncover a novel regulatory mechanism for inactivation of FOXO4 in nasopharyngeal carcinoma. ..
  50. Yu F, Deng H, Yao H, Liu Q, Su F, Song E. Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells. Oncogene. 2010;29:4194-204 pubmed publisher
    ..Together, our data suggest mir-30 as one of the important miRNAs in regulating the stem-like features of T-ICs. ..
  51. Xu M, Liu Q, Nisbet A, Cai X, Yan C, Lin R, et al. Identification and characterization of microRNAs in Clonorchis sinensis of human health significance. BMC Genomics. 2010;11:521 pubmed publisher
  52. Zhang Y, Yan L, Wu Q, Du Z, Chen J, Liao D, et al. miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer. Cancer Res. 2011;71:3552-62 pubmed publisher
    ..Taken together, our findings point to an important role for miR-125b in the molecular etiology of invasive breast cancer, and they suggest miR-125b as a potential theranostic tool in this disease. ..
  53. Xia K, Wang R, Ou X, Fang Z, Tian C, Duan J, et al. OsTIR1 and OsAFB2 downregulation via OsmiR393 overexpression leads to more tillers, early flowering and less tolerance to salt and drought in rice. PLoS ONE. 2012;7:e30039 pubmed publisher
    ..The positive phenotypes (increased tillers and early flowering) and negative phenotypes (reduced tolerance to salt and hyposensitivity to auxin) of OsmiR393-overexpressing rice present a dilemma for molecular breeding. ..
  54. Qin L, Chen Y, Liu X, Ye S, Yu K, Huang Z, et al. Integrative analysis of porcine microRNAome during skeletal muscle development. PLoS ONE. 2013;8:e72418 pubmed publisher
    ..Analysis of temporal profiles of miRNA expression identifies 18 novel candidate myogenic miRNAs in pig, which might provide new insight into regulation mechanism mediated by miRNAs underlying muscle development. ..
  55. Duan F, Qian F, Fang K, Lin K, Wang W, Chen Y. miR-133b, a muscle-specific microRNA, is a novel prognostic marker that participates in the progression of human colorectal cancer via regulation of CXCR4 expression. Mol Cancer. 2013;12:164 pubmed publisher
    ..Our study demonstrated that downregulated miR-133b contributed to increased cell invasion and migration in CRC by negatively regulating CXCR4. These findings may be significant for the development of therapy target for CRC. ..
  56. He S, Lai R, Chen D, Yan W, Zhang Z, Liu Z, et al. Downregulation of miR-221 Inhibits Cell Migration and Invasion through Targeting Methyl-CpG Binding Domain Protein 2 in Human Oral Squamous Cell Carcinoma Cells. Biomed Res Int. 2015;2015:751672 pubmed publisher
    ..In conclusion, downregulation of miR-221 inhibits cell migration and invasion at least partially through targeting MBD2 in the human OSCC cell line UM1. ..
  57. Jiang N, Wang X, Xie X, Liao Y, Liu N, Liu J, et al. lncRNA DANCR promotes tumor progression and cancer stemness features in osteosarcoma by upregulating AXL via miR-33a-5p inhibition. Cancer Lett. 2017;405:46-55 pubmed publisher
    ..DANCR increases CSCs function by upregulating AXL via competitively binding to miR-33a-5p, and this function is sequentially performed through the PI3K-Akt signaling pathway. ..
  58. Lin H, Dai T, Xiong H, Zhao X, Chen X, Yu C, et al. Unregulated miR-96 induces cell proliferation in human breast cancer by downregulating transcriptional factor FOXO3a. PLoS ONE. 2010;5:e15797 pubmed publisher
    ..Taken together, our results suggest that miR-96 may play an important role in promoting proliferation of human breast cancer cells and present a novel mechanism of miRNA-mediated direct suppression of FOXO3a expression in cancer cells. ..
  59. YUAN C, Cai H, Huang Y, Ye Y, ZHAO M, Lu X, et al. [Establishment of a nasopharyngeal carcinoma cell line CNE1 stably overexpressing ebv-miR-BART7 mediated by lentivirus]. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31:419-22 pubmed
  60. Peng D, Luo M, Qiu L, He Y, Wang X. Prognostic implications of microRNA-100 and its functional roles in human epithelial ovarian cancer. Oncol Rep. 2012;27:1238-44 pubmed publisher
    ..Together, these results suggest that low miR-100 expression may be an independent poor prognostic factor and miR-100 can function as a tumor suppressor by targeting PLK1 in human EOCs. ..
  61. Chen L, Zhang R, Li P, Liu Y, Qin K, Fa Z, et al. P53-induced microRNA-107 inhibits proliferation of glioma cells and down-regulates the expression of CDK6 and Notch-2. Neurosci Lett. 2013;534:327-32 pubmed publisher
    ..Our findings collectively demonstrate that p53-induced miR-107 suppresses brain tumor cell growth and down-regulates CDK6 and Notch-2 expression, supporting its tumor suppressor role and utility as a target for glioma therapy. ..
  62. Zhong W, He B, Zhu C, Xiao L, Zhou S, Peng X. [MiR-143 inhibits migration of human nasopharyngeal carcinoma cells by negatively regulating GLI3 gene]. Nan Fang Yi Ke Da Xue Xue Bao. 2013;33:1057-61 pubmed
    ..MiR-143 can inhibit the invasion of NPC cells by negative regulation of GLI3 gene, which sheds light on the role of miR-143 and Hh pathway in NPC. ..
  63. Lin Z, Huang Y, Zhang Y, Han Z, He H, Ling X, et al. MicroRNA-224 inhibits progression of human prostate cancer by downregulating TRIB1. Int J Cancer. 2014;135:541-50 pubmed publisher
    ..In conclusion, these findings reveal that the aberrant expression of miR-224 and TRIB1 may promote PCa progression and have potentials to serve as novel biomarkers for PCa prognosis. ..
  64. Lu L, Qi H, Luo F, Xu H, Ling M, Qin Y, et al. Feedback circuitry via let-7c between lncRNA CCAT1 and c-Myc is involved in cigarette smoke extract-induced malignant transformation of HBE cells. Oncotarget. 2017;8:19285-19297 pubmed publisher
    ..Thus, the present research establishes a new mechanism for the reciprocal regulation between CCAT1 and c-Myc and provides an understanding of cigarette smoke extract-induced lung carcinogenesis. ..
  65. Zhou J, Ma W, Liang S, Zeng Y, Shi R, Yu H, et al. Analysis of microRNA expression profiles during the cell cycle in synchronized HeLa cells. BMB Rep. 2009;42:593-8 pubmed
    ..The study deepens our understanding on cell cycle regulation. [BMB reports 2009; 42(9): 593-598]. ..
  66. Feng Z, Li J, Ren J, Lv Z. [Expression of miR-146a and miR-16 in peripheral blood mononuclear cells of patients with rheumatoid arthritis and their correlation to the disease activity]. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31:320-3 pubmed
    ..01), but not to RF (P>0.05). The elevated expression levels of miR-146a and miR-16 are correlated to RA disease activity, suggesting their value in assessment of the clinical disease activity of RA. ..
  67. Li F, Huang X, Wang Z, Liu F, Zhou X, Zhong L, et al. [Expression of miR-9 in B lymphocytes and B cell lymphomas cell lines and its significance]. Zhonghua Xue Ye Xue Za Zhi. 2011;32:249-53 pubmed
    ..miR-9 highly expressed in cHL cell line and might be a molecular marker for diagnosis and treatment of cHL. ..
  68. Shen Y, Lv Y, Huang L, Liu W, Wen M, Tang T, et al. Testing hypotheses on the rate of molecular evolution in relation to gene expression using microRNAs. Proc Natl Acad Sci U S A. 2011;108:15942-7 pubmed publisher
    ..The observations suggest that, as a miRNA gene becomes more highly (or more ubiquitously) expressed, its sequence evolves toward a structure that minimizes processing errors. ..
  69. Han Z, Yang Q, Liu B, Wu J, Li Y, Yang C, et al. MicroRNA-622 functions as a tumor suppressor by targeting K-Ras and enhancing the anticarcinogenic effect of resveratrol. Carcinogenesis. 2012;33:131-9 pubmed publisher
    ..Therefore, miR-622 is potentially useful as a clinical therapy. MiR-622 impacts the K-Ras signal pathway and the potentially anticarcinogenic or chemotherapeutic properties warrant further investigation. ..
  70. Sun K, Wang W, Lei S, Wu C, Li G. [MicroRNA-221 promotes colon carcinoma cell proliferation in vitro by inhibiting CDKN1C/p57 expression]. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31:1885-9 pubmed
  71. Wang J, Chen H, Liao Y, Chen N, Liu T, Zhang H, et al. Expression and clinical evidence of miR-494 and PTEN in non-small cell lung cancer. Tumour Biol. 2015;36:6965-72 pubmed publisher
    ..Combined detection of PTEN and miR-494 can aid in determining malignancy degree and the prognosis of patients with NSCLC. MiR-494 may be served as a novel prognostic factor and may lead to new treatment strategies for NSCLC. ..
  72. Wang H, Ye Y, Zhu Z, Mo L, Lin C, Wang Q, et al. MiR-124 Regulates Apoptosis and Autophagy Process in MPTP Model of Parkinson's Disease by Targeting to Bim. Brain Pathol. 2016;26:167-76 pubmed publisher
    ..Taken together, these results indicate that upregulation of miR-124 could regulate apoptosis and impaired autophagy process in the MPTP model of PD, thus reducing the loss of DA neurons. ..
  73. Li J, Du S, Sheng X, Liu J, Cen B, Huang F, et al. MicroRNA-29b Inhibits Endometrial Fibrosis by Regulating the Sp1-TGF-β1/Smad-CTGF Axis in a Rat Model. Reprod Sci. 2016;23:386-94 pubmed publisher
    ..Further experiments indicated that miR-29b inhibited endometrial fibrosis via blockade of the Sp1-TGF-β1/Smad-CTGF pathway. In conclusion, agomir-29b may act as a novel and effective therapeutic agent against IUAs. ..
  74. Chen B, Bao Y, Chen X, Yi J, Liu S, Fang Z, et al. Mir-664 promotes osteosarcoma cells proliferation via downregulating of FOXO4. Biomed Pharmacother. 2015;75:1-7 pubmed publisher
    ..These data suggests that miR-664 may represent a novel therapeutic target of microRNA-mediated suppression of cell proliferation in osteosarcoma. ..
  75. Weng J, Zhang H, Wang C, Liang J, Chen G, Li W, et al. miR-373-3p Targets DKK1 to Promote EMT-Induced Metastasis via the Wnt/?-Catenin Pathway in Tongue Squamous Cell Carcinoma. Biomed Res Int. 2017;2017:6010926 pubmed publisher
    ..Taken together, our findings reveal a new regulatory mechanism for miR-373-3p and suggest that miR-373-3p might be a potential target in TSCC therapy. ..
  76. Wang Z, He Y, Cai S, Zhan W, Li Z, Zhu B, et al. Expression and prognostic impact of PRL-3 in lymph node metastasis of gastric cancer: its molecular mechanism was investigated using artificial microRNA interference. Int J Cancer. 2008;123:1439-47 pubmed publisher
  77. Zhang H, Luo X, Zhang P, Huang L, Zheng Y, Wu J, et al. MicroRNA patterns associated with clinical prognostic parameters and CNS relapse prediction in pediatric acute leukemia. PLoS ONE. 2009;4:e7826 pubmed publisher
    ..There are existing pediatric-associated and prognostic parameter-associated miRNAs that are independent of cell lineage and could provide therapeutic direction for individual risk-adapted therapy for pediatric leukemia patients. ..
  78. Li Y, Xu X, Liang Y, Liu S, Xiao H, Li F, et al. miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein expression. Int J Clin Exp Pathol. 2010;3:254-64 pubmed
    ..Together, our data suggest that mir-375 could be a potential therapeutic target for prevention and intervention of beta-cell dysfunction and beta-mass lose in type 2 diabetes. ..
  79. Liao J, Ma L, Guo Y, Zhang Y, Zhou H, Shao P, et al. Deep sequencing of human nuclear and cytoplasmic small RNAs reveals an unexpectedly complex subcellular distribution of miRNAs and tRNA 3' trailers. PLoS ONE. 2010;5:e10563 pubmed publisher
    ..Our results provide the first comprehensive view of the subcellular distribution of diverse sRNAs and new insights into the roles of miRNAs and tRNA 3' trailers in the cell. ..
  80. Luo H, Zou J, Dong Z, Zeng Q, Wu D, Liu L. Up-regulated miR-17 promotes cell proliferation, tumour growth and cell cycle progression by targeting the RND3 tumour suppressor gene in colorectal carcinoma. Biochem J. 2012;442:311-21 pubmed publisher
    ..In conclusion, the present study suggests that miR-17 plays an important role in CRC carcinogenesis by targeting RND3 and may be a therapeutic agent for CRC. ..
  81. Zhu Y, Lu Y, Zhang Q, Liu J, Li T, Yang J, et al. MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein. Nucleic Acids Res. 2012;40:4615-25 pubmed publisher
    ..Our findings highlight the functional association of miR-26a/b and their host genes and provide new insight into the regulatory network of the G1/S-phase transition. ..
  82. Li H, Ji J, Xie Q, Shang H, Zhang H, Xin X, et al. Aberrant expression of liver microRNA in chickens infected with subgroup J avian leukosis virus. Virus Res. 2012;169:268-71 pubmed publisher
    ..The downregulated miRNAs may play important roles in tumor suppression. This finding paves the way for further exploration of epigenetic influence on tumorigenicity upon ALV-J infection...
  83. Song L, Lin C, Gong H, Wang C, Liu L, Wu J, et al. miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops. Cell Res. 2013;23:274-89 pubmed publisher
    ..These findings uncover a novel mechanism for constitutive NF-κB activation in gliomas and support a functionally and clinically relevant epigenetic mechanism in cancer progression. ..
  84. Lu J, Luo H, Liu X, Peng Y, Zhang B, Wang L, et al. miR-9 targets CXCR4 and functions as a potential tumor suppressor in nasopharyngeal carcinoma. Carcinogenesis. 2014;35:554-63 pubmed publisher
    ..Taken together, our results indicate that miR-9 functions as a tumor-suppressive microRNA in NPC, and that its suppressive effects are mediated chiefly by repressing CXCR4 expression. ..
  85. Wang P, Chen S, Fang H, Wu X, Chen D, Peng L, et al. miR-214/199a/199a* cluster levels predict poor survival in hepatocellular carcinoma through interference with cell-cycle regulators. Oncotarget. 2016;7:929-45 pubmed publisher
    ..Our results demonstrate that miR-214 has tumor-suppressive activity in HCC through inhibition of E2F2, CDK3 and CDK6. ..
  86. Mo X, Cao Q, Liang H, Liu J, Li H, Liu F. MicroRNA-610 suppresses the proliferation of human glioblastoma cells by repressing CCND2 and AKT3. Mol Med Rep. 2016;13:1961-6 pubmed publisher
  87. Jiang X, Li X, Wu F, Gao H, Wang G, Zheng H, et al. Overexpression of miR-92a promotes the tumor growth of osteosarcoma by suppressing F-box and WD repeat-containing protein 7. Gene. 2017;606:10-16 pubmed publisher
    ..In summary, this study demonstrates miR-92a probably functions as a driver of tumor progression by targeting FBXW7, and highlights the potential effects of miR-92a on prognosis and treatment of OS. ..
  88. Yuan T, Zhang H, Lin X, Yu J, Yang Q, Liang Y, et al. microRNA-125b reverses the multidrug resistance of nasopharyngeal carcinoma cells via targeting of Bcl-2. Mol Med Rep. 2017;15:2223-2228 pubmed publisher
    ..Collectively, the results of the present study highlight miR‑125b as a potential therapeutic target for reversing MDR in NPC. ..
  89. Zhang P, Tang W, Zhang H, Li Y, Peng Y, Wang J, et al. MiR-646 inhibited cell proliferation and EMT-induced metastasis by targeting FOXK1 in gastric cancer. Br J Cancer. 2017;117:525-534 pubmed publisher
    ..Furthermore, miR-646 regulated Akt/mTOR signalling after FOXK1. miR-646 inhibited GC cell proliferation and the EMT progression in GC cells by targeting FOXK1. ..
  90. Wen X, Wu S, Li Z, Liu Z, Zhang J, Wang G, et al. Ellagitannin (BJA3121), an anti-proliferative natural polyphenol compound, can regulate the expression of MiRNAs in HepG2 cancer cells. Phytother Res. 2009;23:778-84 pubmed publisher
    ..Our results suggested that BJA3121-modifed miRNA expression can mediate, at least in part, the antiproliferative and multigene regulatory action induced by the compound on HepG(2) cancer cells...
  91. Li J, Huang H, Sun L, Yang M, Pan C, Chen W, et al. MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor. Clin Cancer Res. 2009;15:3998-4008 pubmed publisher
    ..We aim to examine miR-21 expression in tongue squamous cell carcinomas (TSCC) and correlate it with patient clinical status, and to investigate its contribution to TSCC cell growth, apoptosis, and tumorigenesis...
  92. Wu Q, Guo R, Lin M, Zhou B, Wang Y. MicroRNA-200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E-cadherin repressor ZEB2. Gynecol Oncol. 2011;122:149-54 pubmed publisher
    ..Our results suggest that loss of expression of miR-200a may play a critical role in the repression of E-cadherin by ZEB2, thereby enhancing migration and invasion in CD133/1+ cells. ..