Experts and Doctors on gene expression regulation in Guangzhou, Guangdong, China


Locale: Guangzhou, Guangdong, China
Topic: gene expression regulation

Top Publications

  1. He X, Zhang Y, Yu F, Yu Z. A novel sialic acid binding lectin with anti-bacterial activity from the Hong Kong oyster (Crassostrea hongkongensis). Fish Shellfish Immunol. 2011;31:1247-50 pubmed publisher
    ..Thus, these results highlight the essential roles of Ch-salectin in immune recognition and host defense against bacterial infection in C. hongkongensis. ..
  2. Yang Q, Wu J, Li C, Wei Y, Sheng O, Hu C, et al. Quantitative proteomic analysis reveals that antioxidation mechanisms contribute to cold tolerance in plantain (Musa paradisiaca L.; ABB Group) seedlings. Mol Cell Proteomics. 2012;11:1853-69 pubmed publisher
    ..To the best of our knowledge, this is the first report of a global investigation on molecular responses of plantain to cold stress by proteomic analysis...
  3. Chen C, Xie Q, Xue Y, Ji J, Chang S, Ma J, et al. Characterization of cytotoxicity-related gene expression in response to virulent Marek's disease virus infection in the bursa of Fabricius. Res Vet Sci. 2013;94:496-503 pubmed publisher
    ..These results suggest that less sustained cytotoxic activities are generated in the bursa of MDV-infected chickens. The findings of this study provide a more detailed insight into the host cytotoxic responses to MDV infection. ..
  4. Sun Y, Liu G, Li Z, Chen Y, Liu Y, Liu B, et al. Modulation of dendritic cell function and immune response by cysteine protease inhibitor from murine nematode parasite Heligmosomoides polygyrus. Immunology. 2013;138:370-81 pubmed publisher
    ..It also interferes with antigen and MHC-II molecule processing and Toll-like receptor signalling pathway, resulting in functionally deficient DC that induce a suboptimum immune response. ..
  5. He Q, Zeng P, Tan J, Ou T, Gu L, Huang Z, et al. G-quadruplex-mediated regulation of telomere binding protein POT1 gene expression. Biochim Biophys Acta. 2014;1840:2222-33 pubmed publisher
    ..Our results first demonstrated that G-quadruplex formation can affect the binding of transcription factor to its nearby binding site, and thus making additional influence to gene transcription. ..
  6. Liang Y, Yao S. Potential role of estrogen in maintaining the imbalanced sympathetic and sensory innervation in endometriosis. Mol Cell Endocrinol. 2016;424:42-9 pubmed publisher
    ..Theoretical elaboration of the underlying mechanisms provides new insights in supporting the therapeutic role of estrogen in endometriosis-associated pain. ..
  7. Nie Y, Cui D, Pan Z, Deng J, Huang Q, Wu K. HSV-1 infection suppresses TGF-beta1 and SMAD3 expression in human corneal epithelial cells. Mol Vis. 2008;14:1631-8 pubmed
    ..i. compared with normal cells, but TGF-beta2 had no change. TGF-beta1 and SMAD3 may be involved in the pathology of corneal diseases associated with HSV-1 infection. ..
  8. Zhang Y, Liu Y, Huang X, Liu X, Jiao B, Meng Z, et al. Two alternatively spliced GPR39 transcripts in seabream: molecular cloning, genomic organization, and regulation of gene expression by metabolic signals. J Endocrinol. 2008;199:457-70 pubmed publisher
    ..The reciprocal regulatory patterns of expression of these two genes suggest that both of them are involved in controlling the physiological response of the organism during starvation. ..
  9. Lin B, Cao Z, Su P, Zhang H, Li M, Lin Y, et al. Characterization and comparative analyses of zebrafish intelectins: highly conserved sequences, diversified structures and functions. Fish Shellfish Immunol. 2009;26:396-405 pubmed publisher
    ..Moreover, these varied features have evolved multiple times independently in different species, resulting in species-specific protein structures and expression patterns. ..

More Information

Publications325 found, 100 shown here

  1. Chen H, Jiang J. Osmotic responses of Dunaliella to the changes of salinity. J Cell Physiol. 2009;219:251-8 pubmed publisher
    ..It is prospected that future research should pay attention to the specific signal transduction pathway and the mechanism of osmoregulation, and to improve the salt tolerance of higher plants by using salt-tolerant genes of Dunaliella. ..
  2. Ma P, Wang Z, Pflugfelder S, Li D. Toll-like receptors mediate induction of peptidoglycan recognition proteins in human corneal epithelial cells. Exp Eye Res. 2010;90:130-6 pubmed publisher
    ..These findings suggest that human corneal epithelium may response to viral or bacterial infection by producing PGLYRPs through TLRs, and the induction of PGLYRP-2 by dsRNA was through TLR3-TRIF-IRF3-NFkB signaling pathways. ..
  3. Zhuo Y, He Y, Leung K, Hou F, Li Y, Chai F, et al. Dexamethasone disrupts intercellular junction formation and cytoskeleton organization in human trabecular meshwork cells. Mol Vis. 2010;16:61-71 pubmed
    ..Our findings not only provide molecular insights to the pathogenesis of GC-induced glaucoma but also suggest that junctional proteins ZO-1 and Cx43 as well as F-actin are targets for developing new modalities in glaucoma therapy. ..
  4. Zhou S, Xie Z, Xiao O, Yang X, Heng B, Sato Y. Inhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus encoding human vasohibin-1. Mol Vis. 2010;16:1389-98 pubmed
    ..To evaluate the activity of recombinant adenovirus encoding human vasohibin-1 (Ad-Vasohibin-1) on mouse corneal neovasularization induced by alkali burn...
  5. Ling F, Wei L, Wang T, Chen Y, Zhu X, Li J, et al. Cloning and characterization of the 5'-flanking region of the pig cocaine- and amphetamine-regulated transcript gene. DNA Cell Biol. 2011;30:91-7 pubmed publisher
  6. Mao X, Ye J, Zhou S, Pi R, Dou J, Zang L, et al. The effects of chronic copper exposure on the amyloid protein metabolisim associated genes' expression in chronic cerebral hypoperfused rats. Neurosci Lett. 2012;518:14-8 pubmed publisher
    ..In contrast, these Cu-exacerbated changes were ameliorated after Cu was withdrawn from drinking water. In summary, our findings demonstrate that chronic Cu exposure might exacerbate AD pathology in 2VO rats. ..
  7. Wang X, Jiang W, Tan H, Zhang D, Zhang H, Wei S, et al. Effects of breed and dietary nutrient density on the growth performance, blood metabolite, and genes expression of target of rapamycin (TOR) signalling pathway of female broiler chickens. J Anim Physiol Anim Nutr (Berl). 2013;97:797-806 pubmed publisher
    ..05). These findings suggested that different genotypes respond differently to changes in dietary nutrient density and that lower-nutrient-density diets are optimal for the long-term housing of broiler chickens. ..
  8. Wu S, Zhong Z, Chen J. Low-magnitude high-frequency vibration inhibits RANKL-induced osteoclast differentiation of RAW264.7 cells. Int J Med Sci. 2012;9:801-7 pubmed publisher
    ..7 cells (P<0.05). Our results suggest that LMHFV can inhibit the RANKL-induced osteoclast differentiation of RAW264.7 cells, which give some new insight into the anabolic effects of LMHFV on bone. ..
  9. Han P, Jin F, Dong X, Fan J, Qiu B, Ren S. Transcript and protein profiling analysis of the Destruxin A-induced response in larvae of Plutella xylostella. PLoS ONE. 2013;8:e60771 pubmed publisher
    ..Transcript and protein profiling analyses will provide an insight into the potential molecular mechanism of action in P. xylostella larvae in response to dtx A. ..
  10. Lu Y, Denlinger D, Xu W. Polycomb repressive complex 2 (PRC2) protein ESC regulates insect developmental timing by mediating H3K27me3 and activating prothoracicotropic hormone gene expression. J Biol Chem. 2013;288:23554-64 pubmed publisher
    ..We believe this is the first report showing that the PRC2 complex functions as an activator and that a low level of H3K27me3 can prolong lifespan (i.e. induce diapause) by controlling PTTH gene expression in insects. ..
  11. Yan Z, Zhuansun Y, Chen R, Li J, Ran P. Immunomodulation of mesenchymal stromal cells on regulatory T cells and its possible mechanism. Exp Cell Res. 2014;324:65-74 pubmed publisher
    ..Furthermore, this is the first explorative study to evaluate the immunomodulation of MSCs on the suppressive capacity of Tregs in MSC-Treg in vitro coculture setting. ..
  12. Huang M, Zeng S, Qiu Q, Xiao Y, Shi M, Zou Y, et al. Niclosamide induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes. Int Immunopharmacol. 2016;31:45-9 pubmed publisher
    ..Collectively, our results reveal that niclosamide inhibits cell proliferation and induces mitochondrial apoptosis of RAFLSs, which is associated with the modulation of Akt signaling pathways. ..
  13. Yang Q, Qiu H, Xie H, Qi Y, Cha H, Qu J, et al. A Schistosoma japonicum Infection Promotes the Expansion of Myeloid-Derived Suppressor Cells by Activating the JAK/STAT3 Pathway. J Immunol. 2017;198:4716-4727 pubmed publisher
    ..japonicum infection. ..
  14. Huang C, Shi J, Guo Y, Huang W, Huang S, Ming S, et al. A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs. Nucleic Acids Res. 2017;45:8647-8660 pubmed publisher
    ..Taken together, our data revealed a novel function for snoRNAs and provided the first evidence that non-coding RNAs may play an important role in regulating mRNA 3' processing. ..
  15. Tan L, Jia H, Liu R, Wu J, Han H, Zuo Y, et al. Inhibition of NF-kappaB in fusogenic membrane glycoprotein causing HL-60 cell death: implications for acute myeloid leukemia. Cancer Lett. 2009;273:114-21 pubmed publisher
    ..This form of cell death should be effective in vivo, gene therapy basing on FMG deserve further study for the treatment of AML...
  16. Dai Z, Dai X, Xiang Q, Feng J, Deng Y, Wang J. Insights into distinct regulatory modes of nucleosome positioning. BMC Genomics. 2009;10:602 pubmed publisher
    ..We suggest two distinct modes of recruitment of Pol II, which are selectively employed by different genes. ..
  17. Liang J, Liu L, Xing D. Photobiomodulation by low-power laser irradiation attenuates A?-induced cell apoptosis through the Akt/GSK3?/?-catenin pathway. Free Radic Biol Med. 2012;53:1459-67 pubmed publisher
    ..Our data demonstrate that LPLI has a prosurvival effect on A?-induced apoptosis and may be an effective therapeutic strategy in treating AD by targeting GSK3?. ..
  18. Guo J, Shu G, Zhou L, Zhu X, Liao W, Wang S, et al. Selective transport of long-chain fatty acids by FAT/CD36 in skeletal muscle of broilers. Animal. 2013;7:422-9 pubmed publisher
    ..These results suggest that chicken FAT/CD36 may selectively transport LA and AA, which may lead to the higher LA deposition in muscle tissue. ..
  19. Qiu Y, Chen J, Liao H, Zhang Y, Wang H, Li S, et al. Tim-3-expressing CD4+ and CD8+ T cells in human tuberculosis (TB) exhibit polarized effector memory phenotypes and stronger anti-TB effector functions. PLoS Pathog. 2012;8:e1002984 pubmed publisher
    ..This study therefore uncovered a previously unknown mechanism for T-cell immune responses regulated by Tim-3, and findings may have implications for potential immune intervention in TB. ..
  20. Huang C, Zhang Y, Wang J, Jiang J, Bao J. MCP-1 impacts RCT by repressing ABCA1, ABCG1, and SR-BI through PI3K/Akt posttranslational regulation in HepG2 cells. J Lipid Res. 2013;54:1231-40 pubmed publisher
    ..Our data suggest that MCP-1 impairs RCT activity in HepG2 cells by a PI3K/Akt-mediated posttranslational regulation of ABCA1, ABCG1, and SR-BI cell-surface expression...
  21. Qiu F, Huang D, Xiao H, Qiu F, Lu L, Nie J. Detection of tyrosine?phosphorylated proteins in hepatocellular carcinoma tissues using a combination of GST?Nck1?SH2 pull?down and two?dimensional electrophoresis. Mol Med Rep. 2013;7:1209-14 pubmed publisher
    ..The optimized method offers a rapid, efficient alternative for the high?quantity screening of tyrosine-phosphorylated protein expression and solubility, which in turn facilitates future studies on tyrosine-phosphorylated proteins. ..
  22. Zeng X, Cheng Y, Qu Y, Xu J, Han Z, Zhang T. Curcumin inhibits the proliferation of airway smooth muscle cells in vitro and in vivo. Int J Mol Med. 2013;32:629-36 pubmed publisher
  23. Xu L, Li Z, Hong C, He J, Ma J, Xiang D, et al. [Expression of B7-related protein-1 on human coronary artery endothelial cells and its clinical significance]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29:1623-5 pubmed
    ..05). B7RP-1 is expressed on the membrane of HCAECs. ox-LDL can promote up-regulate the expression of B7RP-1, which might be one of the immunopathogenesis of atherosclerosis. ..
  24. Cai J, Li W, Su H, Qin D, Yang J, Zhu F, et al. Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells. J Biol Chem. 2010;285:11227-34 pubmed publisher
  25. Tan Y, Liang H, Chen A, Guo X. Coexpression of double or triple copies of the rabies virus glycoprotein gene using a 'self-cleaving' 2A peptide-based replication-defective human adenovirus serotype 5 vector. Biologicals. 2010;38:586-93 pubmed publisher
  26. Ding N, Wang F, Han Y, Xiao H, Xu L, She S. Mitogen-activated protein kinase kinase 6 mediates mechanical stretch-induced high-mobility group box 1 protein expression in pulmonary alveolar epithelial cells. J Trauma Acute Care Surg. 2012;72:162-8 pubmed publisher
    ..We also found that the level of HMGB1 expression was positively correlated with cytokine abundance. Mechanical stretch can induce HMGB1 and cytokine expression in A549 cells by activating MKK6. ..
  27. Tang J, Chen X, Tu W, Guo Y, Zhao Z, Xue Q, et al. Propofol inhibits the activation of p38 through up-regulating the expression of annexin A1 to exert its anti-inflammation effect. PLoS ONE. 2011;6:e27890 pubmed publisher
    ..Therefore, it can be speculated that Annexin A1 might be the key signaling protein in the in vivo and in vitro anti-inflammatory mechanisms of propofol. ..
  28. Liu S, Zhu W, Li S, Ma J, Zhang H, Li Z, et al. Bovine parathyroid hormone enhances osteoclast bone resorption by modulating V-ATPase through PTH1R. Int J Mol Med. 2016;37:284-92 pubmed publisher
    ..Thus, we propose that PTH has a direct effect on osteoblasts and osteoclasts, and that this effect is mediated through PTH1R, thus contributing to bone remodeling. ..
  29. Liu X, Lu H, Chen T, Nallaparaju K, Yan X, Tanaka S, et al. Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation. Cell Rep. 2016;14:1735-1747 pubmed publisher
    ..Thus, our study systemically examines Bcl6-controlled regulatory networks and provides important insights into Bcl6's biological functions in Tfh cells. ..
  30. Xing L, Guo H, Wang D, Sun L, Pan S. Protective effects and mechanisms of Ndfipl on SH-SY5Y cell apoptosis in an in vitro Parkinson's disease model. Genet Mol Res. 2016;15: pubmed publisher
    ..Additionally, the expression of Ndfipl reduced expression of ?-synuclein. In conclusion, Ndfipl plays a significant role in protecting SH-SY5Y cells in in vitro Parkinson's disease models. ..
  31. Tang W, Pan Q, Sun F, Ma J, Tang S, Le K, et al. Involvement of Sp1 binding sequences in basal transcription of the rat fibroblast growth factor-2 gene in neonatal cardiomyocytes. Life Sci. 2009;84:421-7 pubmed publisher
    ..Lastly, ChIP analyses revealed that Sp1 binds to the FGF-2 promoter region in vivo. These results indicate that expression of FGF-2 in neonatal rat cardiomyocytes is associated with Sp1 binding to the FGF-2 promoter. ..
  32. Guo X, Zheng S, Liu L, Feng Q. The sterol carrier protein 2/3-oxoacyl-CoA thiolase (SCPx) is involved in cholesterol uptake in the midgut of Spodoptera litura: gene cloning, expression, localization and functional analyses. BMC Mol Biol. 2009;10:102 pubmed publisher
    ..All of these results taken together suggest that this midgut-specific SlSCPx gene is important for cholesterol uptake and normal development in S. litura...
  33. Xu G, Zhang L, Wang D, Xu R, Liu Z, Han D, et al. Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells. Allergy. 2010;65:581-9 pubmed publisher
    ..Despite of the opposing effects of IL-17A and IL-25 on TSLP regulation in HNECs, IL-25 was dominant to IL-17A, providing a plausible explanation for the simultaneous upregulation of IL-17 cytokines and TSLP in patients with AR. ..
  34. Zhang D, Jiang S, Hu Y, Cui S, Guo H, Wu K, et al. A multidomain galectin involved in innate immune response of pearl oyster Pinctada fucata. Dev Comp Immunol. 2011;35:1-6 pubmed publisher
    ..alginolyticus stimulation. These results suggested that PoGal was a constitutive and inducible acute-phase protein that perhaps involved in innate immune response of pearl oyster. ..
  35. Liao X, Wang Y, Wong C. Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor ? co-activator-1? protein. Br J Pharmacol. 2010;161:771-81 pubmed publisher
    ..Collectively, these results suggest that PGC-1? degradation is an important mechanism behind the cytotoxic effects of Tro in the liver. ..
  36. Xu J, Li H, Wang B, Xu Y, Yang J, Zhang X, et al. VHL inactivation induces HEF1 and Aurora kinase A. J Am Soc Nephrol. 2010;21:2041-6 pubmed publisher
    ..Suppression of this pathway improved the formation of primary cilia and reduced cell motility in VHL-defective renal cancer cells. Our results highlight the gatekeeper role of VHL in the kidney epithelium. ..
  37. Wang Y, Wu Z, Li D, Wang D, Wang X, Feng X, et al. Involvement of oxygen-regulated protein 150 in AMP-activated protein kinase-mediated alleviation of lipid-induced endoplasmic reticulum stress. J Biol Chem. 2011;286:11119-31 pubmed publisher
    ..Our results reveal a novel mechanism by which AMPK regulates ER homeostasis in hepatocytes and suggest that AMPK has a protective role against hypercholesterolemia-related liver damage. ..
  38. Li H, Xi Q, Xiong Y, Cheng X, Qi Q, Yang L, et al. A comprehensive expression profile of microRNAs in porcine pituitary. PLoS ONE. 2011;6:e24883 pubmed publisher
    ..The pituitary gland contains unexpectedly many miRNA types and miRNA actions are involved in important processes for both the development and function of the organ...
  39. Xu H, He X, Fang M, Hu Y, Jia X, Nie Q, et al. Molecular cloning, expression and variation analyses of the dopamine D2 receptor gene in pig breeds in China. Genet Mol Res. 2011;10:3371-84 pubmed publisher
    ..Sixty-one different sequences were identified in this gene; among seven in the coding region, only one altered the encoded amino acid. These findings will help us understand the functions of the DRD2 gene in pigs. ..
  40. Ju W, Zhihong Y, Zhiyou Z, Qin H, Dingding W, Li S, et al. Inhibition of ?-SMA by the ectodomain of FGFR2c attenuates lung fibrosis. Mol Med. 2012;18:992-1002 pubmed publisher
    ..The expression levels of ?-SMA, p-FGFRs, p-ERK1/2 and p-Smad3 in the lungs of sFGFR2c-treated mice were markedly lower. sFGFR2c may have potential for the treatment of lung fibrosis as an FGF-2 antagonist. ..
  41. Shi C, Wu F, Zhu X, Xu J. Incorporation of beta-sitosterol into the membrane increases resistance to oxidative stress and lipid peroxidation via estrogen receptor-mediated PI3K/GSK3beta signaling. Biochim Biophys Acta. 2013;1830:2538-44 pubmed
    ..Given that BS is prevalent in foods such as plant oil, the results provide a better understanding of the beneficial effects of these BS-enriched nutrients on neurodegenerative diseases such as AD. ..
  42. Chen S, Fan Q, Li A, Liao D, Ge J, Laties A, et al. Dynamic mobilization of PGC-1? mediates mitochondrial biogenesis for the protection of RGC-5 cells by resveratrol during serum deprivation. Apoptosis. 2013;18:786-99 pubmed publisher
  43. Xu Y, Lai E, Liu J, Lin J, Yang C, Jia C, et al. IKK interacts with rictor and regulates mTORC2. Cell Signal. 2013;25:2239-45 pubmed publisher
    ..Inactivated IKK interacted with rictor and competed against mTOR, which resulted in a reduced mTORC2 level and a decrease in mTORC2 activity. ..
  44. Jia Q, Wang J, Long J, Zhao Y, Chen S, Zhai J, et al. Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-κB activation and MCP-1 and TGF-β1 expression in rat mesangial cells. Molecules. 2013;18:13061-77 pubmed publisher
    ..These findings suggest that SLs and their derivatives have potential as candidate drugs for the treatment of DN. ..
  45. Li H, Gao S, Ye J, Feng X, Cai Y, Liu Z, et al. COX-2 is involved in ET-1-induced hypertrophy of neonatal rat cardiomyocytes: role of NFATc3. Mol Cell Endocrinol. 2014;382:998-1006 pubmed publisher
    ..These findings provided further insight into the roles of ET-1 in cardiac hypertrophy and suggested a potential therapeutic strategy against cardiac hypertrophy by inhibiting COX-2. ..
  46. Yin H, Pantazatos S, Galfalvy H, Huang Y, ROSOKLIJA G, Dwork A, et al. A pilot integrative genomics study of GABA and glutamate neurotransmitter systems in suicide, suicidal behavior, and major depressive disorder. Am J Med Genet B Neuropsychiatr Genet. 2016;171B:414-426 pubmed publisher
    ..03) in a SNP that may be an eQTL in prefrontal cortex (rs424740, P?=?0.02). These preliminary results implicate GABRG2 in suicide and warrant further investigation and replication in larger samples. ..
  47. Gao Z, Huo L, Cui D, Yang X, Zeng J. The Expression of Bone Morphogenetic Protein 2 and Matrix Metalloproteinase 2 through Retinoic Acid Receptor Beta Induced by All-Trans Retinoic Acid in Cultured ARPE-19 Cells. PLoS ONE. 2016;11:e0150831 pubmed publisher
    ..The upregulation of RARβ and the ATRA-induced secretion in ARPE-19 cells could be inhibited by the RARβ antagonist LE135. ATRA induced upregulation of RARβ in ARPE-19 cells and stimulated these cells to secrete BMP-2 and MMP-2. ..
  48. Zhou Z, Wan J, Hou X, Geng J, Li X, Bai X. MicroRNA-27a promotes podocyte injury via PPAR?-mediated ?-catenin activation in diabetic nephropathy. Cell Death Dis. 2017;8:e2658 pubmed publisher
    ..We propose a novel role of the miR-27a/PPAR?/?-catenin axis in fostering the progression toward more deteriorated podocyte injury in DN. Targeting miR-27a could be a potential therapeutic approach for DN. ..
  49. Li C, McFadden S, Morgan I, Cui D, Hu J, Wan W, et al. All-trans retinoic acid regulates the expression of the extracellular matrix protein fibulin-1 in the guinea pig sclera and human scleral fibroblasts. Mol Vis. 2010;16:689-97 pubmed
    ..Further studies on the role of fibulin-1 in the regulation of eye growth, including during the development of myopia, are therefore warranted...
  50. Ke Q, Wang X, Gao Q, Wu Z, Wan P, Zhan W, et al. Carrier-free epithelial cell sheets prepared by enzymatic degradation of collagen gel. J Tissue Eng Regen Med. 2011;5:138-45 pubmed publisher
    ..This novel method of using collagenase to degrade collagen gel is both simple and effective in preparing intact carrier-free epithelial cell sheets. Such sheets have great potential for application during in vivo corneal regeneration. ..
  51. Zhou K, Gao Q, Zheng S, Pan S, Li P, Suo K, et al. 17?-estradiol induces vasorelaxation by stimulating endothelial hydrogen sulfide release. Mol Hum Reprod. 2013;19:169-76 pubmed publisher
    ..009). In conclusion, the endothelial CSE/H(2)S pathway is activated by E(2) through PKG, which leads to vasodilation. These actions may be relevant to estrogen's anti-atherogenic effect. ..
  52. Deng S, Wang M, Yan Z, Tian Z, Chen H, Yang X, et al. Autophagy in retinal ganglion cells in a rhesus monkey chronic hypertensive glaucoma model. PLoS ONE. 2013;8:e77100 pubmed publisher
    ..Our results suggested that autophagy was activated in RGCs in the chronic hypertensive glaucoma model of rhesus monkeys and that autophagy may have potential as a new target for intervention in glaucoma treatment. ..
  53. Nai W, Threapleton D, Lu J, Zhang K, Wu H, Fu Y, et al. Identification of novel genes and pathways in carotid atheroma using integrated bioinformatic methods. Sci Rep. 2016;6:18764 pubmed publisher
    ..All in all, identification of these genes and pathways not only provides new insights into the pathogenesis of atherosclerosis, but may also aid in the development of prognostic and therapeutic biomarkers for advanced atheroma. ..
  54. Liang X, Duan N, Wang Y, Shu S, Xiang X, Guo T, et al. Advanced oxidation protein products induce endothelial-to-mesenchymal transition in human renal glomerular endothelial cells through induction of endoplasmic reticulum stress. J Diabetes Complications. 2016;30:573-9 pubmed publisher
    ..Collectively, our results indicate that AOPPs trigger EndMT in HRGECs through the induction of ER stress. These findings suggest novel therapeutic strategies for inhibiting renal fibrosis by targeting ER stress. ..
  55. Li B, Xia L, Liu J, Liao L, Zhang Y, Deng M, et al. miR-758-5p regulates cholesterol uptake via targeting the CD36 3'UTR. Biochem Biophys Res Commun. 2017;494:384-389 pubmed publisher
    ..Therefore, targeting miR-758-5p may offer a promising strategy to treat atherosclerotic vascular disease...
  56. Wang J, Zeng Y, Liu R, Huang W, Xiong Y, Wang Y, et al. Recombinant adenovirus vector-mediated functional expression of neurotropin-3 receptor (TrkC) in neural stem cells. Exp Neurol. 2007;203:123-7 pubmed
    ..2% vs. 29.8%; P<0.05, chi(2) test). Thus, our rAd-TrkC vector can transfect NSCs and produce functional TrkC receptors to promote neuronal differentiation of NSCs. ..
  57. Alasaad S, Li Q, Lin R, Martín Atance P, Granados J, Díez Baños P, et al. Genetic variability among Fasciola hepatica samples from different host species and geographical localities in Spain revealed by the novel SRAP marker. Parasitol Res. 2008;103:181-6 pubmed publisher
    ..hepatica. To our knowledge, this is the first application of SRAP marker to study genetic variation in parasites of human and animal health significance. ..
  58. Liu Q, Mao H, Nie J, Chen W, Yang Q, Dong X, et al. Transforming growth factor {beta}1 induces epithelial-mesenchymal transition by activating the JNK-Smad3 pathway in rat peritoneal mesothelial cells. Perit Dial Int. 2008;28 Suppl 3:S88-95 pubmed
    ..This study demonstrated that JNK signaling may play an important role in EMT induced by TGFbeta1 in RPMCs through activation of Smad3, suggesting that JNK inhibitor may prove to be a novel therapeutic agent for peritoneal fibrosis. ..
  59. Chen W, Li W, Lin H. Common carp (Cyprinus carpio) insulin-like growth factor binding protein-2 (IGFBP-2): molecular cloning, expression profiles, and hormonal regulation in hepatocytes. Gen Comp Endocrinol. 2009;161:390-9 pubmed publisher
    ..It is suggested that the MAPK and PI3 kinase-signaling pathways were involved in the decrease of IGFBP-2 mRNA expression induced by GH in primary cultured hepatocytes. ..
  60. Lu W, Ran P, Zhang D, Peng G, Li B, Zhong N, et al. Sildenafil inhibits chronically hypoxic upregulation of canonical transient receptor potential expression in rat pulmonary arterial smooth muscle. Am J Physiol Cell Physiol. 2010;298:C114-23 pubmed publisher
  61. Ye X, Zhang L, Tian Y, Tan A, Bai J, Li S. Identification and expression analysis of the g-type and c-type lysozymes in grass carp Ctenopharyngodon idellus. Dev Comp Immunol. 2010;34:501-9 pubmed publisher
    ..These two types of lysozymes likely use different mechanisms to regulate their expressions. ..
  62. Wu B, Zhang W, Huang J, Liu H, Zhang T. Effect of recombinant Panton-Valentine leukocidin in vitro on apoptosis and cytokine production of human alveolar macrophages. Can J Microbiol. 2010;56:229-35 pubmed publisher
    ..Therefore, we speculated that PVL could play a negative role in HAM function at lower concentrations. ..
  63. Qi X, Teng Y, Yoon Y, Kim D, Cai D, Lee K. Reactive oxygen species are involved in the IFN-?-stimulated production of Th2 chemokines in HaCaT keratinocytes. J Cell Physiol. 2011;226:58-65 pubmed publisher
    ..These results indicate that intracellular ROS and JAKs/p38 MAPK both contribute independently to IFN-?-stimulated production of TARC and MDC in HaCaT keratinocytes, by increasing NF-?B activation. ..
  64. Duan L, Li X, Ouyang L, Quan D, Zheng Q, Ma J, et al. Synthesis of a novel CS-g-MMCs conjugate and the inhabitation on the proliferation of Tenon's capsule fibroblasts in vitro. Eur J Pharm Sci. 2012;46:357-66 pubmed publisher
    ..05). Our results primarily demonstrated that the CS-g-MMCs conjugates have low cytotoxicity and have the effect to inhibit fibroblast proliferation. ..
  65. Yu X, Geng Y, Liang J, Zhang S, Lei H, Zhong S, et al. High levels of glucose induce "metabolic memory" in cardiomyocyte via epigenetic histone H3 lysine 9 methylation. Mol Biol Rep. 2012;39:8891-8 pubmed publisher
  66. Gan J, Zhang D, He D, Zhang X, Chen Z, Luo Q. Promoter methylation negatively correlated with mRNA expression but not tissue differential expression after heat stress. Genet Mol Res. 2013;12:809-19 pubmed publisher
  67. Ding N, Wang F, Xiao H, Xu L, She S. Mechanical ventilation enhances HMGB1 expression in an LPS-induced lung injury model. PLoS ONE. 2013;8:e74633 pubmed publisher
    ..The findings indicated that moderate tidal volume MV augmented LPS induced lung injury by up-regulating HMGB1. The mechanism of HMGB1-mediated lung injury is likely to be signaling through p38 and NF-?B pathways. ..
  68. Xie L, Tang Q, Yang L, Chen L. Insulin-like growth factor I promotes oocyte maturation through increasing the expression and phosphorylation of epidermal growth factor receptor in the zebrafish ovary. Mol Cell Endocrinol. 2016;419:198-207 pubmed publisher
    ..This study sheds light on the cross-talk between two important growth factors in the zebrafish ovary and the mechanism underlying the IGF-I induction on oocyte maturation. ..
  69. Zhang Z, Yuan K, Yue H, Yuan F, Bi H, Weng S, et al. Identification and functional characterization of an endoplasmic reticulum oxidoreductin 1-α gene in Litopenaeus vannamei. Dev Comp Immunol. 2016;57:10-9 pubmed publisher
    ..These results suggested that LvERO1-α plays a critical role in WSSV-induced apoptosis, which likely occurs through the WSSV-activated PERK-eIF2α pathway. ..
  70. Jiang Z, Xiao R. [Effects of Dengue virus infection on PGIS expression and PGI2 secretion of human vascular endothelial cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007;23:48-51 pubmed
    ..The dysfunction of vascular endothelial cell (EC) induced by DV may be related to the pathogenesis of Dengue haemorrhagic fever (DHF) and Dengue shock syndrome(DSS). ..
  71. Chen L, Jiang Q, Zhu X, Shu G, Bin Y, Wang X, et al. Ghrelin ligand-receptor mRNA expression in hypothalamus, proventriculus and liver of chicken (Gallus gallus domesticus): studies on ontogeny and feeding condition. Comp Biochem Physiol A Mol Integr Physiol. 2007;147:893-902 pubmed
    ..These results suggest that the expression pattern of ghrelin and its receptor mRNAs distinctly change in tissues depending on ontogenic stages and feeding states in poultry. ..
  72. Ling F, Li J, Chen Y, Du H, Mei Y, Mo D, et al. Cloning and characterization of the 5'-flanking region of the pig adiponectin gene. Biochem Biophys Res Commun. 2009;381:236-40 pubmed publisher
    ..These results indicated that CREB is an essential regulatory factor for the transcriptional activity of pig adiponectin. ..
  73. Ling F, Li J, Wang C, Liu C, Du H, Xiao Z, et al. [Methylation status of pig adiponectin promoter and its expression]. Yi Chuan. 2009;31:1013-9 pubmed
    ..These results suggested that the methylation of this gene experienced a dynamic process, with the development of individuals, which agreed with the fluctuating trend of gene expression. ..
  74. Deng X, Yang W, Huang Y, Cao Y, Wen S, Xia Q, et al. Gene expression divergence and evolutionary analysis of the drosomycin gene family in Drosophila melanogaster. J Biomed Biotechnol. 2009;2009:315423 pubmed publisher
    ..The possible evolutionary fates of drosomycin genes were discussed according to the combining analysis of gene expression pattern, gene structure, and functional divergence of these genes. ..
  75. Chen J, Xiao S, Yu Z. F-type lectin involved in defense against bacterial infection in the pearl oyster (Pinctada martensii). Fish Shellfish Immunol. 2011;30:750-4 pubmed publisher
    ..These results suggest that PmF-lectin is a member of the F-lectin family and is involved in the innate immune response in pearl oyster. ..
  76. Lin Z, Huang H, Gu Y, Huang K, Hu Y, Ji Z, et al. Glibenclamide ameliorates cerebral edema and improves outcomes in a rat model of status epilepticus. Neuropharmacology. 2017;121:1-11 pubmed publisher
    ..The salutary effects of GBC were correlated to the alleviation of cerebral edema and reduction in neurological injury via down-regulation of SUR1-TRPM4 channel. ..
  77. Lin B, Chen S, Cao Z, Lin Y, Mo D, Zhang H, et al. Acute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: striking similarities and obvious differences with mammals. Mol Immunol. 2007;44:295-301 pubmed
    ..Our results constitute the first demonstration of a similar while different immune response in zebrafish and open new avenues for the investigation of evolutionary conserved and fish specific mechanisms of innate immunity...
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    ..88+/-1.53 and 16.03+/-4.08, respectively. ox-LDL increased expression of ICOSL mRNA and protein(P<0.05). ICOSL can express on the HCAEC. ox-LDL can up-regulate the expression of ICOSL. ..
  79. He X, Zhang Y, Yu Z. An Mpeg (macrophage expressed gene) from the Pacific oyster Crassostrea gigas: molecular characterization and gene expression. Fish Shellfish Immunol. 2011;30:870-6 pubmed publisher
    ..Moreover, Mpeg1 mRNA levels are significantly up-regulated following infection with Vibrio alginolyticus. These results highlight that Cg-Mpeg1 plays an essential role in host defense and elimination of pathogens in C. gigas. ..
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    ..These results contribute to the understanding of the genetic makeup of S. scrofa transcriptome and provide useful information for functional genomic research in future. ..
  81. Huang Y, Huang X, Yan Y, Cai J, Ouyang Z, Cui H, et al. Transcriptome analysis of orange-spotted grouper (Epinephelus coioides) spleen in response to Singapore grouper iridovirus. BMC Genomics. 2011;12:556 pubmed publisher
    ..In this study, we used a 454 pyrosequencing method to investigate differentially-expressed genes in the spleen of the E. coioides infected with Singapore grouper iridovirus (SGIV)...
  82. Xu J, Kang Y, Liao W, Yu L. MiR-194 regulates chondrogenic differentiation of human adipose-derived stem cells by targeting Sox5. PLoS ONE. 2012;7:e31861 pubmed publisher
    ..These findings, taken together, are the first to illustrate the critical role of miR-194 in hASC chondrogenesis, and may provide novel insight beneficial to cell manipulation methods during cartilage regeneration. ..
  83. Wang X, Moreno Y, Wu H, Ma C, Li Y, Zhang J, et al. Proteomic profiles of soluble proteins from the esophageal gland in female Meloidogyne incognita. Int J Parasitol. 2012;42:1177-83 pubmed publisher
    ..This global proteomic profile of SPEGC provides a basis for future studies to elucidate the functions of proteins secreted from female M. incognita on plant responses. ..
  84. Wang H, Chen H, Chen K, Xiao J, He K, Xiang G, et al. Highly expressed MT-ND3 positively associated with histological severity of hepatic steatosis. APMIS. 2014;122:443-51 pubmed publisher
    ..Taken together, MT-ND3 may play important roles in hepatic steatosis progress. Hypoxia, oxidative stress, and lipotoxicity could all influence expression of MT-ND3 and thus may play a role in the progression of hepatic steatosis. ..
  85. Yuan F, Chen Y, Zhang Z, Yue H, Bi H, Yuan K, et al. Down-regulation apoptosis signal-regulating kinase 1 gene reduced the Litopenaeus vannamei hemocyte apoptosis in WSSV infection. Fish Shellfish Immunol. 2016;50:109-16 pubmed publisher
    ..vannamei. These results suggested that down-regulation of LvASK1 decreased the apoptotic rate of hemocytes in WSSV-infected shrimp, and that it could contribute to the reduction of cumulative mortality in WSSV-infected L. vannamei. ..
  86. Fang Y, Li L, Wu Q. [Effects of beta-asaron on gene expression in mouse brain]. Zhong Yao Cai. 2003;26:650-2 pubmed
    ..beta-asaron has effects on multi-target genes in mouse brain. ..
  87. Li Y. Alterations in the expression pattern of TCR zeta chain in T cells from patients with hematological diseases. Hematology. 2008;13:267-75 pubmed publisher
  88. Ling F, Fang W, Chen Y, Li J, Liu X, Wang L, et al. Identification of novel transcripts from the porcine MYL1 gene and initial characterization of its promoters. Mol Cell Biochem. 2010;343:239-47 pubmed publisher
  89. Zhu G, Lu C, Chen C, Feng P, Ma H, Lu R, et al. Pathogenicity of Ureaplasma urealyticum and Ureaplasma parvum in the lower genital tract of female BALB/c mice. Can J Microbiol. 2011;57:987-92 pubmed publisher
    ..The five serotypes tested were all found to be pathogenic, and the pathogenicity varied with serotype 4 showing the greatest pathogenicity...
  90. Chen J, Chen J, Wang J, Kuang J, Shan W, Lu W. Molecular characterization and expression profiles of MaCOL1, a CONSTANS-like gene in banana fruit. Gene. 2012;496:110-7 pubmed publisher
    ..Taken together, our results suggest that MaCOL1 is a transcription activator and may be involved in fruit ripening and stress responses. ..
  91. Zhang R, Fang H, Chen Y, Shen J, Lu H, Zeng C, et al. Gene expression analyses of subchondral bone in early experimental osteoarthritis by microarray. PLoS ONE. 2012;7:e32356 pubmed publisher
    ..These genes may be novel diagnostic markers or therapeutic targets for OA. ..
  92. Nie Y, Wu H, Li P, Xie L, Luo Y, Shen J, et al. Naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-I?B-NF-?B signaling pathways. Eur J Pharmacol. 2012;690:207-13 pubmed publisher
    ..These results indicated that naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs/AP-1 and IKKs/I?B/NF-?B signaling pathways. ..