Experts and Doctors on neuroprotective agents in Fuzhou, Fujian, China


Locale: Fuzhou, Fujian, China
Topic: neuroprotective agents

Top Publications

  1. Liu R, Wang W, Song N, Chen Y, Li L. Diazoxide preconditioning plus subsequent hypothermia increased resistance of rat cultured hippocampal neurons against hypoxia-reoxygenation injury. Chin Med J (Engl). 2006;119:887-93 pubmed
    ..Compared with either individual hypothermia or DZ preconditioning, the combination of both treatments conferred synergistic protection for cultured hippocampal neurons in vitro against hypoxia-reoxygenation insult. ..
  2. Chen X, Chen Y, Zhu Y, Fang F, Chen L. Protective effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons. Acta Pharmacol Sin. 2002;23:829-34 pubmed
    ..01). Rg1 has protective effect against MPTP-induced apoptosis and this effect may be attributed to enhancing Bcl-2 and Bcl-xl expression, reducing Bax and iNOS expression, and inhibiting activation of caspase-3. ..
  3. Que J, Ye M, Zhang Y, Xu W, Li H, Xu W, et al. Bryonolic Acid, a Triterpenoid, Protect Against N-methyl-d-Aspartate-Induced Neurotoxicity in PC12 Cells. Molecules. 2016;21:418 pubmed publisher
    ..Therefore, the present study supports the notion that BA may be a promising neuroprotective agent for the treatment of cerebral ischemia disease. ..
  4. Xu A, Zheng G, Wang Z, Chen X, Jiang Q. Neuroprotective effects of Ilexonin A following transient focal cerebral ischemia in rats. Mol Med Rep. 2016;13:2957-66 pubmed publisher
    ..The results of the present study suggested that the protective effects of Ilexonin A were associated with revascularization, neuronal regeneration, and the regulation of astrocyte and microglia cell activation. ..
  5. Tu X, Yang W, Shi S, Wang C, Chen C. Neuroprotective effect of baicalin in a rat model of permanent focal cerebral ischemia. Neurochem Res. 2009;34:1626-34 pubmed publisher
    ..This protection might be associated with the downregulated expression of iNOS mRNA, COX-2 mRNA, and cleaved caspase-3 protein. ..
  6. Li H, Wu S, Shi N, Lin W, You J, Zhou W. NF-E2-related factor 2 activation in PC12 cells: its protective role in manganese-induced damage. Arch Toxicol. 2011;85:901-10 pubmed publisher
    ..Taken together, these findings suggest that Nrf2 may play an important role in the protection of PC12 cells against MnCl(2) neurotoxicity. ..
  7. Zhao J, Cheng Y, Yang C, Lau S, Lao L, Shuai B, et al. Botanical Drug Puerarin Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Neurotoxicity via Upregulating Mitochondrial Enzyme Arginase-2. Mol Neurobiol. 2016;53:2200-11 pubmed publisher
    ..Thus, puerarin is a useful lead for suppressing NO-mediated neurotoxicity in neurodegenerative diseases. Graphical Abstract Arginase-2 dependent mechanism underlying the neuroprotective activity of puerarin. ..
  8. Zheng K, Zhang J, Zhang C, Zhang Y, Chen X. Curcumin inhibits appoptosin-induced apoptosis via upregulating heme oxygenase-1 expression in SH-SY5Y cells. Acta Pharmacol Sin. 2015;36:544-52 pubmed publisher
    ..Curcumin inhibits appoptosin-induced apoptosis in SH-SY5Y cells by upregulating the expression of HO-1, reducing the production of intracellular heme and ROS, and preventing the ΔΨm loss. ..
  9. Li H, Wu S, Wang Z, Lin W, Zhang C, Huang B. Neuroprotective effects of tert-butylhydroquinone on paraquat-induced dopaminergic cell degeneration in C57BL/6 mice and in PC12 cells. Arch Toxicol. 2012;86:1729-40 pubmed publisher

More Information


  1. Ye Q, Zhang X, Huang B, Zhu Y, Chen X. Astaxanthin suppresses MPP(+)-induced oxidative damage in PC12 cells through a Sp1/NR1 signaling pathway. Mar Drugs. 2013;11:1019-34 pubmed publisher
    ..Moreover, cell immunofluorescence revealed that ATX could suppress Sp1 nuclear transfer. ATX inhibited oxidative stress induced by MPP+ in PC12 cells, via the SP1/NR1 signaling pathway. ..
  2. Liu X, Wang L, Chen Z, Liu L. Liraglutide prevents beta-amyloid-induced neurotoxicity in SH-SY5Y cells via a PI3K-dependent signaling pathway. Neurol Res. 2016;38:313-9 pubmed publisher
    ..Thus, liraglutide may be a preventive or therapeutic agent for Alzheimer's disease. ..
  3. Liu W, Shang G, Yang S, Huang J, Xue X, Lin Y, et al. Electroacupuncture protects against ischemic stroke by reducing autophagosome formation and inhibiting autophagy through the mTORC1-ULK1 complex-Beclin1 pathway. Int J Mol Med. 2016;37:309-18 pubmed publisher
    ..These results suggest that EA protects against ischemic stroke through the inhibition of autophagosome formation and autophagy, which is mediated through the mTORC1-ULK complex-Beclin1 pathway. ..
  4. Ye Q, Huang B, Zhang X, Zhu Y, Chen X. Astaxanthin protects against MPP(+)-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis. BMC Neurosci. 2012;13:156 pubmed publisher
    ..ATX suppresses MPP(+)-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis. ATX should be strongly considered as a potential neuroprotectant and adjuvant therapy for patients with Parkinson's disease. ..
  5. Huang T, Fang F, Chen L, Zhu Y, Zhang J, Chen X, et al. Ginsenoside Rg1 attenuates oligomeric A?(1-42)-induced mitochondrial dysfunction. Curr Alzheimer Res. 2012;9:388-95 pubmed
    ..This finding suggests that ginsenoside Rg1 may attenuate A?-induced neuronal death through the suppression of intracellular mitochondrial oxidative stress and may rescue neurons in AD. ..
  6. Zheng G, Shi W, Chen X, Zhu Y, Zhang J, Jiang Q. [Influence of ilexonin A on the expression of bFGF, GAP-43 and neurogenesis after cerebral ischemia-reperfusion in rats]. Yao Xue Xue Bao. 2011;46:1065-71 pubmed
    ..The possible mechanism of protecting neuronal injury of IA may be related to inhibition on neuronal apoptosis, upregulation of bFGF and GAP-43, and neurogenesis in boundary zone of infarction after cerebral ischemia-reperfusion. ..
  7. Pan X, Chen X, Zhu Y, Chen L, Zhang J, Huang T, et al. Tripchlorolide protects neuronal cells from microglia-mediated beta-amyloid neurotoxicity through inhibiting NF-kappaB and JNK signaling. Glia. 2009;57:1227-38 pubmed publisher
    ..Therefore, T4 may be an effective agent in modulating neuroinflammatory process in AD. ..
  8. Tu X, Yang W, Wang C, Shi S, Zhang Y, Chen C, et al. Zileuton reduces inflammatory reaction and brain damage following permanent cerebral ischemia in rats. Inflammation. 2010;33:344-52 pubmed publisher
    ..The neuroprotective effect of zileuton in cerebral ischemia might be associated with the inhibition of inflammatory reaction. ..
  9. Chen X, Huang T, Zhang J, Song J, Chen L, Zhu Y. Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons. Brain Res. 2008;1200:99-106 pubmed publisher
    ..The present study suggests that Ca(2+), calpain, and p25 in CDK5 pathway may play important roles in Abeta(25-35)-induced tau hyperphosphorylation. ..
  10. Wang P, Ren R, Cai S, Chen X, Ye L. [Neuroprotective effects of topiramate and folic acid on young rats with kindling-induced epilepsy]. Zhongguo Dang Dai Er Ke Za Zhi. 2008;10:65-9 pubmed
    ..TPM has protective effects against epilepsy-induced neuronal damage. The effect is dose-dependent. A combination of TPM and FA can produce a synergistic effect. ..