Experts and Doctors on humans in Xiamen, Fujian, China

Summary

Locale: Xiamen, Fujian, China
Topic: humans

Top Publications

  1. Mao Y, Zhang N, Xu J, Ding Z, Zong R, Liu Z. Significance of heterogeneous Twist2 expression in human breast cancers. PLoS ONE. 2012;7:e48178 pubmed publisher
    ..These findings suggest that heterogeneous expression of Twist2 in tumors may have a functional link to tumor progression. ..
  2. Su J, Jiang L, Wu J, Liu Z, Wu Y. Anti-tumor and anti-virus activity of polysaccharides extracted from Sipunculus nudus(SNP) on Hepg2.2.15. Int J Biol Macromol. 2016;87:597-602 pubmed publisher
    ..These results suggested that SNP suppressed cell viability of Hepg2.2.15 and that could be a novel anti-tumor and anti-HBV agent. ..
  3. Zhang Y, Wang S, Xu A, Chen J, Lin B, Peng X. Affinity proteomic approach for identification of an IgA-like protein in Litopenaeus vannamei and study on its agglutination characterization. J Proteome Res. 2006;5:815-21 pubmed
    ..In addition, our approach suggests that affinity proteomics based on heterogeneous antibody can speed up the identification of Fossman antigens. ..
  4. Wang W, Li Z, Liu R, Hong S, Xu X, Chen Y. [The interaction of the intracellular domain of beta-amyloid precursor protein with JKTBP2]. Shi Yan Sheng Wu Xue Bao. 2005;38:164-70 pubmed
    ..The interaction between JKTBP2(90)-204 and AID was further confirmed by co-immunoprecipitation in the mammalian 293T cells. These results indicate that JKTBP2 may have an important function in AD formation. ..
  5. Lu N, Liu J, Liu J, Zhang C, Jiang F, Wu H, et al. Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha. PLoS ONE. 2012;7:e35722 pubmed publisher
    ..Our findings will offer new strategies to develop improved triptolide analogs for cancer therapy. ..
  6. Hu Y, Si L, Ye Z, Lin Z, Zhou J. Inhibitory effect of ARHI on pancreatic cancer cells and NF-?B activity. Mol Med Rep. 2013;7:1180-4 pubmed publisher
    ..ARHI acts as a tumor suppressor by downregulating the NF??B signaling pathway, which results in the inhibition of cell proliferation, apoptosis and the cell cycle in the pancreatic tumor PANC-1 cell line. ..
  7. Mao Y, Toh H, Ding Z, Sun L, Hong L, Chen C, et al. Differential methylation of CpG islands within the dermo1 gene promoter in several cancer cell lines. Oncol Rep. 2011;25:107-11 pubmed
    ..RT-PCR results demonstrated that dermo1 CpG island hypermethylation was accompanied by a low basal dermo1 expression level. Our data implicate dermo1 as a tumor suppressor gene and a valuable molecular marker for human cancer. ..
  8. Lv X, Liu Z, Zhang H, Tzeng C. Aromatherapy and the central nerve system (CNS): therapeutic mechanism and its associated genes. Curr Drug Targets. 2013;14:872-9 pubmed
    ..A possible signaling pathway from olfactory system to the central nerve system and the associated key molecular elements of aromatherapy are also proposed. ..
  9. Zhang Y, Thompson R, Zhang H, Xu H. APP processing in Alzheimer's disease. Mol Brain. 2011;4:3 pubmed publisher
    ..Therefore, understanding the metabolism/processing of APP is crucial for AD therapeutics. Here we review current knowledge of APP processing regulation as well as the patho/physiological functions of APP and its metabolites. ..

More Information

Publications439 found, 100 shown here

  1. Shi S, He Z, Cai J, Qiu J. [RNA Interference targeting GRP75 decreases cisplatin resistance in human lung adenocarcinoma cell]. Zhongguo Fei Ai Za Zhi. 2011;14:305-10 pubmed publisher
    ..52 and 4.14 respectively. Cisplatin resistance of lung cancer cells is associated with overexpression of GRP75 gene, which could regulate the expressions of p53 and bcl-2. ..
  2. Tian M, Peng S, Martin F, Zhang J, Liu L, Wang Z, et al. Perfluorooctanoic acid induces gene promoter hypermethylation of glutathione-S-transferase Pi in human liver L02 cells. Toxicology. 2012;296:48-55 pubmed publisher
    ..Considering the role of GSTP in detoxification, aberrant methylation may be pivotal in PFOA-mediated toxicity response via the inhibition of SP1 binding to GSTP promoter. ..
  3. Chen Q, Li W, Wan Y, Yu C, Li W. Fibroblast growth factor receptor 4 Gly388Arg polymorphism associated with severity of gallstone disease in a Chinese population. Genet Mol Res. 2012;11:548-55 pubmed publisher
    ..019). In conclusion, the FGFR4 polymorphism is a genetic risk factor contributing to aggravation of gallstone disease. ..
  4. Chen L, Tian X, Li W, Agarwal A, Zhuang G. Expressions of Fas/DcR3 and RGD-FasL mediated apoptosis in pituitary adenomas. Neurol India. 2009;57:28-30 pubmed
    ..Fas can be a novel target for the treatment of pituitary adenomas. RGD-FasL induces apoptosis of pituitary adenoma cells through caspase activation. ..
  5. Yan L, Zhu Z, Zou Y, Huang Y, Liu D, Jia S, et al. Target-responsive "sweet" hydrogel with glucometer readout for portable and quantitative detection of non-glucose targets. J Am Chem Soc. 2013;135:3748-51 pubmed publisher
    ..With the advantages of low cost, rapidity, portability, and ease of use, the method reported here has the potential to be used by the public for portable and quantitative detection of a wide range of non-glucose targets. ..
  6. Zheng J, Petersen F, Yu X. The role of PTPN22 in autoimmunity: learning from mice. Autoimmun Rev. 2014;13:266-71 pubmed publisher
    ..Here we review recently emerged evidence of the interconnection between mouse PTPN22 and autoimmunity. We also discuss the consistence and discrepancy between findings derived from human and mouse studies. ..
  7. Yuan Q, Ge S, Xiong J, Yan Q, Li Z, Hao X, et al. A novel immunoassay for PreS1 and/or core-related antigens for detection of HBsAg variants. J Virol Methods. 2010;168:108-13 pubmed publisher
    ..In addition, a novel premature stop code mutation at position 112 of HBsAg was observed in two patients with chronic hepatitis B with different genotypes. ..
  8. Zhang H, Ma Q, Zhang Y, Xu H. Proteolytic processing of Alzheimer's β-amyloid precursor protein. J Neurochem. 2012;120 Suppl 1:9-21 pubmed publisher
    ..In this review, we describe the mechanisms involved in APP metabolism and the likely functions of its various proteolytic products to give a better understanding of the patho/physiological functions of APP. ..
  9. Xie Q, Li Z, Chen J. WDR5 positively regulates p53 stability by inhibiting p53 ubiquitination. Biochem Biophys Res Commun. 2017;487:333-338 pubmed publisher
    ..Taken together, these data suggest that WDR5 is directly involved in p53 signaling pathway. Our studies provide a new insight into WDR5 functions in A549 cells. ..
  10. Zhang W, Wu X, Shi T, Xu H, Yi J, Shen H, et al. Regulation of Transcription Factor Yin Yang 1 by SET7/9-mediated Lysine Methylation. Sci Rep. 2016;6:21718 pubmed publisher
    ..Our findings revealed a novel regulatory strategy, methylation by lysine methyltransferase, imposed on YY1 protein, and linked YY1 methylation with its biological functions. ..
  11. Wang F, Hua Y, Whelton P, Zhang T, Fernandez C, Zhang H, et al. Relationship Between Birth Weight and the Double Product in Childhood, Adolescence, and Adulthood (from the Bogalusa Heart Study). Am J Cardiol. 2017;120:1016-1019 pubmed publisher
    ..002). In conclusion, birth weight is associated with increased DP beginning in childhood, which may partly mediate the association between low birth weight and increased cardiovascular risk later in life. ..
  12. Zhang H, Lin J, Sun Y, Huang Y, Ye H, Wang X, et al. Compromised white matter microstructural integrity after mountain climbing: evidence from diffusion tensor imaging. High Alt Med Biol. 2012;13:118-25 pubmed publisher
  13. Zhang Z, Ma P, Jing Y, Yan Y, Cai M, Zhang M, et al. BET Bromodomain Inhibition as a Therapeutic Strategy in Ovarian Cancer by Downregulating FoxM1. Theranostics. 2016;6:219-30 pubmed publisher
    ..Our data establish a new treatment strategy against ovarian cancer by employing epigenetic vulnerabilities, and provide a mechanistic rationale for the clinical investigation of BET bromodomain inhibitors in this deadly disease. ..
  14. Lu Z, Liu W, Huang H, He Y, Han Y, Rui Y, et al. Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling. J Biol Chem. 2008;283:13132-9 pubmed publisher
  15. Zhu X, Dai Y, Chen Z, Xie J, Zeng W, Lin Y, et al. Knockdown of ECHS1 protein expression inhibits hepatocellular carcinoma cell proliferation via suppression of Akt activity. Crit Rev Eukaryot Gene Expr. 2013;23:275-82 pubmed
    ..These data demonstrate that ECHS1 may play a role in HCC progression, suggesting that inhibition of ECHS1 expression using ECHS1 shRNA should be further evaluated as a novel target for the control of HCC. ..
  16. Liu W, Ma Q, Wong K, Li W, Ohgi K, Zhang J, et al. Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release. Cell. 2013;155:1581-1595 pubmed publisher
    ..The functions of JMJD6/ Brd4-associated dual histone and RNA demethylase activity on anti-pause enhancers have intriguing implications for these proteins in development, homeostasis, and disease. ..
  17. Li A, Yuan Q, Huang Z, Fan J, Guo R, Lou B, et al. Novel double-antigen sandwich immunoassay for human hepatitis B core antibody. Clin Vaccine Immunol. 2010;17:464-9 pubmed publisher
    ..A monoclonal anti-HBc neutralization confirmatory assay was then used to determine the degree of discordance between specimens. The new assay was found to be superior in both sensitivity and specificity. ..
  18. Liu J, Zhou W, Li S, Sun Z, Lin B, Lang Y, et al. Modulation of orphan nuclear receptor Nur77-mediated apoptotic pathway by acetylshikonin and analogues. Cancer Res. 2008;68:8871-80 pubmed publisher
    ..Together, our results show that certain shikonin derivatives act as modulators of the Nur77-mediated apoptotic pathway and identify a new shikonin-based lead that targets Nur77 for apoptosis induction. ..
  19. Mei Y, Zhang Y, Yamamoto K, Xie W, Mak T, You H. FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation. Proc Natl Acad Sci U S A. 2009;106:5153-8 pubmed publisher
    ..Given the essential role of Pink1 in combating cell death, our findings may help to dissect the mechanisms by which FOXO proteins function as anti-oxidative stress factors. ..
  20. Huang J, Zhu Y, Wen H, Zhang J, Huang S, Niu J, et al. Quadruplex real-time PCR assay for detection and identification of Vibrio cholerae O1 and O139 strains and determination of their toxigenic potential. Appl Environ Microbiol. 2009;75:6981-5 pubmed publisher
    ..These data indicate that the quadruplex real-time PCR assay can both rapidly and accurately detect/identify V. cholerae and reliably predict the toxigenic potential of strains detected...
  21. Sha Y, Song Y, Zheng L, Ma X, Yang D, Huang P, et al. [Congenital adrenal hyperplasia complicated by testicular adrenal rest tumors: one-case clinical analysis]. Zhonghua Nan Ke Xue. 2010;16:816-21 pubmed
    ..To investigate the early diagnosis and treatment of congenital adrenal hyperplasia (CAH) complicated by testicular adrenal rest tumors (TART)...
  22. Xu B, Li S, Zheng R, Gao S, Ding L, Yin Z, et al. Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription. Proc Natl Acad Sci U S A. 2013;110:17480-5 pubmed publisher
  23. Wu Z, Huang C, Zhou T, Lin J, Zhang K, Li W, et al. Association of polymorphisms in AGTR1 and AGTR2 genes with primary aldosteronism in the Chinese Han population. J Renin Angiotensin Aldosterone Syst. 2015;16:880-7 pubmed publisher
    ..The AGTR1 rs3772616 polymorphism can be considered as a hereditary marker for primary aldosteronism, and in the Chinese Han population the rs5193 G allele seems to predispose to it only in women. ..
  24. Su A, Zhang J, Pan Z, Zhou Q, Lv X. Salvage therapy of gemcitabine plus endostar significantly improves progression-free survival (PFS) with platinum-resistant recurrent epithelial ovarian cancer. Asian Pac J Cancer Prev. 2013;14:1841-6 pubmed
    ..Gemcitabine plus endostar significantly improved the prognosis in patients with platinum-resistant recurrent ovarian cancer, especially in those with malignant effusion. The endostar- containing regimen is recommended in this setting. ..
  25. Huang J, Zhou P, Zhou Z, Huang Y. Assessing the influence of land use and land cover datasets with different points in time and levels of detail on watershed modeling in the North River Watershed, China. Int J Environ Res Public Health. 2012;10:144-57 pubmed publisher
    ..This research provided helpful insights into the influence of LULC datasets on watershed modeling. ..
  26. Xu D, Cobb M, Gavilano L, Witherspoon S, Williams D, White C, et al. Inhibition of oncogenic Pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine. Cancer Biol Ther. 2013;14:492-501 pubmed publisher
    ..These results suggest combining drug therapies that inhibit Pim kinases, such as Pim-3, with chemotherapeutic agents, to aid in decreasing chemoresistance in pancreatic cancer. ..
  27. Kang R, Li P, Wang T, Li X, Wei Z, Zhang Z, et al. Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population. Sci Rep. 2016;6:19930 pubmed publisher
  28. Zhao Z, Li Q, Zheng Y, Chen L, Shi S, Jing G. The aberrant expressions of nuclear matrix proteins during the apoptosis of human osteosarcoma cells. Anat Rec (Hoboken). 2010;293:813-20 pubmed publisher
  29. Chen J, Luo Q, Yuan Y, Huang X, Cai W, Li C, et al. Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion. Mol Cell Biol. 2010;30:5621-35 pubmed publisher
    ..This work now links mechanistically Pygo2's role in histone modification to its enhancement of the Wnt-dependent transcriptional program and cancer stem-like cell expansion. ..
  30. He J, Ye J, Cai Y, Riquelme C, Liu J, Liu X, et al. Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly. Nucleic Acids Res. 2011;39:4464-74 pubmed publisher
    ..Our results also support a model wherein p300 promotes the assembly of a higher-order enhanceosome by simultaneous interactions with multiple DNA-bound transcription factors. ..
  31. Luo J, Dai C, Lin S, Huang P. Asymmetric syntheses and Wnt signal inhibitory activity of melleumin A and four analogues of melleumins A and B. Chem Asian J. 2009;4:328-35 pubmed publisher
    ..Among them, unnatural 4-epi-melleumin B (2 a) exhibits a modest inhibitory activity on Wnt signaling. The total synthesis of melleumin A allowed confirmation of its full structure. ..
  32. Xu C, Gu Y, Hou W, Que Y, Gao S, Cheng T, et al. Tetracysteine as a reporter for gene therapy. Biomed Environ Sci. 2009;22:496-501 pubmed publisher
    ..TC could be used in blood sample detection. TC is a new kind of reporter gene for lentiviral vector in future gene therapy. ..
  33. Chen R, Liu M, Zhang K, Zhou Q. Isolation and functional characterization of P-TEFb-associated factors that control general and HIV-1 transcriptional elongation. Methods. 2011;53:85-90 pubmed publisher
  34. Huang Q, Zhang J, Martin F, Peng S, Tian M, Mu X, et al. Perfluorooctanoic acid induces apoptosis through the p53-dependent mitochondrial pathway in human hepatic cells: a proteomic study. Toxicol Lett. 2013;223:211-20 pubmed publisher
    ..We hope these data will shed new light on the molecular mechanisms responsible for PFOA-mediated toxicity in human liver cells, and from such studies useful biomarkers indicative of PFOA exposure could be developed. ..
  35. Sha Y, Xu X, Mei L, Li P, Su Z, He X, et al. A homozygous CEP135 mutation is associated with multiple morphological abnormalities of the sperm flagella (MMAF). Gene. 2017;633:48-53 pubmed publisher
    ..These results provide researchers and clinicians with a deeper understanding of the gene involved with MMAF and will help predict and assess pregnancy outcomes associated with in vitro fertilization. ..
  36. Xu D, Zhang X, Zhao P, Cai J, Zhao D, Tan W, et al. [Association between single nucleotide polymorphisms in the promoter of cyclooxygenase COX-2 gene and hereditary susceptibility to pancreatic cancer]. Zhonghua Yi Xue Za Zhi. 2008;88:1961-5 pubmed
    ..The SNP of -1195A > G and -765G > C in the COX -2 promoter may play an important role in mediating hereditary susceptibility to developing pancreatic cancer. ..
  37. Guo Q, Yan Q, Xiong J, Ge S, Shih J, Ng M, et al. Prevalence of hepatitis E virus in Chinese blood donors. J Clin Microbiol. 2010;48:317-8 pubmed publisher
    ..60% and 0.94%, respectively. HEV viremia was 0.07%. ..
  38. Zhou T, Zong R, Zhang Z, Zhu C, Pan F, Xiao X, et al. SERPINA3K protects against oxidative stress via modulating ROS generation/degradation and KEAP1-NRF2 pathway in the corneal epithelium. Invest Ophthalmol Vis Sci. 2012;53:5033-43 pubmed publisher
    ..Collectively, SA3K protects against oxidative stress by targeting the ROS generation/degradation system and modulating the KEAP1-NRF2 signaling pathway. ..
  39. Han Y, Yang J, Mizuno K, Matsui Y. Effects of vehicle impact velocity, vehicle front-end shapes on pedestrian injury risk. Traffic Inj Prev. 2012;13:507-18 pubmed publisher
  40. Cao W, Hong H, Zhang Y, Chen N, Zeng Y, Wang W. Anthropogenic nitrogen sources and exports in a village-scale catchment in Southeast China. Environ Geochem Health. 2006;28:45-51 pubmed
    ..1% of total N inputs and 15.5% of the inorganic fertilizer N applied. Understanding N sources and exports in a village-scale catchment can provide a knowledge base for amelioration of diffuse agricultural pollution. ..
  41. Bu Y, Shi T, Meng M, Kong G, Tian Y, Chen Q, et al. A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2. Bioorg Med Chem Lett. 2011;21:874-8 pubmed publisher
    ..The present study established a novel powerful model for the high-throughput screening of Shp2 enhancers and successfully identified a new specific Shp2 enhancer, oleanolic acid, from Chinese herbs. ..
  42. Yang D, Fan X, Yin P, Wen Q, Yan F, Yuan S, et al. Significance of decoy receptor 3 (Dcr3) and external-signal regulated kinase 1/2 (Erk1/2) in gastric cancer. BMC Immunol. 2012;13:28 pubmed
    ..DcR3 and ERK1/2 play a vital role in the development of gastric cancer, and they may be new markers for indicating the efficiency of gastric cancer treatment in the future. ..
  43. Xu J, YANG S, Cai S, Dong J, Li X, Chen Z. Identification of biochemical changes in lactovegetarian urine using 1H NMR spectroscopy and pattern recognition. Anal Bioanal Chem. 2010;396:1451-63 pubmed publisher
    ..As an exploration, this work shows the potential of metabolomics when applied to nutritional and physiological studies, and it will aid further studies. ..
  44. Wang R, He J, Su M, Luo J, Xu M, Du X, et al. The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling. EMBO Mol Med. 2013;5:137-48 pubmed publisher
    ..The elimination or reduction of TR3 may reduce cardiac hypertrophy; therefore, TR3 is a potential target for clinical therapy. ..
  45. Li X, Liu Y, Zheng Q, Yao G, Cheng P, Bu G, et al. Ferritin light chain interacts with PEN-2 and affects ?-secretase activity. Neurosci Lett. 2013;548:90-4 pubmed publisher
  46. Zheng K, Zhang J, Zhang C, Zhang Y, Chen X. Curcumin inhibits appoptosin-induced apoptosis via upregulating heme oxygenase-1 expression in SH-SY5Y cells. Acta Pharmacol Sin. 2015;36:544-52 pubmed publisher
    ..Curcumin inhibits appoptosin-induced apoptosis in SH-SY5Y cells by upregulating the expression of HO-1, reducing the production of intracellular heme and ROS, and preventing the ΔΨm loss. ..
  47. Wu X, Cai S, Li Z, Zheng C, Xue X, Zeng J, et al. Potential effects of telbivudine and entecavir on renal function: a systematic review and meta-analysis. Virol J. 2016;13:64 pubmed publisher
    ..0002). This meta-analysis has confirmed that LdT has a renal protective effect whereas ETV does not. However, whether the benefit on renal function outweighs the occurrence of resistance in specific clinical situations is not yet clear. ..
  48. Feng Z, Gao S, Wu Y, Xu X, Hua X, Jin G. Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP β/ζ signaling by menin. Oncogene. 2010;29:5416-26 pubmed publisher
    ..These findings provide mechanistic insights into the molecular basis for menin/PTN-mediated regulation of A549 lung cancer cell migration. ..
  49. Shen D, Zhan Y, Wang Q, Rui G, Zhang Z. Oncogenic potential of cyclin kinase subunit-2 in cholangiocarcinoma. Liver Int. 2013;33:137-48 pubmed publisher
  50. Du Y, Deng L, Li Y, Gan L, Wang Y, Shi G. Decreased PERP expression on peripheral blood mononuclear cells from patient with rheumatoid arthritis negatively correlates with disease activity. Clin Dev Immunol. 2013;2013:256462 pubmed publisher
    ..These results demonstrated that PERP might be involved in the pathogenesis and a potential therapeutic target of RA by regulating the expression of IL-17. ..
  51. Cui D, Huang Z, Liu Y, Ouyang G. The multifaceted role of periostin in priming the tumor microenvironments for tumor progression. Cell Mol Life Sci. 2017;74:4287-4291 pubmed publisher
    ..Here, we summarize the current knowledge of the multifaceted role of periostin in the tumor microenvironments. ..
  52. Tian X, Wang Z, Meng H, Wang Y, Feng W, Wei F, et al. Tat peptide-decorated gelatin-siloxane nanoparticles for delivery of CGRP transgene in treatment of cerebral vasospasm. Int J Nanomedicine. 2013;8:865-76 pubmed publisher
  53. Wang R, Zhang Y, Zhang X, Liu R, Zhang X, Hong S, et al. Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia. FASEB J. 2006;20:1275-7 pubmed
  54. Sun L, Wu H, Zhuang Y, Guan Y. A rare case of pregnancy complicated by mesenteric mass: what does chylous ascites tell us?. World J Gastroenterol. 2007;13:1632-5 pubmed
    ..The authors report the case for its rarity and emphasize on combining clinicopathological, radiological and immunohistochemistry analysis for management of the disease...
  55. Zheng M, Wang Y, Wu X, Wu S, Lu B, Dong M, et al. Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol. 2011;13:263-72 pubmed publisher
    ..The direct regulation of Rheb by PRAK integrates a stress pathway with the mTORC1 pathway in response to energy depletion. ..
  56. Zhou Y, Yang J, Li B, Yin Z, Xu F, Wang B, et al. Clinicopathologic characteristics of intrahepatic cholangiocarcinoma in patients with positive serum a-fetoprotein. World J Gastroenterol. 2008;14:2251-4 pubmed
    ..ICC patients with positive AFP share many clinicopathologic similarities with hepatocellular carcinoma. ..
  57. Wu G, Lu Q, Hasenberg T, Niedergethmann M, Post S, Sturm J, et al. Association between EGF, TGF-{beta}1, TNF-{alpha} gene polymorphisms and cancer of the pancreatic head. Anticancer Res. 2010;30:5257-61 pubmed
    ..The frequencies of the EGF 61*G/G genotype and G allele are significantly increased among patients with pancreatic head cancer. TGF-?1-509*T/C and TNF-? -308*A/G gene polymorphisms are not related to this cancer entity. ..
  58. Guo Q, Xiao L, Zhou Y. Rapid diagnosis of aneuploidy by high-resolution melting analysis of segmental duplications. Clin Chem. 2012;58:1019-25 pubmed publisher
    ..The assay has sufficient throughput to meet the demands of large-scale testing, such as population-based postnatal screening, and is thus suitable for routine use. ..
  59. Zhou Y, Xiao Y, Wu L, Li B, Li H. Laparoscopic liver resection as a safe and efficacious alternative to open resection for colorectal liver metastasis: a meta-analysis. BMC Surg. 2013;13:44 pubmed publisher
    ..Postoperative recurrence, 5-year overall and disease-free survivals were comparable between two groups. LLR for CLM is safe and efficacious. It improves surgical outcomes and uncompromises oncologic outcomes as compared with OLR. ..
  60. Liang J, Ke G, You W, Peng Z, Lan J, Kalesse M, et al. Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin. Mol Cell Biochem. 2008;307:93-100 pubmed
    ..We, therefore, conclude that imp13 functions in myopodin import and we suggest that the regulation of these events is critical for normal and abnormal cellular differentiation. ..
  61. Wu G, Wang X, Keese M, Hasenberg T, Sturm J. [Association between tumor necrosis factor alpha gene polymorphism and colorectal cancer]. Zhonghua Wei Chang Wai Ke Za Zhi. 2008;11:569-71 pubmed
    ..009,P=0.591). TNF-alpha-308G/A gene polymorphism is not associated with the development of colorectal cancer, but TNF-alpha-308 A/A genotype and A allele are related to the progression of colorectal cancer. ..
  62. Liu F, Qiao F, Tong M, Liu L, Fu Z, Dan B, et al. Further evaluation of a novel nano-scale gene vector for in vivo transfection of siRNA. J Cell Biochem. 2011;112:1329-36 pubmed publisher
    ..From all aspects of tumor gene therapy and basic research, LCP is valuable for scientific research and medical applications. ..
  63. Wang J, Zhao B, Yi Y, Zhang W, Wu X, Zhang L, et al. Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF-?B pathways. Biochem Pharmacol. 2012;84:891-9 pubmed publisher
    ..Because small molecules having both of these effects are rare, further exploration of MED as an antitumor lead compound is needed. ..
  64. Lin Z, Zhang Y, Li C, Qian H. Purification antibody by thiophilic magnetic sorbent modified with 2-mercapto-1-methylimidazol. Colloids Surf B Biointerfaces. 2013;108:72-9 pubmed publisher
    ..These magnetic carries brought great potentials in large-scale antibody purification from human plasma attributing to their high specificity and efficiency, stable structure, sensitive magnetic response and excellent reusability. ..
  65. Huang Y, Zhao X, Mei Q, Cheng B, Zhao Y, Shangguan Z. Mutation analysis of the ADAR1 gene in a Chinese Family with dyschromatosis symmetrica hereditaria. Australas J Dermatol. 2014;55:92-3 pubmed publisher
  66. Jiang B, Zhang J, Xia J, Zhao W, Wu Y, Shi M, et al. IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation. Cell Rep. 2017;19:389-400 pubmed publisher
    ..Allograft tumor assays in mice demonstrate that this mechanism contributes to tumorigenesis driven by mutant IDH1, a result confirmed by detection of JNK inactivation in human gliomas harboring IDH1-R132H mutations. ..
  67. Wang J, Huang Y, Fang M, Zhang Y, Zheng Z, Zhao Y, et al. Brefeldin A, a cytotoxin produced by Paecilomyces sp. and Aspergillus clavatus isolated from Taxus mairei and Torreya grandis. FEMS Immunol Med Microbiol. 2002;34:51-7 pubmed
    ..This is the first report of the isolation of the cytotoxin from Paecilomyces sp. and A. clavatus. The relevance of brefeldin A to the association between these fungi and their host plants is discussed. ..
  68. Liu B, Wu J, Zhan Y, Chen H, Zhang X, Wu Q. Regulation of the orphan receptor TR3 nuclear functions by c-Jun N terminal kinase phosphorylation. Endocrinology. 2007;148:34-44 pubmed
    ..Taken together, our findings revealed a novel cross talk between TR3 and JNK signal pathway and shed light on the mechanism of JNK phosphorylation-dependent regulation on TR3 nuclear functions. ..
  69. Gao S, Feng Z, Xu B, Wu Y, Yin P, Yang Y, et al. Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin. Oncogene. 2009;28:4095-104 pubmed publisher
  70. You P, Ma Q, Tao T. Gene diagnosis of oculopharyngeal muscular dystrophy in a Chinese family by a GeneScan method. J Clin Lab Anal. 2010;24:422-5 pubmed publisher
    ..The above results suggest that mutated GCG repeats in PABPN1 gene may cause OPMD in this family, and PABPN1 genotyping could be used as a convenient, highly effective, and reliable gene diagnostic test for OPMD patients. ..
  71. Tan Y, Qiu F, Qu Y, Li C, Shao Y, Xiao Q, et al. Amniotic membrane inhibits squamous metaplasia of human conjunctival epithelium. Am J Physiol Cell Physiol. 2011;301:C115-25 pubmed publisher
    ..In conclusion, AM can inhibit and reverse squamous metaplasia of conjunctival epithelium. This finding may shed new light on prevention and treatment of diseases that involve epithelial squamous metaplasia. ..
  72. Wu H, Chen H, Sun Y, Wan Y, Wang F, Jia B, et al. Imaging integrin ?(v)?(3) positive glioma with a novel RGD dimer probe and the impact of antiangiogenic agent (Endostar) on its tumor uptake. Cancer Lett. 2013;335:75-80 pubmed publisher
    ..99m)Tc-HYNIC-E[c(RGDfK)]2 may be a promising molecular imaging probe for integrin ?v?3 positive tumor imaging and open up the possibility to establish an molecular imaging modality for assessment of tomor antiangiogenic therapy. ..
  73. Liu A, Cai Y, Mao Y, Lin Y, Zheng H, Wu T, et al. Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24. Carcinogenesis. 2014;35:537-45 pubmed publisher
    ..The identification of the Twist2-CD24 signaling pathway provides a potential therapeutic approach to target cancer stem cells in HCCs. ..
  74. Cai M, Ren L, Yin X, Guo Z, Li Y, He T, et al. PET monitoring angiogenesis of infarcted myocardium after treatment with vascular endothelial growth factor and bone marrow mesenchymal stem cells. Amino Acids. 2016;48:811-820 pubmed publisher
    ..18)F-alfatide II PET could reflect angiogenesis of infarcted myocardium after VEGF gene and BMSCs therapy and further provide a non-invasive way of monitoring therapy response of myocardial infarction. ..
  75. Li M, Ouyang L, Zheng Z, Xiang D, Ti A, Li L, et al. E3 ubiquitin ligase FBW7? inhibits cholangiocarcinoma cell proliferation by downregulating c-Myc and cyclin E. Oncol Rep. 2017;37:1627-1636 pubmed publisher
    ..These results suggest that FBW7? plays an essential inhibitory role in CCA progression, indicating that targeting FBW7? substrate c-Myc may be a potential strategy for CCA treatment. ..
  76. Xu P, Lin W, Liu F, TARTAKOFF A, Tao T. Competitive regulation of IPO4 transcription by ELK1 and GABP. Gene. 2017;613:30-38 pubmed publisher
    ..Overexpression of Ets-like transcription factor-1 or GA binding protein results in its down-regulation or up-regulation in cells. Therefore, both Ets-like transcription factor-1 and GA binding protein regulate IPO4 transcription. ..
  77. Xu D, Tang J, Li Q, Shi S, Chen X, Liang Y. Positional and expressive alteration of prohibitin during the induced differentiation of human hepatocarcinoma SMMC-7721 cells. World J Gastroenterol. 2008;14:5008-14 pubmed
  78. Wang T, Liu N, Seet L, Hong W. The emerging role of VHS domain-containing Tom1, Tom1L1 and Tom1L2 in membrane trafficking. Traffic. 2010;11:1119-28 pubmed publisher
    ..Recent studies suggest that Tom1, Tom1L1 and Tom1L2 subfamily of VHS domain proteins, which do not exist in yeast, are emerging as novel regulators for post-Golgi trafficking and signaling. ..
  79. Zhou Y, Cao L, Li B, Zhang R, Sui C, Yin Z, et al. Clinicopathological significance of ZEB1 protein in patients with hepatocellular carcinoma. Ann Surg Oncol. 2012;19:1700-6 pubmed publisher
    ..This study shows that ZEB1 high expression was correlated with HCC malignant progression and subsequent poor patient survival by induction of EMT changes. ..
  80. Chi X, Huang D, Zhao Z, Zhou Z, Yin Z, Gao J. Nanoprobes for in vitro diagnostics of cancer and infectious diseases. Biomaterials. 2012;33:189-206 pubmed publisher
    ..The distinguishing features of nanoprobes for in vitro use, such as harmlessness, ultrasensitivity, multiplicity, and point-of-care use, will bring a bright future of nanodiagnosis. ..
  81. Sun Z, Cao X, Jiang M, Qiu Y, Zhou H, Chen L, et al. Inhibition of ?-catenin signaling by nongenomic action of orphan nuclear receptor Nur77. Oncogene. 2012;31:2653-67 pubmed publisher
    ..Together, our results demonstrate that ?-catenin can be degraded by cytoplasmic Nur77 through their interaction and identify H-9 and ATE-i2-b4 as potent activators of the Nur77-mediated pathway for ?-catenin degradation. ..
  82. Wang M, Lu C, Xu Q, Song S, Hu Z, Zheng Z. Four new citrinin derivatives from a marine-derived Penicillium sp. fungal strain. Molecules. 2013;18:5723-35 pubmed publisher
    ..Their structures were elucidated by spectroscopic and chemical methods. The new compounds showed modest cytotoxic activity against HepG-2 cell line and weak antimicrobial activity against Staphylococcus aureus. ..
  83. Su Y, Zhao B, Guo F, Bin Z, Yang Y, Liu S, et al. Interaction of benzo[a]pyrene with other risk factors in hepatocellular carcinoma: a case-control study in Xiamen, China. Ann Epidemiol. 2014;24:98-103 pubmed publisher
    ..59%, respectively. The high level of BPDE-DNA adducts in blood is associated with HCC and that environmental exposure to B[a]P may increase the risk of HCC, especially among drinkers and populations with hepatitis B virus infection. ..
  84. Wu Q, Zheng Y, Chen D, Li X, Lu C, Zhang Z. Aberrant expression of decoy receptor 3 in human breast cancer: relevance to lymphangiogenesis. J Surg Res. 2014;188:459-65 pubmed publisher
    ..Based on these findings, it is important to further explore the regulation of lymphangiogenesis operated by the reverse tumor necrosis factor signaling of DcR3. ..
  85. Liu Y, Liu Q, Zhang Y, Qiu J. Annexin A3 Knockdown Suppresses Lung Adenocarcinoma. Anal Cell Pathol (Amst). 2016;2016:4131403 pubmed
    ..In summary, Anxa3 knockdown inhibited the growth, migration, invasion, and metastasis of LADC, decreased the activation of the MEK/ERK signaling pathway, and modulated the expression of MMP-2, E-cadherin, and N-cadherin. ..
  86. Ming Zhi Z, Lim A, Yin Wong T. A pilot study of lens extraction in the management of acute primary angle-closure glaucoma. Am J Ophthalmol. 2003;135:534-6 pubmed
    ..Further study with longer follow-up is needed. ..
  87. Bi M, Ma Q, Zhang S, Li J, Zhang Y, Lin L, et al. Local mild hypothermia with thrombolysis for acute ischemic stroke within a 6-h window. Clin Neurol Neurosurg. 2011;113:768-73 pubmed publisher
    ..There was no benefit of combined local hypothermia/IV rtPA treatment compared to IV rtPA alone. PWI/DWI mismatching on MRI can be a selection criteria for IV rtPA treatment within a 6-h window. ..
  88. Wu T, Li S, Zhang J, Ng M, Xia N, Zhao Q. Hepatitis E vaccine development: a 14 year odyssey. Hum Vaccin Immunother. 2012;8:823-7 pubmed publisher
    ..coli production platform on a commercial scale. Safety and efficacy of this vaccine was demonstrated in a large scale phase III clinical trial. ..
  89. Zhou Y, Zhang X, Cao L, Li B, Sui C, Li Y, et al. MCM7 expression predicts post-operative prognosis for hepatocellular carcinoma. Liver Int. 2012;32:1505-9 pubmed publisher
    ..The current findings suggested that MCM7 expression may be a useful predictor of prognosis in patients with HCC after resection. Adjuvant therapy with sorafenib might be a valuable therapeutic strategy for MCM7-positive HCC patients. ..
  90. Sha Y, Sha Y, Mei L, Huang X, Wang X, Lin S, et al. Use of targeted sequence capture and high-throughput sequencing identifies a novel PKD1 mutation involved in adult polycystic kidney disease. Gene. 2017;634:1-4 pubmed publisher
    ..This mutation is currently not present in the 1000 Genomes Project nor ExAC databases and is therefore a novel PKD1 mutation involved in ADPKD. These results provide a novel sequence variant for the genetic analysis of this disease. ..
  91. Liu L, Zheng W, Tong M, Liu G, Zhang H, Fu Z, et al. Ischemic stroke as a primary symptom of neurosyphilis among HIV-negative emergency patients. J Neurol Sci. 2012;317:35-9 pubmed publisher
    ..A high misdiagnosis rate of ischemic stroke was observed among neurosyphilis patients in clinical practice, which prevents patients from receiving the most appropriate treatment, and often results in more severe neurologic damage...
  92. Zhang H, Zhang Y, Chen Y, Huang X, Zhou F, Wang W, et al. Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration. J Neurosci. 2012;32:15565-76 pubmed publisher
    ..Our study identifies appoptosin as a crucial player in apoptosis and a novel pro-apoptotic protein involved in neuronal cell death, providing a possible new therapeutic target for neurodegenerative disorders. ..