Experts and Doctors on cell cycle proteins in Xiamen, Fujian, China


Locale: Xiamen, Fujian, China
Topic: cell cycle proteins

Top Publications

  1. Ke S, Ni X, Zhang Y, Wang Y, Wu B, Gao F. Camptothecin and cisplatin upregulate ABCG2 and MRP2 expression by activating the ATM/NF-?B pathway in lung cancer cells. Int J Oncol. 2013;42:1289-96 pubmed publisher
    ..Our study indicates that ATM may serve as a potential molecular target for MDR formation in lung cancer chemotherapy...
  2. Li W, Yu Z, Ma P, Wang Y, Jin Q. A novel role of Dma1 in regulating forespore membrane assembly and sporulation in fission yeast. Mol Biol Cell. 2010;21:4349-60 pubmed publisher
    ..Our studies therefore revealed a novel function of Dma1 in regulating sporulation in fission yeast. ..
  3. Zhang Y, Xing Y, Zhang L, Mei Y, Yamamoto K, Mak T, et al. Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1. Proc Natl Acad Sci U S A. 2012;109:5717-22 pubmed publisher
    ..We provide data that FOXO3 knockdown mimics Cdt1 down-regulation and affects G1/S transitions. Our results demonstrate a unique role of FOXO3 in binding to Cdt1 and maintaining its level required for cell cycle progression. ..
  4. Zhou Y, Zhang X, Cao L, Li B, Sui C, Li Y, et al. MCM7 expression predicts post-operative prognosis for hepatocellular carcinoma. Liver Int. 2012;32:1505-9 pubmed publisher
    ..The current findings suggested that MCM7 expression may be a useful predictor of prognosis in patients with HCC after resection. Adjuvant therapy with sorafenib might be a valuable therapeutic strategy for MCM7-positive HCC patients. ..
  5. Shen D, Zhan Y, Wang Q, Rui G, Zhang Z. Oncogenic potential of cyclin kinase subunit-2 in cholangiocarcinoma. Liver Int. 2013;33:137-48 pubmed publisher
  6. Ruan K, Ye F, Li C, Liou Y, Lin S, Lin S. PLK1 interacts and phosphorylates Axin that is essential for proper centrosome formation. PLoS ONE. 2012;7:e49184 pubmed publisher
    ..These results suggest that the phosphorylation status of Axin, mediated by PLK1, dynamically regulates its association with ?-tubulin and centrosome formation and segregation...
  7. Lin L, Fang Z, Lin H, You H, Wang J, Su Y, et al. Depletion of Cks1 and Cks2 expression compromises cell proliferation and enhance chemotherapy-induced apoptosis in HepG2 cells. Oncol Rep. 2016;35:26-32 pubmed publisher
    ..The Akt/GSK-3β-related PI3K/Akt signaling pathway may be a key signaling pathway that is involved in the regulation of cell growth and cell death. ..
  8. Li M, Ouyang L, Zheng Z, Xiang D, Ti A, Li L, et al. E3 ubiquitin ligase FBW7? inhibits cholangiocarcinoma cell proliferation by downregulating c-Myc and cyclin E. Oncol Rep. 2017;37:1627-1636 pubmed publisher
    ..These results suggest that FBW7? plays an essential inhibitory role in CCA progression, indicating that targeting FBW7? substrate c-Myc may be a potential strategy for CCA treatment. ..
  9. Shen D, Fang Z, You P, Liu P, Wang F, Huang C, et al. Clinical significance and expression of cyclin kinase subunits 1 and 2 in hepatocellular carcinoma. Liver Int. 2010;30:119-25 pubmed publisher
    ..Overexpression of Cks1 and Cks2 is associated with the aggressive tumour behaviours of HCC, and thus has diagnostic and prognostic value. Further efforts are needed to develop novel biomarkers for HCC based on CKs1 and Cks2 expressions. ..

More Information


  1. Zhang J, Li H, Zhou T, Zhou J, Herrup K. Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase. J Biol Chem. 2012;287:25985-94 pubmed publisher
    ..The data suggest an unsuspected role for Cdk5 during the progression of a normal cell cycle and offer new pharmaceutical targets for regulating neuronal cell cycling and cell death. ..
  2. Wang Y, Li W, Johnson A, Luo Z, Sun X, Feoktistova A, et al. Dnt1 acts as a mitotic inhibitor of the spindle checkpoint protein dma1 in fission yeast. Mol Biol Cell. 2012;23:3348-56 pubmed publisher
    ..Taken together, these data show that Dnt1 acts to restrain Dma1 activity in early mitosis to allow normal mitotic progression. ..
  3. Huang X, Ding L, Pan R, Ma P, Cheng P, Zhang C, et al. WHAMM is required for meiotic spindle migration and asymmetric cytokinesis in mouse oocytes. Histochem Cell Biol. 2013;139:525-34 pubmed publisher
    ..Taken together, our data suggest that WHAMM is required for peripheral spindle migration and asymmetric cytokinesis during mouse oocyte maturation. ..
  4. Zhang L, Mei Y, Fu N, Guan L, Xie W, Liu H, et al. TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21. Proc Natl Acad Sci U S A. 2012;109:20937-42 pubmed publisher
    ..Our findings identify a causal role for TRIM39 in regulating cell cycle progression and the balance between cytostasis and apoptosis after DNA damage via stabilizing p21. ..
  5. Yu Z, Zhang M, Wang G, Xu D, Keifenheim D, Franco A, et al. Fission yeast nucleolar protein Dnt1 regulates G2/M transition and cytokinesis by downregulating Wee1 kinase. J Cell Sci. 2013;126:4995-5004 pubmed publisher
    ..Our findings also define a novel mode of regulation of Wee1 and Cdk1, which is important for integration of the signals controlling the SIN pathway in fission yeast. ..