Experts and Doctors on wnt signaling pathway in Beijing, China
Locale: Beijing, China
Topic: wnt signaling pathway
Zhang Y. Ganoderma lucidum (Reishi) suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/?-catenin signaling. Biochem Biophys Res Commun. 2017;488:679-684 pubmed publisher
..Our results provide evidence that Reishi suppresses breast cancer cell growth and migration through inhibiting Wnt/?-catenin signaling, indicating that Reishi may be a potential natural inhibitor for breast cancer. ..
Chen J, Jia Y, Liu G, Sun Q, Zhang F, Ma S, et al
. Role of LncRNA TUG1 in intervertebral disc degeneration and nucleus pulposus cells via regulating Wnt/?-catenin signaling pathway. Biochem Biophys Res Commun. 2017;491:668-674 pubmed publisher
..Silencing TUG1 may not only protect human NPCs from TNF-?-induced apoptosis and senescence, but also promote cell proliferation by blocking Wnt/?-catenin pathway, which provides a theoretical basis for the clinical treatment of IDD. ..
Jin L, Cao Y, Yu G, Wang J, Lin X, Ge L, et al
. SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway. Cell Mol Biol Lett. 2017;22:14 pubmed publisher
..This elucidates the molecular mechanism underlying the SFRP2-mediated directed differentiation of SCAPs and indicates potential target genes for improving dental tissue regeneration. ..
Ye X, Lin J, Lin Z, Xue A, Li L, Zhao Z, et al
. Axin1 up-regulated 1 accelerates stress-induced cardiomyocytes apoptosis through activating Wnt/?-catenin signaling. Exp Cell Res. 2017;359:441-448 pubmed publisher
..Our data provided novel evidence that therapeutic strategies against Axud1 or Wnt/?-catenin signaling might be promising in relation to RS-induced myocardial injury. ..
Duan H, Yan Z, Chen W, Wu Y, Han J, Guo H, et al
. TET1 inhibits EMT of ovarian cancer cells through activating Wnt/β-catenin signaling inhibitors DKK1 and SFRP2. Gynecol Oncol. 2017;147:408-417 pubmed publisher
..This study uncovers that TET1 has potent tumor-suppressive effects in EOC by activating Wnt/β-catenin signaling inhibitors DKK1 and SFRP2. ..
Jia S, Qu T, Wang X, Feng M, Yang Y, Feng X, et al
. KIAA1199 promotes migration and invasion by Wnt/β-catenin pathway and MMPs mediated EMT progression and serves as a poor prognosis marker in gastric cancer. PLoS ONE. 2017;12:e0175058 pubmed publisher
Zhang J, Zhang X, Zhao X, Jiang M, Gu M, Wang Z, et al
. DKK1 promotes migration and invasion of non-small cell lung cancer via ?-catenin signaling pathway. Tumour Biol. 2017;39:1010428317703820 pubmed publisher
..Mechanically, ?-catenin plays a vital role in DKK1-induced non-small cell lung cancer cell migration and invasion, and DKK1 inhibits the phosphorylation of ?-catenin, resulting in the increased nuclear localization of ?-catenin. ..
Han W, Liu J. Epigenetic silencing of the Wnt antagonist APCDD1 by promoter DNA hyper-methylation contributes to osteosarcoma cell invasion and metastasis. Biochem Biophys Res Commun. 2017;491:91-97 pubmed publisher
..Thus, we have provided the first evidence that APCDD1 expression is epigenetically silenced in OS, which may facilitate invasion and metastasis of OS cells. ..
Huang W, Zhang C, Cui M, Niu J, Ding W. Inhibition of Bevacizumab-induced Epithelial-Mesenchymal Transition by BATF2 Overexpression Involves the Suppression of Wnt/?-Catenin Signaling in Glioblastoma Cells. Anticancer Res. 2017;37:4285-4294 pubmed
..Our findings expanded the understanding of the role of BATF2 in tumors, and also suggested a potential of using BATF2 as a therapeutic target to hinder bevacizumab induced EMT in glioblastoma. ..