Experts and Doctors on transcriptional elongation factors in Beijing, China
Locale: Beijing, China
Topic: transcriptional elongation factors
Liu L, Ai J, Xiao W, Liu J, Wang Y, Xin D, et al
. ELL is an HIF-1alpha partner that regulates and responds to hypoxia response in PC3 cells. Prostate. 2010;70:797-805 pubmed publisher
..Interestingly, the inhibition was alleviated under hypoxia. Our findings suggest that ELL and HIF-1alpha are binding partners and can modulate the functions of each other in hypoxia. ..
Zhang D, Qin Y. The paradox of elongation factor 4: highly conserved, yet of no physiological significance?. Biochem J. 2013;452:173-81 pubmed publisher
..Lastly, we present a hypothesis for back-translocation and discuss the directions future EF4 research should focus on. ..
Liu Z, Zhou Z, Chen G, Bao S. A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation. Biochem Biophys Res Commun. 2007;353:47-53 pubmed
..In addition, mouse homolog of hiws1 is found to express ubiquitously in various tissues. ..
Yang J, Zhang X, Feng J, Leng H, Li S, Xiao J, et al
. The Histone Chaperone FACT Contributes to DNA Replication-Coupled Nucleosome Assembly. Cell Rep. 2016;14:1128-1141 pubmed publisher
..Therefore, FACT collaborates with CAF-1 and Rtt106 in RC nucleosome assembly. ..
Wan L, Wen H, Li Y, Lyu J, Xi Y, Hoshii T, et al
. ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia. Nature. 2017;543:265-269 pubmed publisher
Gao Y, Li C, Wei L, Teng Y, Nakajima S, Chen X, et al
. SSRP1 Cooperates with PARP and XRCC1 to Facilitate Single-Strand DNA Break Repair by Chromatin Priming. Cancer Res. 2017;77:2674-2685 pubmed publisher
..By establishing how SSRP1 facilitates SSB repair, our findings provide a mechanistic rationale to target SSRP1 as a general approach to selectively attack cancer cells. Cancer Res; 77(10); 2674-85. ©2017 AACR. ..
Liu X, Dang Y, Matsu ura T, He Y, He Q, Hong C, et al
. DNA Replication Is Required for Circadian Clock Function by Regulating Rhythmic Nucleosome Composition. Mol Cell. 2017;67:203-213.e4 pubmed publisher
..Together, these results establish circadian clock and cell cycle as interdependent coupled oscillators and identify DNA replication as a critical process in the circadian mechanism. ..