Experts and Doctors on smad2 protein in Shaanxi, China
Locale: Shaanxi, China
Topic: smad2 protein
Zheng X, Gai X, Han S, Moser C, Hu C, Shire A, et al
. The human sulfatase 2 inhibitor 2,4-disulfonylphenyl-tert-butylnitrone (OKN-007) has an antitumor effect in hepatocellular carcinoma mediated via suppression of TGFB1/SMAD2 and Hedgehog/GLI1 signaling. Genes Chromosomes Cancer. 2013;52:225-36 pubmed publisher
..We conclude that OKN-007 or more potent derivatives may be promising agents for the treatment of HCC. ..
Zhao X, Zhao L, Zheng Q, Su J, Guan H, Shang F, et al
. Chymase induces profibrotic response via transforming growth factor-beta 1/Smad activation in rat cardiac fibroblasts. Mol Cell Biochem. 2008;310:159-66 pubmed
..These results suggest that chymase can promote CFs proliferation and collagen synthesis via TGF-beta 1/Smad pathway rather than angiotensin II, which is implicated in the process of MF. ..
Wang H, Liu S, Liu S, Wei W, Zhou X, Lin F, et al
. Enhanced expression and phosphorylation of Sirt7 activates smad2 and ERK signaling and promotes the cardiac fibrosis differentiation upon angiotensin-II stimulation. PLoS ONE. 2017;12:e0178530 pubmed publisher
..Our findings reveal a novel role of Sirt7 and its phosphorylation in the phenotypic conversion of CFs to MFs and might lead to the development of new therapeutic and prognostic tools for cardiac fibrosis. ..
An X, Song Y, Hou J, Zhang Y, Chen K, Ma H, et al
. Chi-miR-4110 promotes granulosa cell apoptosis by targeting Sma- and Mad-related protein 2 (Smad2) in the caprine ovary. PLoS ONE. 2017;12:e0181162 pubmed publisher
..Our findings may provide relevant data for the investigation of miRNA-mediated regulation of ovarian functions. ..