Experts and Doctors on sialyltransferases in Beijing, China

Summary

Locale: Beijing, China
Topic: sialyltransferases

Top Publications

  1. Shang J, Qiu R, Wang J, Liu J, Zhou R, Ding H, et al. Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3-sialyltransferase from human fetal liver. Eur J Biochem. 1999;265:580-8 pubmed
    ..coli and both 32-kDa and 41-kDa proteins in P. pastoris. These results suggested that correct glycosylation of the enzyme might play a key role in its folding that may be directly related to the enzymatic activity. ..
  2. Li G, Zhu L, Zhang H, LV J, Ding J, Zhao M, et al. Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy. Hum Mutat. 2007;28:950-7 pubmed
  3. Ding J, Xu L, Zhu L, Lv J, Zhao M, Zhang H, et al. Activity of alpha2,6-sialyltransferase and its gene expression in peripheral B lymphocytes in patients with IgA nephropathy. Scand J Immunol. 2009;69:174-80 pubmed publisher
    ..17, P > 0.05). These data suggested that reduced sialylation of serum IgA1 may result from decreased expression of ST6GALNAC2. The factors affecting activity of alpha2,6-ST in the sialylation of IgA1 need to be further investigated. ..
  4. Zhu L, Tang W, Li G, Lv J, Ding J, Yu L, et al. Interaction between variants of two glycosyltransferase genes in IgA nephropathy. Kidney Int. 2009;76:190-8 pubmed publisher
    ..Our findings suggest that potential genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN. ..