Experts and Doctors on sialyltransferases in Beijing, China
Locale: Beijing, China
Shang J, Qiu R, Wang J, Liu J, Zhou R, Ding H, et al
. Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3-sialyltransferase from human fetal liver. Eur J Biochem. 1999;265:580-8 pubmed
..coli and both 32-kDa and 41-kDa proteins in P. pastoris. These results suggested that correct glycosylation of the enzyme might play a key role in its folding that may be directly related to the enzymatic activity. ..
Li G, Zhu L, Zhang H, LV J, Ding J, Zhao M, et al
. Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy. Hum Mutat. 2007;28:950-7 pubmed
Ding J, Xu L, Zhu L, Lv J, Zhao M, Zhang H, et al
. Activity of alpha2,6-sialyltransferase and its gene expression in peripheral B lymphocytes in patients with IgA nephropathy. Scand J Immunol. 2009;69:174-80 pubmed publisher
..17, P > 0.05). These data suggested that reduced sialylation of serum IgA1 may result from decreased expression of ST6GALNAC2. The factors affecting activity of alpha2,6-ST in the sialylation of IgA1 need to be further investigated. ..
Zhu L, Tang W, Li G, Lv J, Ding J, Yu L, et al
. Interaction between variants of two glycosyltransferase genes in IgA nephropathy. Kidney Int. 2009;76:190-8 pubmed publisher
..Our findings suggest that potential genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN. ..