Experts and Doctors on protein conformation in Beijing, China


Locale: Beijing, China
Topic: protein conformation

Top Publications

  1. Liu T, Wang X. Zinc induces unfolding and aggregation of dimeric arginine kinase by trapping reversible unfolding intermediate. Acta Biochim Biophys Sin (Shanghai). 2010;42:779-86 pubmed publisher
    ..Zn²(+) can affect unfolding and refolding of dAK by trapping the reversible intermediate. Our study provides important information regarding the effect of Zn²(+) on metabolic enzymes in marine invertebrates. ..
  2. Wang F, Mei Z, Qi Y, Yan C, Hu Q, Wang J, et al. Structure and mechanism of the hexameric MecA-ClpC molecular machine. Nature. 2011;471:331-5 pubmed publisher
    ..These findings have implications for related Clp/Hsp100 molecular machines. ..
  3. He S, Li C, Liu Y, Lai L. Discovery of highly potent microsomal prostaglandin e2 synthase 1 inhibitors using the active conformation structural model and virtual screen. J Med Chem. 2013;56:3296-309 pubmed publisher
    ..The lead compounds 1 and 2 showed HWB IC50 values of 0.3 and 0.7 ?M which are among the most potent mPGES-1 inhibitors reported. These compounds represent new scaffolds for future development of drugs against mPGES-1. ..
  4. Wu Q, Gao Z, Wei Y, Ma G, Zheng Y, Dong Y, et al. Conserved residues that modulate protein trans-splicing of Npu DnaE split intein. Biochem J. 2014;461:247-55 pubmed publisher
    ..The conserved non-catalytic residues of split inteins modulate the efficiency of protein trans-splicing by hydrogen-bond interactions with the catalytic residues at the splice junction. ..
  5. Sun F, Li P, Ding Y, Wang L, Bartlam M, Shu C, et al. Design and structure-based study of new potential FKBP12 inhibitors. Biophys J. 2003;85:3194-201 pubmed
    ..Analysis of volume and surface area effects also gives a new clue for structure-based drug design. ..
  6. Tang L, Bai L, Wang W, Jiang T. Crystal structure of the carnitine transporter and insights into the antiport mechanism. Nat Struct Mol Biol. 2010;17:492-6 pubmed publisher
  7. Su J, Xu X, Li C, Chen W, Wang C. Identification of key residues for protein conformational transition using elastic network model. J Chem Phys. 2011;135:174101 pubmed publisher
    ..The similarity in the positions of the key residues for these two proteins may indicate a common mechanism in their conformational transitions. ..
  8. Wang J, Wu J, Wang Z. Structural insights into the autoactivation mechanism of p21-activated protein kinase. Structure. 2011;19:1752-61 pubmed publisher
    ..Thus, the structure of the asymmetric homodimer mimics a trans-autophosphorylation complex, and suggests that unphosphorylated PAK1 could dynamically adopt both the active and inactive conformations in solution. ..
  9. Ouyang S, Song X, Wang Y, Ru H, Shaw N, Jiang Y, et al. Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity. 2012;36:1073-86 pubmed publisher
    ..This suggests an extra TBK1 binding site, other than serine 358. This study provides a glimpse into the unique architecture of STING and sheds light on the mechanism of c-di-GMP-mediated TBK1 signaling. ..

More Information

Publications289 found, 100 shown here

  1. Yang C, Zhang T, Li Z, Xu L, Liu F, Ruan J, et al. P-glycoprotein is responsible for the poor intestinal absorption and low toxicity of oral aconitine: in vitro, in situ, in vivo and in silico studies. Toxicol Appl Pharmacol. 2013;273:561-8 pubmed publisher
    ..Our data indicate that potential P-gp-mediated drug-drug interactions should be considered carefully in the clinical application of aconite and formulations containing AC. ..
  2. Duan J, Ji X, Feng J, Han W, Zhang P, Cao W, et al. A human neutralizing antibody against a conformational epitope shared by oligomeric SARS S1 protein. Antivir Ther. 2006;11:117-23 pubmed
    ..This study should aid in the manufacture of neutralizing antibody, provide a better understanding the immunological characteristics of SARS protein and facilitate the design of a SARS vaccine. ..
  3. Feng L, Sun H, Zhang Y, Li D, Wang D. Structural insights into the recognition mechanism between an antitumor galectin AAL and the Thomsen-Friedenreich antigen. FASEB J. 2010;24:3861-8 pubmed publisher
    ..The finding provided the new target and approach for the antitumor drug design and relative strategy based on the AAL-TF recognition mode as a prototype model. ..
  4. Cai C, Zhao Y, Tong X, Fu S, Li Y, Wu Y, et al. Crystallization and preliminary X-ray analysis of the vWA domain of human anthrax toxin receptor 1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011;67:64-7 pubmed publisher
    ..X-ray diffraction data were collected to 1.8 Å resolution from a single crystal, which belonged to space group P1 with unit-cell parameters a=65.9, b=66.1, c=74.4 Å, α=63.7, β=88.2, γ=59.9°. ..
  5. Wang X, Chen Z, Wang C, Yan R, Zhang Z, Song J. Predicting residue-residue contacts and helix-helix interactions in transmembrane proteins using an integrative feature-based random forest approach. PLoS ONE. 2011;6:e26767 pubmed publisher
    ..430 and 0.424, according to two different residue contact definitions, respectively. To facilitate the academic community, the TMhhcp server has been made freely accessible at ..
  6. Zhang H, Wan H, Gao Z, Wei Y, Wang W, Liu G, et al. Insights into the catalytic mechanism of 16S rRNA methyltransferase RsmE (m³U1498) from crystal and solution structures. J Mol Biol. 2012;423:576-89 pubmed publisher
    ..In general, our study provides new information on the structure-function relationship of RsmE and thereby suggests a novel catalytic mechanism...
  7. Qu Q, Chen J, Wang Y, Gui W, Wang L, Fan Z, et al. Structural characterization of the self-association of the death domain of p75(NTR.). PLoS ONE. 2013;8:e57839 pubmed publisher
  8. Xu X, Wang X, Zhang Y, Wang D, Ding J. Structural basis for the unique heterodimeric assembly between cerebral cavernous malformation 3 and germinal center kinase III. Structure. 2013;21:1059-66 pubmed publisher
    ..Taken together, these findings provide a precise structural basis for GCKIIIct-CCM3 heterodimerization and the functional performance of GCKIII mediated by CCM3. ..
  9. Qiu B, Zhang K, Wang S, Sun F. C-terminal motif within Sec7 domain regulates guanine nucleotide exchange activity via tuning protein conformation. Biochem Biophys Res Commun. 2014;446:380-6 pubmed publisher
    ..Crystallographic, NMR spectrum and mutagenesis studies suggested that the loop>J motif with a key conserved residue Ile1010 modulates the fine conformation of Sec7 domain and thereby regulates its guanine exchange activity. ..
  10. Ou X, Ji C, Han X, Zhao X, Li X, Mao Y, et al. Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1). J Mol Biol. 2006;357:858-69 pubmed
    ..An electrophilic catalytic mechanism by the epsilon-NH3+ group of Lys204 is proposed on the basis of the structural analyses. In addition, the inhibitory effects of zinc and sulfate on GPDHs are assayed and discussed. ..
  11. Li M, Chen Z, Zhang P, Pan X, Jiang C, An X, et al. Crystal structure studies on sulfur oxygenase reductase from Acidianus tengchongensis. Biochem Biophys Res Commun. 2008;369:919-23 pubmed publisher
    ..Consequently, the binding sites of substrates and a hypothetical catalytic process of SOR were proposed...
  12. Liu C, Li D, Liang Y, Li L, Su X. Ring-opening mechanism revealed by crystal structures of NagB and its ES intermediate complex. J Mol Biol. 2008;379:73-81 pubmed publisher
  13. Fang X, Cui Q, Tong Y, Feng Y, Shan L, Huang L, et al. A stabilizing alpha/beta-hydrophobic core greatly contributes to hyperthermostability of archaeal [P62A]Ssh10b. Biochemistry. 2008;47:11212-21 pubmed publisher
    ..In comparison with homologous mesophilic and thermophilic proteins, it can be presumed that the stabilizing alpha/beta-hydrophobic core in the [P62A]Ssh10b structure greatly contributes to the high thermostability of the protein. ..
  14. Nan B, Liu X, Zhou Y, Liu J, Zhang L, Wen J, et al. From signal perception to signal transduction: ligand-induced dimeric switch of DctB sensory domain in solution. Mol Microbiol. 2010;75:1484-94 pubmed publisher
  15. Lu Y, Pang Y, Park Y, Gao X, Yao J, Zhang X, et al. Genome organization, phylogenies, expression patterns, and three-dimensional protein models of two acetylcholinesterase genes from the red flour beetle. PLoS ONE. 2012;7:e32288 pubmed publisher
    ..Our computational analyses suggest that the TcAce1 protein is a robust acetylcholine (ACh) hydrolase and has susceptibility to sulfhydryl agents whereas the TcAce2 protein is not a catalytically efficient ACh hydrolase. ..
  16. Liu T, Jin X, Zhang X, Yuan H, Cheng J, Lee J, et al. A novel missense SNRNP200 mutation associated with autosomal dominant retinitis pigmentosa in a Chinese family. PLoS ONE. 2012;7:e45464 pubmed publisher
  17. Wang H, Sun L, Su L, Rizo J, Liu L, Wang L, et al. Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol Cell. 2014;54:133-146 pubmed publisher
    ..This property allows MLKL to move from the cytosol to the plasma and intracellular membranes, where it directly disrupts membrane integrity, resulting in necrotic death. ..
  18. Zhang J, Liu L, Mu J, Yang T, Zheng N, Dong H. Chemical Analysis in the Corpus Callosum Following Traumatic Axonal Injury using Fourier Transform Infrared Microspectroscopy: A Pilot Study. J Forensic Sci. 2015;60:1488-94 pubmed publisher
    ..Our study showed that FTIRM could differentiate injured from normal white matter at different time points following TBI via examination of these infrared spectral parameters. ..
  19. Yan G, Cheng S, Zhao G, Wu S, Liu Y, Sun W. A single residual replacement improves the folding and stability of recombinant cassava hydroxynitrile lyase in E. coil. Biotechnol Lett. 2003;25:1041-7 pubmed
    ..Our data in this report suggest that Ser113 significantly contributes to the in vivo folding and stability of MeHNL and demonstrates an economic advantage of mut-HNL1 over the wt-HNL0. ..
  20. Zhao J, Wang W, Yuan Z, Jia R, Zhao Z, Xu X, et al. A study on antigenicity and receptor-binding ability of fragment 450-650 of the spike protein of SARS coronavirus. Virology. 2007;359:362-70 pubmed
    ..Our data suggest a possibility that, although the beta6 strand alone is able to bind with ACE2 with relatively high affinity, residues outside the S-RBM could also assist the receptor binding of SARS-CoV-S protein. ..
  21. Tian J, Wang P, Gao S, Chu X, Wu N, Fan Y. Enhanced thermostability of methyl parathion hydrolase from Ochrobactrum sp. M231 by rational engineering of a glycine to proline mutation. FEBS J. 2010;277:4901-8 pubmed publisher
    ..The results were consistent with the computational predictions, and the mutant G194P was found to have higher thermostability than the wild-type enzyme...
  22. Cao Z, Meng J, Li X, Wu R, Huang Y, He Y. The epitope and neutralization mechanism of AVFluIgG01, a broad-reactive human monoclonal antibody against H5N1 influenza virus. PLoS ONE. 2012;7:e38126 pubmed publisher
    ..The presented data provide critical information for developing novel antiviral therapeutics and vaccines against HPAI H5N1 virus. ..
  23. Wu Y, Qin G, Gao F, Liu Y, Vavricka C, Qi J, et al. Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding. Sci Rep. 2013;3:1551 pubmed publisher
  24. Han X, Qi J, Song H, Wang Q, Zhang Y, Wu Y, et al. Structure of the S1 subunit C-terminal domain from bat-derived coronavirus HKU5 spike protein. Virology. 2017;507:101-109 pubmed publisher
    ..Combined with sequence variation in the HKU5-CTD receptor binding interface, we propose the necessity for surveilling the mutation in BatCoV HKU5 spike protein in case of bat-to-human interspecies transmission. ..
  25. Fan Y, Ju M, Zhou J, Tsou C. Activation of chicken liver dihydrofolate reductase by urea and guanidine hydrochloride is accompanied by conformational change at the active site. Biochem J. 1996;315 ( Pt 1):97-102 pubmed
  26. Park Y, Wu B, Tian W, Zhou H. Effects of osmolytes on unfolding of chicken liver fatty acid synthase. Biochemistry (Mosc). 2002;67:914-7 pubmed
    ..The osmolytes also protected the enzyme from inactivation. ..
  27. Liu Z, Lin H, Ye S, Liu Q, Meng Z, Zhang C, et al. Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis. Proc Natl Acad Sci U S A. 2006;103:8965-70 pubmed
    ..Thus, it is very likely that T-Cc has evolved to guarantee the biological integrity of sperm produced in mammalian testis. ..
  28. Wang F, Liu X, Li H, Liang K, Miner J, Hong M, et al. Structure of the ligand-binding domain (LBD) of human androgen receptor in complex with a selective modulator LGD2226. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006;62:1067-71 pubmed
    ..It is hoped that this will aid in further explaining the selectivity of LGD2226 observed in in vitro and in vivo assays and in developing more selective and effective therapeutic agents. ..
  29. Lv W, Liu Z, Jin H, Yu X, Zhang L, Zhang L. Three-dimensional structure of HIV-1 VIF constructed by comparative modeling and the function characterization analyzed by molecular dynamics simulation. Org Biomol Chem. 2007;5:617-26 pubmed
    ..These novel models of VIF and its complex has therefore provided structural information for investigating the function of VIF at the molecular level. ..
  30. Fu Y, Chen Y, Luo X, Liang Y, Shi H, Gao L, et al. The heparin binding motif of endostatin mediates its interaction with receptor nucleolin. Biochemistry. 2009;48:11655-63 pubmed publisher
  31. Lu J, Li H, Zhang J, Li M, Liu M, An X, et al. Crystal structures of SULT1A2 and SULT1A1 *3: insights into the substrate inhibition and the role of Tyr149 in SULT1A2. Biochem Biophys Res Commun. 2010;396:429-34 pubmed publisher
    ..These latter data imply a significant role of Tyr149 in the catalytic mechanism of SULT1A2. ..
  32. Gao P, Tang Q, An X, Yan X, Liang D. Structure of HsdS subunit from Thermoanaerobacter tengcongensis sheds lights on mechanism of dynamic opening and closing of type I methyltransferase. PLoS ONE. 2011;6:e17346 pubmed publisher
    ..On the basis of structural analysis, biochemical experiments and previous studies, we propose a dynamic opening and closing mechanism for type I methyltransferase...
  33. Zheng B, Zhang Q, Gao J, Han H, Li M, Zhang J, et al. Insight into the interaction of metal ions with TroA from Streptococcus suis. PLoS ONE. 2011;6:e19510 pubmed publisher
    ..Our findings reveal a mechanism for uptake of metal ions in S. suis and this mechanism provides a reasonable explanation as to how SsTroA operates in metal transport. ..
  34. Huang L, Wang P, Tian J, Jiang H, Wu N, Yang P, et al. Improving the acidic stability of a methyl parathion hydrolase by changing basic residues to acidic residues. Biotechnol Lett. 2012;34:1115-21 pubmed publisher
    ..Their half-lives at pH 5.0 were 64, 68, 65 min, respectively, whereas that of WT was 39 min. The acidic stability of proteins may therefore be improved by changing selected basic amino acid residues to acidic ones...
  35. Zhu L, Peigneur S, Gao B, Tytgat J, Zhu S. Two recombinant ?-like scorpion toxins from Mesobuthus eupeus with differential affinity toward insect and mammalian Na(+) channels. Biochimie. 2013;95:1732-40 pubmed publisher
    ..Successful expression together with structural and functional characterization of these two new ?-like scorpion toxins lays basis for further studies of their structure-function relationship. ..
  36. Duan M, Ren H, Mao P, Wei C, Liang Y, Li Y, et al. Crystallization and preliminary X-ray analysis of the C-terminal WRKY domain of Arabidopsis thaliana WRKY1 transcription factor. Biochim Biophys Acta. 2005;1750:14-6 pubmed
    ..The preliminary X-ray analysis was undertaken. The crystal diffracted to 2.50 A resolution in-house and belongs to space group P2(1) with unit-cell parameters a=64.10 A, b=34.88 A, c=114.72 A, beta=90.49 degrees . ..
  37. Zhang H, Zheng B, Peng Y, Lou Z, Feng Y, Rao Z. Expression, purification and crystal structure of a truncated acylpeptide hydrolase from Aeropyrum pernix K1. Acta Biochim Biophys Sin (Shanghai). 2005;37:613-7 pubmed
  38. Li D, Zhang N, Hou Y, Huang Y, Hu Y, Zhang Y, et al. Crystal structures of the transcriptional repressor RolR reveals a novel recognition mechanism between inducer and regulator. PLoS ONE. 2011;6:e19529 pubmed publisher
    ..Based on these structural and other functional investigations, it is proposed that RolR may represent a new subfamily of TetR proteins that are invovled in aromatic degradation and sharing common recognition mode as for RolR. ..
  39. Wang L, Zhao F, Li M, Zhang H, Gao Y, Cao P, et al. Conformational changes of rBTI from buckwheat upon binding to trypsin: implications for the role of the P(8)' residue in the potato inhibitor I family. PLoS ONE. 2011;6:e20950 pubmed publisher
    ..Our results could provide valuable insights for designing a new rBTI-based antitumor drug in the future. ..
  40. Wang S, Gu S, Han L, Guo Y, Zhou J, Zhang Y. Specific involvement of two amino acid residues in cis-nerolidol binding to odorant-binding protein 5 AlinOBP5 in the alfalfa plant bug, Adelphocoris lineolatus (Goeze). Insect Mol Biol. 2013;22:172-82 pubmed publisher
  41. Wu Z, Yi Z, Dong L, Zhang A. Molecular simulation study of the specific combination between four kinds of phthalic acid esters and human serum albumin. Environ Toxicol Pharmacol. 2016;41:259-65 pubmed publisher
    ..Molecular dynamic simulation (MD) revealed that HSA did have a slight conformational change when it bound with PAEs. It also verified the greater stability of HSA-PAEs complex compared to free protein. ..
  42. Xie X, Zhang X, Qi C, Li D, Fleming J, Wang D, et al. Crystallographic observation of the movement of the membrane-distal domain of the T7SS core component EccB1 from Mycobacterium tuberculosis. Acta Crystallogr F Struct Biol Commun. 2016;72:139-44 pubmed publisher
    ..It is proposed that the movement of this domain is related to the ATPase activity of EccB1 and its homologues, as well as to the substrate transport of ESX secretion systems. ..
  43. Dong Y, Bartlam M, Sun L, Zhou Y, Zhang Z, Zhang C, et al. Crystal structure of methyl parathion hydrolase from Pseudomonas sp. WBC-3. J Mol Biol. 2005;353:655-63 pubmed
  44. Liu X, Xu L, Liu Y, Tong X, Zhu G, Zhang X, et al. Crystal structure of the hexamer of human heat shock factor binding protein 1. Proteins. 2009;75:1-11 pubmed publisher
    ..Substitution of this residue with Ile increases the melting temperature by 24 degrees C, implicating that this conserved serine residue is maintained at position 31 for functional purposes. ..
  45. Wang J, Zhang W, Song W, Wang Y, Yu Z, Li J, et al. A biosynthetic route to photoclick chemistry on proteins. J Am Chem Soc. 2010;132:14812-8 pubmed publisher
    ..The genetic encoding of this photoreactive amino acid should make it possible in the future to photoregulate protein function in living systems. ..
  46. Zhang G, Zhang Y, Su Z. CYPSI: a structure-based interface for cytochrome P450s and ligands in Arabidopsis thaliana. BMC Bioinformatics. 2012;13:332 pubmed publisher
    ..thaliana CYPs, which should facilitate investigations into the interactions between CYPs and their substrates. CYPSI has a user-friendly interface, which is available at ..
  47. Liu X, Hammel M, He Y, Tainer J, Jeng U, Zhang L, et al. Structural insights into the interaction of IL-33 with its receptors. Proc Natl Acad Sci U S A. 2013;110:14918-23 pubmed publisher
    ..The collective results confer IL-33 structure-function relationships, supporting and extending a general model for ligand-receptor assembly and activation in the IL-1 family. ..
  48. Li X, Hu J, Wang B, Sheng L, Liu Z, Yang S, et al. Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: herb-drug interactions mediated via P-gp. Toxicol Appl Pharmacol. 2014;275:163-75 pubmed publisher
    ..Taken together, our findings provided the basis for the reliable assessment of the potential risks of herb-drug interactions in humans. ..
  49. Zhang H, Wang G, Ding Y, Wang Z, Barraclough R, Rudland P, et al. The crystal structure at 2A resolution of the Ca2+ -binding protein S100P. J Mol Biol. 2003;325:785-94 pubmed
    ..The effect of mutation of specific amino acids suggests that dimerization in vivo can be affected by amino acids on the dimer interface and in the hydrophobic core. ..
  50. Wang H, Chen Y, Yang H, Chen X, Duan M, Tai P, et al. Ring-like pore structures of SecA: implication for bacterial protein-conducting channels. Proc Natl Acad Sci U S A. 2003;100:4221-6 pubmed
    ..They do not form in solution or in the presence of uncharged phosphatidylcholine. These ring-like phospholipid-induced pore-structures may form the core of bacterial protein-conducting channels through bacterial membranes. ..
  51. Zheng Y, Yamaguchi H, Tian C, Lee M, Tang H, Wang H, et al. Arsenic trioxide (As(2)O(3)) induces apoptosis through activation of Bax in hematopoietic cells. Oncogene. 2005;24:3339-47 pubmed
    ..These data suggest that As(2)O(3) might exert the cell killing in part by inducing Bax activation through a Bcl-2-suppressible pathway in hematopoietic cells that is caspase independent and intracellular ROS regulated. ..
  52. Yan H, Zhang P, Wang C, Liu Z, Chang W. Two lutein molecules in LHCII have different conformations and functions: Insights into the molecular mechanism of thermal dissipation in plants. Biochem Biophys Res Commun. 2007;355:457-63 pubmed
    ..These phenomena suggest the changes in the crystal packing during dehydration might be the cause of internal conformational changes within LHCII. We proposed a conformational change related NPQ model based on the structure analysis. ..
  53. Yu C, Li Y, Xia B, Jin C. Solution structure of the cryptic mannitol-specific phosphotransferase enzyme IIA CmtB from Escherichia coli. Biochem Biophys Res Commun. 2007;362:1001-6 pubmed
    ..Instead, the active pocket of CmtB contains another arginine at a distinct position, suggesting different molecular mechanisms for phosphoryl transfer. ..
  54. Zhou X, Lou Z, Fu S, Yang A, Shen H, Li Z, et al. Crystal structure of ArgP from Mycobacterium tuberculosis confirms two distinct conformations of full-length LysR transcriptional regulators and reveals its function in DNA binding and transcriptional regulation. J Mol Biol. 2010;396:1012-24 pubmed publisher
    ..A model is proposed for the LysR family of dimeric regulators...
  55. Gao X, Zhou L, Jiao X, Lu F, Yan C, Zeng X, et al. Mechanism of substrate recognition and transport by an amino acid antiporter. Nature. 2010;463:828-32 pubmed publisher
    ..Structural analysis identified three potential gates, involving four aromatic residues and Glu 208, which may work in concert to differentially regulate the upload and release of Arg and Agm. ..
  56. Lü S, Zhang Y, Long M. Visualization of allostery in P-selectin lectin domain using MD simulations. PLoS ONE. 2010;5:e15417 pubmed publisher
    ..These results provided an insight into understanding the structural transition and the structure-function relationship of P-selectin allostery. ..
  57. Zhang W, Qi J, Shi Y, Li Q, Gao F, Sun Y, et al. Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus. Protein Cell. 2010;1:459-67 pubmed publisher
  58. Wu Y, Lou Z, Miao Y, Yu Y, Dong H, Peng W, et al. Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein Cell. 2010;1:491-500 pubmed publisher
    ..These results together provide a molecular basis for EV71 RNA replication and reveal a potential target for anti-EV71 drug discovery. ..
  59. Zhang N, Qi J, Feng S, Gao F, Liu J, Pan X, et al. Crystal structure of swine major histocompatibility complex class I SLA-1 0401 and identification of 2009 pandemic swine-origin influenza A H1N1 virus cytotoxic T lymphocyte epitope peptides. J Virol. 2011;85:11709-24 pubmed publisher
    ..Our results not only provide the structural basis of peptide presentation by SLA I but also identify some IV CTL epitope peptides. These results will benefit both vaccine development and swine organ-based xenotransplantation. ..
  60. Bai X, Meng G, Luo M, Zheng X. Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules. J Biol Chem. 2012;287:22387-96 pubmed publisher
    ..Thus, the rigidity of the wedge loop is a key factor in dictating tubule diameters. ..
  61. Xie T, Feng Y, Shan L, Wang J. Modeling of the [E43S]SNase-ssDNA-Cd(2+) complex: structural insight into the action of nuclease on ssDNA. Arch Biochem Biophys. 2013;532:103-13 pubmed publisher
    ..The resulting model enabled the functional roles of SNase to be discussed, in particular the action of nuclease on ssDNA. ..
  62. Niu F, Shaw N, Wang Y, Jiao L, Ding W, Li X, et al. Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation. Proc Natl Acad Sci U S A. 2013;110:9054-9 pubmed publisher
    ..Electron microscopic images of the ribonucleoprotein complexes of LEAV N reveal a filamentous assembly similar to those found in phleboviruses. ..
  63. Feng C, Liu Y, Wang G, Deng Z, Zhang Q, Wu W, et al. Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition. J Biol Chem. 2014;289:11571-83 pubmed publisher
    ..Taken together, our findings provide a structural basis for understanding the substrate recognition specificity of Alkbh5 and offer a foundation for selective drug design against AlkB members. ..
  64. Kang X, Zhao Y, Jiang D, Li X, Wang X, Wu Y, et al. Crystal structure and biochemical studies of Brucella melitensis 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. Biochem Biophys Res Commun. 2014;446:965-70 pubmed publisher
    ..Glu145 and Asp168 were identified as active site residues essential for catalysis. The catalytic mechanism and implications of this structure for broad-based antibiotic design are discussed. ..
  65. Wei Z, Zhang P, Zhou Z, Cheng Z, Wan M, Gong W. Crystal structure of human eIF3k, the first structure of eIF3 subunits. J Biol Chem. 2004;279:34983-90 pubmed
    ..The structure provides key information for understanding the structure and function of the eIF3 complex. ..
  66. Shi H, Wu A, Santos M, Feng Z, Huang L, Chen Y, et al. Cloning and characterization of rat spermatid protein SSP411: a thioredoxin-like protein. J Androl. 2004;25:479-93 pubmed
    ..This suggests that SSP411 may play a role in sperm maturation, fertilization, and/or embryo development, as has been shown in thioredoxin family. ..
  67. Wang T, Yun C, Gu S, Chang W, Liang D. 1.88 A crystal structure of the C domain of hCyP33: a novel domain of peptidyl-prolyl cis-trans isomerase. Biochem Biophys Res Commun. 2005;333:845-9 pubmed
    ..A key residue of the active site is changed from Ala-103-CypA to Ser-239-hCyP33, which may affect the PPIase domain/substrates interactions. ..
  68. Yang H, Xie W, Xue X, Yang K, Ma J, Liang W, et al. Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS Biol. 2005;3:e324 pubmed
    ..Further modification could rapidly lead to the discovery of a single agent with clinical potential against existing and possible future emerging CoV-related diseases. ..
  69. Lei X, Chen Y, Du G, Yu W, Wang X, Qu H, et al. Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2. FASEB J. 2006;20:2147-9 pubmed
    ..We conclude that gossypol converts the antiapoptotic molecule Bcl-2 into a proapoptotic molecule that can mediate the release of cyto c and induce apoptosis. ..
  70. Hou X, Liu R, Ross S, Smart E, Zhu H, Gong W. Crystallographic studies of human MitoNEET. J Biol Chem. 2007;282:33242-6 pubmed
    ..It is proposed that mitoNEET dimer may interact with other proteins via the surface residues in close proximity to the [2Fe-2S] cluster. ..
  71. Xuan J, Yao H, Feng Y, Wang J. Cloning, expression and purification of DNA-binding protein Mvo10b from Methanococcus voltae. Protein Expr Purif. 2009;64:162-6 pubmed publisher
    ..The developed protocol has potential application in the production of the other thermophilic and mesophilic proteins in the Sac10b family. ..
  72. Chen B, Cai Z, Wu W, Huang Y, Pleiss J, Lin Z. Morphing activity between structurally similar enzymes: from heme-free bromoperoxidase to lipase. Biochemistry. 2009;48:11496-504 pubmed publisher
    ..The design strategy used in this study could serve as a useful approach for constructing variants with targeted catalytic properties using the alpha/beta-hydrolase fold. ..
  73. Wang J, Cai X, Zou M, Wang Y, Wang J, Xu D. Thr-114 is an important functional residue of fibroblast growth factor 10 identified by structure-based mutational analysis. Cytokine. 2010;49:338-43 pubmed publisher
    ..These results suggested that Thr-114 is a crucial functional residue for FGF10, and mutating Thr-114 to Ala or Arg would lead to great decrease in receptor-binding affinity and biological activity of FGF10. ..
  74. Sun Y, Wei Z, Hammarstrom L, Zhao Y. The immunoglobulin ? gene in jawed vertebrates: a comparative overview. Dev Comp Immunol. 2011;35:975-81 pubmed publisher
    ..Further studies at the protein levels in additional species may help answer this question. ..
  75. Li S, Duan J, Li D, Ma S, Ye K. Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita. EMBO J. 2011;30:5010-20 pubmed publisher
    ..Our results suggest that Shq1 functions as an assembly chaperone that protects the Cbf5 protein complexes from non-specific RNA binding and aggregation before assembly of H/ACA RNA. ..
  76. Lu X, Qi J, Shi Y, Wang M, Smith D, Heimburg Molinaro J, et al. Structure and receptor binding specificity of hemagglutinin H13 from avian influenza A virus H13N6. J Virol. 2013;87:9077-85 pubmed publisher
    ..Our results expand our understanding of virulence evolution, receptor binding preference, and species tropism of the LPAIVs and HPAIVs. ..
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