Experts and Doctors on nucleosomes in Beijing, China


Locale: Beijing, China
Topic: nucleosomes

Top Publications

  1. Cui P, Lin Q, Zhang L, Ding F, Xin C, Zhang D, et al. The disequilibrium of nucleosomes distribution along chromosomes plays a functional and evolutionarily role in regulating gene expression. PLoS ONE. 2011;6:e23219 pubmed publisher
    ..This feature implies that NO patterns, i.e. nucleosome binding and clustering, are coupled with gene clustering that may be functionally and evolutionarily conserved in regulating gene expression among different cell types. ..
  2. Huang C, Zhang Z, Xu M, Li Y, Li Z, Ma Y, et al. H3.3-H4 tetramer splitting events feature cell-type specific enhancers. PLoS Genet. 2013;9:e1003558 pubmed publisher
    ..We propose that the H3.3 nucleosomes at enhancers may be split by an active mechanism to regulate cell-type specific transcription. ..
  3. Fang Q, Chen P, Wang M, Fang J, Yang N, Li G, et al. Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome. elife. 2016;5: pubmed publisher
    ..Our results suggest that IE1 loosens up the folding of host chromatin during hCMV infections. ..
  4. Xu M, Long C, Chen X, Huang C, Chen S, Zhu B. Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly. Science. 2010;328:94-8 pubmed publisher
    ..Our results support the idea that "silent" histone modifications within large heterochromatic regions are maintained by copying modifications from neighboring preexisting histones without the need for H3-H4 splitting events. ..
  5. Li G, Reinberg D. Chromatin higher-order structures and gene regulation. Curr Opin Genet Dev. 2011;21:175-86 pubmed publisher
    ..We also discuss the structural plasticity/dynamics and epigenetic inheritance of higher-order chromatin and the roles of chromatin higher-order organization in eukaryotic gene regulation. ..
  6. Xie W, Ling T, Zhou Y, Feng W, Zhu Q, Stunnenberg H, et al. The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions. Proc Natl Acad Sci U S A. 2012;109:8161-6 pubmed publisher
    ..The results uncover a unique mechanism by which ATP-dependent chromatin remodeling complexes with opposing activities establish a specific chromatin state and regulate transcription. ..
  7. Zhu P, Li G. Structural insights of nucleosome and the 30-nm chromatin fiber. Curr Opin Struct Biol. 2016;36:106-15 pubmed publisher
  8. Cui P, Zhang L, Lin Q, Ding F, Xin C, Fang X, et al. A novel mechanism of epigenetic regulation: nucleosome-space occupancy. Biochem Biophys Res Commun. 2010;391:884-9 pubmed publisher
    ..We therefore proposed that nucleosome-space occupancy as a novel mechanism of epigenetic gene regulation, creating a vital environment for transcriptional activation. ..
  9. Peng B, Hu Q, Liu X, Wang L, Chang Q, Li J, et al. Duchesnea phenolic fraction inhibits in vitro and in vivo growth of cervical cancer through induction of apoptosis and cell cycle arrest. Exp Biol Med (Maywood). 2009;234:74-83 pubmed publisher
    ..All together, these data sustain our contention that DPF has anticancer properties and merits further investigation as a potential therapeutic agent. ..

More Information


  1. Liu X, Dang Y, Matsu ura T, He Y, He Q, Hong C, et al. DNA Replication Is Required for Circadian Clock Function by Regulating Rhythmic Nucleosome Composition. Mol Cell. 2017;67:203-213.e4 pubmed publisher
    ..Together, these results establish circadian clock and cell cycle as interdependent coupled oscillators and identify DNA replication as a critical process in the circadian mechanism. ..
  2. Liu X, Li M, Xia X, Li X, Chen Z. Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure. Nature. 2017;544:440-445 pubmed publisher
    ..Snf2 locally deforms nucleosomal DNA at the site of binding, priming the substrate for the remodelling reaction. Together, these findings provide mechanistic insights into chromatin remodelling. ..
  3. Yang J, Zhang X, Feng J, Leng H, Li S, Xiao J, et al. The Histone Chaperone FACT Contributes to DNA Replication-Coupled Nucleosome Assembly. Cell Rep. 2016;14:1128-1141 pubmed publisher
    ..Therefore, FACT collaborates with CAF-1 and Rtt106 in RC nucleosome assembly. ..
  4. Song F, Chen P, Sun D, Wang M, Dong L, Liang D, et al. Cryo-EM study of the chromatin fiber reveals a double helix twisted by tetranucleosomal units. Science. 2014;344:376-80 pubmed publisher
    ..The asymmetric binding and the location of histone H1 in chromatin play a role in the formation of the 30-nanometer fiber. Our results provide mechanistic insights into how nucleosomes compact into higher-order chromatin fibers. ..
  5. Yuan W, Wu T, Fu H, Dai C, Wu H, Liu N, et al. Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. Science. 2012;337:971-5 pubmed publisher
    ..We propose that PRC2 can sense the chromatin environment to exert its role in the maintenance of transcriptional states. ..
  6. Chen K, Wang L, Yang M, Liu J, Xin C, Hu S, et al. Sequence signatures of nucleosome positioning in Caenorhabditis elegans. Genomics Proteomics Bioinformatics. 2010;8:92-102 pubmed publisher
  7. Wang Y, Zhang H, Chen Y, Sun Y, Yang F, Yu W, et al. LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell. 2009;138:660-72 pubmed publisher
    ..By enlisting LSD1, the NuRD complex expands its chromatin remodeling capacity to include ATPase, histone deacetylase, and histone demethylase. ..
  8. Chen K, Meng Q, Ma L, Liu Q, Tang P, Chiu C, et al. A novel DNA sequence periodicity decodes nucleosome positioning. Nucleic Acids Res. 2008;36:6228-36 pubmed publisher
    ..We conclude that this novel DNA sequence periodicity is a signature of nucleosome organization suggesting that nucleosomes are well-positioned with regularity, especially near the 5'-end of transcripts. ..
  9. Lu Z, Zhou J, Wang X, Guan Z, Bai H, Liu Z, et al. Nucleosomes correlate with in vivo progression pattern of de novo methylation of p16 CpG islands in human gastric carcinogenesis. PLoS ONE. 2012;7:e35928 pubmed publisher
    ..Nucleosomes may function as the basic extension/progression unit of de novo methylation of p16 CpG islands in vivo. ..
  10. Shen M, Zhou T, Xie W, Ling T, Zhu Q, Zong L, et al. The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation. PLoS ONE. 2013;8:e62668 pubmed publisher
  11. Yang D, Fang Q, Wang M, Ren R, Wang H, He M, et al. N?-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat Struct Mol Biol. 2013;20:1116-8 pubmed publisher
    ..By X-ray crystallography, we show here that the acetylated N terminus of Sir3 does not interact with the nucleosome directly. Instead, it stabilizes a nucleosome-binding loop in the BAH domain. ..
  12. Yang X, Yu W, Shi L, Sun L, Liang J, Yi X, et al. HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly. Mol Cell. 2011;44:39-50 pubmed publisher
    ..Our data indicate that HAT4 is an important player in the organization and function of the genome and may contribute to the diversity and complexity of higher eukaryotic organisms. ..
  13. Lu L, Li L, Lv X, Wu X, Liu D, Liang C. Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin. Cell Res. 2011;21:1182-95 pubmed publisher
    ..These results suggest a dynamic interplay between SIRT1 and hMOF in regulating H4K16 acetylation. ..
  14. Li R, Zhang H, Yu W, Chen Y, Gui B, Liang J, et al. ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 2009;28:2763-76 pubmed publisher
    ..These findings may shed new light on the EGFR-related breast carcinogenesis and might offer a potential new target for breast cancer therapy. ..
  15. Zhang Y, Yang X, Gui B, Xie G, Zhang D, Shang Y, et al. Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27. J Biol Chem. 2011;286:42414-25 pubmed publisher