Experts and Doctors on neurons in Jiangsu, China


Locale: Jiangsu, China
Topic: neurons

Top Publications

  1. Liu X, Pei D, Guan Q, Sun Y, Wang X, Zhang Q, et al. Neuroprotection of Tat-GluR6-9c against neuronal death induced by kainate in rat hippocampus via nuclear and non-nuclear pathways. J Biol Chem. 2006;281:17432-45 pubmed
    ..Tat-GluR6-9c, the peptide we constructed, gives new insight into seizure therapy. ..
  2. Chen M, Wang Y, Liu Y, Hou X, Zhang Q, Meng F, et al. Possible mechanisms underlying the protective effects of SY-21, an extract of a traditional Chinese herb, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampus. Brain Res. 2003;989:180-6 pubmed
    ..These results demonstrate that SY-21 has a prominent neuroprotective action against brain ischemic insult, and the mechanism may involve the regulation of the tyrosine phosphorylation of NR2A by changing the above interactions. ..
  3. Yang Y, Liu M, Gu Y, Lin S, Ding F, Gu X. Effect of chitooligosaccharide on neuronal differentiation of PC-12 cells. Cell Biol Int. 2009;33:352-6 pubmed publisher
    ..All the data suggest that chitooligosaccharide possesses good nerve cell affinity by supporting nerve cell adhesion and promoting neuronal differentiation and neurite outgrowth. ..
  4. Yu H, Xu J, Li C, Zhou C, Zhang F, Han D, et al. Coupling between neuronal nitric oxide synthase and glutamate receptor 6-mediated c-Jun N-terminal kinase signaling pathway via S-nitrosylation contributes to ischemia neuronal death. Neuroscience. 2008;155:1120-32 pubmed publisher
    ..Thus, our results provide the coupling of nNOS with GluR6 by S-nitrosylation during the early stages of ischemia-reperfusion, which can be a new approach for stroke therapy. ..
  5. Wang M, Qi D, Zhou C, Han D, Li P, Zhang F, et al. Ischemic preconditioning protects the brain against injury via inhibiting CaMKII-nNOS signaling pathway. Brain Res. 2016;1634:140-149 pubmed publisher
    ..Taken together, the results suggest that IPC could diminish ischemic brain injury through CaMKII-mediated up-regulation of nNOS ser847-phosphorylation signaling pathway. ..
  6. Hu A, Yuan H, Wu L, Chen R, Chen Q, Zhang T, et al. The effect of constitutive over-expression of insulin-like growth factor 1 on the cognitive function in aged mice. Brain Res. 2016;1631:204-13 pubmed publisher
    ..Accordingly, our findings indicated that IGF-1 may mitigate the aged-associated cognitive decline via promoting neurogenesis in the hippocampus and activating CaMKII and ERK signaling by binding with IGF-1R. ..
  7. Zhou R, Wang S, Zhu X. Prenatal ethanol exposure attenuates GABAergic inhibition in basolateral amygdala leading to neuronal hyperexcitability and anxiety-like behavior of adult rat offspring. Neuroscience. 2010;170:749-57 pubmed publisher
    ..The data provide the functional evidence that prenatal EtOH exposure attenuates GABAergic inhibition in the BLA resulting in neuronal hyperexcitability and anxiety-like behavior of adult rat offspring. ..
  8. Lu X, Geng X, Zhang L, Zeng Y. The methodology for labeling the distal cerebrospinal fluid-contacting neurons in rats. J Neurosci Methods. 2008;168:98-103 pubmed publisher
    ..Three methodology were described to label the dCSF-CNs including tetramethylbenzidine-sodium tungstate (TMB-ST) method, CB-HRP-immunofluorescence procedures and CB-HRP-immunoelectron microscopic procedures. ..
  9. Yin X, Yan J, Yang G, Chen L, Xu X, Hong X, et al. PDZ1 inhibitor peptide protects neurons against ischemia via inhibiting GluK2-PSD-95-module-mediated Fas signaling pathway. Brain Res. 2016;1637:64-70 pubmed publisher

More Information


  1. Wang Y, Guo L, Jiang H, Zheng L, Zhang A, Zhen X. Allosteric Modulation of Sigma-1 Receptors Elicits Rapid Antidepressant Activity. CNS Neurosci Ther. 2016;22:368-77 pubmed publisher
    ..The present data provide the first evidence that allosteric modulation of sigma-1 receptors may represent a new approach for antidepressant drug discovery. ..
  2. Lv Q, Liu Y, Han D, Xu J, Zong Y, Wang Y, et al. Neuroprotection of GluK1 kainate receptor agonist ATPA against ischemic neuronal injury through inhibiting GluK2 kainate receptor-JNK3 pathway via GABA(A) receptors. Brain Res. 2012;1456:1-13 pubmed publisher
    ..In sum, the findings indicate that activation of GluK1 by ATPA at specific dosages may promote GABA release, which then suppresses post-synaptic GluK2-JNK3 signaling-mediated cerebral ischemic injury via GABA(A)R. ..
  3. Tang M, Song Q, Li N, Jiang Z, Huang R, Cheng G. Enhancement of electrical signaling in neural networks on graphene films. Biomaterials. 2013;34:6402-11 pubmed publisher
    ..These results offer a better understanding of interactions between graphene and NSCs, also they clearly present the great potentials of graphene as neural interface in tissue engineering. ..
  4. Hu S, Zhu J, Pei D, Zong Y, Yan J, Hou X, et al. Overexpression of the PDZ1 domain of PSD-95 diminishes ischemic brain injury via inhibition of the GluR6.PSD-95.MLK3 pathway. J Neurosci Res. 2009;87:3626-38 pubmed publisher
    ..Overall, the essential role of the PDZ1 domain of PSD-95 in apoptotic cell death in neurons provides an experimental foundation for gene therapy of neurodegenerative diseases with overexpression of the PDZ1 domain. ..
  5. Zhou C, Li C, Yu H, Zhang F, Han D, Zhang G. Neuroprotection of gamma-aminobutyric acid receptor agonists via enhancing neuronal nitric oxide synthase (Ser847) phosphorylation through increased neuronal nitric oxide synthase and PSD95 interaction and inhibited protein phosphatase activity in ce. J Neurosci Res. 2008;86:2973-83 pubmed publisher
    ..Our results suggest that GABA receptor agonists may serve as a potential and important neuroprotectant in therapy for ischemic stroke. ..
  6. Xu Y, Hou X, Liu Y, Zong Y. Different protection of K252a and N-acetyl-L-cysteine against amyloid-beta peptide-induced cortical neuron apoptosis involving inhibition of MLK3-MKK7-JNK3 signal cascades. J Neurosci Res. 2009;87:918-27 pubmed publisher
    ..The late signal events of MLK3 activation after Abeta treatment may play an important role in AD neuronal loss and will be a promising pharmacological target for AD therapeutic intervention. ..
  7. Gao S, Mo J, Chen L, Wang Y, Mao X, Shi Y, et al. Astrocyte GGTI-mediated Rac1 prenylation upregulates NF-κB expression and promotes neuronal apoptosis following hypoxia/ischemia. Neuropharmacology. 2016;103:44-56 pubmed publisher
    ..Our findings suggest that astrocyte GGTI-mediated Rac1 activation contributed to the DND and that GGTI-Rac1-NF-κB signaling may be a potential target for the therapy of ischemic stroke. ..
  8. Zhang F, Li C, Wang R, Han D, Zhang Q, Zhou C, et al. Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion. Neuroscience. 2007;150:938-49 pubmed
  9. Qu Z, Miao W, Hu S, Li C, Zhuo X, Zong Y, et al. N-methyl-D-aspartate receptor-dependent denitrosylation of neuronal nitric oxide synthase increase the enzyme activity. PLoS ONE. 2012;7:e52788 pubmed publisher
    ..nNOS dephosphorylation may be induced by the enzyme denitrosylation, which suggest that S-nitrosylation/denitrosylation of nNOS may be an important mechanism in regulating the enzyme activity. ..
  10. Jiang Q, Gu Z, Zhang G. Activation, involvement and nuclear translocation of c-Jun N-terminal protein kinase 1 and 2 in glutamate-induced apoptosis in cultured rat cortical neurons. Brain Res. 2002;956:194-201 pubmed
  11. Cao J, Li F, Zhu Y, Yuan H, Yu Z, Gao D. Expressions and possible roles of GDNF receptors in the developing dopaminergic neurons. Brain Res Bull. 2010;83:321-30 pubmed publisher
    ..These data suggested that the expression of either TH mRNA or TH protein was subject to the mediation of different transmembrane receptor combinations of GDNF. ..
  12. Sun N, Hao J, Li X, Yin X, Zong Y, Zhang G, et al. GluR6-FasL-Trx2 mediates denitrosylation and activation of procaspase-3 in cerebral ischemia/reperfusion in rats. Cell Death Dis. 2013;4:e771 pubmed publisher
    ..This is the first evidence that cerebral I/R mediates procaspase-3 denitrosylation and activation through GluR6-FasL-Trx2 pathway, which leads to neuronal apoptosis and cell death. ..
  13. Li Y, Gu J, Liu Y, Long H, Wang G, Yin G, et al. iNOS participates in apoptosis of spinal cord neurons via p-BAD dephosphorylation following ischemia/reperfusion (I/R) injury in rat spinal cord. Neurosci Lett. 2013;545:117-22 pubmed publisher
    ..These results indicate that the activity of iNOS plays a critical role in the apoptosis of spinal cord neurons by influencing the dephosphorylation of p-BAD (Ser 136) and the interaction between BAD and 14-3-3. ..
  14. Fan J, Zhang N, Yin G, Zhang Z, Cheng G, Qian W, et al. Edaravone protects cortical neurons from apoptosis by inhibiting the translocation of BAX and Increasing the interaction between 14-3-3 and p-BAD. Int J Neurosci. 2012;122:665-74 pubmed publisher
    ..In summary, the present study indicates that edaravone could protect neurons by inhibiting: (1) the activity of JNK, (2) the disassociation of BAD from 14-3-3, and (3) the translocation of BAX from cytosol to mitochondria. ..
  15. Dong F, Wang S, Wang Y, Yang X, Jiang J, Wu D, et al. Quercetin ameliorates learning and memory via the Nrf2-ARE signaling pathway in d-galactose-induced neurotoxicity in mice. Biochem Biophys Res Commun. 2017;491:636-641 pubmed publisher
    ..In conclusion, quercetin protected mice from d-galactose-induced cognitive functional impairment and neuronal cell apoptosis via activation of the Nrf2-ARE signaling pathway. ..
  16. Du C, Tan R, Hou X. Fyn kinases play a critical role in neuronal apoptosis induced by oxygen and glucose deprivation or amyloid-? peptide treatment. CNS Neurosci Ther. 2012;18:754-61 pubmed publisher
    ..Fyn is a potential therapeutic target for the treatment of ischemic stroke and AD. ..
  17. Di J, Li C, Yu H, Zheng J, Zhang G. nNOS downregulation attenuates neuronal apoptosis by inhibiting nNOS-GluR6 interaction and GluR6 nitrosylation in cerebral ischemic reperfusion. Biochem Biophys Res Commun. 2012;420:594-9 pubmed publisher
    ..In summary, our results suggest that nNOS binds with GluR6 via PSD95 and then produces endogenous NO to S-nitrosylate GluR6 in cerebral ischemia-reperfusion, which provides a new approach for stroke therapy. ..
  18. Wang W, Hu S, Li C, Zhou C, Qi S, Zhang G. Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia. Brain Res. 2010;1328:162-70 pubmed publisher
    ..These results suggest that overexpression of the PDZ1 domain can perturb the binding of PSD-95 to NMDA receptor, suppress the activity of both NMDA receptor and nNOS, and thus have a neuroprotective effect. ..
  19. Zhao Y, Huang Q, Yang J, Lou M, Wang A, Dong J, et al. Autophagy impairment inhibits differentiation of glioma stem/progenitor cells. Brain Res. 2010;1313:250-8 pubmed publisher
    ..These results suggest that bust autophagic activity target at PTEN might be a potential therapy target for glioma therapy. ..
  20. Zhang Q, Han D, Hu S, Li C, Yu C, Wang R, et al. Positive modulation of AMPA receptors prevents downregulation of GluR2 expression and activates the Lyn-ERK1/2-CREB signaling in rat brain ischemia. Hippocampus. 2010;20:65-77 pubmed publisher
    ..Our results revealed that positive modulation of AMPARs could exert neuroprotective effects and the possible signaling pathways underlied. ..
  21. Wen X, Li C, Zong Y, Yu C, Xu J, Han D, et al. Dual inhibitory roles of geldanamycin on the c-Jun NH2-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activatio. Neuroscience. 2008;156:483-97 pubmed publisher
    ..In summary, our results indicated that GA showed a dual inhibitory role on JNK3 activation and exerted strong neuroprotection in vivo and in vitro, which provides a new possible approach for stroke therapy. ..
  22. Du C, Gao J, Tai J, Liu Y, Qi J, Wang W, et al. Increased tyrosine phosphorylation of PSD-95 by Src family kinases after brain ischaemia. Biochem J. 2009;417:277-85 pubmed publisher
    ..Thus the present study reveals an additional mechanism for the regulation of PSD-95 by tyrosine phosphorylation. This mechanism may be of pathological significance since it is associated with excitotoxicity in the ischaemic brain. ..
  23. Cao J, Wang H, Yu J, Liu H, Gao D. The involvement of NF-kappaB p65/p52 in the effects of GDNF on DA neurons in early PD rats. Brain Res Bull. 2008;76:505-11 pubmed publisher
    ..And it was the noncanonical NF-kappaB signaling pathway, which contained the NF-kappaB p65/p52 complex that was involved in the effects of GDNF on DA neurons. ..
  24. Cao J, Wang H, Yu J, Yang H, Xiao C, Gao D. Involvement of NCAM in the effects of GDNF on the neurite outgrowth in the dopamine neurons. Neurosci Res. 2008;61:390-7 pubmed publisher
    ..These results suggest that NCAM is involved in the promotive effect of GDNF on the neurite outgrowth in lesioned DA neurons, but not involved in the promotive effect of GDNF on TH expression in these neurons. ..
  25. Miao B, Yin X, Pei D, Zhang Q, Zhang G. Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation. J Biol Chem. 2005;280:21693-9 pubmed
    ..Taken together, our results indicate that preconditioning can inhibit activation of JNK signaling pathway via NMDA receptor-mediated Akt1 activation and induce neuroprotection in hippocampal CA1 region. ..
  26. Li L, Xu B, Zhu Y, Chen L, Sokabe M, Chen L. DHEA prevents A?25-35-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling. Neuropharmacology. 2010;59:323-33 pubmed publisher
    ..These findings suggest that DHEA prevents the Abeta(25-35)-impaired survival and dendritic growth of newborn neurons through a sigma(1) receptor-mediated modulation of PI3K-Akt-mTOR-p70S6k signaling. ..
  27. Fan J, Long H, Li Y, Liu Y, Zhou W, Li Q, et al. Edaravone protects against glutamate-induced PERK/EIF2?/ATF4 integrated stress response and activation of caspase-12. Brain Res. 2013;1519:1-8 pubmed publisher
  28. Yu C, Li C, Pei D, Zong Y, Shi Q, Wen X, et al. Neuroprotection against transient focal cerebral ischemia and oxygen-glucose deprivation by interference with GluR6-PSD95 protein interaction. Neurochem Res. 2009;34:2008-21 pubmed publisher
    ..Tat-GluR6-9c, the peptide we constructed, gives a new insight into the therapy for ischemic stroke. ..