Experts and Doctors on micrornas in Jiangsu, China


Locale: Jiangsu, China
Topic: micrornas

Top Publications

  1. Wang M, Gu H, Wang S, Qian H, Zhu W, Zhang L, et al. Circulating miR-17-5p and miR-20a: molecular markers for gastric cancer. Mol Med Rep. 2012;5:1514-20 pubmed publisher
    ..Taken together, the levels of circulating miR-17-5p/20a may be a promising non-invasive molecular marker for pathological progression, prediction of prognosis and monitoring of chemotherapeutic effects for gastric cancer. ..
  2. Liu H, Yue D, Chen Y, Gao S, Huang Y. Improving performance of mammalian microRNA target prediction. BMC Bioinformatics. 2010;11:476 pubmed publisher
    ..It holds the promise to achieve continuing improvement whenever better training data that contain additional verified or high confidence positive targets and properly selected negative targets are available. ..
  3. Fei B, Wu H. MiR-378 inhibits progression of human gastric cancer MGC-803 cells by targeting MAPK1 in vitro. Oncol Res. 2012;20:557-64 pubmed publisher
    ..Taken together, our results showed that miR-378 might act as tumor suppressors in GC, and it may provide novel diagnostic and therapeutic options for human GC clinical operation in the future. ..
  4. Chen W, Fan X, Mao L, Zhang J, Li J, Wu J, et al. MicroRNA-224: as a potential target for miR-based therapy of cancer. Tumour Biol. 2015;36:6645-52 pubmed publisher
    ..MiR-224 regulates its targets by modulating messenger RNA (mRNA) stability and/or protein translation, and it would provide new insight into molecular targeting cancer treatment. ..
  5. Tao Y, Wang Z, Wang L, Shi J, Guo X, Zhou W, et al. Downregulation of miR-106b attenuates inflammatory responses and joint damage in collagen-induced arthritis. Rheumatology (Oxford). 2017;56:1804-1813 pubmed publisher
    ..These findings indicate that miR-106b inhibition can ameliorate CIA-associated inflammation and bone destruction and thus may serve as a potential therapeutic for human RA treatment. ..
  6. Tao T, Chen M, Jiang R, Guan H, Huang Y, Su H, et al. Involvement of EZH2 in aerobic glycolysis of prostate cancer through miR-181b/HK2 axis. Oncol Rep. 2017;37:1430-1436 pubmed publisher
    ..Taken together, these findings provide the first evidence that EZH2/miR-181b/HK2 pathway plays a positive role in PCa development. Targeting this aberrantly activated pathway may provide a new therapeutic strategy against PCa. ..
  7. Xia S, Yan K, Wang Y. Increased miR-381a-3p Contributes to Osteoarthritis by Targeting IkB?. Ann Clin Lab Sci. 2016;46:247-53 pubmed
    ..In summary, enhanced miR-381a-3p expression contributed to the injury of OA mainly by inhibiting the expression of I?B?. ..
  8. Shi J, Liu Y, Liu J, Zhou J. Hsa-miR-449a genetic variant is associated with risk of gastric cancer in a Chinese population. Int J Clin Exp Pathol. 2015;8:13387-92 pubmed
    ..279, 95% CI: 1.012-1.617, P = 0.043). In conclusion, our findings suggest that miR-449a rs112310158 is a genetic risk factor for GC. ..
  9. Xu C, Li S, Chen T, Hu H, Ding C, Xu Z, et al. miR-296-5p suppresses cell viability by directly targeting PLK1 in non-small cell lung cancer. Oncol Rep. 2016;35:497-503 pubmed publisher
    ..Taken together, the present study indicated that miR-296-5p regulated PLK1 expression and could function as a tumor suppressor in NSCLC progression, which provides a potential target for gene therapy of NSCLC. ..

More Information


  1. Zhang H, Jiang L, Sun D, Li J, Tang J. MiR-139-5p: promising biomarker for cancer. Tumour Biol. 2015;36:1355-65 pubmed publisher
  2. Wang N, Zhou Y, Jiang L, Li D, Yang J, Zhang C, et al. Urinary microRNA-10a and microRNA-30d serve as novel, sensitive and specific biomarkers for kidney injury. PLoS ONE. 2012;7:e51140 pubmed publisher
    ..In conclusion, the present study collectively demonstrates that urinary miR-10a and miR-30d represent a novel noninvasive, sensitive, specific and potentially high-throughput method for detecting renal injury. ..
  3. Li L, Hou D, Guo Y, Yang J, Liu Y, Zhang C, et al. Role of microRNA-214-targeting phosphatase and tensin homolog in advanced glycation end product-induced apoptosis delay in monocytes. J Immunol. 2011;186:2552-60 pubmed publisher
    ..Our findings define a new role for miR-214-targeting PTEN in AGE-induced monocyte survival. ..
  4. Xu Y, Xi Q, Ge W, Zhang X. Identification of serum microRNA-21 as a biomarker for early detection and prognosis in human epithelial ovarian cancer. Asian Pac J Cancer Prev. 2013;14:1057-60 pubmed
    ..These findings indicate that serum miR-21 may serve as a novel diagnostic and prognostic marker, and be used as a therapeutic target for the treatment of EOC. ..
  5. Xu L, Xiang J, Shen J, Zou X, Zhai S, Yin Y, et al. Oncogenic MicroRNA-27a is a target for genistein in ovarian cancer cells. Anticancer Agents Med Chem. 2013;13:1126-32 pubmed
  6. Xu S, Yi X, Zhou W, Cheng W, Ge J, Zhang Z. Downregulation of miR-129 in peripheral blood mononuclear cells is a diagnostic and prognostic biomarker in prostate cancer. Int J Clin Exp Pathol. 2015;8:14335-44 pubmed
    ..Overexpression of miR-129 exerts tumor suppressive functions and abrogates prostate cancer growth. ..
  7. Li H, Hui L, Xu W, Shen H, Chen Q, Long L, et al. Triptolide modulates the sensitivity of K562/A02 cells to adriamycin by regulating miR-21 expression. Pharm Biol. 2012;50:1233-40 pubmed publisher
    ..Our findings indicated that triptolide modulates the sensitivity of K562/A02 cells to adriamycin by regulating miR-21 expression. Triptolide inhibited miR-21 expression and enhanced PTEN levels in K562/A02 cells. ..
  8. Xu H, Sun Q, Lu L, Luo F, Zhou L, Liu J, et al. MicroRNA-218 acts by repressing TNFR1-mediated activation of NF-?B, which is involved in MUC5AC hyper-production and inflammation in smoking-induced bronchiolitis of COPD. Toxicol Lett. 2017;280:171-180 pubmed publisher
  9. Wu J, He D, Yue B, Zhang C, Fang X, Chen H. miR-101-1 expression pattern in Qinchuan cattle and its role in the regulation of cell differentiation. Gene. 2017;636:64-69 pubmed publisher
    ..The results show that amyloid precursor protein (APP) is the target gene of miR-101-1. Therefore, our results shed light on miR-101-1 in the regulation of the skeletal muscle development. ..