Experts and Doctors on iga glomerulonephritis in Beijing, China


Locale: Beijing, China
Topic: iga glomerulonephritis

Top Publications

  1. Tan Y, Zhang J, Liu G, Zhang H, Zhao M. The level of urinary secretory immunoglobulin A (sIgA) of patients with IgA nephropathy is elevated and associated with pathological phenotypes. Clin Exp Immunol. 2009;156:111-6 pubmed publisher
    ..231, P < 0.001). The levels of urinary sIgA were associated closely with histopathological phenotypes of IgAN and might be used as a non-invasive biomarker to evaluate kidney injury in IgAN. ..
  2. Zhang L, Zhao J. [The recent research situation of Euonymus alatus]. Zhongguo Zhong Yao Za Zhi. 2005;30:1895-8 pubmed
    ..It is effective for diabetes, hyperglycemia, chronic nephropathy, rheumatoid arthritis, urinary tract infection and prostate diseases, etc internal diseases, no matter singleness or together with other herbs. ..
  3. Xu L, Yan Y, Zhang J, Zhang Y, Zhao M. The glycans deficiencies of macromolecular IgA1 is a contributory factor of variable pathological phenotypes of IgA nephropathy. Clin Exp Immunol. 2005;142:569-75 pubmed
    ..This suggests that aberrant glycosylation of IgA1 in serum macromolecules might be a contributory factor in the pathogenesis of IgAN. ..
  4. Lv J, Zhang H, Cui Z, Su T, Zhang Y, Wang H. Delayed severe pneumonia in mycophenolate mofetil-treated patients with IgA nephropathy. Nephrol Dial Transplant. 2008;23:2868-72 pubmed publisher
    ..This finding and its risk factors need to be further evaluated. ..
  5. Yu L, Jiang L, Zhou X, Zhu L, Zhang H. Common genetic variants in the chromogranin a promoter are associated with renal injury in IgA nephropathy patients with malignant hypertension. Ren Fail. 2010;32:41-6 pubmed publisher
    ..014. The present study suggested the genetic variants in the chromogranin A promoter may not involve in the onset of malignant hypertension, but the variants might play a role in the renal dysfunction in patients with IgAN-MHT. ..
  6. Zhu L, Yu L, Wang C, LV J, Li G, Zhang H, et al. Genetic effect of the NPHS2 gene variants on proteinuria in minimal change disease and immunoglobulin A nephropathy. Nephrology (Carlton). 2009;14:728-34 pubmed publisher
  7. Li G, Nie G, Zhang H, LV J, Shen Y, Wang H. Do the mutations of C1GALT1C1 gene play important roles in the genetic susceptibility to Chinese IgA nephropathy?. BMC Med Genet. 2009;10:101 pubmed publisher
    ..The c.-347-190G>A polymorphism and the somatic mutation of encoding region of C1GALT1C1 gene were not significantly related to the genetic susceptibility to IgAN in Northern Chinese population. ..
  8. Zhu L, Tang W, Li G, Lv J, Ding J, Yu L, et al. Interaction between variants of two glycosyltransferase genes in IgA nephropathy. Kidney Int. 2009;76:190-8 pubmed publisher
    ..Our findings suggest that potential genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN. ..
  9. Ding J, Xu L, Zhu L, Lv J, Zhao M, Zhang H, et al. Activity of alpha2,6-sialyltransferase and its gene expression in peripheral B lymphocytes in patients with IgA nephropathy. Scand J Immunol. 2009;69:174-80 pubmed publisher
    ..17, P > 0.05). These data suggested that reduced sialylation of serum IgA1 may result from decreased expression of ST6GALNAC2. The factors affecting activity of alpha2,6-ST in the sialylation of IgA1 need to be further investigated. ..

More Information


  1. Li G, Zhang H, Lv J, Hou P, Wang H. Tandem repeats polymorphism of MUC20 is an independent factor for the progression of immunoglobulin A nephropathy. Am J Nephrol. 2006;26:43-9 pubmed
    ..However, IgAN patients with SL/LL genotypes had a higher risk of the progression to end-stage renal disease. ..
  2. Li G, Zhu L, Zhang H, LV J, Ding J, Zhao M, et al. Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy. Hum Mutat. 2007;28:950-7 pubmed
  3. Li G, Zhang H, Lv J, Shen Y, Wang H. Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy. Kidney Int. 2007;71:448-53 pubmed
    ..0298, P=1.258 x 10(-5), OR=3.03) were significantly higher in patients than in controls. The present study suggested that the polymorphisms of C1GALT1 gene were associated with the genetic susceptibility to IgAN in Chinese population...
  4. Zhang J, Jiang L, Liu G, Wang S, Zou W, Zhang H, et al. Levels of urinary complement factor H in patients with IgA nephropathy are closely associated with disease activity. Scand J Immunol. 2009;69:457-64 pubmed publisher
    ..The levels of urinary factor H may be a useful biomarker to evaluate kidney injury in IgAN. ..
  5. Li G, Zhang H, Lu J, Hou P, Zhou Y, Ma X, et al. [Variable number of tandem repeats polymorphism of MUC20 is associated with the progression of IgA nephropathy]. Zhonghua Yi Xue Za Zhi. 2005;85:1333-8 pubmed
    ..The SL/LL genotype was likely to be a risk factor for rapid progression of renal function in the patients with IgAN. ..
  6. Cui T, Ichikawa T, Yang M, Dong X, Li J, Cui T. An emerging role of deubiquitinating enzyme cylindromatosis (CYLD) in the tubulointerstitial inflammation of IgA nephropathy. Biochem Biophys Res Commun. 2009;390:307-12 pubmed publisher
  7. Xu L, Zhao M. Aberrantly glycosylated serum IgA1 are closely associated with pathologic phenotypes of IgA nephropathy. Kidney Int. 2005;68:167-72 pubmed
    ..The aim of the current study is to investigate whether aberrantly glycosylated IgA1 was associated with pathologic phenotypes of IgAN...
  8. Wang Y, Zhao M, Zhang Y, Li X, Wang H. Binding capacity and pathophysiological effects of IgA1 from patients with IgA nephropathy on human glomerular mesangial cells. Clin Exp Immunol. 2004;136:168-75 pubmed
    ..This suggests that direct interaction between IgA1 and HMC and subsequential pathophysiological responses may play an important role in the pathogenesis for IgAN...