Experts and Doctors on gene expression in Beijing, China


Locale: Beijing, China
Topic: gene expression

Top Publications

  1. Bai H, Gu L, Zhou J, Deng D. p16 hypermethylation during gastric carcinogenesis of Wistar rats by N-methyl-N'-nitro-N-nitrosoguanidine. Mutat Res. 2003;535:73-8 pubmed
    ..These results suggest that CpG island hypermethylation may account for the silencing of p16 in rat stomach and is an early event whose accumulation will finally lead to gastric carcinogenesis. ..
  2. Yang X, Dong X, Li Y, Wang Y, Chen W. Purification and refolding of a novel cancer/testis antigen BJ-HCC-2 expressed in the inclusion bodies of Escherichia coli. Protein Expr Purif. 2004;33:332-8 pubmed
    ..This method of protein purification and refolding is easy to manipulate and may be applicable to the hydrophobic proteins that are unable to be purified by other methods. ..
  3. Zhang Y, Liu X, Wang M. Cloning, expression, and characterization of two novel cuticle-degrading serine proteases from the entomopathogenic fungus Cordyceps sinensis. Res Microbiol. 2008;159:462-9 pubmed publisher
    ..Bioassay revealed that Csp1 and Csp2 degraded the cuticle proteins of larval Hepialus sp. in vitro. This is the first report of serine proteases from C. sinensis. ..
  4. Chen W, Wang L, Liu H, Long L, Li S. Peroxisome proliferator-activated receptor delta-agonist, GW501516, ameliorates insulin resistance, improves dyslipidaemia in monosodium L-glutamate metabolic syndrome mice. Basic Clin Pharmacol Toxicol. 2008;103:240-6 pubmed publisher
  5. Wang H, Luo H, Bai Y, Wang Y, Yang P, Shi P, et al. An acidophilic beta-galactosidase from Bispora sp. MEY-1 with high lactose hydrolytic activity under simulated gastric conditions. J Agric Food Chem. 2009;57:5535-41 pubmed publisher
    ..Thus, BgalA may be a better digestive supplement for alleviating symptoms associated with lactase deficiency. ..
  6. Jin Y, An X, Ye Z, Cully B, Wu J, Li J. RGS5, a hypoxia-inducible apoptotic stimulator in endothelial cells. J Biol Chem. 2009;284:23436-43 pubmed publisher
    ..Moreover, RGS5 antagonizes the angiogenic effect of VEGF by increasing the activation of p38 signaling, suggesting that RGS5 could be an important target for apoptotic therapy. ..
  7. Kou Z, Kang L, Yuan Y, Tao Y, Zhang Y, Wu T, et al. Mice cloned from induced pluripotent stem cells (iPSCs). Biol Reprod. 2010;83:238-43 pubmed publisher
    ..Furthermore, the cloned mice are fertile and can produce second-generation offspring. These efforts strengthen the possibility of utilizing iPSCs to generate gene-modified large animals for pharmaceutical purposes in the future. ..
  8. Yan Y, Chen X, Yang K, Sun Z, Fu Y, Zhang Y, et al. Overexpression of an F-box protein gene reduces abiotic stress tolerance and promotes root growth in rice. Mol Plant. 2011;4:190-7 pubmed publisher
    ..Growth restraint in plants is an acclimatization strategy against abiotic stress. Our results also suggest that MAIF1 plays the negative role in response to abiotic stress possibly by regulating root growth. ..
  9. Lin T, Meng Q, Sui D, Peng D, Li Y, Liu X, et al. Molecular cloning and expression analysis of porcine ghrelin o-acyltransferase. Biochem Genet. 2011;49:576-86 pubmed publisher
    ..GOAT was also detected in liver, lung, brain, testis, spleen, kidney, heart, muscle, lipid, and ovary. Our results provide an important basis for further research on GOAT function and the relationship between ghrelin and GOAT. ..

More Information

Publications347 found, 100 shown here

  1. Zhang W, Wang F, Wang B, Zhang J, Yu J. Intraarticular gene delivery of CTLA4-FasL suppresses experimental arthritis. Int Immunol. 2012;24:379-88 pubmed publisher
    ..Our results indicate that rAAV.CTLA4-FasL profoundly suppressed experimental model of RA, implicating the potential therapeutic applications for suppression of RA by local joint delivery of CTLA4-FasL. ..
  2. Li N, Zhao G, Chen T, Xue L, Ma L, Niu J, et al. Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis. Cell Death Dis. 2012;3:e283 pubmed publisher
    ..Thus, our data imply that p33ING1-CSIG axis functions as a novel pro-apoptotic regulator in response to DNA damage...
  3. Mou X, Wu Y, Cao H, Meng Q, Wang Q, Sun C, et al. Generation of disease-specific induced pluripotent stem cells from patients with different karyotypes of Down syndrome. Stem Cell Res Ther. 2012;3:14 pubmed publisher
    ..iPSCs were generated from patients with DS. The iPSCs derived from different types of DS may be used in DS modeling, patient-care optimization, drug discovery, and eventually, autologous cell-replacement therapies. ..
  4. Li M, Zhu M, Zhu B, Wang Z. Cholera toxin suppresses expression of ubiquitin editing enzyme A20 and enhances transcytosis. Cell Physiol Biochem. 2013;31:495-504 pubmed publisher
    ..The microbial product, cholera toxin, interferes with the expression of A20 in intestinal epithelial cells, which compromises the intestinal epithelial barrier function. ..
  5. Wang Y, Zhang Y, Wang Z, Zhang X, Yang S. A missense mutation in CHS1, a TIR-NB protein, induces chilling sensitivity in Arabidopsis. Plant J. 2013;75:553-65 pubmed publisher
    ..This study revealed the role of a TIR-NB-type gene in plant growth and cell death under chilling stress, and suggests that temperature modulates the stability of the TIR-NB protein in Arabidopsis. ..
  6. Zeng K, Liao L, Song X, Lv H, Song F, Yu Q, et al. Caruifolin D from artemisia absinthium L. inhibits neuroinflammation via reactive oxygen species-dependent c-jun N-terminal kinase and protein kinase c/NF-κB signaling pathways. Eur J Pharmacol. 2015;767:82-93 pubmed publisher
    ..and also suggested that caruifolin D was a major anti-inflammatory component from Artemisia absinthium L., which might be developed as a drug candidate for neuroinflammation-related diseases. ..
  7. Cao D, Wang J, Ju Z, Liu Q, Li S, Tian H, et al. Regulations on growth and development in tomato cotyledon, flower and fruit via destruction of miR396 with short tandem target mimic. Plant Sci. 2016;247:1-12 pubmed publisher
    ..Overall, these results revealed novel roles of miR396 in regulating flower and fruit development, and provided a new potential way for improving tomato fruit yield. ..
  8. Li H, Wang Q, Wang R, Zhang Y, Wang X, Wang H. Global regulator SoxR is a negative regulator of efflux pump gene expression and affects antibiotic resistance and fitness in Acinetobacter baumannii. Medicine (Baltimore). 2017;96:e7188 pubmed publisher
    ..These results reveal that the global regulator SoxR is a negative regulator of efflux pump gene expression, and contributes to antibiotic resistance and fitness in A. baumannii. ..
  9. He Q, Li G, Wang X, Wang S, Hu J, Yang L, et al. A Decrease of Histone Deacetylase 6 Expression Caused by Helicobacter Pylori Infection is Associated with Oncogenic Transformation in Gastric Cancer. Cell Physiol Biochem. 2017;42:1326-1335 pubmed publisher
    ..HP infection could promote HDAC1 and HDAC4 expression as determined by Western blotting. HDAC6 is a promising biomarker for early diagnosis and prognosis during the oncogenic transformation of gastric cancer. ..
  10. Zhong L, Song H, Wang W, Li J, Ma M. MEFV M694V mutation has a role in susceptibility to ankylosing spondylitis: A meta-analysis. PLoS ONE. 2017;12:e0182967 pubmed publisher
    ..The present study indicates that the MEFV M694V mutation may contribute to the pathogenesis of AS. The associations between the other mutations and AS need to be validated with more relevant and well-designed studies. ..
  11. Chen X, Zhang W, Gao Y, Su X, Zhai Z. Senescence-like changes induced by expression of p21(waf1/Cip1) in NIH3T3 cell line. Cell Res. 2002;12:229-33 pubmed
    ..0, which is known to be a marker of senescence. Our results suggest that p2l(Waf1/Cip1) can also induce senescence-like changes in murine cells. ..
  12. Li L, Bin L, Li F, Liu Y, Chen D, Zhai Z, et al. TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways. J Cell Sci. 2005;118:555-63 pubmed
    ..These data have established a physical and functional association between TRIP6 and RIP2, and suggest that RIP2's involvement in multiple NF-kappaB and ERK activation pathways is mediated through TRIP6. ..
  13. Li J, Chen Z, Hou L, Fan H, Weng S, Xu C, et al. High-level expression, purification, and characterization of non-tagged Aspergillus flavus urate oxidase in Escherichia coli. Protein Expr Purif. 2006;49:55-9 pubmed
    ..8 g cell paste/L). The results presented here exhibit the ability to generate multi-gram quantities of rUox from E. coli that may be used for the development of pharmaceutics of reducing the hyperuricemia. ..
  14. Sun Y, Huang Y, Xu Q, Wang H, Bai B, Sui J, et al. HIV-1 Tat depresses DNA-PK(CS) expression and DNA repair, and sensitizes cells to ionizing radiation. Int J Radiat Oncol Biol Phys. 2006;65:842-50 pubmed
    ..These observations provide new insight into the increased tissue reactions of AIDS cancer patients to radiotherapy. ..
  15. Yu Z, Meng Q, Yu H, Fan B, Yu S, Fei J, et al. Expression and bioactivity of recombinant human lysozyme in the milk of transgenic mice. J Dairy Sci. 2006;89:2911-8 pubmed
    ..This work will certainly permit a better understanding of how mammary gland bioreactor systems can be applied to produce rHlys in other mammals, such as cattle...
  16. Cheng C, Lan Y, Liu Y, Zhang Z, Shu Y. [Genetic analysis of NS1 fragment of human H5N1 influenza virus isolated in Anhui province and its expression in Escherichia coli]. Wei Sheng Wu Xue Bao. 2007;47:418-22 pubmed
    ..As a result, the work paves the way for further understanding the role of NSI in human H5N1 infection and development of new antiviral drugs against influenza virus. ..
  17. Yanjun Z, Guangyu L, Bin F, Qing W, Ving J, Aizhen L. Study of hypoxia-induced expression of HIF-1alpha in retina pigment epithelium. Bull Exp Biol Med. 2007;143:323-7 pubmed
    ..Hypoxia-induced increase in the level of HIF-1alpha in RPE. It can be an important step in choriodal neovascularization. ..
  18. Zhang L, Zheng S, Wu H, Wu Y, Liu S, Fan M, et al. Identification of BLyS (B lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for Nogo-66 receptor. J Neurosci. 2009;29:6348-52 pubmed publisher
    ..Thus, BLyS can function independently of myelin-associated inhibitors and likely serves as a redundant NgR ligand that negatively influences axonal outgrowth in CNS. ..
  19. Tang X, Lu X, Guo W, Ren T, Zhao H, Zhao F, et al. Different expression of Sox9 and Runx2 between chondrosarcoma and dedifferentiated chondrosarcoma cell line. Eur J Cancer Prev. 2010;19:466-71 pubmed publisher
    ..In SW1353 cells, however, gene expressions were reversed. These findings provide evidence that Sox9 and Runx2 are involved in the occurrence and development of DDCS...
  20. Hao L, Ge X, Wan H, Hu S, Lercher M, Yu J, et al. Human functional genetic studies are biased against the medically most relevant primate-specific genes. BMC Evol Biol. 2010;10:316 pubmed publisher
    ..Future studies should thus be designed to specifically explore the properties of primate-specific genes. ..
  21. Li L, Zhu B, Yang P, Fu D, Zhu Y, Luo Y. The regulation mode of RIN transcription factor involved in ethylene biosynthesis in tomato fruit. J Sci Food Agric. 2011;91:1822-8 pubmed publisher
    ..These results will help to further clarify the mechanism of tomato fruit development and ripening, and to maintain quality and prolong shelf life of tomato fruit. ..
  22. Li H, Li X, Lu Y, Wang X, Zheng S. Staphylococcus sciuri exfoliative toxin C is a dimer that modulates macrophage functions. Can J Microbiol. 2011;57:722-9 pubmed publisher
    ..7 cells. These results suggest that ExhC may play an important role in innate immune response against S. sciuri infection. ..
  23. Wang J, Xu B, Yuan P, Zhang P, Li Q, Ma F, et al. TOP2A amplification in breast cancer is a predictive marker of anthracycline-based neoadjuvant chemotherapy efficacy. Breast Cancer Res Treat. 2012;135:531-7 pubmed publisher
    ..The TOP2A amplification is related to anthracycline-based neoadjuvant chemotherapy sensitivity, and TOP2A should be included in future studies in breast cancer as a predictive marker. ..
  24. Zhang L, Zhao G, Xia C, Jia J, Liu X, Kong X. A wheat R2R3-MYB gene, TaMYB30-B, improves drought stress tolerance in transgenic Arabidopsis. J Exp Bot. 2012;63:5873-85 pubmed publisher
    ..These results indicate that the TaMYB30-B protein plays important roles in plant stress tolerance, and modification of its expression may improve drought stress tolerance in crop plants. ..
  25. Chu L, Wang B, Xu B, Dong N. Aqueous cytokines as predictors of macular edema in non-diabetic patients following uncomplicated phacoemulsification cataract surgery. Mol Vis. 2013;19:2418-25 pubmed
    ..To ascertain whether cytokines in the aqueous humor can predict macular edema (ME) in non-diabetic patients following uncomplicated phacoemulsification cataract surgery...
  26. Gossan N, Zhang F, Guo B, Jin D, Yoshitane H, Yao A, et al. The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor. Nucleic Acids Res. 2014;42:5765-75 pubmed publisher
  27. Kennedy J, Xiong N, Yu J, Zai C, Pouget J, Li J, et al. Increased Nigral SLC6A3 Activity in Schizophrenia Patients: Findings From the Toronto-McLean Cohorts. Schizophr Bull. 2016;42:772-81 pubmed publisher
    ..These findings collectively suggest that increased nigralSLC6A3activity may be a risk factor for SCZ, and may help to explain high rates of comorbidity with substance abuse. ..
  28. He N, Feng G, Li Y, Xu Y, Xie X, Wang H, et al. Embryonic stem cell preconditioned microenvironment suppresses tumorigenic properties in breast cancer. Stem Cell Res Ther. 2016;7:95 pubmed publisher
    ..This study may act as a platform to understand tumor cell plasticity and may offer new therapeutic strategies to inhibit breast cancer progression. ..
  29. Song Y, Huang X, Shen G, Liu X, Zhang X. [Comparison of paired box genes 8 and 2 expression in epithelium tissues and the related tumors]. Zhonghua Zhong Liu Za Zhi. 2017;39:424-428 pubmed publisher
  30. He H, Cai L, Skogerbø G, Deng W, Liu T, Zhu X, et al. Profiling Caenorhabditis elegans non-coding RNA expression with a combined microarray. Nucleic Acids Res. 2006;34:2976-83 pubmed
    ..Taken together, our microarray analysis presents a more complete and detailed picture of a non-coding transcriptome than hitherto has been presented for any other multicellular organism. ..
  31. Tang Q, Hu Y, Kang L, Wang C. Characterization of glucose-induced glucose oxidase gene and protein expression in Helicoverpa armigera larvae. Arch Insect Biochem Physiol. 2012;79:104-19 pubmed publisher
    ..These results proved that GOX expressions in larval labial salivary glands induced by dietary glucose were exhibited not only on transcriptional levels, but also on translational/posttranslational levels. ..
  32. Zhang W, Jian G, Jiang T, Wang S, Qi F, Xu S. Cotton gene expression profiles in resistant Gossypium hirsutum cv. Zhongzhimian KV1 responding to Verticillium dahliae strain V991 infection. Mol Biol Rep. 2012;39:9765-74 pubmed publisher
    ..The result from real-time quantitative reverse transcription polymerase chain reaction showed that these genes were activated quickly and transiently after inoculation with V. dahliae. ..
  33. Ma J, Han B, Yang Y, Peng J. Retinoic acid synthesis and metabolism are concurrent in the mouse uterus during peri-implantation. Cell Tissue Res. 2012;350:525-37 pubmed publisher
    ..Therefore, the expression of Cyp26a1 in luminal and glandular epithelium might block the adverse effect of RA in order to promote successful embryo implantation. ..
  34. Zha L, Liu S, Su P, Yuan Y, Huang L. Cloning, prokaryotic expression and functional analysis of squalene synthase (SQS) in Magnolia officinalis. Protein Expr Purif. 2016;120:28-34 pubmed publisher
    ..These results indicated that MoSQSΔTM was functional, thereby establishing an important foundation for the study of triterpenoid biosynthesis in M. officinalis. ..
  35. Peng Y, Wang S, Li K, Liu J, Zheng Y, Shan S, et al. Identification of odorant binding proteins and chemosensory proteins in Microplitis mediator as well as functional characterization of chemosensory protein 3. PLoS ONE. 2017;12:e0180775 pubmed publisher
    ..The MmedCSP3 may be involved in locating host insects. Our data provide a base for further investigating the physiological roles of OBPs and CSPs in M. mediator, and extend the function of MmedCSP3 in chemoreception of M. mediator. ..
  36. Li H, Cui D, Tong X, Ma N, Gao Y, Cui X, et al. [The role of matrix metalloproteinases in extracellular matrix remodelling in chronic obstructive pulmonary disease rat models]. Zhonghua Nei Ke Za Zhi. 2002;41:393-8 pubmed
  37. Tian D, Li X, Shi Y, Wan Y, Wang X, Chang J, et al. Changes of hypothalamic alpha-MSH and CART peptide expression in diet-induced obese rats. Peptides. 2004;25:2147-53 pubmed
    ..Failure of hypothalamic anorexigenic peptides CART and alpha-MSH to increase their content in response to HIF diet may play a key role for overly high energy consumption, resulting in obesity. ..
  38. Cui N, Nomura T, Noma H, Yokoo K, Takagi R, Hashimoto S, et al. Effect of YM529 on a model of mandibular invasion by oral squamous cell carcinoma in mice. Clin Cancer Res. 2005;11:2713-9 pubmed
    ..YM529, a third-generation bisphosphonate, can suppress osteoclast-mediated bone invasion by OSCC. The mechanism of this effect might involve inhibition of cytokines such as IL-6, PTHrP, TNF-alpha, and RANK by YM529. ..
  39. Wan Y, Yan Z, Liu K, Zheng Y, D Ovidio R, Shewry P, et al. Comparative analysis of the D genome-encoded high-molecular weight subunits of glutenin. Theor Appl Genet. 2005;111:1183-90 pubmed
    ..The implications of these results for HMW subunit evolution and wheat quality improvement are discussed. ..
  40. Zhao J, Hua Y, Sun D, Meng X, Xiao H, Ma X. Genome-wide microRNA profiling in human fetal nervous tissues by oligonucleotide microarray. Childs Nerv Syst. 2006;22:1419-25 pubmed
    ..A series of microRNAs were found specifically and higher-expressed in the human fetal nervous system and confirmed consistently by Northern blot, which may play a critical role in nervous system development. ..
  41. Tang H, Chen S, Wang H, Wu H, Lu Q, Han D. TAM receptors and the regulation of erythropoiesis in mice. Haematologica. 2009;94:326-34 pubmed publisher
    ..Axl and Mer play an important role in regulating erythropoiesis. This finding provides a novel insight into the mechanism of erythropoiesis. ..
  42. Zheng Y, Xue Y, Zhang Y, Zhou C, Schwaneberg U, Ma Y. Cloning, expression, and characterization of a thermostable glucoamylase from Thermoanaerobacter tengcongensis MB4. Appl Microbiol Biotechnol. 2010;87:225-33 pubmed publisher
    ..The cations Ca2+, Mn2+, Co2+, Mg2+, and reducing agent DTT showed no obvious effects on the action of TtcGA. In contrast, the enzyme was inactivated by Zn2+, Pb2+, Cu2+, and EDTA...
  43. Zhao B, Wang Z, Yi B, Ma H, Xu H. hRad21 overexpresses and localizes to the ALT-associated promyelocytic leukemia body in ALT cells. Cancer Biol Ther. 2010;9:978-83 pubmed
    ..Thus, one role of hRAD21 appeared to involve telomere maintenance in ALT cells. We suggested that hRAD21 facilitated telomere HR in ALT cells by participating in APB formation. ..
  44. Li Q, Wang Y, Zheng Q, Zhao Z, Ping G, Zhang L. [Effects of the cell wall of Streptococcus mutans on the expression of TLR4, IL-6 and IL-8 by EAhy926 cells]. Wei Sheng Wu Xue Bao. 2010;50:204-10 pubmed
  45. Ma Z, Hong Q, Wang Y, Tan H, Xiao C, Liang Q, et al. Ferulic acid attenuates adhesion molecule expression in gamma-radiated human umbilical vascular endothelial cells. Biol Pharm Bull. 2010;33:752-8 pubmed
    ..FA appears to be a potential therapeutic agent for treating various inflammatory disorders including radiation induced inflammation. ..
  46. Xue Q, Zhou Y, Zhu S, Bulun S. Hypermethylation of the CpG island spanning from exon II to intron III is associated with steroidogenic factor 1 expression in stromal cells of endometriosis. Reprod Sci. 2011;18:1080-4 pubmed publisher
  47. Sun Y, Huang L, Pelosi P, Wang C. Expression in antennae and reproductive organs suggests a dual role of an odorant-binding protein in two sibling Helicoverpa species. PLoS ONE. 2012;7:e30040 pubmed publisher
  48. Xiong X, Wang X, Wen B, Graves S, Stenos J. Potential serodiagnostic markers for Q fever identified in Coxiella burnetii by immunoproteomic and protein microarray approaches. BMC Microbiol. 2012;12:35 pubmed publisher
    ..Our results demonstrate that these 7 Coxiella proteins gave a modest sensitivity and specificity for recognizing of Q fever patient sera, suggesting that they are potential serodiagnostic markers for Q fever. ..
  49. Chen M, Zhang A, Zhang Q, Zhang B, Nan J, Li X, et al. Arabidopsis NMD3 is required for nuclear export of 60S ribosomal subunits and affects secondary cell wall thickening. PLoS ONE. 2012;7:e35904 pubmed publisher
    ..This new facet is that the nuclear export of 60S ribosomal subunits and the formation of RER may play regulatory roles in coordinating protein synthesis in cytoplasm and transcription in nuclei. ..
  50. Guo L, Tang B, Dong W, Liang P, Gao X. Cloning, characterisation and expression profiling of the cDNA encoding the ryanodine receptor in diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae). Pest Manag Sci. 2012;68:1605-14 pubmed publisher
    ..xylostella at various levels. The results provided the basis for further understanding of the mechanisms of resistance to diamide insecticides in P. xylostella. ..
  51. Yang Y, Tan W. [Progress on development and research of coronavirus based vector]. Bing Du Xue Bao. 2012;28:297-302 pubmed
    ..Thus, coronavirus-based vector is becoming a promising and useful tool for vaccine development and gene delivery. ..
  52. Zhang Y, Deng J, Zhang Y, Guo F, Li C, Zou Z, et al. Functionalized single-walled carbon nanotubes cause reversible acute lung injury and induce fibrosis in mice. J Mol Med (Berl). 2013;91:117-28 pubmed publisher
    ..In addition, we notify that the type of functional groups should be considered in nanomedicine application as differently functionalized SWCNTs generated different effects on the lung toxicity. ..
  53. Zhang X, Wang T, Deng T, Xiong W, Lui P, Li N, et al. Damaged spermatogenic cells induce inflammatory gene expression in mouse Sertoli cells through the activation of Toll-like receptors 2 and 4. Mol Cell Endocrinol. 2013;365:162-73 pubmed publisher
    ..The results provide novel insights into the mechanisms underlying damaged spermatogenic cell-induced testicular inflammation. ..
  54. Zhou J, Zhang H, Li J, Sheng X, Zong S, Luo Y, et al. Molecular cloning and expression profile of a Halloween gene encoding Cyp307A1 from the seabuckthorn carpenterworm, Holcocerus hippophaecolus. J Insect Sci. 2013;13:56 pubmed publisher
    ..These results suggest that the sequence character and expression profile of HhSpo were well conserved and provided the basic information for its functional analysis. ..
  55. Yang G, Geng X, Song J, Wu Y, Yan H, Zhan Z, et al. Insulin-like growth factor 2 enhances regulatory T-cell functions and suppresses food allergy in an experimental model. J Allergy Clin Immunol. 2014;133:1702-8.e5 pubmed publisher
    ..Activation of IGF2R enhances Treg cell functions in suppressing other Teff cell activities and inhibiting allergic inflammation in the intestine. ..
  56. Yang Y, Qi S, Wang D, Wang K, Zhu L, Chai T, et al. Toxic effects of thifluzamide on zebrafish (Danio rerio). J Hazard Mater. 2016;307:127-36 pubmed publisher
    ..These might be responsible for the adverse expansion of the apoptosis- and immune-related genes, which would facilitate the action of these factors in programmed cell death and might play a key role during the toxic events. ..
  57. Shi Y, Chen L, Xu Y, Hu X, Ao Y, Wang J. Acetabular Labral Reconstruction With Autologous Tendon Tissue in a Porcine Model: In Vivo Histological Assessment and Gene Expression Analysis of the Healing Tissue. Am J Sports Med. 2016;44:1031-9 pubmed publisher
    ..Autologous tendon tissue can be considered as a viable option for acetabular labral reconstruction. ..
  58. Cui R, Cai G, Yin Z, Cheng Y, Yang Q, Tian T. Transretinoic acid inhibits rats gastric epithelial dysplasia induced by N-methyl-N-nitro-N-nitrosoguanidine: influences on cell apoptosis and expression of its regulatory genes. World J Gastroenterol. 2001;7:394-8 pubmed
  59. Jin X, Brandazza A, Navarrini A, Ban L, Zhang S, Steinbrecht R, et al. Expression and immunolocalisation of odorant-binding and chemosensory proteins in locusts. Cell Mol Life Sci. 2005;62:1156-66 pubmed
    ..Sensilla chaetica on other parts of the body showed the same expression of CSP-I as those on the antenna...
  60. Peng F, Duan Z, Zheng L, Xie Z, Gao H, Zhang H, et al. Purification of recombinant human interferon-epsilon and oligonucleotide microarray analysis of interferon-epsilon-regulated genes. Protein Expr Purif. 2007;53:356-62 pubmed
    ..Particularly, differential regulation of genes related to central nervous system by rhIFN-epsilon suggests a role for IFN-epsilon in maintenance of the structure and function of brain. ..
  61. Chen X, Li Y, Huang J, Cao D, Yang G, Liu W, et al. Study of tauopathies by comparing Drosophila and human tau in Drosophila. Cell Tissue Res. 2007;329:169-78 pubmed
    ..These results suggest that the two tau genes differ significantly. This comparison between species-specific isoforms may help to clarify whether the homologous tau genes are conserved. ..
  62. Kang B, Guo R, Tan X, Zhao M, Tang Z, Lu Y. Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer. Mutat Res. 2008;638:17-25 pubmed
    ..05). These results indicated that ATM phosphorylation status might be a prognostic marker for individual therapy in advanced GC patients. ..
  63. Bai Z, Ye Y, Chen D, Shen D, Xu F, Cui Z, et al. Homeoprotein Cdx2 and nuclear PTEN expression profiles are related to gastric cancer prognosis. APMIS. 2007;115:1383-90 pubmed publisher
    ..014). These data suggest that combined analysis of Cdx2 and nuclear PTEN expression can have significant value in distinguishing histological types of gastric cancer and assessing prognosis in patients with gastric cancer. ..
  64. Yang J, Yang C, Jiang H, Qiao C. Overexpression of methyl parathion hydrolase and its application in detoxification of organophosphates. Biodegradation. 2008;19:831-9 pubmed publisher
    ..Additionally, the products of pesticide hydrolysis generated by treatment with the enzyme extract were determined to be virtually nontoxic. ..
  65. Xu X, Wang Z, Fan K, Wang S, Jia C, Han H, et al. Localization of the ActIII actinorhodin polyketide ketoreductase to the cell wall. FEMS Microbiol Lett. 2008;287:15-21 pubmed publisher
  66. Li P, Liu Y, Liu S. Genetic and biochemical identification of the chorismate mutase from Corynebacterium glutamicum. Microbiology. 2009;155:3382-91 pubmed publisher
    ..Conserved hypothetical proteins homologous to CM0819 were identified in all known Corynebacterium genomes, suggesting a universal occurrence of CM0819-like CMs in the genus Corynebacterium. ..
  67. Hong Y, Wang J, Zhang P, Yang S, Song K, Yu F, et al. Histopathological and gene expression analysis of mice exposed to diethylstilbestrol. Toxicol Mech Methods. 2010;20:105-11 pubmed publisher
    ..The study provides evidence that DES has an acute effect on gene expression. The results may facilitate the discovery of the genotoxic mechanism of DES and allow one to discover new DES-responsive genes. ..
  68. Han L, Hu Z, Liu Y, Wang X, Hopkins K, Lieberman H, et al. Mouse Rad1 deletion enhances susceptibility for skin tumor development. Mol Cancer. 2010;9:67 pubmed publisher
  69. Wang Y, Meng L, Hu H, Zhang Y, Zhao C, Li Q, et al. Oct-4B isoform is differentially expressed in breast cancer cells: hypermethylation of regulatory elements of Oct-4A suggests an alternative promoter and transcriptional start site for Oct-4B transcription. Biosci Rep. 2011;31:109-15 pubmed publisher
    ..In addition, we speculate that the transcription of Oct-4B in MCF-7 cells is differentially regulated by additional regulatory elements. This work will enhance the understanding of Oct-4 gene in differential regulation. ..
  70. Zhao Y, Zhang F, Zhu S, Duan H, Li Y, Zhou Z, et al. The association of a single nucleotide polymorphism in the promoter region of the LAMA1 gene with susceptibility to Chinese high myopia. Mol Vis. 2011;17:1003-10 pubmed
    ..Our results indicate that the polymorphism of rs2089760, located in the promoter region of LAMA1, may be associated with high myopia in the Chinese population and should be investigated further. ..
  71. Wang Q, Chang L, Wang X, Liu X. Expression, crystallization and preliminary X-ray analysis of a ferric binding protein from Thermus thermophilus HB8. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011;67:723-6 pubmed publisher
    ..6, b = 63.6, c = 266.7 Å, α = β = 90.0, γ = 120.0°). ..
  72. Huang W, Shang W, Li D, Wu W, Hou S. Simvastatin protects osteoblast against H2O2-induced oxidative damage via inhibiting the upregulation of Nox4. Mol Cell Biochem. 2012;360:71-7 pubmed publisher
    ..We concluded that simvastatin protected osteoblast against H(2)O(2)-induced oxidative damage, at least in part, via inhibiting the upregulation of Nox4. ..
  73. Liu K, Luo H, Yue D, Ge S, Yuan F, Yan L, et al. Molecular cloning and characterization of the sheep ?-TTP gene and its expression in response to different vitamin E status. Gene. 2012;494:225-30 pubmed publisher
    ..The results showed that dietary vitamin E levels did not affect ?-TTP mRNA expression significantly while the low vitamin E supplemented level groups of sheep had significantly higher ?-TTP protein compared to high-vitamin E groups...
  74. Li Y, Wang J, Li C, Ke X. Contribution of PD-L1 to oncogenesis of lymphoma and its RNAi-based targeting therapy. Leuk Lymphoma. 2012;53:2015-23 pubmed publisher
  75. Yang J, Wang X, Wang Y, Guo Z, Luo D, Jia J, et al. Dopaminergic neuronal conversion from adult rat skeletal muscle-derived stem cells in vitro. Neurochem Res. 2012;37:1982-92 pubmed publisher
    ..The present results indicate that adult skeletal muscle-derived stem cells could provide a promising cell source for autologous transplantation for neurodegenerative diseases in the future, especially the Parkinson's disease. ..
  76. Hu P, Li X, Lei N, Lan X, Zhao Q, Guan W, et al. Study on characteristics of chemokine CXCL10 gene cloned from cDNA expression library of Ujumqin sheep. Biomed Res Int. 2013;2013:217942 pubmed publisher
    ..Expression of recombinant CXCL10 gene in Escherichia coli had a time- and temperature-dependency on the amount of protein expression, and a small quantity of inducer was needed. ..
  77. Ren C, Du J, Xi C, Yu Y, Hu A, Zhan J, et al. Kindlin-2 inhibits serous epithelial ovarian cancer peritoneal dissemination and predicts patient outcomes. Biochem Biophys Res Commun. 2014;446:187-94 pubmed publisher
    ..Collectively, we concluded that inadequate Kindlin-2 is an independent risk factor for serous epithelial ovarian cancer patients. ..
  78. Li W, Guo A, Wang L, Kong Q, Wang R, Han L, et al. Expression of peptide fragments from proADM and involvement of mitogen-activated protein kinase signaling pathways in pulmonary remodeling induced by high pulmonary blood flow. Congenit Anom (Kyoto). 2016;56:28-34 pubmed publisher
  79. Cui Y, Han J, Xiao Z, Chen T, Wang B, Chen B, et al. The miR-20-Rest-Wnt signaling axis regulates neural progenitor cell differentiation. Sci Rep. 2016;6:23300 pubmed publisher
    ..This novel regulatory circuit provides additional insight into how microRNAs interact with signaling molecules during neural differentiation of NPCs, allowing for fine-tuning of intricate cellular processes. ..
  80. Zhang Y, Liang Y, Qiu D, Yuan J, Yang X. Comparison of cerato-platanin family protein BcSpl1 produced in Pichia pastoris and Escherichia coli. Protein Expr Purif. 2017;136:20-26 pubmed publisher
    ..coli expression system produces higher BcSpl1 yields than the P. pastoris system. This high-yield expression of BcSpl1 may be relevant for future large-scale applications of this elicitor to improve crop production. ..
  81. Zhang J, Zhi H, Ding F, Luo A, Liu Z. Transglutaminase 3 expression in C57BL/6J mouse embryo epidermis and the correlation with its differentiation. Cell Res. 2005;15:105-10 pubmed
    ..The above findings suggest that the expression of TGM3 plays a important role in the epidermis differentiation in embryogenesis. ..
  82. Hong B, Tong Z, Ma N, Li J, Kasuga M, Yamaguchi Shinozaki K, et al. Heterologous expression of the AtDREB1A gene in chrysanthemum increases drought and salt stress tolerance. Sci China C Life Sci. 2006;49:436-45 pubmed
    ..These results indicate that heterologous AtDREB1A can confer drought and salt tolerance in transgenic chrysanthemum, and improvement of the stress tolerance may be related to enhancement of proline content and SOD activity. ..
  83. Li Y, Li S, Dai Y, Du W, Zhao C, Wang L, et al. Nuclear reprogramming in embryos generated by the transfer of yak (Bos grunniens) nuclei into bovine oocytes and comparison with bovine-bovine SCNT and bovine IVF embryos. Theriogenology. 2007;67:1331-8 pubmed
    ..In conclusion, we inferred that the normal allocation of ICM and TE cells in yak-bovine SCNT embryos and embryo-specific gene reprogramming may be important for successful inter-species animal cloning. ..
  84. Lei L, Du C, Yang P, Xie F, Ou P, Han W, et al. Screening of strain-specific Actinobacillus pleuropneumoniae genes using a combination method. J Microbiol Methods. 2009;77:145-51 pubmed publisher
    ..Our findings indicated that the three-step method could be utilized to identify unique antigen-coding genes and may be a powerful and efficient technique for serotype-specific identification of pathogens and polyvalent vaccine design...
  85. Kui H, Luo H, Shi P, Bai Y, Yuan T, Wang Y, et al. Gene cloning, expression, and characterization of a thermostable xylanase from Nesterenkonia xinjiangensis CCTCC AA001025. Appl Biochem Biotechnol. 2010;162:953-65 pubmed publisher
    ..66 micromol min(-1) mg(-1) and 9.22 mg ml(-1) and 16.05 micromol min(-1) mg(-1), respectively. The predominant hydrolysis products were xylobiose and xylotriose when using oat spelt xylan or birchwood xylan as substrate. ..
  86. Yu J, Yin P, Liu F, Cheng G, Guo K, Lu A, et al. Effect of heat stress on the porcine small intestine: a morphological and gene expression study. Comp Biochem Physiol A Mol Integr Physiol. 2010;156:119-28 pubmed publisher
    ..The results of the bioinformatic analysis from the present study will be beneficial to further investigate the underlying mechanisms involved in heat stress-induced damage in the pig small intestine...
  87. Li X, Ji L, Li Y, Zhang Y. [The effect of soy isoflavones on ATP binding cassette A1 expression level in rats without ovaries with atherosclerotic plaque]. Zhonghua Yu Fang Yi Xue Za Zhi. 2009;43:895-9 pubmed
    ..To study the effect of soy isoflavones (SI) on ATP binding cassette A1 (ABCA1) expression in rats without ovary with atherosclerosis...
  88. Zhang J, Li D. Effect of conjugated linoleic acid on inhibition of prolyl hydroxylase 1 in hearts of mice. Lipids Health Dis. 2012;11:22 pubmed publisher
    ..This process also implies a reprogramming of basal metabolism and oxidative damage protection in myocardium in mice. All the effects shown in hearts of mice are due to c9, t11 CLA but not t10, c12 CLA. ..
  89. Sun L, Zhao R, Zhang L, Zhang T, Xin W, Lan X, et al. Salvianolic acid A inhibits PDGF-BB induced vascular smooth muscle cell migration and proliferation while does not constrain endothelial cell proliferation and nitric oxide biosynthesis. Molecules. 2012;17:3333-47 pubmed publisher
    ..Thus, the present study suggests a novel adjunct pharmacological strategy to prevent angioplasty-related restenosis. ..
  90. Wu Z, Satterfield M, Bazer F, Wu G. Regulation of brown adipose tissue development and white fat reduction by L-arginine. Curr Opin Clin Nutr Metab Care. 2012;15:529-38 pubmed publisher
    ..This enhances the oxidation of energy substrates and, thus, reduces white fat accretion in the body. L-arginine holds great promise in preventing and treating obesity in humans. ..
  91. Chen Y, Li F, Ma Y, Chong K, Xu Y. Overexpression of OrbHLH001, a putative helix-loop-helix transcription factor, causes increased expression of AKT1 and maintains ionic balance under salt stress in rice. J Plant Physiol. 2013;170:93-100 pubmed publisher
    ..The mechanism may have potential use in rice molecular breeding. ..
  92. Jia X, Yang J, Song W, Li P, Wang X, Guan C, et al. Involvement of large conductance Ca(2+)-activated K (+) channel in laminar shear stress-induced inhibition of vascular smooth muscle cell proliferation. Pflugers Arch. 2013;465:221-32 pubmed publisher
    ..This finding is important for understanding the mechanism by which SS regulates VSMC proliferation, and should be helpful in developing strategies to prevent flow-initiated vascular disease formation. ..