Experts and Doctors on cyclophilins in Beijing, China
Locale: Beijing, China
Duan X, Ji B, Yu K, Liu J, Hei F, Long C. Pharmacological postconditioning protects isolated rat hearts against ischemia-reperfusion injury: the role of mitochondrial permeability transition pore. ASAIO J. 2011;57:197-202 pubmed publisher
..05). Postconditioning prevented apoptosis-related mitochondrial permeabilization and dysfunction after cardioplegic arrest. Cyclosporine A postconditioning had a better effect than classic postconditioning in myocardial performance. ..
Wang T, Yun C, Gu S, Chang W, Liang D. 1.88 A crystal structure of the C domain of hCyP33: a novel domain of peptidyl-prolyl cis-trans isomerase. Biochem Biophys Res Commun. 2005;333:845-9 pubmed
..A key residue of the active site is changed from Ala-103-CypA to Ser-239-hCyP33, which may affect the PPIase domain/substrates interactions. ..
Hu H, Huang C, Liu H, Han Y, Yu L, Bi R. Crystallization and preliminary X-ray crystallographic studies of human cyclophilin J. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005;61:216-8 pubmed
..0 A resolution and preliminary crystallographic studies have been completed. The space group of the crystals is P3(1)21, with unit-cell parameters a = b = 40.597, c = 170.732 A, alpha = beta = 90, gamma = 120 degrees. ..
Chen A, WANG G, Qu Z, Lu C, Liu N, Wang F, et al
. Ectopic expression of ThCYP1, a stress-responsive cyclophilin gene from Thellungiella halophila, confers salt tolerance in fission yeast and tobacco cells. Plant Cell Rep. 2007;26:237-45 pubmed
..The present results suggest that ThCYP1 may participate in response to stresses in the salt cress, perhaps by regulating appropriate folding of certain stress-related proteins, or in the signal transduction processes. ..
Li B, Xu W, Xu Y, Zhang Y, Wang T, Bai Y, et al
. Integrative study on proteomics, molecular physiology, and genetics reveals an accumulation of cyclophilin-like protein, TaCYP20-2, leading to an increase of Rht protein and dwarf in a novel GA-insensitive mutant (gaid) in Wheat. J Proteome Res. 2010;9:4242-53 pubmed publisher
..It suggests that TaCYP20-2 is a new member that regulates wheat stem development mediated by DELLA protein degradation of GA signaling pathway. ..
Wang H, Zhang Y, Wang T, You H, Jia J. N-methyl-4-isoleucine cyclosporine attenuates CCl -induced liver fibrosis in rats by interacting with cyclophilin B and D. J Gastroenterol Hepatol. 2011;26:558-67 pubmed publisher
..NIM811 attenuates liver fibrosis in a CCl(4)-induced rat liver fibrosis model, which may be related to binding with cyclophilin B and D. ..
Wang Z, Liu X, Zhao Z, Xu C, Zhang K, Chen C, et al
. Cyclophilin E functions as a negative regulator to influenza virus replication by impairing the formation of the viral ribonucleoprotein complex. PLoS ONE. 2011;6:e22625 pubmed publisher
..The data presented here will help us to better understand the molecular mechanisms of host restriction barriers, host adaptation, and tissue tropism of influenza A virus. ..
Zhu C, Wang Y, Li Y, Bhatti K, Tian Y, Wu J. Overexpression of a cotton cyclophilin gene (GhCyp1) in transgenic tobacco plants confers dual tolerance to salt stress and Pseudomonas syringae pv. tabaci infection. Plant Physiol Biochem. 2011;49:1264-71 pubmed publisher
..Therefore, we suggest that GhCyp1 may be a suitable candidate gene to produce transgenic plants with tolerance to abiotic and biotic stresses...
Zhang Y, Li B, Xu Y, Li H, Li S, Zhang D, et al
. The cyclophilin CYP20-2 modulates the conformation of BRASSINAZOLE-RESISTANT1, which binds the promoter of FLOWERING LOCUS D to regulate flowering in Arabidopsis. Plant Cell. 2013;25:2504-21 pubmed publisher
..Therefore, a conformational change of BZR1 mediated by CYP20-2 causes altered flowering through modulation of FLD expression...