Experts and Doctors on cyclophilins in Beijing, China


Locale: Beijing, China
Topic: cyclophilins

Top Publications

  1. Duan X, Ji B, Yu K, Liu J, Hei F, Long C. Pharmacological postconditioning protects isolated rat hearts against ischemia-reperfusion injury: the role of mitochondrial permeability transition pore. ASAIO J. 2011;57:197-202 pubmed publisher
    ..05). Postconditioning prevented apoptosis-related mitochondrial permeabilization and dysfunction after cardioplegic arrest. Cyclosporine A postconditioning had a better effect than classic postconditioning in myocardial performance. ..
  2. Wang T, Yun C, Gu S, Chang W, Liang D. 1.88 A crystal structure of the C domain of hCyP33: a novel domain of peptidyl-prolyl cis-trans isomerase. Biochem Biophys Res Commun. 2005;333:845-9 pubmed
    ..A key residue of the active site is changed from Ala-103-CypA to Ser-239-hCyP33, which may affect the PPIase domain/substrates interactions. ..
  3. Hu H, Huang C, Liu H, Han Y, Yu L, Bi R. Crystallization and preliminary X-ray crystallographic studies of human cyclophilin J. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005;61:216-8 pubmed
    ..0 A resolution and preliminary crystallographic studies have been completed. The space group of the crystals is P3(1)21, with unit-cell parameters a = b = 40.597, c = 170.732 A, alpha = beta = 90, gamma = 120 degrees. ..
  4. Chen A, WANG G, Qu Z, Lu C, Liu N, Wang F, et al. Ectopic expression of ThCYP1, a stress-responsive cyclophilin gene from Thellungiella halophila, confers salt tolerance in fission yeast and tobacco cells. Plant Cell Rep. 2007;26:237-45 pubmed
    ..The present results suggest that ThCYP1 may participate in response to stresses in the salt cress, perhaps by regulating appropriate folding of certain stress-related proteins, or in the signal transduction processes. ..
  5. Li B, Xu W, Xu Y, Zhang Y, Wang T, Bai Y, et al. Integrative study on proteomics, molecular physiology, and genetics reveals an accumulation of cyclophilin-like protein, TaCYP20-2, leading to an increase of Rht protein and dwarf in a novel GA-insensitive mutant (gaid) in Wheat. J Proteome Res. 2010;9:4242-53 pubmed publisher
    ..It suggests that TaCYP20-2 is a new member that regulates wheat stem development mediated by DELLA protein degradation of GA signaling pathway. ..
  6. Wang H, Zhang Y, Wang T, You H, Jia J. N-methyl-4-isoleucine cyclosporine attenuates CCl -induced liver fibrosis in rats by interacting with cyclophilin B and D. J Gastroenterol Hepatol. 2011;26:558-67 pubmed publisher
    ..NIM811 attenuates liver fibrosis in a CCl(4)-induced rat liver fibrosis model, which may be related to binding with cyclophilin B and D. ..
  7. Wang Z, Liu X, Zhao Z, Xu C, Zhang K, Chen C, et al. Cyclophilin E functions as a negative regulator to influenza virus replication by impairing the formation of the viral ribonucleoprotein complex. PLoS ONE. 2011;6:e22625 pubmed publisher
    ..The data presented here will help us to better understand the molecular mechanisms of host restriction barriers, host adaptation, and tissue tropism of influenza A virus. ..
  8. Zhu C, Wang Y, Li Y, Bhatti K, Tian Y, Wu J. Overexpression of a cotton cyclophilin gene (GhCyp1) in transgenic tobacco plants confers dual tolerance to salt stress and Pseudomonas syringae pv. tabaci infection. Plant Physiol Biochem. 2011;49:1264-71 pubmed publisher
    ..Therefore, we suggest that GhCyp1 may be a suitable candidate gene to produce transgenic plants with tolerance to abiotic and biotic stresses...
  9. Zhang Y, Li B, Xu Y, Li H, Li S, Zhang D, et al. The cyclophilin CYP20-2 modulates the conformation of BRASSINAZOLE-RESISTANT1, which binds the promoter of FLOWERING LOCUS D to regulate flowering in Arabidopsis. Plant Cell. 2013;25:2504-21 pubmed publisher
    ..Therefore, a conformational change of BZR1 mediated by CYP20-2 causes altered flowering through modulation of FLD expression...

More Information


  1. Shang W, Gao H, Lu F, Ma Q, Fang H, Sun T, et al. Cyclophilin D regulates mitochondrial flashes and metabolism in cardiac myocytes. J Mol Cell Cardiol. 2016;91:63-71 pubmed publisher
    ..In addition, tissue-specific CyP-D expression may partly explain the differential regulation of mitoflashes in the two types of striated muscles. ..