Experts and Doctors on cell cycle proteins in Beijing, China


Locale: Beijing, China
Topic: cell cycle proteins

Top Publications

  1. Liu X, Lv Y, Xie Y, Hong Q, Cai G, Zhang S, et al. Change of MAX interactor 1 expression in an anti-Thy1 nephritis model and its effect on mesangial cell proliferation. Cell Physiol Biochem. 2011;27:391-400 pubmed publisher
  2. Huang J, Teng L, Liu T, Li L, Chen D, Li F, et al. Identification of a novel serine/threonine kinase that inhibits TNF-induced NF-kappaB activation and p53-induced transcription. Biochem Biophys Res Commun. 2003;309:774-8 pubmed
    ..Our findings suggest that SHIK is a negative regulator of NF-kappaB- and p53-mediated gene transcription. ..
  3. Yin S, Sun X, Schatten H, Sun Q. Molecular insights into mechanisms regulating faithful chromosome separation in female meiosis. Cell Cycle. 2008;7:2997-3005 pubmed
    ..Here, we discuss the molecular mechanisms underlying faithful chromosome separation in meiosis from three aspects: spindle checkpoint, two-step releases of cohesion, and the specific space-time protection of cohesin. ..
  4. Yuan J, Li M, Wei L, Yin S, Xiong B, Li S, et al. Astrin regulates meiotic spindle organization, spindle pole tethering and cell cycle progression in mouse oocytes. Cell Cycle. 2009;8:3384-95 pubmed
    ..Taken together, these data strongly suggest that Astrin is critical for meiotic spindle assembly and maturation in mouse oocytes. ..
  5. Guo Y, Zhang X, Yang M, Miao X, Shi Y, Yao J, et al. Functional evaluation of missense variations in the human MAD1L1 and MAD2L1 genes and their impact on susceptibility to lung cancer. J Med Genet. 2010;47:616-22 pubmed publisher
    ..These results suggest that genetic variants in MAD1L1 and MAD2L1 confer susceptibility to lung cancer, which might result from reduced spindle checkpoint function due to attenuated function of MAD1L1 and/or MAD2L1. ..
  6. Shen Z, Seppänen H, Kauttu T, Vainionpää S, Ye Y, Wang S, et al. Vasohibin-1 expression is regulated by transforming growth factor-?/bone morphogenic protein signaling pathway between tumor-associated macrophages and pancreatic cancer cells. J Interferon Cytokine Res. 2013;33:428-33 pubmed publisher
    ..Therefore, Vasohibin-1 expression is regulated by the TGF-?/BMP signaling between TAMs and pancreatic cancer cells. These results might shed a new light on the antiangiogenesis therapy in the pancreatic cancer. ..
  7. Fan H, Tong C, Teng C, Lian L, Li S, Yang Z, et al. Characterization of Polo-like kinase-1 in rat oocytes and early embryos implies its functional roles in the regulation of meiotic maturation, fertilization, and cleavage. Mol Reprod Dev. 2003;65:318-29 pubmed
    ..In conclusion, Plk1 may be a multifunctional kinase that plays pivotal regulatory roles in microtubule assembly during rat oocyte meiotic maturation, fertilization, and early embryonic mitosis. ..
  8. Wu M, Xu L, Zhai Z, Shu H. SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription. J Biol Chem. 2003;278:27072-9 pubmed
    ..Taken together, these data suggest that SINK is critically involved in a novel negative feedback control pathway of NF-kappaB-induced gene expression. ..
  9. Yin Y, Li Y, Qiao H, Wang H, Yang X, Zhang H, et al. TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma. Br J Cancer. 2005;93:458-63 pubmed
    ..In conclusion, these data suggest that TSPY is a novel cancer/testis (CT) antigen and may be a potential candidate in vaccine strategy for immunotherapy in HCC patients. ..

More Information

Publications206 found, 100 shown here

  1. Huo L, Fan H, Zhong Z, Chen D, Schatten H, Sun Q. Ubiquitin-proteasome pathway modulates mouse oocyte meiotic maturation and fertilization via regulation of MAPK cascade and cyclin B1 degradation. Mech Dev. 2004;121:1275-87 pubmed
  2. Tong T, Ji J, Jin S, Li X, Fan W, Song Y, et al. Gadd45a expression induces Bim dissociation from the cytoskeleton and translocation to mitochondria. Mol Cell Biol. 2005;25:4488-500 pubmed
    ..These findings identify a novel link that connects stress protein Gadd45a to the apoptotic machinery and address the importance of cytoskeletal stability in apoptotic response to DNA damage. ..
  3. Yang F, Xu Y, Li J, Duan S, Fu Y, Zhang Y, et al. Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression. Int J Biochem Cell Biol. 2009;41:2240-50 pubmed publisher
    ..Thus, p48.2 may represent a novel type of intracellular protein functioning as a negative regulator at the G0/G1 phase. ..
  4. Wu Y, Zhang Y, Zhang H, Yang X, Wang Y, Ren F, et al. p15RS attenuates Wnt/{beta}-catenin signaling by disrupting {beta}-catenin·TCF4 Interaction. J Biol Chem. 2010;285:34621-31 pubmed publisher
    ..Our data suggest that p15RS inhibits Wnt signaling by interrupting ?-catenin·TCF4 complex formation and that Wnt signaling initiates downstream gene expression by removing p15RS from promoters. ..
  5. Gao G, Sun J, Gao J, Xiong L, Yu L, Gao Y. Chronic stress promoted the growth of ovarian carcinoma via increasing serum levels of norepinephrine and interleukin-10 and altering nm23 and NDRG1 expression in tumor tissues in nude mice. Biosci Trends. 2013;7:56-63 pubmed
    ..Results obtained in the current study suggested that chronic stress promoted the growth of ovarian carcinoma in nude mice through increasing serum levels of NE and IL-10 and altering nm23 and NDRG1 expression in tumor tissues. ..
  6. Luo Q, Li Y, Shen Y, Cheng Z. Ten years of gene discovery for meiotic event control in rice. J Genet Genomics. 2014;41:125-37 pubmed publisher
    ..So far, 28 rice meiotic genes have been characterized. In this review, we give an overview of the discovery of rice meiotic genes in the last ten years, with a particular focus on their functions in meiosis. ..
  7. Guo T, Zhao S, Zhao S, Chen M, Li G, Jiao X, et al. Mutations in MSH5 in primary ovarian insufficiency. Hum Mol Genet. 2017;26:1452-1457 pubmed publisher
    ..Our studies confirmed that perturbation of genes involved in DNA damage repair could lead to non-syndromic POI. The underlying mechanism-inability to repair DNA damage-will receive increasing attention with respect to POI. ..
  8. Liu J, Liu H, Zhang X, Gao P, Wang J, Hu Z. Identification and characterization of P15RS, a novel P15(INK4b) related gene on G1/S progression. Biochem Biophys Res Commun. 2002;299:880-5 pubmed
    ..Expressing antisense P15RS in MLIK6 cells can up-regulate the expression of cyclinD1 and cyclinE. These data indicate that P15RS may act as a negative regulator in G(1) phase. ..
  9. Sun Y, Li J, He J, Zhou L, Chen K. Tissue microarray analysis of multiple gene expression in intestinal metaplasia, dysplasia and carcinoma of the stomach. Histopathology. 2005;46:505-14 pubmed
    ..p53 was useful for distinguishing LGD from HGD. High-level expression of cyclin E might be an indicator for malignant transformation of dysplasia. ..
  10. Liu X, Du L, Feng R. c-Src regulates cell cycle proteins expression through protein kinase B/glycogen synthase kinase 3 beta and extracellular signal-regulated kinases 1/2 pathways in MCF-7 cells. Acta Biochim Biophys Sin (Shanghai). 2013;45:586-92 pubmed publisher
    ..These results suggest that c-Src suppression by PP2 or siRNAs may regulate the progression of cell cycle through AKT/GSK3? and ERK1/2 pathways. ..
  11. Xu L, Liu F, Lechner E, Genschik P, Crosby W, Ma H, et al. The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. Plant Cell. 2002;14:1919-35 pubmed
    ..These results suggest that the COI1-mediated JA response is dependent on the SCF(COI1) complexes in Arabidopsis and that the AXR1-dependent modification of the AtCUL1 subunit of SCF(COI1) complexes is important for JA signaling. ..
  12. He W, Zhao Y, Zhang C, An L, Hu Z, Liu Y, et al. Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1. Nucleic Acids Res. 2008;36:6406-17 pubmed publisher
    ..Our data indicate that Rad9 is an important factor in MMR and carries out its MMR function specifically through interaction with MLH1. ..
  13. An J, Huang Y, Xu Q, Zhou L, Shang Z, Huang B, et al. DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression. BMC Mol Biol. 2010;11:18 pubmed publisher
    ..It can directly phosphorylate H2AX independent of ATM and indirectly modulate the phosphorylation level of gamma H2AX via the Akt/GSK3 beta signal pathway. ..
  14. Deng M, Li F, Ballif B, Li S, Chen X, Guo L, et al. Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17. J Biol Chem. 2009;284:7875-88 pubmed publisher
    ..Taken together, these data indicate that Ankrd17 is an important downstream effector of cyclin E/Cdk2 and positively regulates G(1)/S transition. ..
  15. Jiang K, Shen Z, Ye Y, Yang X, Wang S. A novel molecular marker for early detection and evaluating prognosis of gastric cancer: N-myc downstream regulated gene-1 (NDRG1). Scand J Gastroenterol. 2010;45:898-908 pubmed publisher
    ..NDRG1 could be developed as a marker contributing to diagnosis and evaluating prognosis in gastric cancer, as well as a potential therapeutic target of gastric cancer. ..
  16. Bai X, Margariti A, Hu Y, Sato Y, Zeng L, Ivetic A, et al. Protein kinase C{delta} deficiency accelerates neointimal lesions of mouse injured artery involving delayed reendothelialization and vasohibin-1 accumulation. Arterioscler Thromb Vasc Biol. 2010;30:2467-74 pubmed publisher
    ..To use protein kinase C (PKC) ?-knockout mice to investigate the role of PKC? in lesion development and to understand the underlying mechanism of the vascular disease...
  17. Yang N, Wang W, Wang Y, Wang M, Zhao Q, Rao Z, et al. Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1. Proc Natl Acad Sci U S A. 2012;109:17954-9 pubmed publisher
  18. Shang Z, Yu L, Li B, Tu W, Wang Y, Liu X, et al. 4E-BP1 participates in maintaining spindle integrity and genomic stability via interacting with PLK1. Cell Cycle. 2012;11:3463-71 pubmed publisher
    ..These results demonstrate that 4E-BP1, beyond its role in translation regulation, can function as a regulator of mitosis via interacting with PLK1, and possibly plays a role in genomic stability maintaining. ..
  19. Qiao H, Wang H, Zhao L, Zhou J, Huang J, Zhang Y, et al. The F-box protein AhSLF-S2 physically interacts with S-RNases that may be inhibited by the ubiquitin/26S proteasome pathway of protein degradation during compatible pollination in Antirrhinum. Plant Cell. 2004;16:582-95 pubmed
  20. Peng B, Chang Q, Wang L, Hu Q, Wang Y, Tang J, et al. Suppression of human ovarian SKOV-3 cancer cell growth by Duchesnea phenolic fraction is associated with cell cycle arrest and apoptosis. Gynecol Oncol. 2008;108:173-81 pubmed
    ..All together, these data sustain our contention that DPF has anticancer properties and merits further investigation as a potential therapeutic agent. ..
  21. Zhao B, Wang Z, Yi B, Ma H, Xu H. hRad21 overexpresses and localizes to the ALT-associated promyelocytic leukemia body in ALT cells. Cancer Biol Ther. 2010;9:978-83 pubmed
    ..Thus, one role of hRAD21 appeared to involve telomere maintenance in ALT cells. We suggested that hRAD21 facilitated telomere HR in ALT cells by participating in APB formation. ..
  22. Wu X, Shi Y, Li J, Xu L, Fang Y, Li X, et al. A role for the RNA-binding protein MOS2 in microRNA maturation in Arabidopsis. Cell Res. 2013;23:645-57 pubmed publisher
    ..These data suggest that MOS2 promotes pri-miRNA processing through facilitating the recruitment of pri-miRNAs by the Dicing complexes. ..
  23. Fang N, Zhang W, Xu S, Lin H, Wang Z, Liu H, et al. TRIB3 alters endoplasmic reticulum stress-induced ?-cell apoptosis via the NF-?B pathway. Metabolism. 2014;63:822-30 pubmed publisher
    ..TRIB3 mediated ER stress-induced ?-cell apoptosis via the NF-?B pathway. ..
  24. Zhu D, Maier A, Lee J, Laubinger S, Saijo Y, Wang H, et al. Biochemical characterization of Arabidopsis complexes containing CONSTITUTIVELY PHOTOMORPHOGENIC1 and SUPPRESSOR OF PHYA proteins in light control of plant development. Plant Cell. 2008;20:2307-23 pubmed publisher
    ..This study thus provides an in-depth biochemical view of the SPA-COP1 E3 ligase complexes and offers new insights into the molecular basis for their distinct roles in the light control of plant development. ..
  25. Xie P, Li L, Xing G, Tian C, Yin Y, He F, et al. ATM-mediated NuSAP phosphorylation induces mitotic arrest. Biochem Biophys Res Commun. 2011;404:413-8 pubmed publisher
    ..The phosphorylation and interaction occur specifically at G2/M-phase. Collectively, our work has uncovered an ATM-dependent checkpoint pathway that prevents mitotic progression by targeting a microtubule-associated protein, NuSAP. ..
  26. Zhao Q, Qin L, Jiang F, Wu B, Yue W, Xu F, et al. Structure of human spindlin1. Tandem tudor-like domains for cell cycle regulation. J Biol Chem. 2007;282:647-56 pubmed
    ..We further identified associations of spindlin1 with nucleic acid to provide a biochemical basis for its cell cycle regulation and other functions. ..
  27. Wang X, Suh C, Zhu Z, Fan Q. Minichromosome maintenance protein 5 homologue in Caenorhabditis elegans plays essential role for postembryonic development. Biochem Biophys Res Commun. 2007;359:965-71 pubmed
    ..elegans might function associated with cell division as its homologues in S. cerevisiae. ..
  28. Shang Z, Huang B, Xu Q, Zhang S, Fan R, Liu X, et al. Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage. Cancer Res. 2010;70:3657-66 pubmed publisher
  29. Zhang Y, Wang W, Chen J, Zhang K, Gao F, Gao B, et al. Structural insights into the intrinsic self-assembly of Par-3 N-terminal domain. Structure. 2013;21:997-1006 pubmed publisher
    ..This work unequivocally provides the structural basis for Par-3 NTD self-association and characterizes one type of protein domain that can self-assemble via electrostatic interactions. ..
  30. Li W, Yi P, Zhu Z, Zhang X, Li W, Ou G. Centriole translocation and degeneration during ciliogenesis in Caenorhabditis elegans neurons. EMBO J. 2017;36:2553-2566 pubmed publisher
    ..Together, our results provide a comprehensive model of ciliogenesis in sensory neurons and reveal the importance of the dynein-dependent centriole translocation in this process. ..
  31. Gao M, Dong W, Hu M, Yu M, Guo L, Qian L, et al. GADD45alpha mediates arsenite-induced cell apoptotic effect in human hepatoma cells via JNKs/AP-1-dependent pathway. J Cell Biochem. 2010;109:1264-73 pubmed publisher
    ..The approaches to up-regulate GADD45alpha levels might be helpful in improving the chemotherapeutic action of arsenite on certain solid tumors including hepatoma...
  32. Liu J, Song Y, Tian B, Qian J, Dong Y, Liu J, et al. Functional proteomic analysis of promyelocytic leukaemia nuclear bodies in irradiation-induced MCF-7 cells. J Biochem. 2010;148:659-67 pubmed publisher
    ..The proteins identified in this study will significantly improve our understanding of the dynamic organization and multiple functions of PML NBs in DDR. ..
  33. Guo Y, Chen J, Shi L, Fan Z. Valosin-containing protein cleavage by granzyme K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target tumor cells. J Immunol. 2010;185:5348-59 pubmed publisher
    ..In support of this, target tumor cells with silenced VCP expression are more sensitive, whereas cells overexpressing VCP are more resistant to GzmK-mediated cytotoxicity. ..
  34. Liu J, Luo S, Zhao H, Liao J, Li J, Yang C, et al. Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain. Nucleic Acids Res. 2012;40:3898-912 pubmed publisher
    ..Our results suggest a novel mechanism for the regulation of MDC1 function through T4 phosphorylation and FHA-mediated dimerization. ..
  35. Zeng M, Ren L, Mizuno K, Nestoras K, Wang H, Tang Z, et al. CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection. Nat Commun. 2016;7:11364 pubmed publisher
    ..Finally, we establish that this histone regulatory cascade similarly controls DSB resection in human cells. ..
  36. Zhao B, Zhao H, Zhao N, Zhu X. Cholangiocarcinoma cells express somatostatin receptor subtype 2 and respond to octreotide treatment. J Hepatobiliary Pancreat Surg. 2002;9:497-502 pubmed
    ..These effects are partially mediated by enhancing the expression of p27kipl, and decreasing the amounts of cyclin E-CDK2 complex. ..
  37. Yang X, Zhou J, Sun L, Wei Z, Gao J, Gong W, et al. Structural basis for the function of DCN-1 in protein Neddylation. J Biol Chem. 2007;282:24490-4 pubmed
    ..The structural and biochemical results are consistent with the role of DCN-1 as a scaffold protein in a multisubunit neddylation E3 ligase complex. ..
  38. Lu Q, Lu Z, Liu Q, Guo L, Ren H, Fu J, et al. Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembly via importin-?/?. Cell Res. 2012;22:1562-75 pubmed publisher
    ..Our findings reveal a novel molecular mechanism for NE assembly in Xenopus egg extracts. ..
  39. Jin S, Mazzacurati L, Zhu X, Tong T, Song Y, Shujuan S, et al. Gadd45a contributes to p53 stabilization in response to DNA damage. Oncogene. 2003;22:8536-40 pubmed
  40. Wang M, Tang D, Wang K, Shen Y, Qin B, Miao C, et al. OsSGO1 maintains synaptonemal complex stabilization in addition to protecting centromeric cohesion during rice meiosis. Plant J. 2011;67:583-94 pubmed publisher
    ..Finally, we found that the centromeric localization of OsSGO1 depends on OsAM1, not other meiotic proteins such as OsREC8, PAIR2, OsMER3, or ZEP1...
  41. Takada M, Zhang W, Suzuki A, Kuroda T, Yu Z, Inuzuka H, et al. FBW7 Loss Promotes Chromosomal Instability and Tumorigenesis via Cyclin E1/CDK2-Mediated Phosphorylation of CENP-A. Cancer Res. 2017;77:4881-4893 pubmed publisher
    ..Overall, our results revealed a pathway that cyclin E1/CDK2 activation coupled with FBW7 loss promotes CIN and tumor progression via CENP-A-mediated centromere dysfunction. Cancer Res; 77(18); 4881-93. ©2017 AACR. ..
  42. Tao J, Zhang L, Chong K, Wang T. OsRAD21-3, an orthologue of yeast RAD21, is required for pollen development in Oryza sativa. Plant J. 2007;51:919-30 pubmed
  43. Wang H, Zhao Y, Li L, McNutt M, Wu L, Lu S, et al. An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment. J Biol Chem. 2008;283:2564-74 pubmed
    ..These data taken together show for the first time that 5-aza-CdR activates the ATR signaling pathway, which elicits a specific p53 phosphorylation-acetylation cascade to induce p21(Waf1/Cip1) expression. ..
  44. Yang M, Zhang L, Bi N, Ji W, Tan W, Zhao L, et al. Association of P53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy. Int J Radiat Oncol Biol Phys. 2011;79:1402-7 pubmed publisher
    ..These results indicate that genetic polymorphisms in the ATM-P53 pathway influence susceptibility to RP and genotyping P53 and ATM polymorphisms might help to identify patients susceptible to developing RP when receiving radiotherapy. ..
  45. Zhang Y, Zhao H, Wang J, Ge J, Li Y, Gu J, et al. Structural insight into Caenorhabditis elegans sex-determining protein FEM-2. J Biol Chem. 2013;288:22058-66 pubmed publisher
  46. Li X, Liu X, Sun F, Gao J, Zhou H, Gao G, et al. Crystal structure of the N-terminal SH3 domain of mouse betaPIX, p21-activated kinase-interacting exchange factor. Biochem Biophys Res Commun. 2006;339:407-14 pubmed
    ..The unique large and planar hydrophobic pocket may contribute to the promiscuity of betaPIX-SH3 domain resulting in its multiple biological functions. ..
  47. Shen E, Lei Y, Liu Q, Zheng Y, Song C, Marc J, et al. Identification and characterization of INMAP, a novel interphase nucleus and mitotic apparatus protein that is involved in spindle formation and cell cycle progression. Exp Cell Res. 2009;315:1100-16 pubmed publisher
    ..We propose that INMAP is a novel protein that plays essential role in spindle formation and cell-cycle progression. ..
  48. Ma L, Li N, He X, Zhang Q. [miR-449b and miR-34c on inducing down-regulation of cell cycle-related proteins and cycle arrests in SKOV3-ipl cell, an ovarian cancer cell line]. Beijing Da Xue Xue Bao Yi Xue Ban. 2011;43:129-33 pubmed
    ..miR-449b and miR-34c resulted in cell cycle arrests and down-regulation of CDK6, CDC25A and CyclinA in high malignant ovarian cancer cell line SKOV3-ipl. ..
  49. Du J, Du Q, Zhang Y, Sajdik C, Ruan Y, Tian X, et al. Expression of cell-cycle regulatory proteins BUBR1, MAD2, Aurora A, cyclin A and cyclin E in invasive ductal breast carcinomas. Histol Histopathol. 2011;26:761-8 pubmed publisher
    ..In conclusion, this study suggests that evaluation of BUBR1, MAD2 and Aurora A expression levels is likely to improve accuracy of prognostic predictions in IDBC. ..
  50. Zhang S, Song M, Yang T, Fan R, Liu X, Zhou P. HIV-1 Tat impairs cell cycle control by targeting the Tip60, Plk1 and cyclin B1 ternary complex. Cell Cycle. 2012;11:1217-34 pubmed publisher
    ..Tat, Tip60, cyclin B1 and Plk1 interactions provide new a mechanistic explanation for Tat-mediated cell cycle dysregulation and apoptosis. ..
  51. Quan Z, Sun P, Lin G, Xi R. TSC1/2 regulates intestinal stem cell maintenance and lineage differentiation through Rheb-TORC1-S6K but independently of nutritional status or Notch regulation. J Cell Sci. 2013;126:3884-92 pubmed publisher
  52. Zhang C, Zhang C, He Y, Hang H. Phosphorylation sites on Tyr28 and the C-terminus of Rad9 are required for inhibition of premature chromosomal condensation across the entire S phase. Cell Physiol Biochem. 2008;22:295-306 pubmed publisher
    ..Taken together, these results suggest that phosphorylation of Rad9 plays a critical role in the activation of the S/M checkpoint, and that downstream proteins cdc2 and 14-3-3sigma mediate this function. ..
  53. Zhao F, Hou N, Yang X, He X, Liu Y, Zhang Y, et al. Ataxia telangiectasia-mutated-Rad3-related DNA damage checkpoint signaling pathway triggered by hepatitis B virus infection. World J Gastroenterol. 2008;14:6163-70 pubmed
    ..Meanwhile, survival of IR-treated host cells was reduced by HBV infection. HBV infection activates ATR DNA damage response to replication stress and abrogates the checkpoint signaling controlled by DNA damage response. ..
  54. Zhang Y, Peng Z, Zhao Y, Chen L. microRNA-25 Inhibits Cell Apoptosis of Human Gastric Adenocarcinoma Cell Line AGS via Regulating CCNE1 and MYC. Med Sci Monit. 2016;22:1415-20 pubmed
    ..This study provides basic evidence for using miR-25 as a possible therapeutic target in treating gastric carcinoma. ..
  55. Shao S, Wang Y, Jin S, Song Y, Wang X, Fan W, et al. Gadd45a interacts with aurora-A and inhibits its kinase activity. J Biol Chem. 2006;281:28943-50 pubmed
    ..These findings identify a novel mechanism for Gadd45a in the maintenance of centrosome stability and broaden understandings of p53- and BRCA1-regulated signaling pathways in maintaining genomic fidelity. ..
  56. Wang W, Chen Z, Mao Z, Zhang H, Ding X, Chen S, et al. Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes. EMBO Rep. 2011;12:1160-6 pubmed publisher
    ..Finally, Spindlin1 localizes to the active ribosomal DNA (rDNA) repeats, and Spindlin1 facilitates the expression of rRNA genes. ..
  57. Xiang B, Dong D, Shi N, Gao W, Yang Z, Cui Y, et al. PSA-responsive and PSMA-mediated multifunctional liposomes for targeted therapy of prostate cancer. Biomaterials. 2013;34:6976-91 pubmed publisher
    ..In terms of targeting capacity and therapeutic potency, the combination of a PSA-responsive and PSMA-mediated liposome presents a promising platform for therapy and diagnosis of PSMA/PSA-positive PC. ..
  58. Duan J, Duan J, Zhang Z, Tong T. Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening. Int J Biochem Cell Biol. 2005;37:1407-20 pubmed
    ..Our findings indicate that several aging theories can be merged together by a common mechanism of oxidative damage, and that the level of oxidative DNA-damage-and-repair capacity may be exploited as reliable markers of cell senescence. ..
  59. Qin L, Tong T, Song Y, Xue L, Fan F, Zhan Q. Aurora-A interacts with Cyclin B1 and enhances its stability. Cancer Lett. 2009;275:77-85 pubmed publisher
    ..These results provide new insight into the mechanism of how deregulated Aurora-A contributes to genomic instability and carcinogenesis. ..
  60. Yang F, Zhang W, Li D, Zhan Q. Gadd45a suppresses tumor angiogenesis via inhibition of the mTOR/STAT3 protein pathway. J Biol Chem. 2013;288:6552-60 pubmed publisher
    ..Taken together, these findings provide the first evidence that Gadd45a inhibits tumor angiogenesis via blocking of the mTOR/STAT3 pathway. ..
  61. Zhang L, Tie Y, Tian C, Xing G, Song Y, Zhu Y, et al. CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM. Cell Signal. 2006;18:1386-95 pubmed
    ..Our data provide the first evidence that ATM, a predominantly nuclear kinase, could be relocalized to the plasma membrane by CKIP-1 and shed new light on the multi-functional CKIP-1. ..
  62. Zhang P, Cong B, Yuan H, Chen L, Lv Y, Bai C, et al. Overexpression of spindlin1 induces metaphase arrest and chromosomal instability. J Cell Physiol. 2008;217:400-8 pubmed publisher
    ..Taken together, these data demonstrated that excess spindlin1 protein may be detrimental for spindle microtubule organization, chromosomal stability and can potentially contribute to the development of cancer. ..
  63. Huang J, Zhang L, Liu W, Liao Q, Shi T, Xiao L, et al. CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest. Histochem Cell Biol. 2012;138:41-55 pubmed publisher
    ..Together, our findings indicate that CCDC134 might act as a novel regulator of hADA2a, and plays roles in the PCAF complex via hADA2a to affect its acetyltransferase activity and UV-induced DNA damage repair. ..
  64. Zhu J, Liu W, Zhou W, Hu Y, He Y. A Nucleus-encoded topological specificity factor PpMinE in Physcomitrella patens has conserved function similar to its chloroplast-encoded ancestor. J Genet Genomics. 2007;34:229-38 pubmed
    ..According to the phylogenetic tree, PpMinE protein has a close relationship with the highland plants, which suggests that the transfer events of MinE gene from plastid to nucleus might have occurred before the origin of the land plants. ..
  65. Jia X, Yang S, Zhou J, Li S, Ni J, An G, et al. Inhibition of CHK1 kinase by Gö6976 converts 8-chloro-adenosine-induced G2/M arrest into S arrest in human myelocytic leukemia K562 cells. Biochem Pharmacol. 2009;77:770-80 pubmed publisher
    ..These observations may provide aid in better understanding of the mechanisms of 8-Cl-cAMP and 8-Cl-Ado actions and in potential design of the combined therapy. ..
  66. Qu M, Yang B, Tao L, Yates J, Russell P, Dong M, et al. Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint. PLoS Genet. 2012;8:e1002817 pubmed publisher
    ..These results suggest that the main role of Crb2 and 9-1-1 in DNA damage checkpoint signaling is recruiting Chk1 to sites of DNA lesions. ..
  67. Zhou Z, Cao J, Li S, An G, Ni J, Jia H. p53 Suppresses E2F1-dependent PLK1 expression upon DNA damage by forming p53-E2F1-DNA complex. Exp Cell Res. 2013;319:3104-15 pubmed publisher
    ..The model of p53 action on E2F1-activated PLK1 gene may explain at least partly how p53 as a suppressor regulates the downstream effects of E2F1 in cellular stresses including DNA damage stress. ..
  68. Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, et al. E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3. Cell Signal. 2008;20:942-8 pubmed publisher
    ..Cotransfection of SIAH1 could withdraw up-regulation of TGF-beta signaling by TRB3, suggesting SIAH1-induced degradation of TRB3 represents a potential regulatory mechanism for TGF-beta signaling. ..
  69. Wei Q, Li J, Liu T, Tong X, Ye X. Phosphorylation of minichromosome maintenance protein 7 (MCM7) by cyclin/cyclin-dependent kinase affects its function in cell cycle regulation. J Biol Chem. 2013;288:19715-25 pubmed publisher
    ..These data suggest that the phosphorylation of MCM7 on Ser-121 by cyclin/Cdks is involved in preventing DNA rereplication as well as in regulation of the mitotic exit. ..
  70. Su X, Zhu G, Ding X, Lee S, Dou Y, Zhu B, et al. Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. Genes Dev. 2014;28:622-36 pubmed publisher
    ..Mutagenesis of Spindlin1 reader pockets impairs activation of Wnt target genes. Taken together, our work connects a histone "lysine-arginine" methylation pattern readout by Spindlin1-to-Wnt signaling at the transcriptional level. ..
  71. Gao L, Liu F, Zhang H, Sun J, Ma Y. CHFR hypermethylation, a frequent event in acute myeloid leukemia, is independently associated with an adverse outcome. Genes Chromosomes Cancer. 2016;55:158-68 pubmed publisher
    ..In conclusion, hypermethylation of the CHFR promoter, frequent in AML, is associated with adverse outcome, and can thus be used for risk stratification. ..
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