Experts and Doctors on carrier proteins in Beijing, China


Locale: Beijing, China
Topic: carrier proteins

Top Publications

  1. Pang H, Bartlam M, Zeng Q, Miyatake H, Hisano T, Miki K, et al. Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor. J Biol Chem. 2004;279:1491-8 pubmed
    ..The structure suggests an interesting new role of iron in biology and that Pirin may be involved in novel mechanisms of gene regulation. ..
  2. Ma W, Zhang D, Hou Y, Li Y, Sun Q, Sun X, et al. Reduced expression of MAD2, BCL2, and MAP kinase activity in pig oocytes after in vitro aging are associated with defects in sister chromatid segregation during meiosis II and embryo fragmentation after activation. Biol Reprod. 2005;72:373-83 pubmed
    ..These events in turn cause abnormal sister chromatid segregation during meiosis II, embryo fragmentation, and apoptosis. ..
  3. Gong Y, Wang X, Liu J, Shi L, Yin B, Peng X, et al. NSPc1, a mainly nuclear localized protein of novel PcG family members, has a transcription repression activity related to its PKC phosphorylation site at S183. FEBS Lett. 2005;579:115-21 pubmed
    ..Taken together, results from our study suggest that NSPc1, as a typical PcG family member, has powerful transcriptional repression ability, which may be related to the PKC signaling pathway. ..
  4. Zhu D, Zhu Y, Huang R, Xiang Y, Yang N, Lu H, et al. Crystal structure of the copper homeostasis protein (CutCm) from Shigella flexneri at 1.7 A resolution: the first structure of a new sequence family of TIM barrels. Proteins. 2005;58:764-8 pubmed
  5. Zhu Y, Zhu D, Lu H, Yang N, Li G, Wang D. Purification and preliminary crystallographic studies of CutC, a novel copper homeostasis protein from Shigella flexneri. Protein Pept Lett. 2005;12:823-6 pubmed
    ..7 A and 2.1 A. They belong to the space group C2221 and similar cell dimension. The native protein crystals have cell parameters: a=75.3267, b=97.6718, c=132.6910. ..
  6. Liang J, Zhang H, Zhang Y, Zhang Y, Shang Y. GAS, a new glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function. EMBO Rep. 2009;10:51-7 pubmed publisher
    ..Our data thus indicate that GAS is a new transcription cofactor and that different SRCs are associated with distinct secondary cofactors. ..
  7. Zhang J, Zhang X, Guo Y, Xu L, Pei D. Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein. J Biol Chem. 2009;284:21659-69 pubmed publisher
    ..On the other hand, knockdown of WASp alleviates the phenotype induced by SNX33. Taken together, our results suggest that SNX33 plays a role in maintaining cell shape and cell cycle progression through its interaction with WASp. ..
  8. Gao L, Zhang N, Bai J, Ding Q, Wang Z, Zhu Z, et al. The apelin-APJ pathway exists in cardiomyogenic cells derived from mesenchymal stem cells in vitro and in vivo. Cell Transplant. 2010;19:949-58 pubmed publisher
    ..Our finding indicated that the expression of the apelin-APJ pathway during differentiation of BMSCs into CMGs may be an important mechanism in regulation of myocardial regeneration and functional recovery after BMSC transplantation. ..
  9. Huo Y, Bai L, Xu M, Jiang T. Crystal structure of the N-terminal region of human Topoisomerase II? binding protein 1. Biochem Biophys Res Commun. 2010;401:401-5 pubmed publisher
    ..Structural comparisons together with peptide binding studies indicate that the tandem BRCT1-2 domains are the binding region for phosphorylated Ser387 in Rad9. ..

More Information

Publications275 found, 100 shown here

  1. Xu S, Cheng F, Liang J, Wu W, Zhang J. Maternal xNorrin, a canonical Wnt signaling agonist and TGF-? antagonist, controls early neuroectoderm specification in Xenopus. PLoS Biol. 2012;10:e1001286 pubmed publisher
    ..Thus, xNorrin is an unusual molecule that acts on two major signaling pathways, Wnt and TGF-?, in opposite ways and is essential for early neuroectoderm specification...
  2. Xu G, Sztalryd C, Londos C. Degradation of perilipin is mediated through ubiquitination-proteasome pathway. Biochim Biophys Acta. 2006;1761:83-90 pubmed
    ..We conclude that the degradation of perilipin is mediated through an ubiquitination-proteasome pathway, which suggests another mode for the post-translational regulation of perilipin. ..
  3. Wang A, Liu H, Zhang Y. Increased expression of fascin associated with malignant transformation of sinonasal inverted papilloma. Chin Med J (Engl). 2007;120:375-9 pubmed
    ..Precancerous lesions of IP exhibit elevated levels of fascin that may be associated with carcinogenesis of IP. Fascin may play a role in the formation of IP and EP. ..
  4. Wang C, Ma Z, Scott M, Huang X. The cholesterol trafficking protein NPC1 is required for Drosophila spermatogenesis. Dev Biol. 2011;351:146-55 pubmed publisher
    ..Together, our study reveals a sterol-dependent, ecdysone-independent mechanism of NPC1 function in Drosophila spermatogenesis. ..
  5. Nie J, Liu L, He F, Fu X, Han W, Zhang L. CKIP-1: a scaffold protein and potential therapeutic target integrating multiple signaling pathways and physiological functions. Ageing Res Rev. 2013;12:276-81 pubmed publisher
    ..Strikingly, CKIP-1 has been recently demonstrated to be a promising target for treatment of osteoporosis in rat models. In addition, more evidences suggest that CKIP-1 might also function as a potential tumor suppressor. ..
  6. Yuan S, Xu J, Ge Y, Yan Z, Du G, Wang N. Prokaryotic ubiquitin-like ThiS fusion enhances the heterologous protein overexpression and aggregation in Escherichia coli. PLoS ONE. 2013;8:e62529 pubmed publisher
  7. Chen X, Song F, Dai Y, Bao X, Jin Y. A novel mutation of the growth hormone receptor gene (GHR) in a Chinese girl with Laron syndrome. J Pediatr Endocrinol Metab. 2003;16:1183-9 pubmed
  8. Zhang Y, Kang Y, Tian C, Zeng Y, Jia L, Ma X, et al. Overexpression of Nrdp1 in the heart exacerbates doxorubicin-induced cardiac dysfunction in mice. PLoS ONE. 2011;6:e21104 pubmed publisher
    ..Nrdp1 may be a new therapeutic target in protecting against the cardiotoxic effects of DOX. ..
  9. Chen S, Xu Y, Zhang K, Wang X, Sun J, Gao G, et al. Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA. Nat Struct Mol Biol. 2012;19:430-5 pubmed publisher
    ..ZAP molecules interact to form a dimer that binds to a ZAP-responsive RNA molecule containing two ZAP-binding modules. These results provide insights into how ZAP binds specifically to complex target RNA. ..
  10. He R, Wu Q, Zhou H, Huang N, Chen J, Teng J. Cep57 protein is required for cytokinesis by facilitating central spindle microtubule organization. J Biol Chem. 2013;288:14384-90 pubmed publisher
    ..Thus, our data reveal that Cep57 is essential for cytokinesis via regulation of central spindle assembly and formation of the midbody. ..
  11. Yan X, Zou Q, Zeng X, Zhang J. [Sequence analysis on sorbitol fermentation related genes in Vibrio cholerae]. Zhonghua Liu Xing Bing Xue Za Zhi. 2005;26:444-7 pubmed
    ..The 36th amino acid mutation of sugar fermentation stimulation protein in epidemic and nonepidemic strains might change the activity of the protein which might be associated with sorbitol fermentation. ..
  12. Wang H, Zhu Z, Wang H, Yang S, Mo D, Li K. Characterization of different expression patterns of calsarcin-1 and calsarcin-2 in porcine muscle. Gene. 2006;374:104-11 pubmed publisher
    ..This result suggests that the pig may be a suitable animal model to study the function of calsarcins in human heart disease...
  13. Kong Y, Cao W, Xi X, Ma C, Cui L, He W. The NKG2D ligand ULBP4 binds to TCRgamma9/delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D. Blood. 2009;114:310-7 pubmed publisher
    ..Taken together, our data suggest that ULBP4 functions as a ligand for both TCRgammadelta and NKG2D and may play a key role in immune surveillance of tumor development and clearance of viral infection. ..
  14. Cui W, Wei Z, Chen Q, Cheng Y, Geng L, Zhang J, et al. Structure-based design of peptides against G3BP with cytotoxicity on tumor cells. J Chem Inf Model. 2010;50:380-7 pubmed publisher
    ..Our results demonstrate that it is feasible to use the peptides to enhance the efficacy of clinical drugs and to kill cancer cells selectively. We believe that our work should be very useful for finding new therapies for cancers. ..
  15. Zhang M, Zhang Y, Xu Z. POSH is involved in Eiger-Basket (TNF-JNK) signaling and embryogenesis in Drosophila. J Genet Genomics. 2010;37:605-19 pubmed publisher
  16. Rong W, Feng F, Zhou J, He C. Effector-triggered innate immunity contributes Arabidopsis resistance to Xanthomonas campestris. Mol Plant Pathol. 2010;11:783-93 pubmed publisher
    ..In rar1 and sgt1b mutants, AvrXccC acts as a virulence factor, presumably because of impaired resistance gene function. ..
  17. Wang L, Li J, Jia M, Yue W, Ruan Y, Lu T, et al. No association of polymorphisms in the CDK5, NDEL1, and LIS1 with autism in Chinese Han population. Psychiatry Res. 2011;190:369-71 pubmed publisher
    ..Our study did not detect a significant association. It indicated that common genetic variations in these genes might not play a role in the genetic predisposition to autism. ..
  18. Wang X, Ding J, Wang D. Crystallization and preliminary X-ray analysis of the C-terminal domain of CCM2, part of a novel adaptor protein involved in cerebral cavernous malformations. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012;68:683-6 pubmed publisher
    ..9 and 2.7 Å, respectively. Both crystals belonged to space group I4(1)22 with similar unit-cell parameters. The native crystals had unit-cell parameters a = b = 113.29, c = 101.62 Å. ..
  19. Yan D, Dai J, Wu Q. Characterization of an ammonium transporter in the oleaginous alga Chlorella protothecoides. Appl Microbiol Biotechnol. 2013;97:919-28 pubmed publisher
    ..protothecoides. Together, these results imply that the ammonium transporter CpAMT1 could be the initial sensor of nitrogen deficiency and channels the carbon excess toward lipid biosynthesis...
  20. Huang Y, Shen Z, Chen Q, Huang P, Zhang H, Du S, et al. Endogenous sulfur dioxide alleviates collagen remodeling via inhibiting TGF-β/Smad pathway in vascular smooth muscle cells. Sci Rep. 2016;6:19503 pubmed publisher
    ..These findings indicated that endogenous SO2 alleviated collagen remodeling by controlling TGF-β1/TβRI/Smad2/3-mediated modulation of collagen synthesis and degradation. ..
  21. Gong X, Qian H, Zhou X, Wu J, Wan T, Cao P, et al. Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection. Cell. 2016;165:1467-1478 pubmed publisher
    ..Our structural and biochemical characterizations provide an important framework for mechanistic understanding of NPC1-mediated intracellular cholesterol trafficking and Ebola virus infection. ..
  22. Hu C, Song G, Huang W, Liu G, Deng C, Zeng H, et al. Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays. Mol Cell Proteomics. 2012;11:669-80 pubmed publisher
  23. Liu C, Gao H, Cao L, Gui S, Liu Q, Li C, et al. The role of FSCN1 in migration and invasion of pituitary adenomas. Mol Cell Endocrinol. 2016;419:217-24 pubmed publisher
    ..In addition, reduction of FSCN1 can obviously down-regulate the level of Notch1 and DLL3. Our data may help in deciding whether FSCN1 can be a predictor for invasion and recurrence of PAs. ..
  24. Yang H, Jin G, Meng L, Zhang J, Liu W, Shou C. Screening and identification of proteins interacting with nucleostemin. World J Gastroenterol. 2005;11:4812-4 pubmed
    ..NS and PPP2R5A interact in yeast and mammalian cells, respectively, which is helpful for addressing the function of NS in cancer development and progression. ..
  25. Zhang Y, Wang H, Kage Nakadai E, Mitani S, Wang X. C. elegans secreted lipid-binding protein NRF-5 mediates PS appearance on phagocytes for cell corpse engulfment. Curr Biol. 2012;22:1276-84 pubmed publisher
    ..During programmed cell death, apoptotic cells are rapidly removed by phagocytes. How dying cells are recognized remains poorly understood...
  26. Yang H, Tan Y, Zhang T, Tang L, Wang J, Ke Y, et al. Identification of novel protein-protein interactions of Yersinia pestis type III secretion system by yeast two hybrid system. PLoS ONE. 2013;8:e54121 pubmed publisher
    ..Several potential new interactions among T3SS components could help to understand the assembly and regulation of Yersinia T3SS. ..
  27. Chen D, Xu G, Tang W, Jing Y, Ji Q, Fei Z, et al. Antagonistic basic helix-loop-helix/bZIP transcription factors form transcriptional modules that integrate light and reactive oxygen species signaling in Arabidopsis. Plant Cell. 2013;25:1657-73 pubmed publisher
    ..Together, this study reveals that the PIF1/PIF3-HY5/HYH transcriptional modules mediate crosstalk between light and ROS signaling and sheds light on a new mechanism by which plants adapt to the light environments. ..
  28. Hu B, Li S, Zhang X, Zheng X. HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation. Nucleic Acids Res. 2014;42:5582-93 pubmed publisher
    ..This study unravels a novel mechanism for the regulation of H2A ubiquitination and elucidates how regulators of H2A ubiquitination affect cell cycle. ..
  29. Chen D, Li X, Zhai Z, Shu H. A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation. J Biol Chem. 2002;277:15985-91 pubmed
    ..Moreover, immunofluorescent staining indicates that ZIN is a cytoplasmic protein and that it colocalizes with RIP. Our findings suggest that ZIN is an inhibitor of TNF- and IL1-induced NF-kappa B activation pathways. ..
  30. Wu X, Zhu Z, Yerle M, Wang H, Wang H, Gu M, et al. Radiation hybrid mapping of four genes (MYBPC1, LUM, ZRF1 and ATP2B4) expressed in embryo skeleton muscle to pig chromosomes 5 and 9. Anim Genet. 2004;35:472-3 pubmed
  31. Zhang L, Xing G, Tie Y, Tang Y, Tian C, Li L, et al. Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis. EMBO J. 2005;24:766-78 pubmed
    ..CKIP-1 is the first case of a c-Jun-interacting protein that regulates AP-1 activity via caspase-3-dependent cleavage and translocation. ..
  32. He J, Bellini M, Inuzuka H, Xu J, Xiong Y, Yang X, et al. Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. J Biol Chem. 2006;281:2820-7 pubmed
  33. Zhang Y, Lv F, Jin L, Peng W, Song R, Ma J, et al. MG53 participates in ischaemic postconditioning through the RISK signalling pathway. Cardiovasc Res. 2011;91:108-15 pubmed publisher
    ..We conclude that MG53 participates in PostC-mediated cardioprotection largely through tethering CaV3 and PI3K and subsequent activation of the RISK pathway. ..
  34. Liang Y, Liu X, Chang H, Ji L, Huang G, Fu Z, et al. Epidemiological and molecular characteristics of clinical isolates of Streptococcus pyogenes collected between 2005 and 2008 from Chinese children. J Med Microbiol. 2012;61:975-83 pubmed publisher
    ..0 (69.6?%), emm18.0 (66.7?%), emm22.0 (75.9?%) and emm80.0 (80.0?%) genotypes. The most prevalent emm genotypes in mainland China in recent years were emm1.0 and emm12.0. All isolates remained sensitive to ?-lactams and quinolone. ..
  35. Shi F, Yang Y, Kouadir M, Fu Y, Yang L, Zhou X, et al. Inhibition of phagocytosis and lysosomal acidification suppresses neurotoxic prion peptide-induced NALP3 inflammasome activation in BV2 microglia. J Neuroimmunol. 2013;260:121-5 pubmed publisher
    ..We concluded that phagocytosis and lysosomal acidification are necessary for PrP106-126-induced NALP3 activation in BV2 cells. ..
  36. Zhang X, Jiang L, Wang G, Yu L, Zhang Q, Xin Q, et al. Structural insights into the abscisic acid stereospecificity by the ABA receptors PYR/PYL/RCAR. PLoS ONE. 2013;8:e67477 pubmed publisher
    ..Our results provide novel insights of the bioactivity of ABA enantiomers onto PYLs, and shed light on designing the selective ABA receptors agonists. ..
  37. Yan L, Miao Q, Sun Y, Yang F. tBid forms a pore in the liposome membrane. FEBS Lett. 2003;555:545-50 pubmed
    ..Taking into account the tBid three-dimensional structure, we propose that tBid could penetrate into the hydrophobic core of membrane, resulting in the leakage of entrapped content from LUVs via a pore-forming mechanism. ..
  38. Liu L, Chen G, Ji X, Gao G. ZAP is a CRM1-dependent nucleocytoplasmic shuttling protein. Biochem Biophys Res Commun. 2004;321:517-23 pubmed
    ..The NES was mapped to amino acids 284-LEDVSVDV-291. These findings help to understand why ZAP specifically prevents the accumulation of viral RNA in the cytoplasm. These findings also suggest possible functions of ZAP in the nucleus. ..
  39. Zhang M, Wang R, Wang Y, Diao F, Lu F, Gao D, et al. The CXXC finger 5 protein is required for DNA damage-induced p53 activation. Sci China C Life Sci. 2009;52:528-38 pubmed publisher
    ..These findings suggest that CF5 plays a crucial role in ATM-p53 signaling in response to DNA damage. ..
  40. Wang X, Zhou B. Dietary zinc absorption: A play of Zips and ZnTs in the gut. IUBMB Life. 2010;62:176-82 pubmed publisher
    ..The utilization of Drosophila model in elucidating molecular mechanisms of dietary zinc absorption is also discussed in this review...
  41. Wang Z, Li S, Shi Q, Yan R, Liu G, Dai K. Calmodulin antagonists induce platelet apoptosis. Thromb Res. 2010;125:340-50 pubmed publisher
    ..Therefore, these findings indicate that CaM antagonists induce platelet apoptosis. The elevation of the cytosolic Ca(2+) levels may be involved in the regulation of CaM antagonists-induced platelet apoptosis. ..
  42. Wang X, Lv F, Gao G. Mutagenesis analysis of the zinc-finger antiviral protein. Retrovirology. 2010;7:19 pubmed publisher
    ..The mutants that bind normally to the target RNA, the exosome, and the RNA helicase p72 may be useful tools for further understanding the mechanism underlying ZAP's antiviral activity. ..
  43. Hu X, Guo Y, Huang B, Bun S, Zhang L, Li J, et al. The effect of glucagon-like peptide 2 injection on performance, small intestinal morphology, and nutrient transporter expression of stressed broiler chickens. Poult Sci. 2010;89:1967-74 pubmed publisher
    ..Glucagon-like peptide 2 injection also had a positive effect on the growth performance of healthy broiler chickens. ..
  44. Deng J, Liu S, Zou L, Xu C, Geng B, Xu G. Lipolysis response to endoplasmic reticulum stress in adipose cells. J Biol Chem. 2012;287:6240-9 pubmed publisher
  45. Sun M, Liu Y, Walker W, Liu C, Lin K, Gu S, et al. Identification and characterization of pheromone receptors and interplay between receptors and pheromone binding proteins in the diamondback moth, Plutella xyllostella. PLoS ONE. 2013;8:e62098 pubmed publisher
    ..If the chemical signal is not the pheromone component, but instead, a pheromone analog with a similar structure, the complex would have a decreased ability to activate downstream pheromone receptors. ..
  46. Zhao C, Liu Y, Ni Y, Yang J, Hui H, Sun Z, et al. SCIRR39 promotes neurite extension via RhoA in NGF-induced PC12 cells. Dev Neurosci. 2013;35:373-83 pubmed publisher
    ..Our results indicated that SCIRR39 increased the neurite extension in NGF-treated PC12 cells via RhoA, suggesting that SCIRR39 contributes to the regeneration of neuron injury by specifically altering the differentiation program. ..
  47. Hu J, Yang R, Wen C, Li H, Zhao H. [Expression of NLRP3 inflammasome in BALB/c mice with imiquimod-induced psoriasis-like inflammation and therapeutic effect of mustard seed (Sinapis Alba Linn)]. Nan Fang Yi Ke Da Xue Xue Bao. 2013;33:1394-8 pubmed
    ..NLRP3 inflammasome is involved in imiquimod-induced psoriasis-like inflammation in mice, and mustard seed may suppress the inflammation induced by IL-1? and IL-18 through down-regulating the expression of NLRP3 inflammasome. ..
  48. Shang Y, He J, Feng Q, Zhang Y, Guo J, Li J, et al. CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma. Oncogene. 2017;36:4191-4200 pubmed publisher
    ..Our findings shed new light into understanding of ovarian carcinomas and may provide a new therapeutic strategy for ovarian cancer. ..
  49. He J, Jiang H, Tansey J, Tang C, Pu S, Xu G. Calyculin and okadaic acid promote perilipin phosphorylation and increase lipolysis in primary rat adipocytes. Biochim Biophys Acta. 2006;1761:247-55 pubmed
    ..This suggests a two-step strategy governed by a kinase and a phosphatase to modulate the steady state of perilipin phosphorylation and hence the lipolysis response to hormonal stimulation. ..
  50. Liu J, Zhao D, Liu S, Liu J, Qin L, Wu Z. [Study on the distribution and association of cholesteryl ester transfer protein-TaqIB polymorphism and plasma concentration in general population]. Zhonghua Liu Xing Bing Xue Za Zhi. 2003;24:300-3 pubmed
    ..CETP-TaqIB polymorphism was a determinant of plasma CETP concentration. However, the effect could be modified by other factors, such as lipids, smoking and alcohol consumption. ..
  51. Zhang Y, Wu H, Lv F, Xiao R. MG53: Biological Function and Potential as a Therapeutic Target. Mol Pharmacol. 2017;92:211-218 pubmed publisher
    ..In this review, we comprehensively summarize current research progress on the biologic functions and therapeutic potential of MG53. ..
  52. Zhang M, Wang L, Miao S, Koide S. Isolation and sequencing of the cDNA encoding the 75-kD human sperm protein related to infertility. Chin Med J (Engl). 1992;105:998-1003 pubmed
    ..The fusion protein was purified by affinity chromatography on an anti-beta-galactosidase-Sepharose column. It is proposed that production of anti-75-kD antibodies may be the underlying cause of the infertility. ..
  53. Shi N, Zhou W, Tang K, Gao Y, Jin J, Gao F, et al. Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of human dok-5 protein. Acta Crystallogr D Biol Crystallogr. 2002;58:2170-2 pubmed
    ..Subsequently, three different wavelength data sets were collected to 2.3 A resolution from the derivative crystal at the Advanced Photon Source, Argonne National Laboratory. ..
  54. Liu B, Yu S, Li T. Multinucleated giant cells in various forms of giant cell containing lesions of the jaws express features of osteoclasts. J Oral Pathol Med. 2003;32:367-75 pubmed
    ..The similar characteristics and mechanisms in the differentiation of MGCs in these lesions also suggest that there might be a similar kind of pathogenesis involved in the formation of the MGCs in these lesions ..
  55. Xu L, Xiao N, Liu F, Ren H, Gu J. Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria. Proc Natl Acad Sci U S A. 2009;106:1530-5 pubmed publisher
    ..Therefore, gC1qR is a physiological inhibitor of the RIG-I and MDA5-mediated antiviral signaling pathway. These data uncover a new viral mechanism used to negatively control antiviral signaling in host cells. ..
  56. Zhuo D, Niu X, Chen Y, Xin D, Guo Y, Mao Z. Vitamin D3 up-regulated protein 1(VDUP1) is regulated by FOXO3A and miR-17-5p at the transcriptional and post-transcriptional levels, respectively, in senescent fibroblasts. J Biol Chem. 2010;285:31491-501 pubmed publisher
    ..These results indicated that VDUP1 expression was regulated by FOXO3A at the transcriptional level and by miR-17-5p at the post-transcriptional levels during the senescence process. ..
  57. Bai L, Deng X, Li Q, Wang M, An W, Deli A, et al. Down-regulation of the cavin family proteins in breast cancer. J Cell Biochem. 2012;113:322-8 pubmed publisher
    ..Thus, the caveolae is a potential therapeutic target and the expression of cavin family proteins could be a useful prognostic indicator of breast cancer progression. ..
  58. Zhang T, Mei X, Feng J, Berg B, Zhang Y, Guo Y. Characterization of three pheromone-binding proteins (PBPs) of Helicoverpa armigera (Hübner) and their binding properties. J Insect Physiol. 2012;58:941-8 pubmed publisher
  59. Wang B, Liu Y, Yang Y, Zhang Y, Hao J, Yang H, et al. Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP. Clin Sci (Lond). 2013;124:203-14 pubmed publisher
    ..Moreover, p62 and VPRBP were associated with poor prognosis in lung ADC (adenocarcinoma) (p62, P=0.019; VPRBP, P=0.005). Patients with low expression of both p62 and VPRBP showed the best prognosis. ..
  60. Zhong L, Zhou W, Wang H, Ding S, Lu Q, Wen X, et al. Chloroplast small heat shock protein HSP21 interacts with plastid nucleoid protein pTAC5 and is essential for chloroplast development in Arabidopsis under heat stress. Plant Cell. 2013;25:2925-43 pubmed publisher
    ..Our results suggest that HSP21 and pTAC5 are required for chloroplast development under heat stress by maintaining PEP function. ..
  61. Zhang L, Tie Y, Tian C, Xing G, Song Y, Zhu Y, et al. CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM. Cell Signal. 2006;18:1386-95 pubmed
    ..Our data provide the first evidence that ATM, a predominantly nuclear kinase, could be relocalized to the plasma membrane by CKIP-1 and shed new light on the multi-functional CKIP-1. ..
  62. Zhang Y, Yan L, Zhou Z, Yang P, Tian E, Zhang K, et al. SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans. Cell. 2009;136:308-21 pubmed publisher
    ..Our study reveals a mechanism for preferential degradation of protein aggregates by autophagy and emphasizes the physiological significance of selective autophagy during animal development. ..
  63. Ye K, Jia R, Lin J, Ju M, Peng J, Xu A, et al. Structural organization of box C/D RNA-guided RNA methyltransferase. Proc Natl Acad Sci U S A. 2009;106:13808-13 pubmed publisher
    ..We also built a model of a native C/D RNP with substrate and fibrillarin in an active conformation. Our results provide insight into the overall organization and mechanism of action of C/D RNA-guided RNA methyltransferases...
  64. Shen G, Zhang F, Liu X, Zhang J. Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia. FEBS Lett. 2010;584:4366-72 pubmed publisher
    ..Our results demonstrated that HIF1 promotes glycogen accumulation through regulating PPP1R3C expression under hypoxia, which revealed a novel metabolic adaptation of cells to hypoxia. ..
  65. Wang Y, Bai Y, Li X, Hu Q, Lin C, Xiao Z, et al. Fetal human neural progenitors can be the target for tumor transformation. Neuroreport. 2004;15:1907-12 pubmed
    ..These data have implications for providing a novel tool to test the feasibility of new anticancer treatment strategies and raise the possibility of a risk for the use of hNPCs in cell transplantation. ..
  66. Wang J, Bu D, Li T, Zheng R, Zhang B, Chen X, et al. Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus. Br J Dermatol. 2005;153:558-64 pubmed
  67. Shi W, Wang H, Pan G, Geng Y, Guo Y, Pei D. Regulation of the pluripotency marker Rex-1 by Nanog and Sox2. J Biol Chem. 2006;281:23319-25 pubmed
    ..Taking these findings together, we conclude that Rex-1 is a direct target of Nanog, which is augmented by Sox2 and Oct-3/4. ..
  68. Zhang W, Yang X, Shi J, Sun K, Hui R. Polymorphism of SG13S114T/A in the ALOX5AP gene and the risk for stroke in a large Chinese cohort. Yi Chuan Xue Bao. 2006;33:678-84 pubmed
  69. Chen X, Feng Y, Hao C, Guo X, He X, Zhou Z, et al. DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release. J Cell Biol. 2008;181:791-801 pubmed publisher
    ..These findings suggest that dysbindin functions to regulate exocytosis and vesicle biogenesis in endocrine cells and neurons. Our work also suggests a possible mechanism in the pathogenesis of schizophrenia at the synaptic level. ..
  70. Chen X, Hu T, Liang G, Yang M, Zong S, Miao S, et al. A novel testis protein, RSB-66, interacting with INCA1 (inhibitor of Cdk interacting with cyclin A1). Biochem Cell Biol. 2008;86:345-51 pubmed publisher
    ..The alpha helix in the RSB-66 C terminal and two amino acid residues (tyr117 and his119) appear to be crucial for its function. ..
  71. Zhang Q, Jiang J, Han P, Yuan Q, Zhang J, Zhang X, et al. Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals. Cell Res. 2011;21:579-87 pubmed publisher
    ..This study also shows that relatively homogeneous embryonic atrial- and ventricular-like myocyte populations can be efficiently derived from hESCs by specifically regulating Noggin and retinoid signals. ..
  72. Gao Y, Li T, Chang Y, Wang Y, Zhang W, Li W, et al. Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability. Nat Cell Biol. 2011;13:924-33 pubmed publisher
    ..These results suggest that CUEDC2 is a key regulator of mitosis progression, and that CUEDC2 dysregulation might contribute to tumour development by causing chromosomal instability...
  73. Shi C, Zhang K, Wang X, Shen Y, Xu Q. A study of the combined effects of the EHD3 and FREM3 genes in patients with major depressive disorder. Am J Med Genet B Neuropsychiatr Genet. 2012;159B:336-42 pubmed publisher
    ..001) and those carrying the rs644926(A) allele (P?=?0.00077). The combined effect of the EHD3 and FREM3 genes may play an important role in developing MDD. © 2012 Wiley Periodicals, Inc. ..
  74. Liu X, Liu S, Feng Y, Liu J, Chen Y, Pham K, et al. Structural insights into the N-terminal GIY-YIG endonuclease activity of Arabidopsis glutaredoxin AtGRXS16 in chloroplasts. Proc Natl Acad Sci U S A. 2013;110:9565-70 pubmed publisher
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