Genomes and Genes
Experts and Doctors on caenorhabditis elegans in Beijing, China
Locale: Beijing, China
Topic: caenorhabditis elegans
Publications103 found, 100 shown here
- Li X, Chen B, Yoshina S, Cai T, Yang F, Mitani S, et al. Inactivation of Caenorhabditis elegans aminopeptidase DNPP-1 restores endocytic sorting and recycling in tat-1 mutants. Mol Biol Cell. 2013;24:1163-75 pubmed publisher..Our data reveal the involvement of an aminopeptidase in regulating endocytic sorting and recycling and suggest possible roles of peptide signaling and/or protein metabolism in these processes. ..
- Xu Y, Sun F. Purification, crystallization and preliminary crystallographic analysis of 3-hydroxyacyl-CoA dehydrogenase from Caenorhabditis elegans. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013;69:515-9 pubmed publisher..Analyses of computed Matthews coefficient and self-rotation functions suggested that there are two cHAD molecules in one asymmetric unit in both crystals, forming identical dimers but packing in distinct manners. ..
- Ding H, Qiu S, Bunzel R, Luo D, Arabashi A, Lu S, et al. Purification, nanocrystallization and preliminary X-ray analysis of a C-terminal part of tropomodulin protein 1, isoform A, from Caenorhabditis elegans. Acta Crystallogr D Biol Crystallogr. 2003;59:1106-8 pubmed..98 A at 100 K using a synchrotron X-ray source (SER-CAT). The crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 31.7, b = 50.6, c = 107.1 A, and contained one molecule per asymmetric unit. ..
- Zhang L, Jie G, Zhang J, Zhao B. Significant longevity-extending effects of EGCG on Caenorhabditis elegans under stress. Free Radic Biol Med. 2009;46:414-21 pubmed publisher..As the death rate of a population is closely related to the mortality caused by external stress, it could be concluded that the survival-enhancing effects of EGCG on C. elegans under stress are very important for antiaging research. ..
- Sun Y, Guo X, Hinnebusch B, Darby C. The Yersinia pestis Rcs phosphorelay inhibits biofilm formation by repressing transcription of the diguanylate cyclase gene hmsT. J Bacteriol. 2012;194:2020-6 pubmed publisher..Biofilm development is negatively regulated by the Rcs phosphorelay signal transduction system. In this study, we show that Rcs-negative regulation is accomplished by repressing transcription of hmsT...
- Wang X, Liu M, Li W, Suh C, Zhu Z, Jin Y, et al. The function of a spindle checkpoint gene bub-1 in C. elegans development. PLoS ONE. 2009;4:e5912 pubmed publisher..elegans bub-1 is required both maternally and zygotically. Further, our genetic analysis is consistent with that the function of bub-1 in C. elegans is likely similar to its yeast and mammalian homologs. ..
- Zhang Z, Zhao Y, Wang X, Lin R, Zhang Y, Ma H, et al. The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans. Food Funct. 2016;7:1975-84 pubmed publisher..Thereby, Tyr-Ala could be used as a potential medicine in anti-aging research. ..
- Shen Q, Qin F, Gao Z, Cui J, Xiao H, Xu Z, et al. Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans. Mol Cell Biol. 2009;29:3881-93 pubmed publisher..These findings suggest that WAN-1 is involved in the central cell-killing process and cooperates with the core cell death machinery to promote programmed cell death in C. elegans. ..
- Shu W, Ni M, Bo X, Zheng Z, Wang S. EvoRSR: an integrated system for exploring evolution of RNA structural robustness. BMC Bioinformatics. 2009;10:249 pubmed publisher..While the current EvoRSR environment is a versatile analysis framework, future versions can include features to enhance evolutionary studies of robustness. ..
- Song S, Ge Q, Wang J, Chen H, Tang S, Bi J, et al. TRIM-9 functions in the UNC-6/UNC-40 pathway to regulate ventral guidance. J Genet Genomics. 2011;38:1-11 pubmed publisher..Over-expression of the Netrin/UNC-6 receptor Frazzled suppresses the guidance defects in trim-9 mutants. Our study reveals an evolutionarily conserved function of TRIM-9 in the UNC-40/Frazzled-mediated UNC-6/Netrin attraction pathway. ..
- He H, Cai L, Skogerbø G, Deng W, Liu T, Zhu X, et al. Profiling Caenorhabditis elegans non-coding RNA expression with a combined microarray. Nucleic Acids Res. 2006;34:2976-83 pubmed..Taken together, our microarray analysis presents a more complete and detailed picture of a non-coding transcriptome than hitherto has been presented for any other multicellular organism. ..
- Wang Y, Chen J, Wei G, He H, Zhu X, Xiao T, et al. The Caenorhabditis elegans intermediate-size transcriptome shows high degree of stage-specific expression. Nucleic Acids Res. 2011;39:5203-14 pubmed publisher..Assuming functional roles for most of the novel loci, the data imply a nematode is-ncRNA tool kit of considerable size and variety. ..
- Zhou D, Yang R. Formation and regulation of Yersinia biofilms. Protein Cell. 2011;2:173-9 pubmed publisher..Pseudotuberculosis and Y. Pestis, but Y. Pestis has evolved changes in the regulation of biofilm development, thereby acquiring efficient arthropod-borne transmission. ..
- Yin J, Huang Y, Guo P, Hu S, Yoshina S, Xuan N, et al. GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans. J Cell Biol. 2017;216:1775-1794 pubmed publisher..Loss of gop-1 also abolishes association of UNC-108 with endosomes, causing defects in endosome and dense core vesicle maturation. Thus, GOP-1 is an activator of UNC-108/Rab2 in multiple processes. ..
- Zhai R, Meng G, Zhao Y, Liu B, Zhang G, Zheng X. A novel nuclear-localized protein with special adenylate kinase properties from Caenorhabditis elegans. FEBS Lett. 2006;580:3811-7 pubmed..These results suggest that ADLP is more likely a member of the AK6 family. Furthermore, RNAi experiments targeting ADLP were conducted and showed that RNAi treatment resulted in the suppression of worm growth. ..
- Ding M, Shen K. The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases. Bioessays. 2008;30:1075-83 pubmed publisher..Here we summarize recent discoveries centered on the role of the UPS in synapse remodeling and draw attention to the potential link between the synaptic UPS dysfunction and the pathology of neurodegenerative diseases. ..
- Zhou J, Yang Z, Dong W, Tang R, Sun L, Yan C. Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals. Biomaterials. 2011;32:9059-67 pubmed publisher..The in vitro and in vivo studies confirm that NaYF(4):Yb,Tm NCs could be served as an excellent NIR emission bioprobe with low toxicity...
- Zhang H, He X, Bai W, Guo X, Zhang Z, Chai Z, et al. Ecotoxicological assessment of lanthanum with Caenorhabditis elegans in liquid medium. Metallomics. 2010;2:806-10 pubmed..The assessment we performed in the present work could be developed as a standardized test design for aquatic toxicological research...
- Lu Q, Yang P, Huang X, Hu W, Guo B, Wu F, et al. The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes. Dev Cell. 2011;21:343-57 pubmed publisher..Our study demonstrates that autophagic PtdIns(3)P effectors play distinct roles in autophagosome formation and also provides a framework for understanding the concerted action of autophagy genes in protein aggregate degradation. ..
- Ezemaduka A, Yu J, Shi X, Zhang K, Yin C, Fu X, et al. A small heat shock protein enables Escherichia coli to grow at a lethal temperature of 50°C conceivably by maintaining cell envelope integrity. J Bacteriol. 2014;196:2004-11 pubmed publisher..Together, our data indicate that maintaining the cell envelope integrity is crucial for the E. coli cells to grow at high temperatures and also shed new light on the development of thermophilic bacteria for industrial application...
- He H, Wang J, Liu T, Liu X, Li T, Wang Y, et al. Mapping the C. elegans noncoding transcriptome with a whole-genome tiling microarray. Genome Res. 2007;17:1471-7 pubmed..After combining overlapping transcripts, we estimate that at least 70% of the total C. elegans genome is transcribed. ..
- Feng G, Yi P, Yang Y, Chai Y, Tian D, Zhu Z, et al. Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression. Development. 2013;140:3838-47 pubmed publisher..We have thus identified TFs that function at distinct developmental stages to ensure appropriate neuroblast lineage progression and suggest that their vertebrate homologs might similarly regulate neural development. ..
- Qu W, Ren C, Li Y, Shi J, Zhang J, Wang X, et al. Reliability analysis of the Ahringer Caenorhabditis elegans RNAi feeding library: a guide for genome-wide screens. BMC Genomics. 2011;12:170 pubmed publisher..elegans RNAi feeding library, we strongly suggest the user examine the reliability information of the bacterial strains in the CelRNAi database before performing RNAi experiments, as well as the post-RNAi experiment analysis. ..
- Wu D, Chai Y, Zhu Z, Li W, Ou G, Li W. CED-10-WASP-Arp2/3 signaling axis regulates apoptotic cell corpse engulfment in C. elegans. Dev Biol. 2017;428:215-223 pubmed publisher..Together, our results suggest CED-10 reorganizes the actin cytoskeleton by recruiting the WASP-Arp2/3 actin nucleation factors during apoptotic cell engulfment. ..
- Yang M, Sun J, Sun X, Shen Q, Gao Z, Yang C. Caenorhabditis elegans protein arginine methyltransferase PRMT-5 negatively regulates DNA damage-induced apoptosis. PLoS Genet. 2009;5:e1000514 pubmed publisher..These findings suggest that PRMT-5 likely represses CEP-1 transcriptional activity through CBP-1, which represents a novel regulatory mechanism of p53-dependent apoptosis. ..
- Wu Y, Wu M, He G, Zhang X, Li W, Gao Y, et al. Glyceraldehyde-3-phosphate dehydrogenase: a universal internal control for Western blots in prokaryotic and eukaryotic cells. Anal Biochem. 2012;423:15-22 pubmed publisher..coli gapC. Taken together, our results indicate that GAPDH could be universally used as an internal control for the Western blot analysis of prokaryotic and eukaryotic samples. ..
- Chen D, Jian Y, Liu X, Zhang Y, Liang J, Qi X, et al. Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003517 pubmed publisher..These findings reveal a non-classical role of clathrin and AP2 and establish them as indispensable regulators in phagocytic receptor-mediated apoptotic cell clearance...
- Yang Y, Sun Y, Luo X, Zhang Y, Chen Y, Tian E, et al. Polycomb-like genes are necessary for specification of dopaminergic and serotonergic neurons in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2007;104:852-7 pubmed..Our studies revealed that the PcG-like genes are crucial for coordinately regulating the expression of discrete aspects of neuronal identities in C. elegans. ..
- Yang P, Zhang H. The coiled-coil domain protein EPG-8 plays an essential role in the autophagy pathway in C. elegans. Autophagy. 2011;7:159-65 pubmed..EPG-8 directly interacts with the C. elegans Beclin 1 homolog, BEC-1. Our study demonstrates that epg-8 may function as a highly divergent homolog of the yeast autophagy gene Atg14. ..
- Xu J, Sun X, Jing Y, Wang M, Liu K, Jian Y, et al. MRG-1 is required for genomic integrity in Caenorhabditis elegans germ cells. Cell Res. 2012;22:886-902 pubmed publisher..Altogether, these findings suggest that MRG-1 is critical for genomic integrity by promoting meiotic DSB repair and synapsis progression in meiosis. ..
- Wu F, Li Y, Wang F, Noda N, Zhang H. Differential function of the two Atg4 homologues in the aggrephagy pathway in Caenorhabditis elegans. J Biol Chem. 2012;287:29457-67 pubmed publisher..1; atg-4.2 double mutants. Our study reveals that ATG-4.1 and ATG-4.2 are functionally redundant yet display differential LGG-1 processing and deconjugating activity in the aggrephagy pathway in C. elegans. ..
- Lin L, Yang P, Huang X, Zhang H, Lu Q, Zhang H. The scaffold protein EPG-7 links cargo-receptor complexes with the autophagic assembly machinery. J Cell Biol. 2013;201:113-29 pubmed publisher..Our results indicate that under physiological conditions a scaffold protein endows cargo specificity and also elevates degradation efficiency by linking the cargo-receptor complex with the autophagic machinery. ..
- Li S, Yang P, Tian E, Zhang H. Arginine methylation modulates autophagic degradation of PGL granules in C. elegans. Mol Cell. 2013;52:421-33 pubmed publisher..Our study reveals that posttranslational arginine methylation regulates the association of the cargo-receptor complex with the scaffold protein, providing a mechanism for modulating degradation efficiency in selective autophagy...
- Xue H, Xian B, Dong D, Xia K, Zhu S, Zhang Z, et al. A modular network model of aging. Mol Syst Biol. 2007;3:147 pubmed..Network simulations further suggest that aging might preferentially attack key regulatory nodes that are important for the network stability, implicating a potential molecular basis for the stochastic nature of aging. ..
- Chen D, Xiao H, Zhang K, Wang B, Gao Z, Jian Y, et al. Retromer is required for apoptotic cell clearance by phagocytic receptor recycling. Science. 2010;327:1261-4 pubmed publisher..Thus, retromer is an essential mediator of apoptotic cell clearance by regulating phagocytic receptor(s) during cell corpse engulfment. ..
- Yu Y, Wang L, Jiu Y, Zhan Y, Liu L, Xia Z, et al. HID-1 is a novel player in the regulation of neuropeptide sorting. Biochem J. 2011;434:383-90 pubmed publisher..Epistasis analysis suggests that rab-2 is epistatic to hid-1. ..
- Sun Y, Yang P, Zhang Y, Bao X, Li J, Hou W, et al. A genome-wide RNAi screen identifies genes regulating the formation of P bodies in C. elegans and their functions in NMD and RNAi. Protein Cell. 2011;2:918-39 pubmed publisher..Our study offers insights into the cellular mechanisms that regulate the formation of P bodies and also provides a framework for system-level understanding of NMD and RNAi in the context of the development of multicellular organisms...
- Ding Y, Zhang S, Yang L, Na H, Zhang P, Zhang H, et al. Isolating lipid droplets from multiple species. Nat Protoc. 2013;8:43-51 pubmed publisher..On the basis of previous studies, this 7-h protocol can yield 15-100 ?g of protein-equivalent high-quality LDs that satisfy the requirements for current LD research in most organisms...
- Cheng Z, Yi P, Wang X, Chai Y, Feng G, Yang Y, et al. Conditional targeted genome editing using somatically expressed TALENs in C. elegans. Nat Biotechnol. 2013;31:934-7 pubmed publisher..Our results show that TALENs expressed in the somatic cells of model organisms provide a versatile tool for functional genomics. ..
- Zhang T, Sun Y, Tian E, Deng H, Zhang Y, Luo X, et al. RNA-binding proteins SOP-2 and SOR-1 form a novel PcG-like complex in C. elegans. Development. 2006;133:1023-33 pubmed..Surprisingly, homologs of SOR-1 and SOP-2 are not found in other organisms, including the congeneric species C. briggsae, suggesting an unexpected lack of evolutionary constraint on an essential global gene regulatory system. ..
- Cai Q, Sun Y, Huang X, Guo C, Zhang Y, Zhu Z, et al. The Caenorhabditis elegans PcG-like gene sop-2 regulates the temporal and sexual specificities of cell fates. Genetics. 2008;178:1445-56 pubmed publisher..In summary, our studies reveal that sop-2 integrates spatial, temporal, and sexual cues during C. elegans development. ..
- Zhang Y, Yan L, Zhou Z, Yang P, Tian E, Zhang K, et al. SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans. Cell. 2009;136:308-21 pubmed publisher..Our study reveals a mechanism for preferential degradation of protein aggregates by autophagy and emphasizes the physiological significance of selective autophagy during animal development. ..
- Tian Y, Li Z, Hu W, Ren H, Tian E, Zhao Y, et al. C. elegans screen identifies autophagy genes specific to multicellular organisms. Cell. 2010;141:1042-55 pubmed publisher..This study establishes C. elegans as a multicellular genetic model to delineate the autophagy pathway and provides mechanistic insights into the metazoan-specific autophagic process. ..
- Wang X, Wang X, Li L, Wang D. Lifespan extension in Caenorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16. Biochem Biophys Res Commun. 2010;400:613-8 pubmed publisher..1 and daf-16 but not eat-2 or hsf-1. In summary, we report the function and the putative mechanism of DMSO in lifespan extension of C. elegans. This study draws attention to using DMSO as a solvent when conducting aging studies. ..
- Chen B, Jiang Y, Zeng S, Yan J, Li X, Zhang Y, et al. Endocytic sorting and recycling require membrane phosphatidylserine asymmetry maintained by TAT-1/CHAT-1. PLoS Genet. 2010;6:e1001235 pubmed publisher..Our data suggest that CHAT-1 and TAT-1 maintain membrane phosphatidylserine asymmetry, thus promoting membrane tubulation and regulating endocytic sorting and recycling. ..
- Kang Y, Xu J, Liu Y, Sun J, Sun D, Hu Y, et al. Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem Biophys Res Commun. 2011;410:189-94 pubmed publisher..However, CED-2 was found to interact with the N-terminal region of CED-5. Our findings suggest that CED-2 may regulate cell corpse engulfment by interacting with CED-5 through the N-terminal region rather than the PXXP motif. ..
- Ma X, Zhu Y, Li C, Shang Y, Meng F, Chen S, et al. Comparative transcriptome sequencing of germline and somatic tissues of the Ascaris suum gonad. BMC Genomics. 2011;12:481 pubmed publisher..Widespread study of A. suum would be facilitated by more comprehensive genome resources and, to this end, we have produced a gonad transcriptome of A. suum...
- Kang Y, Zhao D, Liang H, Liu B, Zhang Y, Liu Q, et al. Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment. Genes Dev. 2012;26:1339-50 pubmed publisher..Our results reveal the first full-length structure of a bridging molecule and the mechanism underlying bridging molecule-mediated apoptotic cell recognition. ..
- Ren C, Li Y, Han R, Gao D, Li W, Shi J, et al. GLB-13 is associated with oxidative stress resistance in Caenorhabditis elegans. IUBMB Life. 2013;65:423-34 pubmed publisher..Our data provided evidence for the first time that glb-13 is associated with the resistance against oxidative stress-induced toxicity. ..
- Xin L, Yamujala R, Wang Y, Wang H, Wu W, Lawton M, et al. Acetylcholineestarase-inhibiting alkaloids from Lycoris radiata delay paralysis of amyloid beta-expressing transgenic C. elegans CL4176. PLoS ONE. 2013;8:e63874 pubmed publisher..Lycoris compounds were shown to significantly inhibit the gene expression of ace-1 and ace-2. Additionally, the Lycoris compounds may modulate inflammatory and stress-related gene expressions to combat the A?-toxicity in C. elegans...
- Li T, Chen J, Li X, Ding X, Wu Y, Zhao L, et al. Absolute quantification of a steroid hormone that regulates development in Caenorhabditis elegans. Anal Chem. 2013;85:9281-7 pubmed publisher..These mutants are able to escape the dauer fate and most of them grow into fertile adults when supplied with exogenous DA. Therefore, a DA spike in the L2 stage is critical for the reproductive development of C. elegans. ..
- Mann F, Van Nostrand E, Friedland A, Liu X, Kim S. Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans. PLoS Genet. 2016;12:e1005956 pubmed publisher..Overexpression of elt-2 extends lifespan and slows the rate of gene expression changes that occur during normal aging. Thus, our results identify the developmental regulator ELT-2 as a major driver of normal aging in C. elegans. ..
- Zhong H, Wu X, Huang H, Fan Q, Zhu Z, Lin S. Vertebrate MAX-1 is required for vascular patterning in zebrafish. Proc Natl Acad Sci U S A. 2006;103:16800-5 pubmed..Our findings therefore suggest that max-1, acting upstream of the ephrin pathway, is critically required in vascular patterning in vertebrate species. ..
- Xia D, Huang X, Zhang H. The temporally regulated transcription factor sel-7 controls developmental timing in C. elegans. Dev Biol. 2009;332:246-57 pubmed publisher..elegans. ..
- Cai Q, Wang W, Gao Y, Yang Y, Zhu Z, Fan Q. Ce-wts-1 plays important roles in Caenorhabditis elegans development. FEBS Lett. 2009;583:3158-64 pubmed publisher..In addition, CE-WTS-1::GFP is enriched near the inner cell membrane, implying its possible membrane-related function. ..
- Qi S, Pang Y, Hu Q, Liu Q, Li H, Zhou Y, et al. Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell. 2010;141:446-57 pubmed publisher..The structure of the CED-4 apoptosome reveals shared principles for the NB-ARC family of AAA(+) ATPases and suggests a mechanism for the activation of CED-3. ..
- Sleumer M, Wei G, Wang Y, Chang H, Xu T, Chen R, et al. Regulatory elements of Caenorhabditis elegans ribosomal protein genes. BMC Genomics. 2012;13:433 pubmed publisher..Our results indicate that C. elegans RPGs are regulated by a complex novel series of regulatory elements that is evolutionarily distinct from those of all other species examined up until now. ..
- An L, Pang Y, Gao H, Tao L, Miao K, Wu Z, et al. Heterologous expression of C. elegans fat-1 decreases the n-6/n-3 fatty acid ratio and inhibits adipogenesis in 3T3-L1 cells. Biochem Biophys Res Commun. 2012;428:405-10 pubmed publisher..Our results indicate that a reduced n-6/n-3 ratio inhibits adipogenesis through several mechanisms and that n-3 PUFAs more effectively inhibit adipogenesis (but not lipogenesis) than do n-6 PUFAs...
- Han M, Chang H, Zhang P, Chen T, Zhao Y, Zhang Y, et al. C13C4.5/Spinster, an evolutionarily conserved protein that regulates fertility in C. elegans through a lysosome-mediated lipid metabolism process. Protein Cell. 2013;4:364-72 pubmed publisher..5(ok2087) mutants. Taken together, these results indicate that C13C4.5 may regulate the fertility of C. elegans by changing the size and fat content of lipid droplets by interfering with lysosomal morphology and function...
- Wang X, Zhou F, Lv S, Yi P, Zhu Z, Yang Y, et al. Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration. Proc Natl Acad Sci U S A. 2013;110:11175-80 pubmed publisher..Thus, MIG-13 links the Wnt signaling and Hox genes that guide migrations, to the actin cytoskeleton, which executes the motility response in neuronal migration. ..
- Meng J, Ma X, Tao H, Jin X, Witvliet D, Mitchell J, et al. Myrf ER-Bound Transcription Factors Drive C.Â elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation. Dev Cell. 2017;41:180-194.e7 pubmed publisher..MYRF-1 and MYRF-2 are the first genes identified to be indispensable for promoting synaptic rewiring in C.Â elegans. These findings reveal a molecular mechanism underlying synaptic rewiring and developmental circuit plasticity. ..
- Zhao Y, Chen Y, Miao G, Zhao H, Qu W, Li D, et al. The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. Mol Cell. 2017;67:974-989.e6 pubmed publisher..Our study provides mechanistic insights into the establishment and disassociation of ER-IM contacts and reveals that VMP1 modulates SERCA activity to control ER contacts. ..
- Deng W, Zhu X, Skogerbø G, Zhao Y, Fu Z, Wang Y, et al. Organization of the Caenorhabditis elegans small non-coding transcriptome: genomic features, biogenesis, and expression. Genome Res. 2006;16:20-9 pubmed..Preliminary estimates indicate that the C. elegans transcriptome contains approximately 2700 small non-coding RNAs, potentially acting as regulatory elements in nematode development. ..
- Wang X, Suh C, Zhu Z, Fan Q. Minichromosome maintenance protein 5 homologue in Caenorhabditis elegans plays essential role for postembryonic development. Biochem Biophys Res Commun. 2007;359:965-71 pubmed..elegans might function associated with cell division as its homologues in S. cerevisiae. ..
- Deng H, Xia D, Fang B, Zhang H. The Flightless I homolog, fli-1, regulates anterior/posterior polarity, asymmetric cell division and ovulation during Caenorhabditis elegans development. Genetics. 2007;177:847-60 pubmed..Furthermore, the function of fli-1 in C. elegans can be functionally substituted by the Drosophila Fli I. Our studies demonstrate that fli-1 plays an important role in regulating the actin-dependent events during C. elegans development. ..
- Xiao H, Chen D, Fang Z, Xu J, Sun X, Song S, et al. Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in Caenorhabditis elegans. Mol Biol Cell. 2009;20:21-32 pubmed publisher..Our findings thus provide direct evidence for the important role of endosomal/lysosomal degradation in proper clearance of apoptotic cells during programmed cell death. ..
- Li Z, Zhai Y, Fang J, Zhou Q, Geng Y, Sun F. Purification, crystallization and preliminary crystallographic analysis of very-long-chain acyl-CoA dehydrogenase from Caenorhabditis elegans. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:426-30 pubmed publisher..A preliminary molecular-replacement solution further confirmed the presence of two molecules in one asymmetric unit, which yields a Matthews coefficient V(M) of 2.76 A(3) Da(-1) and a solvent content of 55%. ..
- Wan L, Nie G, Zhang J, Luo Y, Zhang P, Zhang Z, et al. ?-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease. Free Radic Biol Med. 2011;50:122-9 pubmed publisher..In aggregate, these results demonstrate that A? accumulation in neuronal cells correlated with neuronal iron homeostasis disruption and probably contributed to the pathogenesis of AD. ..
- Liu M, Liu P, Zhang L, Cai Q, Gao G, Zhang W, et al. mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C. elegans. Cell Res. 2011;21:1605-18 pubmed publisher..Further bioinformatic and functional analyses demonstrate that mir-35 targets evolutionally conserved lin-23 and gld-1. Together, our study reveals a novel function of mir-35 family in cell division regulation. ..
- Zhang Y, Wang H, Kage Nakadai E, Mitani S, Wang X. C. elegans secreted lipid-binding protein NRF-5 mediates PS appearance on phagocytes for cell corpse engulfment. Curr Biol. 2012;22:1276-84 pubmed publisher..During programmed cell death, apoptotic cells are rapidly removed by phagocytes. How dying cells are recognized remains poorly understood...
- Liu Z, Chen L, Shang Y, Huang P, Miao L. The micronutrient element zinc modulates sperm activation through the SPE-8 pathway in Caenorhabditis elegans. Development. 2013;140:2103-7 pubmed publisher..These data indicate that zinc regulates sperm activation in both male and hermaphrodite C. elegans, a finding with important implications for understanding hermaphroditic evolution...
- Shen E, Song C, Lin Y, Zhang W, Su P, Liu W, et al. Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans. Nature. 2014;508:128-32 pubmed publisher..elegans lifespan across genetic, environmental and stochastic factors. They also support the notion that the rate of ageing, although adjustable in later life, has been set to a considerable degree before reproduction ceases. ..
- Zhu Z, Liu J, Yi P, Tian D, Chai Y, Li W, et al. A proneural gene controls C. elegans neuroblast asymmetric division and migration. FEBS Lett. 2014;588:1136-43 pubmed publisher..Our studies thus uncovered previously unknown functions of a proneural gene in neuroblast development. ..
- Lai Y, Xiang M, Liu S, Li E, Che Y, Liu X. A novel high-throughput nematicidal assay using embryo cells and larvae of Caenorhabditis elegans. Exp Parasitol. 2014;139:33-41 pubmed publisher..8-500?g/ml. These results indicate that the proposed two-step screening assay represents an efficient and labor-saving method for screening natural nematicidal products. ..
- Li W, Yi P, Zhu Z, Zhang X, Li W, Ou G. Centriole translocation and degeneration during ciliogenesis in Caenorhabditis elegans neurons. EMBO J. 2017;36:2553-2566 pubmed publisher..Together, our results provide a comprehensive model of ciliogenesis in sensory neurons and reveal the importance of the dynein-dependent centriole translocation in this process. ..
- Dong X, Peng Y, Peng Y, Xu F, He X, Wang F, et al. Characterization and crystallization of human DPY-30-like protein, an essential component of dosage compensation complex. Biochim Biophys Acta. 2005;1753:257-62 pubmed..Efforts are now under way to determine the molecular structure of the DPY-30-like. These studies will open a new avenue towards the structure-based functional analysis of human DPY-30-like and dosage compensation machinery. ..
- Lu Q, Zhang Y, Hu T, Guo P, Li W, Wang X. C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells. Development. 2008;135:1069-80 pubmed publisher..UNC-108 co-localizes with RAB-5, RAB-7 and LMP-1 to the phagosome and promotes cell corpse degradation, possibly by mediating phagosome maturation. ..
- Shi B, Guo X, Wu T, Sheng S, Wang J, Skogerbø G, et al. Genome-scale identification of Caenorhabditis elegans regulatory elements by tiling-array mapping of DNase I hypersensitive sites. BMC Genomics. 2009;10:92 pubmed publisher..elegans and C. briggsae genomes. We describe the first genome-wide analysis of C. elegans DHSs, and show that the distribution of DHSs is strongly associated with functional elements in the genome. ..
- Zou W, Lu Q, Zhao D, Li W, Mapes J, Xie Y, et al. Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells. PLoS Genet. 2009;5:e1000679 pubmed publisher..We propose that MTM-1 negatively regulates cell corpse engulfment through the CED-5/CED-12/CED-10 module by dephosphorylating PtdIns(3)P on the plasma membrane. ..
- Ren H, Zhang H. Wnt signaling controls temporal identities of seam cells in Caenorhabditis elegans. Dev Biol. 2010;345:144-55 pubmed publisher..Our study reveals a novel function of Wnt signaling in controlling the timing of seam cell development in C. elegans. ..
- Li W, Zou W, Yang Y, Chai Y, Chen B, Cheng S, et al. Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell. J Cell Biol. 2012;197:27-35 pubmed publisher..Thus, autophagy genes act within the phagocyte to promote apoptotic cell degradation. ..
- Zhang P, Zhang H. Autophagy modulates miRNA-mediated gene silencing and selectively degrades AIN-1/GW182 in C. elegans. EMBO Rep. 2013;14:568-76 pubmed publisher..Thus, autophagy activity modulates miRNA-mediated gene silencing and degrades a core miRISC component. ..
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