Experts and Doctors on brucellosis in Beijing, China


Locale: Beijing, China
Topic: brucellosis

Top Publications

  1. Kang X, Zhao Y, Jiang D, Li X, Wang X, Wu Y, et al. Crystal structure and biochemical studies of Brucella melitensis 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. Biochem Biophys Res Commun. 2014;446:965-70 pubmed publisher
    ..Glu145 and Asp168 were identified as active site residues essential for catalysis. The catalytic mechanism and implications of this structure for broad-based antibiotic design are discussed. ..
  2. Ding J, Pan Y, Jiang H, Cheng J, Liu T, Qin N, et al. Whole genome sequences of four Brucella strains. J Bacteriol. 2011;193:3674-5 pubmed publisher
    ..melitensis M28-12 and vaccine strains B. melitensis M5 and M111 and B. suis S2, which show different virulences and pathogenicities, which will help to design a more effective brucellosis vaccine. ..
  3. Qu Q, Zhu Z, Wang Y, Zhong Z, Zhao J, Qiao F, et al. Rapid and quantitative detection of Brucella by up-converting phosphor technology-based lateral-flow assay. J Microbiol Methods. 2009;79:121-3 pubmed publisher
    ..0 x 10(3) to 3.9 x 10(5)CFU/mg. The UPT-LF assay showed high specificity, reproducibility and stability, providing great potential for Brucella on-site detection. ..
  4. Zhao Z, Li M, Luo D, Xing L, Wu S, Duan Y, et al. Protection of mice from Brucella infection by immunization with attenuated Salmonella enterica serovar typhimurium expressing A L7/L12 and BLS fusion antigen of Brucella. Vaccine. 2009;27:5214-9 pubmed publisher
    ..Taken together, Salmonella-based subunit vaccines are a promising vaccine strategy in the prevention of Brucella infection. ..
  5. Zhu L, Feng Y, Zhang G, Jiang H, Zhang Z, Wang N, et al. Brucella suis strain 2 vaccine is safe and protective against heterologous Brucella spp. infections. Vaccine. 2016;34:395-400 pubmed publisher
    ..Our study demonstrated that the S2 vaccine is of low virulence, stimulates good humoral and cellular immunity and protects animals against infection by heterologous, virulent Brucella species. ..
  6. Wang Y, Ke Y, Wang Z, Yuan X, Qiu Y, Zhen Q, et al. Genome sequences of three live attenuated vaccine strains of Brucella species and implications for pathogenesis and differential diagnosis. J Bacteriol. 2012;194:6012-3 pubmed publisher
    ..suis S2-30, and B. abortus 104M. Primary genome sequence analysis identified mutations, deletions, and insertions which have implications for attenuation and signatures for differential diagnosis. ..
  7. Shi Y, Lai S, Chen Q, Mu D, Li Y, Li X, et al. [Analysis on the epidemiological features of human brucellosis in northern and southern areas of China, 2015-2016]. Zhonghua Liu Xing Bing Xue Za Zhi. 2017;38:435-440 pubmed publisher
    ..6%??????????????2.2?1?2.7?1???m?48?????????38~58?????????????86.8%????62.7%????????????????3?7?? ??? ?????????????????????????????????????????????????????????????????????????????????. ..
  8. Deqiu S, Donglou X, Jiming Y. Epidemiology and control of brucellosis in China. Vet Microbiol. 2002;90:165-82 pubmed
  9. Feng Y, Peng X, Jiang H, Peng Y, Zhu L, Ding J. Rough brucella strain RM57 is attenuated and confers protection against Brucella melitensis. Microb Pathog. 2017;107:270-275 pubmed publisher
    ..melitensis. Our data presented here provided additional insight into the mechanism of LPS synthesis of Brucella spp. ..

More Information


  1. Jiang H, Wang H, Xu L, Hu G, Ma J, Xiao P, et al. MLVA genotyping of Brucella melitensis and Brucella abortus isolates from different animal species and humans and identification of Brucella suis vaccine strain S2 from cattle in China. PLoS ONE. 2013;8:e76332 pubmed publisher
    ..MLVA typing could be an essential assay to improve brucellosis surveillance and control programs. ..
  2. Cui M, Wang T, Xu J, Ke Y, Du X, Yuan X, et al. Impact of Hfq on global gene expression and intracellular survival in Brucella melitensis. PLoS ONE. 2013;8:e71933 pubmed publisher
    ..These findings highlight the involvement of Hfq as a key regulator of Brucella gene expression and facilitate our understanding of the role of Hfq in environmental stress adaptation and intracellular survival of B. melitensis. ..
  3. Wang Z, Niu J, Wang S, Lv Y, Wu Q. In vivo differences in the virulence, pathogenicity, and induced protective immunity of wboA mutants from genetically different parent Brucella spp. Clin Vaccine Immunol. 2013;20:174-80 pubmed publisher
    ..and also indicated that future rough vaccine strain development could be promising if suitable parent Brucella strains and/or genes were selected. ..
  4. Wang Y, Ke Y, Zhen Q, Yuan X, Xu J, Qiu Y, et al. Complete genome sequence of Brucella canis BCB018, a strain isolated from a human patient. J Bacteriol. 2012;194:6697-8 pubmed publisher
    ..Here, we report the draft genome sequence of a Brucella canis isolate, BCB018, isolated from a human patient, providing precious resources for comparative genomics analysis of Brucella field strains...
  5. Fu S, Xu J, Li X, Xie Y, Qiu Y, Du X, et al. Immunization of mice with recombinant protein CobB or AsnC confers protection against Brucella abortus infection. PLoS ONE. 2012;7:e29552 pubmed publisher
    ..Altogether, the present study showed that CobB or AsnC protein could be useful antigen candidates for the development of subunit vaccines against brucellosis with adequate immunogenicity and protection efficacy...
  6. Wang Y, Bai Y, Qu Q, Xu J, Chen Y, Zhong Z, et al. The 16M?vjbR as an ideal live attenuated vaccine candidate for differentiation between Brucella vaccination and infection. Vet Microbiol. 2011;151:354-62 pubmed publisher
    ..These results suggest that 16M?vjbR is an ideal live attenuated vaccine candidate against B. melitensis and deserves further evaluation for vaccine development...
  7. Yu D, Hu X, Cai H. A combined DNA vaccine encoding BCSP31, SOD, and L7/L12 confers high protection against Brucella abortus 2308 by inducing specific CTL responses. DNA Cell Biol. 2007;26:435-43 pubmed
    ..The success of our combined DNA vaccine in a mouse model suggests its potential efficacy against brucellosis infection in large animals. ..
  8. Wu Q, Pei J, Turse C, Ficht T. Mariner mutagenesis of Brucella melitensis reveals genes with previously uncharacterized roles in virulence and survival. BMC Microbiol. 2006;6:102 pubmed
    ..melitensis genome. Conjugation was performed efficiently and rapidly in less than one generation in order to minimize the formation of siblings while assuring the highest level of genome coverage...