Experts and Doctors on aging in Beijing, China


Locale: Beijing, China
Topic: aging

Top Publications

  1. Ma Y, Zhou W, Cheng J. [Study on effect and mechanism of liuwei dihuang decoction in modulating hypothalamus-pituitary-ovary axis in senescence accelerated mice model]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004;24:325-30 pubmed
    ..LW could improve or modulate the HPO axis functional disturbance in SAMP8. ..
  2. Wang Y, Xu L, Zhang L, Yang H, Ma Y, Jonas J. Optic disc size in a population based study in northern China: the Beijing Eye Study. Br J Ophthalmol. 2006;90:353-6 pubmed
    ..In Chinese people highly hyperopic eyes have significantly smaller optic discs, and highly myopic eyes have significantly larger optic discs than emmetropic eyes. ..
  3. Jiang M, Xiang Y, Wang D, Gao J, Liu D, Liu Y, et al. Dysregulated expression of miR-146a contributes to age-related dysfunction of macrophages. Aging Cell. 2012;11:29-40 pubmed publisher
    ..These data indicate that the dysregulated expression of miR-146a results in the age-associated dysfunction of macrophages, and miR-146a may be a good target for the treatment of age-related inflammatory diseases. ..
  4. Liu W, Xu J, Wang H, Xu C, Ji C, Wang Y, et al. Isoflurane-induced spatial memory impairment by a mechanism independent of amyloid-beta levels and tau protein phosphorylation changes in aged rats. Neurol Res. 2012;34:3-10 pubmed publisher
    ..However, there were no differences in the levels of A-beta and tau among SIG, NSIG, training, and control groups. Isoflurane may induce spatial memory impairment through non-A-beta or tau neuropathogenesis mechanisms in aged rats. ..
  5. Zhang Z, Zhao Y, Wang X, Lin R, Zhang Y, Ma H, et al. The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans. Food Funct. 2016;7:1975-84 pubmed publisher
    ..Thereby, Tyr-Ala could be used as a potential medicine in anti-aging research. ..
  6. Huang Y, Wu X, Li L. Detection of the break in interaural correlation is affected by interaural delay, aging, and center frequency. J Acoust Soc Am. 2009;126:300-9 pubmed publisher
    ..The results suggest that there are age- and frequency-related temporal declines in maintaining fine-structure signals for interaural integration. These declines may affect the recognition of sound sources in reverberant environments. ..
  7. Mann F, Van Nostrand E, Friedland A, Liu X, Kim S. Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans. PLoS Genet. 2016;12:e1005956 pubmed publisher
    ..Overexpression of elt-2 extends lifespan and slows the rate of gene expression changes that occur during normal aging. Thus, our results identify the developmental regulator ELT-2 as a major driver of normal aging in C. elegans. ..
  8. Xie G, Cheng X, Xu X. [Risk factors of chronic obstructive pulmonary disease in patients with chronic bronchitis]. Zhonghua Yi Xue Za Zhi. 2001;81:1356-9 pubmed
    ..Ex-smoking can almost decrease the relative risk of COPD to the approximative risk level of non-smoking. ..
  9. He X, Zhou W, Bi M, Du G. Neuroprotective effects of icariin on memory impairment and neurochemical deficits in senescence-accelerated mouse prone 8 (SAMP8) mice. Brain Res. 2010;1334:73-83 pubmed publisher

More Information

Publications149 found, 100 shown here

  1. Wang Y, Li X, Guo Y, Chan L, Guan X. alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice. Metabolism. 2010;59:967-76 pubmed publisher
    ..Thus, LA may be a promising supplement for treatment of obesity and/or insulin resistance in older patients. ..
  2. Ren Y, Yang X, Niu X, Liu S, Ren G. Chemical characterization of the avenanthramide-rich extract from oat and its effect on D-galactose-induced oxidative stress in mice. J Agric Food Chem. 2011;59:206-11 pubmed publisher
    ..The results demonstrated that ARE possessed the antioxidant activity and was effective against D-galactose-induced oxidative stress. ..
  3. Wang M, Wu X, Li L, Schneider B. The effects of age and interaural delay on detecting a change in interaural correlation: The role of temporal jitter. Hear Res. 2011;275:139-49 pubmed publisher
    ..The implications of these results for age-related changes in stream segregation are discussed. ..
  4. Xuan Q, Xu S, Lu D, Yu S, Zhou M, Ueda K, et al. Increased expression of ?-synuclein in aged human brain associated with neuromelanin accumulation. J Neural Transm (Vienna). 2011;118:1575-83 pubmed publisher
    ..Our results suggest that age related accumulation of NM might induce ?-synuclein over-expression and thereby make dopamine neurons more vulnerable to injuries. ..
  5. Wang Z, Zhang Y, Yuan Y, Chen N. Developmental expression of chemokine-like factor 1, a novel member of chemokines family, in postnatal rat cerebral cortex. Neurosci Lett. 2012;519:51-5 pubmed publisher
  6. Wang H, Wang L, Liu X, Li C, Xu S, Farooq A. Neuroprotective effects of forsythiaside on learning and memory deficits in senescence-accelerated mouse prone (SAMP8) mice. Pharmacol Biochem Behav. 2013;105:134-41 pubmed publisher
    ..These findings demonstrated that forsythiaside may be a useful treatment against amnesia. ..
  7. Wang X, Zheng J, Ning Z, Qu L, Xu G, Yang N. Laying performance and egg quality of blue-shelled layers as affected by different housing systems. Poult Sci. 2009;88:1485-92 pubmed publisher
    ..In a proper marketing system, lower productivity could be balanced by a higher price for the better quality of blue-shelled eggs. ..
  8. Zhang G, Cheng X, Zhou W, Zhang Y. Age-related expression of STUB1 in senescence-accelerated mice and its response to anti-Alzheimer's disease traditional Chinese medicine. Neurosci Lett. 2008;438:371-5 pubmed publisher
    ..The data suggested that a deficiency in STUB1 may lead to a reduction in aberrant protein scavenging, causing abnormal protein accumulation in the brain of SAMP8. Thus, STUB1 might be a potential target for anti-AD TCM. ..
  9. Wang C, Wei D, Wang B, Zhang J, Zhang K, Ma M, et al. Effect of lifestyle on the prevalence of the metabolic syndrome among farmers, migrants with Yi ethnicity and Han population in Sichuan province of China. Asia Pac J Clin Nutr. 2010;19:266-73 pubmed
  10. Li C, Deng H, Li D, Li Z. Advances and challenges in screening traditional Chinese anti-aging materia medica. Chin J Integr Med. 2013;19:243-52 pubmed publisher
    ..To further improve screening studies in TCAM, we suggest that the D-galactose aging model be incorporated into the lifespan test in the New Drugs of Traditional Chinese Medicine Research Guide. ..
  11. Xiao J, Weng J, Ji L, Jia W, Lu J, Shan Z, et al. Worse pancreatic β-cell function and better insulin sensitivity in older Chinese without diabetes. J Gerontol A Biol Sci Med Sci. 2014;69:463-70 pubmed publisher
    ..Insulin insufficiency and insulin resistance may contribute disproportionately to abnormal glucose tolerance in people of different age. ..
  12. Tian L, Ma L, Wang L. Alterations of functional connectivities from early to middle adulthood: Clues from multivariate pattern analysis of resting-state fMRI data. Neuroimage. 2016;129:389-400 pubmed publisher
    ..Overall, the present study indicated that the RSFCs undergo notable alterations from early to middle adulthood and highlighted the necessity of careful considerations of possible influences of these alterations in related studies. ..
  13. Zhang D, Liu G, Shi J, Zhang J. Effects of Coeloglossum. viride var. bracteatum extract on memory deficits and pathological changes in senescent mice. Basic Clin Pharmacol Toxicol. 2006;98:55-60 pubmed
    ..Treatment of CE (2.5, 5 ameliorated the memory impairment; rectified the biochemistry and neural system changes in mice. These results suggest that CE offers promise as a tool for treatment of senescence-related diseases. ..
  14. Li M, Li J, Zhao A, Gu J. Do young patients with colorectal cancer have a poorer prognosis than old patients?. J Surg Res. 2011;167:231-6 pubmed publisher
    ..Other clinicopathologic characteristics, and tumor markers such as CEA, MMP-2, and p27(kip1), were also similar between young and old CRC patients. ..
  15. Huangfu J, Liu J, Sun Z, Wang M, Jiang Y, Chen Z, et al. Antiaging effects of astaxanthin-rich alga Haematococcus pluvialis on fruit flies under oxidative stress. J Agric Food Chem. 2013;61:7800-4 pubmed publisher
    ..These results, taken together, strongly support the antiaging properties of HP and its therapeutic rather than preventive potential against aging-related diseases. ..
  16. Li Y, Ma H, Lu Y, Tan B, Xu L, Lawal T, et al. Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E2 in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis. Biomed Res Int. 2016;2016:2574637 pubmed publisher
    ..This work demonstrates that Menoprogen inhibits GC apoptosis in aged female rats and thereby increases E2 production. This represents a novel mechanism of action for this herbal medicine in the treatment of menopausal symptoms. ..
  17. Qin Y, Tian Y. A microarray gene analysis of peripheral whole blood in normal adult male rats after long-term GH gene therapy. Cell Mol Biol Lett. 2010;15:177-95 pubmed publisher
    ..This will contribute to an increased mechanistic understanding of the effects of chronic GH gene therapy abuse/misuse in normal subjects. ..
  18. Hu J, Yang M, Deng X, Lu J. [Effect of Kidney-Tonifying and Blood-Promoting Recipe on the expression of CD11b/CD18 and Bcl-2/Bax in aged patients with kidney deficiency and blood stasis syndrome]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:760-2 pubmed
  19. Wuri G, Wang D, Zhou Y, Zhu S. Effects of surgical stress on long-term memory function in mice of different ages. Acta Anaesthesiol Scand. 2011;55:474-85 pubmed publisher
    ..037). Partial hepatectomy did not produce significant long-term effects on memory function in 4-month-old mice. However, it significantly improved long-term memory function in 16-month-old mice. ..
  20. Yang W, Guo W, Liu H, Xu Y, Chen L, Hu B. Age-related changes in the ratio of Mcl-1/Bax expression in the rat cochlea. Acta Otolaryngol. 2012;132:123-32 pubmed publisher
    ..Importantly, the changes in Mcl-1 and Bax expression are spatially related to the sensory cells showing the sign of degeneration. ..
  21. Zhai Y, Shi X, Fitzgerald S, Qian H, Kraus V, Sereny M, et al. High sensitivity C-reactive protein associated with different health predictors in middle-aged and oldest old Chinese. Biomed Environ Sci. 2012;25:257-66 pubmed publisher
    ..HDL-C is a stronger predictor of elevated hsCRP than other metabolic factors in the middle-aged population. For the oldest old persons, high TG, low HDL-C, and FBG predict elevated plasma hsCRP. ..
  22. Shen E, Song C, Lin Y, Zhang W, Su P, Liu W, et al. Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans. Nature. 2014;508:128-32 pubmed publisher
    ..elegans lifespan across genetic, environmental and stochastic factors. They also support the notion that the rate of ageing, although adjustable in later life, has been set to a considerable degree before reproduction ceases. ..
  23. Ren L, Liang H, Diao L, He S. Changing dendritic field size of mouse retinal ganglion cells in early postnatal development. Dev Neurobiol. 2010;70:397-407 pubmed publisher
    ..These findings indicate different RGCs show different modes of growth, whereas most subtypes exhibit a fast expansion followed by a retraction phase to reach the adult size. ..
  24. Chen Z, Miao G, Liu M, Hao G, Liu Y, Fang X, et al. Age-related up-regulation of beta3-adrenergic receptor in heart-failure rats. J Recept Signal Transduct Res. 2010;30:227-33 pubmed publisher
    ..beta3-AR protein levels increased significantly when heart failure worsened in aging rats. These results suggest that beta3-AR expression in age-related heart-failure rats and left ventricular function were highly correlated. ..
  25. Shi J, Song X, Yu P, Tang Z, Mitnitski A, Fang X, et al. Analysis of frailty and survival from late middle age in the Beijing Longitudinal Study of Aging. BMC Geriatr. 2011;11:17 pubmed publisher
    ..01). A dose-response relationship was observed as frailty increased. A Frailty Index employed in a Chinese sample, showed properties comparable with Western data, but deficit accumulation appeared to be more lethal than in the West. ..
  26. Li W, van Tol M, Li M, Miao W, Jiao Y, Heinze H, et al. Regional specificity of sex effects on subcortical volumes across the lifespan in healthy aging. Hum Brain Mapp. 2014;35:238-47 pubmed publisher
    ..Given strong involvement of the basal ganglia in both cognitive aging and emotional regulation, our findings may be crucial for studies investigating the onset and prevalence of dementia and depressive symptoms in male and female aging. ..
  27. Tian G, Wei W, Zhang W, Zhang L, You H, Liu W, et al. Increasing age associated with elevated cardio-ankle vascular index scores in patients with type 2 diabetes mellitus. J Int Med Res. 2013;41:435-44 pubmed publisher
    ..Patients with type 2 diabetes had an increased risk of arterial stiffness, based on the CAVI score, compared with nondiabetic patients; this, in turn, could increase their risk of developing other cardiovascular complications. ..
  28. Wu N, Liu H, Chen J, Zhao L, Zuo W, Ming Y, et al. Comparison of apparent diffusion coefficient and T2 relaxation time variation patterns in assessment of age and disc level related intervertebral disc changes. PLoS ONE. 2013;8:e69052 pubmed publisher
    ..ADC values may be a more sensitive parameter than T2 in assessing age and disc level related intervertebral disc changes. ..
  29. Xu D, Yang C, Wang L. Cerebral amyloid angiopathy in aged Chinese: a clinico-neuropathological study. Acta Neuropathol. 2003;106:89-91 pubmed
  30. Liang Y, Friedman D, Zhou Q, Yang X, Sun L, Guo L, et al. Prevalence of primary open angle glaucoma in a rural adult Chinese population: the Handan eye study. Invest Ophthalmol Vis Sci. 2011;52:8250-7 pubmed publisher
    ..Given the rapid aging and myopic shift (acquired myopia) in China's population, POAG is likely to increase in prevalence in the coming decades. ..
  31. Pan H, Cai N, Li M, Liu G, Izpisua Belmonte J. Autophagic control of cell 'stemness'. EMBO Mol Med. 2013;5:327-31 pubmed publisher
    ..Here, we shall discuss the accumulating evidence suggesting that autophagy plays a critical role in the homeostatic control of stem cell functions during aging, tissue regeneration, and cellular reprogramming. ..
  32. Dai P, Yang W, Jiang S, Gu R, Yuan H, Han D, et al. Correlation of cochlear blood supply with mitochondrial DNA common deletion in presbyacusis. Acta Otolaryngol. 2004;124:130-6 pubmed
    ..The symptoms of presbyacusis may occur when the function of the acoustic neural system is impaired as a result of abnormal mtDNA metabolism reaching a particular threshold. ..
  33. Suo L, Meng Q, Pei Y, Yan C, Fu X, Bunch T, et al. Changes in acetylation on lysine 12 of histone H4 (acH4K12) of murine oocytes during maternal aging may affect fertilization and subsequent embryo development. Fertil Steril. 2010;93:945-51 pubmed publisher
  34. Ding L, Yang F. Muscle weakness is related to slip-initiated falls among community-dwelling older adults. J Biomech. 2016;49:238-43 pubmed publisher
    ..Our findings could provide guidance to identify individuals at increased risk of falling using the derived optimal cutoff values of knee strength capacity among older adults. ..
  35. Zhuang H, Ali K, Ardu S, Tredwin C, Hu B. Autophagy in dental tissues: a double-edged sword. Cell Death Dis. 2016;7:e2192 pubmed publisher
  36. Zhang C, Chen P, Fei Y, Liu B, Ma K, Fu X, et al. Wnt/?-catenin signaling is critical for dedifferentiation of aged epidermal cells in vivo and in vitro. Aging Cell. 2012;11:14-23 pubmed publisher
    ..These results suggested that activation of Wnt/?-catenin pathway induced the dedifferentiation of aged epidermal cells, which suggest a new approach to generate epidermal stem cell-like cells. ..
  37. Su W, Chen H, Li S, Wu D. Correlational study of the serum levels of the glial fibrillary acidic protein and neurofilament proteins in Parkinson's disease patients. Clin Neurol Neurosurg. 2012;114:372-5 pubmed publisher
  38. Chen C, He W, Wang Y, Deng L, Jia F. Nutritional status of children during and post-global economic crisis in China. Biomed Environ Sci. 2011;24:321-8 pubmed publisher
    ..A proper national nutritional strategy for children under 2 years old, including nutrition supplementation for pregnant women and in-home fortification for complementary feeding, should be initiated. ..
  39. Xue H, Xian B, Dong D, Xia K, Zhu S, Zhang Z, et al. A modular network model of aging. Mol Syst Biol. 2007;3:147 pubmed
    ..Network simulations further suggest that aging might preferentially attack key regulatory nodes that are important for the network stability, implicating a potential molecular basis for the stochastic nature of aging. ..
  40. Li Z, Rong X, Liu Y, Ni C, Tian X, Mo N, et al. Activation of the canonical nuclear factor-?B pathway is involved in isoflurane-induced hippocampal interleukin-1? elevation and the resultant cognitive deficits in aged rats. Biochem Biophys Res Commun. 2013;438:628-34 pubmed publisher
    ..Overall, our results demonstrate that isoflurane-induced cognitive deficits may stem from upregulation of hippocampal IL-1?, partially via activation of the canonical NF-?B pathway, in aged rats. ..
  41. Richardson A, Fischer K, Speakman J, De Cabo R, Mitchell S, Peterson C, et al. Measures of Healthspan as Indices of Aging in Mice-A Recommendation. J Gerontol A Biol Sci Med Sci. 2016;71:427-30 pubmed publisher
    ..Finally, we strongly recommend that functional measurements be performed in both males and females so that sex differences in the rate of functional decline in different domains are taken into consideration. ..
  42. Yang W, Hu B, Sun J, Zhai S, Henderson D. Death mode-dependent reduction in succinate dehydrogenase activity in hair cells of aging rat cochleae. Chin Med J (Engl). 2010;123:1633-8 pubmed
    ..These results suggest that mitochondrial energetic function is involved in the regulation of cell death pathways in the pathogenesis of aging cochleae. ..
  43. He M, Abdou A, Ellwein L, Naidoo K, Sapkota Y, Thulasiraj R, et al. Age-related prevalence and met need for correctable and uncorrectable near vision impairment in a multi-country study. Ophthalmology. 2014;121:417-422 pubmed publisher
    ..Prevalence of correctable NVI is greatest among persons of working age, and rates of correction are low in many settings, suggesting that strategies targeting the workplace may be needed. ..
  44. Chen C, Meng S, Xue Y, Han Y, Sun C, Deng J, et al. Epigenetic modification of PKMζ rescues aging-related cognitive impairment. Sci Rep. 2016;6:22096 pubmed publisher
    ..These results indicated that PKMζ might be a potential target for the treatment of aging-related cognitive impairment, suggesting a potential therapeutic avenue. ..
  45. Bi X, Zhao H, Zhang Z, Zhang J. Association of RFC1 A80G and MTHFR C677T polymorphisms with Alzheimer's disease. Neurobiol Aging. 2009;30:1601-7 pubmed publisher
    ..No significant effect of RFC1 G80A and MTHFR C677T polymorphisms on plasma folate and homocysteine levels was detected. ..
  46. Zhang X, Zhang Q, Wang D. Litter size variation in hypothalamic gene expression determines adult metabolic phenotype in Brandt's voles (Lasiopodomys brandtii). PLoS ONE. 2011;6:e19913 pubmed publisher
    ..Thus, we conclude that litter size may be an important and central determinant of metabolic fitness in adulthood. ..
  47. Zhang X, Han D, Ding D, Dai P, Yang W, Jiang S, et al. Cochlear mitochondrial DNA3867bp deletion in aged mice. Chin Med J (Engl). 2002;115:1390-3 pubmed
    ..The ratio of deleted mtDNA/total mtDNA in 17 - 19 month old mice was higher than in 7 - 10 month old mice (P < 0.001). Cochlear mtDNA 3867bp deletion in aged mice may be related to presbycusis. ..
  48. Xin Y, Wang Y, Zhang H, Li J, Wang W, Wei Y, et al. Aging adversely impacts biological properties of human bone marrow-derived mesenchymal stem cells: implications for tissue engineering heart valve construction. Artif Organs. 2010;34:215-22 pubmed publisher
    ..However, the proliferative and differentiation properties of aged cells, as well as cytokine release and migratory abilities, are significantly impaired. ..
  49. Xu B, Xiong F, Tian R, Zhan S, Gao Y, Qiu W, et al. Temporal lobe in human aging: A quantitative protein profiling study of samples from Chinese Human Brain Bank. Exp Gerontol. 2016;73:31-41 pubmed publisher
    ..Our results suggest a series of changes across a wide range of proteins in the human temporal lobe that may relate to aging and age-related neurodegenerative disorders. ..
  50. Xu L, Liu L, Yuan M, Li S, Yue X, Lai J, et al. Short photoperiod condition increases susceptibility to stress in adolescent male rats. Behav Brain Res. 2016;300:38-44 pubmed publisher
    ..The present study provides evidence of the susceptibility to the seasonality of stress-related disorders in adolescence. ..
  51. Yang R, Fu S, Zhao L, Zhen B, Ye L, Niu X, et al. Quantitation of circulating GDF-11 and β2-MG in aged patients with age-related impairment in cognitive function. Clin Sci (Lond). 2017;131:1895-1904 pubmed publisher
    ..However, it is possible that the relatively small sample size in the present study affected the quality of the statistical analysis, and future studies are needed to further validate our findings. ..
  52. Xin M, Chen H, Luo B, Sun J. Severe acute pancreatitis in the elderly: etiology and clinical characteristics. World J Gastroenterol. 2008;14:2517-21 pubmed
    ..It is crucial to monitor and improve the functions of major organs so as to prevent MODS in the aged with SAP. ..
  53. Piao X, Cai P, Liu S, Hou N, Hao L, Yang F, et al. Global expression analysis revealed novel gender-specific gene expression features in the blood fluke parasite Schistosoma japonicum. PLoS ONE. 2011;6:e18267 pubmed publisher
    ..In this study, the polyadenylated transcripts from male and female S. japonicum were isolated for deep sequencing and the sequences were systematically analysed...
  54. Han L, Li M, Liu Y, Han C, Ye P. Atorvastatin may delay cardiac aging by upregulating peroxisome proliferator-activated receptors in rats. Pharmacology. 2012;89:74-82 pubmed publisher
    ..Pretreatment with PPAR inhibitors attenuated the inhibitory effect of AVT on the expression of inflammatory cytokines. AVT may retard the cardiac aging process by upregulating PPARs. ..
  55. Liang D, Han G, Feng X, Sun J, Duan Y, Lei H. Concerted perturbation observed in a hub network in Alzheimer's disease. PLoS ONE. 2012;7:e40498 pubmed publisher
    ..Therefore, it is potentially useful for the development of biomarkers and network medicine for AD. ..
  56. Fang E, Scheibye Knudsen M, Jahn H, Li J, Ling L, Guo H, et al. A research agenda for aging in China in the 21st century. Ageing Res Rev. 2015;24:197-205 pubmed publisher
    ..We propose ideas for preparation of the impending aging burden and the creation of a nurturing environment conducive to healthy aging in China. ..
  57. Chen Z, Meng H, Xing G, Yuan H, Zhao F, Liu R, et al. Age-related differences in pulmonary and cardiovascular responses to SiO2 nanoparticle inhalation: nanotoxicity has susceptible population. Environ Sci Technol. 2008;42:8985-92 pubmed
    ..Our results suggest that different ages may require different biomarkers for identifying pulmonary toxicity during inhalation of nanoparticles. ..
  58. He R, Lu J, Miao J. Formaldehyde stress. Sci China Life Sci. 2010;53:1399-404 pubmed publisher
    ..Chronic impairments of the brain resulted from formaldehyde stress could be one of the mechanisms involved in the process of senile dementia during ageing. ..
  59. Cui J, Shi S, Sun X, Cai G, Cui S, Hong Q, et al. Mitochondrial autophagy involving renal injury and aging is modulated by caloric intake in aged rat kidneys. PLoS ONE. 2013;8:e69720 pubmed publisher
    ..The study firstly suggests that HC diet inhibits renal autophagy and aggravates renal oxidative damage and aging, while CR enhances renal autophagy and ameliorates oxidative damage and aging in the kidneys. ..
  60. Li Q, Zhao H, Zhang Z, Liu Z, Pei X, Wang J, et al. Long-term green tea catechin administration prevents spatial learning and memory impairment in senescence-accelerated mouse prone-8 mice by decreasing Abeta1-42 oligomers and upregulating synaptic plasticity-related proteins in the hippocampus. Neuroscience. 2009;163:741-9 pubmed publisher
    ..05% or 0.1% green tea catechin administration may prevent spatial learning and memory decline of SAMP8 mice by decreasing Abeta(1-42) oligomers and upregulating synaptic plasticity-related proteins in the hippocampus. ..
  61. Tang Z, Wang C, Song X, Shi J, Mitnitski A, Fang X, et al. Co-occurrence of cardiometabolic diseases and frailty in older Chinese adults in the Beijing Longitudinal Study of Ageing. Age Ageing. 2013;42:346-51 pubmed publisher
    ..Healthcare providers who work with older adults with such problems need to develop methods to adapt their treatments to the needs of frail older adults. ..
  62. Yin H, Shi Z, Yu Y, Hu J, Wang R, Luan Z, et al. Protection against osteoporosis by statins is linked to a reduction of oxidative stress and restoration of nitric oxide formation in aged and ovariectomized rats. Eur J Pharmacol. 2012;674:200-6 pubmed publisher
    ..In conclusion, protection against osteoporosis by statins is linked to a reduction of oxidative stress and restoration of NO formation in aged and ovariectomized rats. ..
  63. Tao L, Lei Y, Wang G, Zhu L, Wang Y. Effect of extracts from Radix Ginseng, Radix Notoginseng and Rhizoma Chuanxiong on delaying aging of vascular smooth muscle cells in aged rats. Chin J Integr Med. 2012;18:582-90 pubmed publisher
    ..05). VSMCs obtained from old rats showed typical signs of cellular senescence and vascular aging. EXT had an effect on delaying senescence of VSMCs in vitro by altering the p16-cyclinD/CDK-Rb pathway. ..
  64. Wang Q, Pang W, Cui Z, Shi J, Liu Y, Liu B, et al. Upregulation of soluble epoxide hydrolase in proximal tubular cells mediated proteinuria-induced renal damage. Am J Physiol Renal Physiol. 2013;304:F168-76 pubmed publisher
  65. Shao L, Li Q, Tan Z. L-carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts. Biochem Biophys Res Commun. 2004;324:931-6 pubmed
    ..We suggest that the reduction in telomere shortening rate and damages in telomeric DNA made an important contribution to the life-extension effect of carnosine. ..
  66. Yang S, Qiao H, Wen L, Zhou W, Zhang Y. D-serine enhances impaired long-term potentiation in CA1 subfield of hippocampal slices from aged senescence-accelerated mouse prone/8. Neurosci Lett. 2005;379:7-12 pubmed
    ..These results suggest that absence of d-serine or dysfunction of the astrocytes possibly was one of mechanisms underlying the decrease of NMDA receptor-dependent LTP and cognition in aged SAMP8. ..
  67. Tong Z, Zhang J, Luo W, Wang W, Li F, Li H, et al. Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia. Neurobiol Aging. 2011;32:31-41 pubmed publisher
  68. An J, Zheng J, Li J, Zeng D, Qu L, Xu G, et al. Effect of myofiber characteristics and thickness of perimysium and endomysium on meat tenderness of chickens. Poult Sci. 2010;89:1750-4 pubmed publisher
    ..27) and the thickness of endomysium (-0.29) and positively correlated with the thickness of perimysium (0.20). It is suggested that muscle membrane should be considered in evaluating meat tenderness of the chicken. ..
  69. Yang Y, Cheng X, Zhang G, Zhou W, Zhang Y. Autocrine motility factor receptor is involved in the process of learning and memory in the central nervous system. Behav Brain Res. 2012;229:412-8 pubmed publisher
    ..This indicated that AMFR is involved in the process of learning and memory in the central nervous system. These results may provide useful clues for understanding the etiology of AD. ..
  70. Song J, Shao Q, Tian Y, Na Y, Chen S, Wang Y, et al. [Association between lower urinary tract symptoms and erectile dysfunction in males aged 50 years and above: results from a multicenter community-based cross-sectional survey (BPC-BPH)]. Zhonghua Yi Xue Za Zhi. 2011;91:2706-9 pubmed
    ..To survey the incidence of lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) in males aged ? 50 years and explore the correlation between LUTS and ED...
  71. Li H, Zhou C, Chen D, Fang N, Yao Y, Li L. Failure to protect against myocardial ischemia-reperfusion injury with sevoflurane postconditioning in old rats in vivo. Acta Anaesthesiol Scand. 2013;57:1024-31 pubmed publisher
    ..SpostC-mediated cardioprotection in young rats is not effective in senescent rats, which may at least be the consequence of failure to activate Akt and ERK1/2, and resultant failure to inhibit mPTP opening. ..
  72. Li M, Guo K, Adachi Y, Ikehara S. Immune Dysfunction Associated with Abnormal Bone Marrow-Derived Mesenchymal Stroma Cells in Senescence Accelerated Mice. Int J Mol Sci. 2016;17: pubmed publisher
    ..We also found increased reactive oxygen stress and decreased PI3K and MAPK on the BMMSCs. These results suggested the BMMSCs were abnormal in SAMP10, and that this might be related to the immune system dysfunction in these mice. ..
  73. Liao X, Vasilakos A, He Y. Small-world human brain networks: Perspectives and challenges. Neurosci Biobehav Rev. 2017;77:286-300 pubmed publisher
    ..Finally, we highlight several challenging issues and areas for future research in this rapidly growing field. ..
  74. Sun X, Chen Y, Chen X, Wang J, Xi C, Lin S, et al. Change of glomerular filtration rate in healthy adults with aging. Nephrology (Carlton). 2009;14:506-13 pubmed publisher
    ..In the clinically healthy adults, GFR declined with age. MDRD and CG equation are not suitable to estimate GFR in healthy adults. The predicted equation established by cystatin C and C-reactive protein may be more accurate. ..
  75. Cao J, Zou H, Zhu B, Wang H, Li J, Ding Y, et al. Sex hormones and androgen receptor: risk factors of coronary heart disease in elderly men. Chin Med Sci J. 2010;25:44-9 pubmed
    ..05). Elderly male patients with CHD are found to have low levels of DHEAS, TT, FT, SHBG, and AR, while high concentrations of E2 and FSH. Low levels of TT and SHBG may be the potential risk factors of CHD in elderly men. ..
  76. Zhao M, Shi X, Liang J, Miao Y, Xie W, Zhang Y, et al. Expression of pro- and anti-angiogenic isoforms of VEGF in the mouse model of oxygen-induced retinopathy. Exp Eye Res. 2011;93:921-6 pubmed publisher
    ..Therefore, anti-angiogenic therapy that could alter the ratio of VEGFxxxb/VEGFxxx may be more effective. ..
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