Experts and Doctors on protein transport in Chongqing, Chongqing Shi, China


Locale: Chongqing, Chongqing Shi, China
Topic: protein transport

Top Publications

  1. Sheng Y, Xiong Y, Xu M, Kuang X, Wang D, Yang X. [Effect of Nm23-H1 Nuclear Localization on Proliferation of ?Human Lung Adenocarcinoma Cell Line A549]. Zhongguo Fei Ai Za Zhi. 2017;20:226-232 pubmed publisher
    ..000,1??????a549???g0?/g1??????35.69%???????28.28%?t=1.461, p=0.217?????????g2?/m??????58.7%??????31.30%?t=4.560, p=0.010???? nm23-h1?????a549????????????????g2?/m?????????????. ..
  2. Zhang Y, Yu J, Shi C, Huang Y, Wang Y, Yang T, et al. Lef1 contributes to the differentiation of bulge stem cells by nuclear translocation and cross-talk with the Notch signaling pathway. Int J Med Sci. 2013;10:738-46 pubmed publisher
  3. Zhang Z, Yang X, Wang D, Wang G, Yang Z, Qing Y, et al. Nm23-H1 protein binds to APE1 at AP sites and stimulates AP endonuclease activity following ionizing radiation of the human lung cancer A549 cells. Cell Biochem Biophys. 2011;61:561-72 pubmed publisher
    ..In conclusion, our data point to a mechanism by which Nm23-H1 protects cells against oxidative stress through the engagement of DNA BER enzyme APE1. ..
  4. Deng W, Yang Y, Ren Z, Audran Delalande C, Mila I, Wang X, et al. The tomato SlIAA15 is involved in trichome formation and axillary shoot development. New Phytol. 2012;194:379-90 pubmed publisher
    ..These phenotypes uncover novel and specialized roles for Aux/IAAs in plant developmental processes, clearly indicating that members of the Aux/IAA gene family in tomato perform both overlapping and specific functions...
  5. Chen X, Zhang Y, Cai Q, Yao Z. ID2: A negative transcription factor regulating oligodendroglia differentiation. J Neurosci Res. 2012;90:925-32 pubmed publisher
    ..This could have important implications for demyelinating diseases, and interfering with these pathways might represent a viable therapeutic approach for these diseases. ..
  6. Chen L, Zuo G, Wu J, Zeng G, Li T, Liu Z, et al. [Intercellular transfer of P-glycoprotein in hepatocellular cell line HepG2]. Zhonghua Gan Zang Bing Za Zhi. 2009;17:839-42 pubmed
    ..30, P > 0.05). P-gp can transfer from drug resistant hepatocellular cells to sensitive hepatocellular carcinoma cells. This study suggests a novel mechanism of multidrug resistance in hepatocellular carcinoma. ..
  7. Xu S, Pi H, Zhang L, Zhang N, Li Y, Zhang H, et al. Melatonin prevents abnormal mitochondrial dynamics resulting from the neurotoxicity of cadmium by blocking calcium-dependent translocation of Drp1 to the mitochondria. J Pineal Res. 2016;60:291-302 pubmed publisher
    ..Melatonin has significant pharmacological potential in protecting against the neurotoxicity of Cd by blocking the disbalance of mitochondrial fusion and fission. ..
  8. Song X, Wang Y, DU H, Fan Y, Yang X, Wang X, et al. Overexpression of HepaCAM inhibits cell viability and motility through suppressing nucleus translocation of androgen receptor and ERK signaling in prostate cancer. Prostate. 2014;74:1023-33 pubmed publisher
    ..Therefore, it was indicated that HepaCAM may be a potential therapeutic target for prostate cancer. ..
  9. Zhou J, Perelman J, Kolosov V, Zhou X. Neutrophil elastase induces MUC5AC secretion via protease-activated receptor 2. Mol Cell Biochem. 2013;377:75-85 pubmed publisher

More Information


  1. Ding H, Zeng H, Huang L, Dong Y, Duan Y, Mao X, et al. Helicobacter pylori chaperone-like protein CagT plays an essential role in the translocation of CagA into host cells. J Microbiol Biotechnol. 2012;22:1343-9 pubmed
    ..These results suggest that CagT is expressed on both the inner and outer bacterial membranes, where it serves as a unique type IV secretion system component that is involved in CagA secretion and cag PAI apparatus assembly...
  2. Li Y, Wang G, Lin K, Yin H, Zhou C, Liu T, et al. Rab1 GTPase promotes expression of beta-adrenergic receptors in rat pulmonary microvascular endothelial cells. Int J Biochem Cell Biol. 2010;42:1201-1209 pubmed publisher
    ..These data reveal that beta-ARs function in RPMVECs could be modulated by manipulating beta-ARs traffic from the ER to the Golgi body. We propose the ER-to-Golgi transport as a regulatory site for control of permeability of RPMVECs. ..
  3. Zhang P, He X, Tan J, Zhou X, Zou L. ?-arrestin2 mediates ?-2 adrenergic receptor signaling inducing prostate cancer cell progression. Oncol Rep. 2011;26:1471-7 pubmed publisher
    ..This study demonstrates that ?Arr2 is involved in prostate carcinogenesis induced by stress and provides potential therapeutic targets for cancer. ..
  4. Zhang T, Wang F, Xu H, Yi L, Qin Y, Chang H, et al. Activation of nuclear factor erythroid 2-related factor 2 and PPAR? plays a role in the genistein-mediated attenuation of oxidative stress-induced endothelial cell injury. Br J Nutr. 2013;109:223-35 pubmed publisher
    ..The present findings suggest that the beneficial effects of genistein involving the activation of cytoprotective antioxidant genes may represent a novel strategy in the prevention and treatment of cardiovascular endothelial damage. ..
  5. Wang Y, Mao M, Xu J. Cell-surface nucleolin is involved in lipopolysaccharide internalization and signalling in alveolar macrophages. Cell Biol Int. 2011;35:677-85 pubmed publisher
    ..Furthermore, C23 participates in the regulation of LPS-induced inflammation of AMs, which indicates that cell-surface C23 is a new and promising therapeutic target for the treatment of bacterial infections. ..
  6. Lin Y, Meng Y, Wang Y, Luo J, Katsuma S, Yang C, et al. Vitellogenin receptor mutation leads to the oogenesis mutant phenotype "scanty vitellin" of the silkworm, Bombyx mori. J Biol Chem. 2013;288:13345-55 pubmed publisher
    ..These results showed that BmVgR has an important role in transporting proteins for egg formation and embryonic development in B. mori. ..
  7. Luo H, Huang J, Liao W, Huang Q, Gao Y. The antioxidant effects of garlic saponins protect PC12 cells from hypoxia-induced damage. Br J Nutr. 2011;105:1164-72 pubmed publisher
  8. Tao N, Ren J, Tang H, Ran L, Zhou H, Liu B, et al. Deacetylation of Ku70 by SIRT6 attenuates Bax-mediated apoptosis in hepatocellular carcinoma. Biochem Biophys Res Commun. 2017;485:713-719 pubmed publisher
    ..SIRT6 may serve as a promising target for developing targeted therapies for HCC in the future. ..
  9. Liu M, Liu H, Wang X, Chen P, Chen H. IL-6 induction of hepatocyte proliferation through the Tmub1-regulated gene pathway. Int J Mol Med. 2012;29:1106-12 pubmed publisher
    ..The data from the current study demonstrate that Tmub1 plays a negative role in IL-6-induced hepatocyte proliferation, and indicate that the interaction between Tmub1 and CAML may mediate the function of Tmub1 in hepatocytes. ..
  10. Zeng B, Hu J, Yuan R, Hu L, Zhong L, Kang K. Increased expression of importin13 in endometriosis and endometrial carcinoma. Med Sci Monit. 2012;18:CR361-7 pubmed
  11. Sun F, Zhou B, Lin X, Duan L. Proteomic analysis identifies nuclear protein effectors in PKC-delta signaling under high glucose-induced apoptosis in human umbilical vein endothelial cells. Mol Med Rep. 2011;4:865-72 pubmed publisher
    ..Our data show that PKC-delta is an important mediator of cell apoptosis and cell cycle arrest in HUVECs under high glucose stress. ..
  12. Zheng G, Yu C, Yang Z. Puerarin suppresses production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through regulating MAPK phosphorylation, O-GlcNAcylation and NF-?B translocation. Int J Oncol. 2012;40:1610-8 pubmed publisher
  13. Liu Y, Wang L, Long Z, Wu Y, Wan Q, Jiang J, et al. Inhibiting PTEN protects hippocampal neurons against stretch injury by decreasing membrane translocation of AMPA receptor GluR2 subunit. PLoS ONE. 2013;8:e65431 pubmed publisher
    ..So inhibition of PTEN or blockage of GluR2-lacking AMPARs may attenuate the death of hippocampal neurons post injury through decreasing the translocation of GluR2 subunit on the membrane effectively. ..
  14. Tian Q, Wang X, Li C, Lu W, Yang L, Jiang Y, et al. Functional characterization of the poplar R2R3-MYB transcription factor PtoMYB216 involved in the regulation of lignin biosynthesis during wood formation. PLoS ONE. 2013;8:e76369 pubmed publisher
    ..These results suggest that PtoMYB216 is specific transcriptional activators of lignin biosynthesis and involved in the regulation of wood formation in poplar. ..
  15. Long R, Yang Q, Kang J, Zhang T, Wang H, Li M, et al. Overexpression of a novel salt stress-induced glycine-rich protein gene from alfalfa causes salt and ABA sensitivity in Arabidopsis. Plant Cell Rep. 2013;32:1289-98 pubmed publisher
    ..These results provide indirect evidence that MsGRP plays important roles in seed germination and seedling growth of alfalfa under some abiotic stress conditions...
  16. Xie X, Law H, Wang L, Li X, Yang X, Liu E. Lipopolysaccharide induces IL-6 production in respiratory syncytial virus-infected airway epithelial cells through the toll-like receptor 4 signaling pathway. Pediatr Res. 2009;65:156-62 pubmed publisher
  17. Zhao Q, Che X, Zhang H, Tan G, Liu L, Jiang D, et al. Thioredoxin-Interacting Protein Mediates Apoptosis in Early Brain Injury after Subarachnoid Haemorrhage. Int J Mol Sci. 2017;18: pubmed publisher
    ..Collectively, these results suggest that TXNIP may participate in EBI after SAH by mediating apoptosis. The blockage of TXNIP induced by PERK could be a potential therapeutic strategy for SAH treatment. ..
  18. Yin H, Li Q, Qian G, Wang Y, Li Y, Wu G, et al. Rab1 GTPase regulates phenotypic modulation of pulmonary artery smooth muscle cells by mediating the transport of angiotensin II type 1 receptor under hypoxia. Int J Biochem Cell Biol. 2011;43:401-8 pubmed publisher
  19. Niu J, Mei F, Wang L, Liu S, Tian Y, Mo W, et al. Phosphorylated olig1 localizes to the cytosol of oligodendrocytes and promotes membrane expansion and maturation. Glia. 2012;60:1427-36 pubmed publisher
    ..Our results suggest a novel role for a phosphorylated cytosolic Olig1 in membrane expansion and maturation of oligodendrocytes. ..
  20. Yao Z, Yang S, He W, Li L, Xu R, Zhang X, et al. P311 promotes renal fibrosis via TGFβ1/Smad signaling. Sci Rep. 2015;5:17032 pubmed publisher
    ..In conclusion, this study demonstrate that P311 plays a key role in renal fibrosis via TGFβ1/Smad signaling, which could be a novel target for the management of renal fibrosis. ..
  21. Deng J, Huang Q, Wang F, Liu Y, Wang Z, Wang Z, et al. The role of caveolin-1 in blood-brain barrier disruption induced by focused ultrasound combined with microbubbles. J Mol Neurosci. 2012;46:677-87 pubmed publisher
    ..This research sheds light on the mechanism of a transient, targeted, and reversible opening of the BBB induced by FUS combined with microbubbles. ..