Experts and Doctors on mitochondrial proteins in Chongqing, Chongqing Shi, China

Summary

Locale: Chongqing, Chongqing Shi, China
Topic: mitochondrial proteins

Top Publications

  1. Liu B, Chen L, Li S, Wang Z, Cheng W. Smac/DIABLO regulates the apoptosis of hypertrophic scar fibroblasts. Int J Mol Med. 2013;32:615-22 pubmed publisher
    ..In conclusion, Smac/DIABLO decreases the proliferation and increases the apoptosis of HSFBs. To our knowledge, the data from our study suggest for the first time that Smac/DIABLO is a novel therapeutic target for HS. ..
  2. Xu S, Zhong M, Zhang L, Wang Y, Zhou Z, Hao Y, et al. Overexpression of Tfam protects mitochondria against beta-amyloid-induced oxidative damage in SH-SY5Y cells. FEBS J. 2009;276:3800-9 pubmed publisher
    ..These beneficial effects may be attributable to the roles of Tfam in maintaining mtDNA nucleoid formation and mtDNA copy number. ..
  3. Li S, Ye F, Cai W, Hu H, Hu P, Ren H, et al. Quantitative proteome analysis of multidrug resistance in human ovarian cancer cell line. J Cell Biochem. 2010;109:625-33 pubmed publisher
    ..These data will be valuable for further study of the mechanisms of MDR in the ovarian cancer. ..
  4. Ma S, Yu H, Zhao Z, Luo Z, Chen J, Ni Y, et al. Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity. J Mol Cell Biol. 2012;4:88-96 pubmed publisher
    ..Our results reveal a previously unrecognized role for TRPM8, suggesting that stimulation of this channel mediates BAT thermogenesis, which could constitute a promising way to treat obesity. ..
  5. Xu S, Chen Y, Lin H, Pi H, Zhang N, Zhao C, et al. Damage to mtDNA in liver injury of patients with extrahepatic cholestasis: the protective effects of mitochondrial transcription factor A. Free Radic Biol Med. 2012;52:1543-51 pubmed publisher
    ..The mtDNA damage is attributable to the loss of TFAM. TFAM has mtDNA-protective effects against the hepatotoxicity of bile acid during cholestasis. ..
  6. Sun J, Pu Y, Wang P, Chen S, Zhao Y, Liu C, et al. TRPV1-mediated UCP2 upregulation ameliorates hyperglycemia-induced endothelial dysfunction. Cardiovasc Diabetol. 2013;12:69 pubmed publisher
    ..TRPV1 activation by capsaicin might protect against hyperglycemia-induced endothelial dysfunction through a mechanism involving the PKA/UCP2 pathway. ..
  7. Pu Y, Zhang H, Wang P, Zhao Y, Li Q, Wei X, et al. Dietary curcumin ameliorates aging-related cerebrovascular dysfunction through the AMPK/uncoupling protein 2 pathway. Cell Physiol Biochem. 2013;32:1167-77 pubmed publisher
    ..Curcumin improves aging-related cerebrovascular dysfunction via the AMPK/UCP2 pathway. ..
  8. Wang Q, Huang L, Hong Z, Lv Z, Mao Z, Tang Y, et al. The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response. PLoS Pathog. 2017;13:e1006264 pubmed publisher
    ..Collectively, this study uncovers RNF185 as the first E3 ubiquitin ligase of cGAS, shedding light on the regulation of cGAS activity in innate immune responses. ..
  9. Li N, Wang J, Gao F, Tian Y, Song R, Zhu S. The role of uncoupling protein 2 in the apoptosis induced by free fatty acid in rat cardiomyocytes. J Cardiovasc Pharmacol. 2010;55:161-7 pubmed publisher
    ..In summary, free fatty acids induced UCP2 expression through peroxisome proliferator-activated receptor alpha in adult rat cardiomyocytes. ..

More Information

Publications12

  1. Li M, Vascotto C, Xu S, Dai N, Qing Y, Zhong Z, et al. Human AP endonuclease/redox factor APE1/ref-1 modulates mitochondrial function after oxidative stress by regulating the transcriptional activity of NRF1. Free Radic Biol Med. 2012;53:237-48 pubmed publisher
    ..Taken together, our results reveal APE1 as a new coactivator of NRF1, which highlights an additional regulatory role of APE1 in maintenance of mitochondrial functionality. ..
  2. Xu Y, Liu Y, Xia C, GAO P, Liu J. Evidence for involvement of uncoupling proteins in cerebral mitochondrial oxidative phosphorylation deficiency of rats exposed to 5,000 m high altitude. Neurochem Res. 2013;38:282-9 pubmed publisher
    ..In conclusion, UCPs mediated proton leak is closely related to cerebral mitochondria oxidative phosphorylation deficiency during acute high altitude hypoxia and NEFA is involved in this signaling pathway. ..
  3. Xu S, Pi H, Zhang L, Zhang N, Li Y, Zhang H, et al. Melatonin prevents abnormal mitochondrial dynamics resulting from the neurotoxicity of cadmium by blocking calcium-dependent translocation of Drp1 to the mitochondria. J Pineal Res. 2016;60:291-302 pubmed publisher
    ..Melatonin has significant pharmacological potential in protecting against the neurotoxicity of Cd by blocking the disbalance of mitochondrial fusion and fission. ..