Experts and Doctors on zebrafish in Saskatoon, Saskatchewan, Canada


Locale: Saskatoon, Saskatchewan, Canada
Topic: zebrafish

Top Publications

  1. Ji K, Liu X, Lee S, Kang S, Kho Y, Giesy J, et al. Effects of non-steroidal anti-inflammatory drugs on hormones and genes of the hypothalamic-pituitary-gonad axis, and reproduction of zebrafish. J Hazard Mater. 2013;254-255:242-251 pubmed publisher
    ..The results demonstrated that ibuprofen could modulate hormone production and related gene transcription of the HPG axis in a sex-dependent way, which could cause adverse effects on reproduction and the development of offspring. ..
  2. Higley E, Grund S, Jones P, Schulze T, Seiler T, Lubcke von Varel U, et al. Endocrine disrupting, mutagenic, and teratogenic effects of upper Danube River sediments using effect-directed analysis. Environ Toxicol Chem. 2012;31:1053-62 pubmed publisher
    ..Furthermore, to our knowledge this is the first study using the recently developed H295R assay within EDA strategies. ..
  3. Naderi M, Jamwal A, Chivers D, Niyogi S. Modulatory effects of dopamine receptors on associative learning performance in zebrafish (Danio rerio). Behav Brain Res. 2016;303:109-19 pubmed publisher
    ..Taken together, our results shed first light on modulatory role of dopamine receptors in different aspects of learning and memory in zebrafish. ..
  4. Naderi M, Jamwal A, Ferrari M, Niyogi S, Chivers D. Dopamine receptors participate in acquisition and consolidation of latent learning of spatial information in zebrafish (Danio rerio). Prog Neuropsychopharmacol Biol Psychiatry. 2016;67:21-30 pubmed publisher
    ..The current study opens the door to future studies to investigate the involvement of dopamine receptors in various aspects of cognitive processes. ..
  5. Bugiak B, Weber L. Phenotypic anchoring of gene expression after developmental exposure to aryl hydrocarbon receptor ligands in zebrafish. Aquat Toxicol. 2010;99:423-37 pubmed publisher
    ..However, further experiments are needed to confirm this difference and to determine whether the relationship is causative or merely associative. ..
  6. Lele Z, Hartson S, Martin C, Whitesell L, Matts R, Krone P. Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90. Dev Biol. 1999;210:56-70 pubmed
    ..The data are consistent with there being a temporal and spatial requirement for Hsp90 function within somitic cells which is necessary for the formation of eng-2-expressing muscle pioneers and possibly other striated muscle fiber types. ..
  7. Sass J, Martin C, Krone P. Restricted expression of the zebrafish hsp90alpha gene in slow and fast muscle fiber lineages. Int J Dev Biol. 1999;43:835-8 pubmed
    ..Thus, hsp90alpha is expressed in developing muscle progenitors during short temporal and spatial windows of both slow and fast fiber lineages in the zebrafish somite. ..
  8. Krone P, Blechinger S, Evans T, Ryan J, Noonan E, Hightower L. Use of fish liver PLHC-1 cells and zebrafish embryos in cytotoxicity assays. Methods. 2005;35:176-87 pubmed
    ..This has allowed the development of an hsp70/eGFP reporter gene system in stable transgenic zebrafish that serves as a reliable yet extremely quick indicator of cell-specific toxicity in the context of the multicellular, living embryo. ..
  9. Bugiak B, Weber L. Hepatic and vascular mRNA expression in adult zebrafish (Danio rerio) following exposure to benzo-a-pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Aquat Toxicol. 2009;95:299-306 pubmed publisher
    ..The vascular-specific changes in gene expression will be linked to future studies examining alterations in cardiovascular function produced by acute AhR agonist exposure in adult fish. ..

More Information


  1. Evans T, Belak Z, Ovsenek N, Krone P. Heat shock factor 1 is required for constitutive Hsp70 expression and normal lens development in embryonic zebrafish. Comp Biochem Physiol A Mol Integr Physiol. 2007;146:131-40 pubmed
    ..These data also suggest that HSF1 and HSF2 play distinct roles in non-mammalian vertebrates, similarly to what has been demonstrated previously in mouse. ..
  2. Korbas M, Blechinger S, Krone P, Pickering I, George G. Localizing organomercury uptake and accumulation in zebrafish larvae at the tissue and cellular level. Proc Natl Acad Sci U S A. 2008;105:12108-12 pubmed publisher
    ..This novel approach is a powerful tool for directly investigating the molecular toxicology of heavy metals, and should be equally applicable to the study of a wide range of elements in developing embryos. ..
  3. Swan C, Evans T, Sylvain N, Krone P. Zebrafish HSF4: a novel protein that shares features of both HSF1 and HSF4 of mammals. Cell Stress Chaperones. 2012;17:623-37 pubmed publisher
    ..This, together with the lack of an observable phenotype following morpholino-based antisense knockdown of hsf4, suggests that zHSF4 is unlikely to play a role in regulating early embryonic lens development. ..
  4. MacKay A, Mhanni A, McGowan R, Krone P. Immunological detection of changes in genomic DNA methylation during early zebrafish development. Genome. 2007;50:778-85 pubmed
    ..Although zebrafish sperm DNA is strongly methylated, the zebrafish genome is not detectably methylated through cleavage and early blastula stages but is heavily remethylated in blastula and early gastrula stages. ..
  5. Dolgova N, Hackett M, MacDonald T, Nehzati S, James A, Krone P, et al. Distribution of selenium in zebrafish larvae after exposure to organic and inorganic selenium forms. Metallomics. 2016;8:305-12 pubmed publisher
    ..These results suggest that pigmented tissues might serve as a storage reservoir for selenium. ..
  6. Krone P, Lele Z, Sass J. Heat shock genes and the heat shock response in zebrafish embryos. Biochem Cell Biol. 1997;75:487-97 pubmed
    ..The data raise a number of interesting questions regarding the function and regulation of these heat shock genes in zebrafish embryos during normal development and following exposure to environmental stress. ..
  7. Lele Z, Engel S, Krone P. hsp47 and hsp70 gene expression is differentially regulated in a stress- and tissue-specific manner in zebrafish embryos. Dev Genet. 1997;21:123-33 pubmed
    ..The results suggest the presence of different inducible regulatory mechanisms for these genes which operate in a cell- and stress-specific manner in zebrafish embryos. ..
  8. Sass J, Weinberg E, Krone P. Specific localization of zebrafish hsp90 alpha mRNA to myoD-expressing cells suggests a role for hsp90 alpha during normal muscle development. Mech Dev. 1996;54:195-204 pubmed
    ..The expression patterns strongly suggest that the hsp90 alpha gene plays a specific role in the normal process of myogenesis in addition to providing protection to all cells of the embryo during periods of environmental stress. ..
  9. Falcinelli S, Rodiles A, Unniappan S, Picchietti S, Gioacchini G, Merrifield D, et al. Probiotic treatment reduces appetite and glucose level in the zebrafish model. Sci Rep. 2016;6:18061 pubmed publisher
    ..rhamnosus in the treatment of impaired glucose tolerance and food intake disorders by gut microbiota manipulation. ..
  10. Sundarrajan L, Yeung C, Hahn L, Weber L, Unniappan S. Irisin regulates cardiac physiology in zebrafish. PLoS ONE. 2017;12:e0181461 pubmed publisher
    ..Collectively, these results identified muscle proteins as novel targets of irisin, and added irisin to the list of peptide modulators of cardiovascular physiology in zebrafish. ..
  11. Taherian A, Krone P, Ovsenek N. A comparison of Hsp90alpha and Hsp90beta interactions with cochaperones and substrates. Biochem Cell Biol. 2008;86:37-45 pubmed publisher
    ..These results reveal both functional similarities and key functional differences in the individual members of this protein family. ..
  12. Blechinger S, Kusch R, Haugo K, Matz C, Chivers D, Krone P. Brief embryonic cadmium exposure induces a stress response and cell death in the developing olfactory system followed by long-term olfactory deficits in juvenile zebrafish. Toxicol Appl Pharmacol. 2007;224:72-80 pubmed
  13. Blechinger S, Evans T, Tang P, Kuwada J, Warren J, Krone P. The heat-inducible zebrafish hsp70 gene is expressed during normal lens development under non-stress conditions. Mech Dev. 2002;112:213-5 pubmed
    ..In contrast, both the endogenous hsp70 gene and the transgene were strongly expressed throughout the embryo following heat shock at the same developmental stages. ..
  14. Lele Z, Krone P. Expression of genes encoding the collagen-binding heat shock protein (Hsp47) and type II collagen in developing zebrafish embryos. Mech Dev. 1997;61:89-98 pubmed
    ..Appearance of the larger transcript occurs following somitogenesis, a time which coincides with the co-activation of hsp47 and col2a1 gene expression in tissues outside of the notochord. ..
  15. Thomas J, Wiseman S, Giesy J, Janz D. Effects of chronic dietary selenomethionine exposure on repeat swimming performance, aerobic metabolism and methionine catabolism in adult zebrafish (Danio rerio). Aquat Toxicol. 2013;130-131:112-22 pubmed publisher
    ..Overall the results of this study suggest chronic exposure of adult zebrafish to SeMet in the diet can cause both cellular and organismal effects that could affect fitness and survivability of fish. ..
  16. Thomas J, Janz D. Dietary selenomethionine exposure in adult zebrafish alters swimming performance, energetics and the physiological stress response. Aquat Toxicol. 2011;102:79-86 pubmed publisher
    ..Our results suggest that environmentally relevant dietary Se-Met exposure can alter both behavioral and physiological responses in adult fish, and such consequences could threaten fitness of adult fish in Se impacted aquatic ecosystems. ..
  17. Evans T, Yamamoto Y, Jeffery W, Krone P. Zebrafish Hsp70 is required for embryonic lens formation. Cell Stress Chaperones. 2005;10:66-78 pubmed
  18. Raine J, Lallemand L, Pettem C, Janz D. Effects of Chronic Dietary Selenomethionine Exposure on the Visual System of Adult and F1 Generation Zebrafish (Danio rerio). Bull Environ Contam Toxicol. 2016;97:331-6 pubmed publisher
    ..These results demonstrate that environmentally relevant elevated dietary SeMet exposure can affect the visual system of both exposed adult zebrafish and their progeny, which could affect fitness and survivability. ..