Genomes and Genes
Experts and Doctors on virus replication in Montréal, Quebec, Canada
Locale: Montréal, Quebec, Canada
Topic: virus replication
- Xu H, Colby Germinario S, Asahchop E, Oliveira M, McCallum M, Schader S, et al. Effect of mutations at position E138 in HIV-1 reverse transcriptase and their interactions with the M184I mutation on defining patterns of resistance to nonnucleoside reverse transcriptase inhibitors rilpivirine and etravirine. Antimicrob Agents Chemother. 2013;57:3100-9 pubmed publisher..Of course, other factors may also affect the concept of barrier to resistance. ..
- Shah W, Peng H, Carbonetto S. Role of non-raft cholesterol in lymphocytic choriomeningitis virus infection via alpha-dystroglycan. J Gen Virol. 2006;87:673-8 pubmed..This may reflect the association of DG with cholesterol outside lipid rafts and suggests that association of DG with non-raft cholesterol is critical for infection by LCMV through alpha-DG. ..
- Clerzius G, Shaw E, Daher A, Burugu S, Gélinas J, Ear T, et al. The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication. Retrovirology. 2013;10:96 pubmed publisher..HIV-1 has evolved to replicate in cells with high levels of TRBP, to induce the expression of ADAR1 and to change the function of PACT for PKR inhibition and increased replication. ..
- Lisco A, Vanpouille C, Tchesnokov E, Grivel J, Biancotto A, Brichacek B, et al. Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues. Cell Host Microbe. 2008;4:260-270 pubmed publisher..These data suggest that ACV anti-HIV-1 activity may contribute to the response of HIV/HHV-coinfected patients to ACV treatment and could guide strategies for the development of new HIV-1 RT inhibitors. ..
- Sgarbanti M, Arguello M, tenOever B, Battistini A, Lin R, Hiscott J. A requirement for NF-kappaB induction in the production of replication-competent HHV-8 virions. Oncogene. 2004;23:5770-80 pubmed
- Fradet Turcotte A, Morin G, Lehoux M, Bullock P, Archambault J. Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replication. Virology. 2010;399:65-76 pubmed publisher..These quantitative and high-throughput assays should greatly facilitate the study of SV40 and HPV31 DNA replication and the identification of small-molecule inhibitors of this process. ..
- Xu H, Colby Germinario S, Huang W, Oliveira M, Han Y, Quan Y, et al. Role of the K101E substitution in HIV-1 reverse transcriptase in resistance to rilpivirine and other nonnucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother. 2013;57:5649-57 pubmed publisher..The coexistence of K101E and E138K does not impair either viral replication or enzyme fitness. We conclude that K101E can play a significant role in resistance to RPV. ..
- Fradet Turcotte A, Moody C, Laimins L, Archambault J. Nuclear export of human papillomavirus type 31 E1 is regulated by Cdk2 phosphorylation and required for viral genome maintenance. J Virol. 2010;84:11747-60 pubmed publisher..On the basis of these results, we propose that nuclear export of E1 is required, at least in part, to limit accumulation of this viral helicase in the nucleus in order to prevent its detrimental effect on cellular proliferation...
- Brunelle M, Brakier Gingras L, Lemay G. Replacement of murine leukemia virus readthrough mechanism by human immunodeficiency virus frameshift allows synthesis of viral proteins and virus replication. J Virol. 2003;77:3345-50 pubmed..This system could be a most interesting alternative to study ribosomal frameshift in the context of a virus amenable to the use of a simple animal model. ..
- Klein M, Campeol N, Lalonde R, Brenner B, Wainberg M. Didanosine, interferon-alfa and ribavirin: a highly synergistic combination with potential activity against HIV-1 and hepatitis C virus. AIDS. 2003;17:1001-8 pubmed..This novel triple combination has the potential to provide simultaneous activity against both HIV and hepatitis C and deserves further study to determine if can be safely administered in the clinical setting. ..
- Guo F, Gabor J, Cen S, Hu K, Mouland A, Kleiman L. Inhibition of cellular HIV-1 protease activity by lysyl-tRNA synthetase. J Biol Chem. 2005;280:26018-23 pubmed..Using a novel bioluminescence resonance energy transfer assay to directly measure HIV-1 protease activity in vivo also indicates that the overexpression of LysRS in the cell reduces viral protease activity. ..
- Quan Y, Xu H, Han Y, MesplÃ¨de T, Wainberg M. JAK-STAT Signaling Pathways and Inhibitors Affect Reversion of Envelope-Mutated HIV-1. J Virol. 2017;91: pubmed publisher..JAK-STAT signaling pathways are able to play major roles in these processes. This work sheds new light on factors that can govern HIV infection of target cells. ..
- Steenbergen R, Joyce M, Lund G, Lewis J, Chen R, Barsby N, et al. Lipoprotein profiles in SCID/uPA mice transplanted with human hepatocytes become human-like and correlate with HCV infection success. Am J Physiol Gastrointest Liver Physiol. 2010;299:G844-54 pubmed publisher..Our data suggest that the weakest link in the HCV infection chain does not appear to be the presence of human hepatocytes per se. We believe that HCV infection also depends on the presence of sufficient levels of human lipoproteins. ..
- Svitkin Y, Costa Mattioli M, Herdy B, Perreault S, Sonenberg N. Stimulation of picornavirus replication by the poly(A) tail in a cell-free extract is largely independent of the poly(A) binding protein (PABP). RNA. 2007;13:2330-40 pubmed..These results suggest that the poly(A) tail functions in picornavirus replication largely independent of PABP. ..
- Guo F, Cen S, Niu M, Saadatmand J, Kleiman L. Inhibition of tRNA?(Lys)-primed reverse transcription by human APOBEC3G during human immunodeficiency virus type 1 replication. J Virol. 2006;80:11710-22 pubmed..A similar reduction in tRNA(3)(Lys) priming and viral infectivity is also seen in the naturally nonpermissive cell H9, albeit at significantly lower levels of hA3G expression. ..
- van Grevenynghe J, Procopio F, He Z, Chomont N, Riou C, Zhang Y, et al. Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection. Nat Med. 2008;14:266-74 pubmed publisher..The crucial role of FOXO3a in the survival of memory cells will help shed light on the underlying immunological mechanisms that control viral replication in EC subjects. ..
- ..These studies have made E1 one of the best characterized helicases and provided unique insights on how PVs usurp different host-cell machineries to replicate and amplify their genome in a tightly controlled manner. ..
- Nguyen T, Abdelbary H, Arguello M, Breitbach C, Leveille S, Diallo J, et al. Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis. Proc Natl Acad Sci U S A. 2008;105:14981-6 pubmed publisher..HDIs could have a profoundly positive impact on the clinical implementation of OV therapeutics. ..
- Liang Z, Liu R, Lin Y, Liang C, Tan J, Qiao W. HIV-1 Vpr protein activates the NF-ÎºB pathway to promote G2/M cell cycle arrest. Virol Sin. 2015;30:441-8 pubmed publisher..Our results suggest that the NF-ÎºB pathway is probably involved in Vpr-induced G2/M cell cycle arrest. ..
- Bourbeau D, Lau C, Jaime J, Koty Z, Zehntner S, Lavoie G, et al. Improvement of antitumor activity by gene amplification with a replicating but nondisseminating adenovirus. Cancer Res. 2007;67:3387-95 pubmed..1% at 365 days. In conclusion, Ad(dPS)CU-IRES-E1A in the presence of 5-FC produces more potent tumoricidal effects than its replication-deficient counterparts. ..
- Zeng Y, Pinard M, Jaime J, Bourget L, Uyen Le P, O Connor McCourt M, et al. A ligand-pseudoreceptor system based on de novo designed peptides for the generation of adenoviral vectors with altered tropism. J Gene Med. 2008;10:355-67 pubmed publisher..We have established a new system to produce AdVs ablated of natural tropism. This system should permit the retargeting of AdVs by inserting new ligands within the fiber or through the interaction with bispecific adaptors. ..
- Arts E, Mak J, Kleiman L, Wainberg M. DNA found in human immunodeficiency virus type 1 particles may not be required for infectivity. J Gen Virol. 1994;75 ( Pt 7):1605-13 pubmed..However such viruses were as infections for CD4+ cells as wild-type virus. We conclude that retrovirus-derived DNA in HIV-1 particles is not required for infection and does not play a significant role in this process. ..
- Chatel Chaix L, Melan on P, Racine M, Baril M, Lamarre D. Y-box-binding protein 1 interacts with hepatitis C virus NS3/4A and influences the equilibrium between viral RNA replication and infectious particle production. J Virol. 2011;85:11022-37 pubmed publisher..Our data support that HCV hijacks YB-1-containing ribonucleoparticles and that YB-1-NS3/4A-HCV RNA complexes regulate the equilibrium between HCV RNA replication and viral particle production...
- Fletcher R, Arion D, Borkow G, Wainberg M, Dmitrienko G, Parniak M. Synergistic inhibition of HIV-1 reverse transcriptase DNA polymerase activity and virus replication in vitro by combinations of carboxanilide nonnucleoside compounds. Biochemistry. 1995;34:10106-12 pubmed..We believe this to be the first example of synergistic inhibition of HIV-1 RT by combinations of structurally related nonnucleoside inhibitors...
- Grandvaux N, Gaboriau F, Harris J, tenOever B, Lin R, Hiscott J. Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response. FEBS J. 2005;272:3120-31 pubmed..These results show for the first time that the ArgII gene is an early IRF-3-regulated gene, which participates in the IFN-independent antiviral response through polyamine production and induction of apoptosis...
- Krishnamoorthy J, Mounir Z, Raven J, Koromilas A. The eIF2alpha kinases inhibit vesicular stomatitis virus replication independently of eIF2alpha phosphorylation. Cell Cycle. 2008;7:2346-51 pubmed..Thus, the anti-viral properties of eIF2alpha kinases are not always related to their inhibitory effects on host protein synthesis as previously thought and are possibly mediated by phosphorylation of proteins other than eIF2alpha. ..
- Tota J, Ramanakumar A, Jiang M, Dillner J, Walter S, Kaufman J, et al. Epidemiologic approaches to evaluating the potential for human papillomavirus type replacement postvaccination. Am J Epidemiol. 2013;178:625-34 pubmed publisher..This may result in an apparent increase in previously undetected types postvaccination. ..
- Xiao Y, Chen G, Richard J, Rougeau N, Li H, Seidah N, et al. Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases. Virology. 2008;372:384-97 pubmed..Collectively, these results suggest that cell surface processing of extracellular Vpr by PCs might regulate the levels of active soluble Vpr. ..
- Turcotte K, Gauthier S, Mitsos L, Shustik C, Copeland N, Jenkins N, et al. Genetic control of myeloproliferation in BXH-2 mice. Blood. 2004;103:2343-50 pubmed..Our results suggest a model in which Myls-dependent myeloproliferation in BXH-2 acts as a predisposing factor for the subsequent development of virally induced myeloid leukemia characteristic of this strain...
- Battisti P, Daher A, Bannwarth S, Voortman J, Peden K, Hiscott J, et al. Additive activity between the trans-activation response RNA-binding protein, TRBP2, and cyclin T1 on HIV type 1 expression and viral production in murine cells. AIDS Res Hum Retroviruses. 2003;19:767-78 pubmed..These results suggest an activity of CycT1 and TRBP2 at different steps in HIV-1 expression and indicate the requirement for another posttranscriptional factor in murine cells for full HIV replication. ..
- Mesplede T, Quashie P, Osman N, Han Y, Singhroy D, Lie Y, et al. Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure. Retrovirology. 2013;10:22 pubmed publisher..Since H51Y and R263K may define a unique resistance pathway to dolutegravir, our results are consistent with the absence of resistance mutations in antiretroviral drug-naive patients treated with this drug. ..
- Iannello A, Boulassel M, Samarani S, Tremblay C, Toma E, Routy J, et al. IL-21 enhances NK cell functions and survival in healthy and HIV-infected patients with minimal stimulation of viral replication. J Leukoc Biol. 2010;87:857-67 pubmed publisher..These data suggest that IL-21 may serve as a valuable therapeutic tool for enhancing NK cell responses and inhibiting viral replication in HIV-infected patients. ..
- Anstett K, Brenner B, Mesplede T, Wainberg M. HIV-1 Resistance to Dolutegravir Is Affected by Cellular Histone Acetyltransferase Activity. J Virol. 2017;91: pubmed publisher..However, our results suggest that some drug-resistant viruses may differentially respond to such stimulation, which may complicate the attainment of this goal. Our future work will further illuminate the mechanisms involved. ..
- Geleziunas R, Bour S, Boulerice F, Hiscott J, Wainberg M. Diminution of CD4 surface protein but not CD4 messenger RNA levels in monocytic cells infected by HIV-1. AIDS. 1991;5:29-33 pubmed..These data suggest that HIV-1-mediated depletion of cell-surface CD4 in monocytes does not involve transcript down-modulation as has been reported in T lymphocytes. ..
- Xing L, Niu M, Kleiman L. In vitro and in vivo analysis of the interaction between RNA helicase A and HIV-1 RNA. J Virol. 2012;86:13272-80 pubmed publisher..Furthermore, these mutant RHAs do not promote the in vivo annealing of tRNA(3)(Lys) to viral RNA, nor are they packaged into virions, demonstrating that the dsRBDs are essential for the role of RHA in HIV-1 replication. ..
- Stegen C, Yakova Y, Henaff D, Nadjar J, Duron J, Lippé R. Analysis of virion-incorporated host proteins required for herpes simplex virus type 1 infection through a RNA interference screen. PLoS ONE. 2013;8:e53276 pubmed publisher..Altogether, these findings underscore the power and biological relevance of combining proteomics and RNA interference to identify novel host-pathogen interactions. ..
- Xu H, Colby Germinario S, Oliveira M, Han Y, Quan Y, Zanichelli V, et al. The connection domain mutation N348I in HIV-1 reverse transcriptase enhances resistance to etravirine and rilpivirine but restricts the emergence of the E138K resistance mutation by diminishing viral replication capacity. J Virol. 2014;88:1536-47 pubmed publisher..These findings help to explain the low viral replication capacity of viruses containing the E138K/N348I mutations and how N348I delayed or prevented the emergence of E138K in patients with M184V-containing viruses...
- Quan Y, Xu H, Wainberg M. Defective HIV-1 quasispecies in the form of multiply drug-resistant proviral DNA within cells can be rescued by superinfection with different subtype variants of HIV-1 and by HIV-2 and SIV. J Antimicrob Chemother. 2014;69:21-7 pubmed publisher..We then wished to determine whether such rescue could be affected by viruses of different subtypes or even by other members of the retrovirus family...
- Roulston A, Lin R, Beauparlant P, Wainberg M, Hiscott J. Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors. Microbiol Rev. 1995;59:481-505 pubmed..Elevated levels of several inflammatory cytokines have been detected in the sera of HIV-1-infected individuals. Secretion of myeloid cell-derived cytokines may both increase virus production and contribute to AIDS-associated disorders. ..
- Invernizzi C, Xie B, Frankel F, Feldhammer M, Roy B, Richard S, et al. Arginine methylation of the HIV-1 nucleocapsid protein results in its diminished function. AIDS. 2007;21:795-805 pubmed..These findings may lead to ways of driving HIV-infected cells out of latency with drugs that inhibit PRMT6. ..
- Baril M, Dulude D, Gendron K, Lemay G, Brakier Gingras L. Efficiency of a programmed -1 ribosomal frameshift in the different subtypes of the human immunodeficiency virus type 1 group M. RNA. 2003;9:1246-53 pubmed..2 kcal/mole to -26.2 kcal/mole). The fact that the frameshift efficiencies fall within a narrow range for all of the subtypes of HIV-1 group M stresses the potential of the frameshift event as an antiviral target. ..
- Clerzius G, Gélinas J, Daher A, Bonnet M, Meurs E, Gatignol A. ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication. J Virol. 2009;83:10119-28 pubmed publisher..They suggest that ADAR1 and TRBP belong to a multiprotein complex that inhibits PKR during the HIV infection of lymphocytes. ..
- Quan Y, Motakis D, Buckheit R, Xu Z, Flavin M, Parniak M, et al. Sensitivity and resistance to (+)-calanolide A of wild-type and mutated forms of HIV-1 reverse transcriptase. Antivir Ther. 1999;4:203-9 pubmed..These results suggest that (+)-calanolide A and nevirapine might have rationale as a combination therapy for HIV disease. ..
- Jacques A, Bleau C, Turbide C, Beauchemin N, Lamontagne L. Macrophage interleukin-6 and tumour necrosis factor-alpha are induced by coronavirus fixation to Toll-like receptor 2/heparan sulphate receptors but not carcinoembryonic cell adhesion antigen 1a. Immunology. 2009;128:e181-92 pubmed publisher..These results suggest that TLR2 and heparan sulphate receptors can act as new viral PPRs involved in inflammatory responses...
- Le Sage V, Mouland A. Viral subversion of the nuclear pore complex. Viruses. 2013;5:2019-42 pubmed publisher..The present review examines the different strategies and the specific nucleoporins utilized during viral infections as a means of promoting their life cycle and inhibiting host viral defenses. ..
- Turcotte K, Gauthier S, Tuite A, Mullick A, Malo D, Gros P. A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia-like syndrome in BXH-2 mice. J Exp Med. 2005;201:881-90 pubmed..This event is required for retroviral replication, and subsequent insertional mutagenesis that causes leukemia in BXH-2 mice. ..
- Colina R, Costa Mattioli M, Dowling R, Jaramillo M, Tai L, Breitbach C, et al. Translational control of the innate immune response through IRF-7. Nature. 2008;452:323-8 pubmed publisher..These findings highlight the role of 4E-BPs as negative regulators of type-I IFN production, via translational repression of Irf7 mRNA. ..
- Gosselin A, Monteiro P, Chomont N, Diaz Griffero F, Said E, Fonseca S, et al. Peripheral blood CCR4+CCR6+ and CXCR3+CCR6+CD4+ T cells are highly permissive to HIV-1 infection. J Immunol. 2010;184:1604-16 pubmed publisher..It is necessary that new therapeutic strategies against HIV interfere with viral replication/persistence in discrete CCR6(+) T cell subsets. ..
- Svitkin Y, Sonenberg N. Cell-free synthesis of encephalomyocarditis virus. J Virol. 2003;77:6551-5 pubmed..Excess input RNA impaired RNA replication and virus production but not translation. This suggests the existence of a negative-feedback mechanism for regulation of RNA replication by the viral plus-strand RNA or proteins...
- Clerzius G, Gélinas J, Gatignol A. Multiple levels of PKR inhibition during HIV-1 replication. Rev Med Virol. 2011;21:42-53 pubmed publisher..Enhancing PKR activation by counteracting its inhibitory partners could establish an increased innate immune antiviral pathway against HIV-1 and could enhance the efficacy of the IFN treatment. ..
- Blanchette P, Branton P. Manipulation of the ubiquitin-proteasome pathway by small DNA tumor viruses. Virology. 2009;384:317-23 pubmed publisher..In this review we explore the specific ways that small DNA tumor viruses exploit the ubiquitin-proteasome pathway for their own benefit...
- Kleiman L, Halwani R, Javanbakht H. The selective packaging and annealing of primer tRNALys3 in HIV-1. Curr HIV Res. 2004;2:163-75 pubmed..The annealing is facilitated by viral proteins such as unprocessed Gag, nucleocapsid, and reverse transcriptase. ..
- Beauparlant P, Kwon H, Clarke M, Lin R, Sonenberg N, Wainberg M, et al. Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication. J Virol. 1996;70:5777-85 pubmed..These experiments suggest a strategy that may contribute to inhibition of HIV-1 gene expression by interfering with the NF-kappa B/Rel signaling pathway. ..
- Stojanova A, Caro C, Jarjour R, Oster S, Penn L, Germinario R. Repression of the human immunodeficiency virus type-1 long terminal repeat by the c-Myc oncoprotein. J Cell Biochem. 2004;92:400-13 pubmed..Taken together, these results indicate that c-Myc is an important regulator of HIV-1 transcription that potentially contributes to the latent proviral state. ..
- Herdy B, Jaramillo M, Svitkin Y, Rosenfeld A, Kobayashi M, Walsh D, et al. Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E. Nat Immunol. 2012;13:543-550 pubmed publisher..Thus, regulated phosphorylation of eIF4E has a key role in antiviral host defense by selectively controlling the translation of an mRNA that encodes a critical suppressor of the innate antiviral response. ..
- Valiente Echeverría F, Melnychuk L, Mouland A. Viral modulation of stress granules. Virus Res. 2012;169:430-7 pubmed publisher..This review discusses recent advances in our understanding of the interactions between viruses and the host response and how virus-induced modulations in SG abundance play fundamental roles in dictating the success of viral replication...
- Loret S, El Bilali N, Lippé R. Analysis of herpes simplex virus type I nuclear particles by flow cytometry. Cytometry A. 2012;81:950-9 pubmed publisher..This opens new research avenues in virology to study capsid assembly, maturation and egress, analyze mutant phenotypes, and define host factors associated with specific viral intermediates. ..
- Emmerling V, Pegel A, Milian E, Venereo Sanchez A, Kunz M, Wegele J, et al. Rational plasmid design and bioprocess optimization to enhance recombinant adeno-associated virus (AAV) productivity in mammalian cells. Biotechnol J. 2016;11:290-7 pubmed publisher..In summary, we demonstrate substantial bioprocess optimizations leading to more efficient and scalable production processes suggesting a promising way for flexible large-scale rAAV manufacturing. ..
- Xing L, Niu M, Zhao X, Kleiman L. Different activities of the conserved lysine residues in the double-stranded RNA binding domains of RNA helicase A in vitro and in the cell. Biochim Biophys Acta. 2014;1840:2234-43 pubmed publisher..The conserved lysine residues of dsRBDs are key to the interaction of RNA helicase A with substrate RNA in the cell, but not in vitro. ..
- Xie B, Invernizzi C, Richard S, Wainberg M. Arginine methylation of the human immunodeficiency virus type 1 Tat protein by PRMT6 negatively affects Tat Interactions with both cyclin T1 and the Tat transactivation region. J Virol. 2007;81:4226-34 pubmed..Finding a way of inhibiting or stimulating PRMT6 activity might help to drive quiescently infected cells out of latency or combat HIV-1 replication, respectively. ..
- Svitkin Y, Sonenberg N. A highly efficient and robust in vitro translation system for expression of picornavirus and hepatitis C virus RNA genomes. Methods Enzymol. 2007;429:53-82 pubmed..With further optimization of cell-free conditions, the entire reconstitution of infectious HCV synthesis in vitro might become feasible...
- Gagnon D, Sénéchal H, D Abramo C, Alvarez J, McBride A, Archambault J. Genetic analysis of the E2 transactivation domain dimerization interface from bovine papillomavirus type 1. Virology. 2013;439:132-9 pubmed publisher..Results for this mutational analysis suggest that the TAD dimerization interface is not essential for either process but may contribute to the DNA replication activity of BPV1 E2. ..
- Ajamian L, Mouland A. Implications of RNA helicases in HIV-1 replication: possible roles in latency. Curr HIV Res. 2011;9:588-94 pubmed
- Lu J, Pan Q, Rong L, He W, Liu S, Liang C. The IFITM proteins inhibit HIV-1 infection. J Virol. 2011;85:2126-37 pubmed publisher..Altogether, these data suggest that the IFITM proteins serve as important components of the innate immune system to restrict HIV-1 infection. ..
- Welbourn S, Pause A. The hepatitis C virus NS2/3 protease. Curr Issues Mol Biol. 2007;9:63-9 pubmed..However, several recent studies are beginning to clarify possible roles of the cleaved NS2 protein in modulation of host cell gene expression and apoptosis. ..
- Iannello A, Boulassel M, Samarani S, Tremblay C, Toma E, Routy J, et al. HIV-1 causes an imbalance in the production of interleukin-18 and its natural antagonist in HIV-infected individuals: implications for enhanced viral replication. J Infect Dis. 2010;201:608-17 pubmed publisher..The infection and the cytokine milieu play a role in this decreased production. The increased biological activities of IL-18 may enhance viral replication in human CD4(+) T cells. ..
- Nguyen T, Wilson M, Hiscott J. Oncolytic viruses and histone deacetylase inhibitors--a multi-pronged strategy to target tumor cells. Cytokine Growth Factor Rev. 2010;21:153-9 pubmed publisher..This review discusses the results obtained with the different OV/HDI combinations, the rationale supporting these combinations and the advantages for oncolytic virus therapy. ..
- Monette A, Pante N, Mouland A. HIV-1 remodels the nuclear pore complex. J Cell Biol. 2011;193:619-31 pubmed publisher..This detailed analysis highlights the profound effects on NE composition induced by HIV-1 infection, providing further evidence of the magnitude of viral control over the cell biology of its host...
- Kafaie J, Dolatshahi M, Ajamian L, Song R, Mouland A, Rouiller I, et al. Role of capsid sequence and immature nucleocapsid proteins p9 and p15 in Human Immunodeficiency Virus type 1 genomic RNA dimerization. Virology. 2009;385:233-44 pubmed publisher..This represents the first evidence that a capsid mutation can affect HIV-1 RNA dimerization. ..
- Belzile J, Duisit G, Rougeau N, Mercier J, Finzi A, Cohen E. HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase. PLoS Pathog. 2007;3:e85 pubmed
- Lehoux M, Jacques A, Lusignan S, Lamontagne L. Murine viral hepatitis involves NK cell depletion associated with virus-induced apoptosis. Clin Exp Immunol. 2004;137:41-51 pubmed..Larger NK+ syncytia were observed in L2-MHV3-infected cells than in YAC-MHV3-infected cells. These results suggest that NK cell production is impaired by viral infection favouring fulminant hepatitis. ..
- Lainé S, Scarborough R, Levesque D, Didierlaurent L, Soye K, Mougel M, et al. In vitro and in vivo cleavage of HIV-1 RNA by new SOFA-HDV ribozymes and their potential to inhibit viral replication. RNA Biol. 2011;8:343-53 pubmed..Our results strongly suggest that SOFA-HDV ribozymes have a great potential to target HIV-1 and to be used as therapeutic agents in combination therapy...
- Sukarieh R, Sonenberg N, Pelletier J. Nuclear assortment of eIF4E coincides with shut-off of host protein synthesis upon poliovirus infection. J Gen Virol. 2010;91:1224-8 pubmed publisher..We postulate that eIF4E nuclear relocalization may contribute to the shut-off of host protein synthesis that is a hallmark of poliovirus infection by perturbing the circular status of actively translating mRNAs. ..
- Hanna Z, Weng X, Kay D, Poudrier J, Lowell C, Jolicoeur P. The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck. J Virol. 2001;75:9378-92 pubmed..Our findings indicate that Hck is an important, but not an essential, effector of Nef and suggest that another factor(s), yet to be identified, may be more critical for disease development. ..
- Jia R, Ding S, Pan Q, Liu S, Qiao W, Liang C. The C-terminal sequence of IFITM1 regulates its anti-HIV-1 activity. PLoS ONE. 2015;10:e0118794 pubmed publisher..The results also demonstrate the importance of the C-terminal region of IFITM1 in modulating the antiviral function through controlling protein subcellular localization. ..
- Fillebeen C, Rivas Estilla A, Bisaillon M, Ponka P, Muckenthaler M, Hentze M, et al. Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus. J Biol Chem. 2005;280:9049-57 pubmed publisher..Our data provide a direct molecular link between iron and HCV replication...
- Yang Y, Guo F, Cen S, Kleiman L. Inhibition of initiation of reverse transcription in HIV-1 by human APOBEC3F. Virology. 2007;365:92-100 pubmed