Genomes and Genes
Experts and Doctors on synaptic transmission in Montréal, Quebec, Canada
Locale: Montréal, Quebec, Canada
Topic: synaptic transmission
- Ghamari Langroudi M, Bourque C. Flufenamic acid blocks depolarizing afterpotentials and phasic firing in rat supraoptic neurones. J Physiol. 2002;545:537-42 pubmed..Finally, the absence of a depolarization and increased membrane resistance upon application of FFA suggests that the DAP in MNCs may not be due to the inhibition of resting K(+) current, but to the activation of CAN channels. ..
- Dorr A, Debonnel G. Effect of vagus nerve stimulation on serotonergic and noradrenergic transmission. J Pharmacol Exp Ther. 2006;318:890-8 pubmed..LC firing rates significantly increase earlier than the DRN basal firing. As the LC has an excitatory influence on DRN, it is possible that the increased DRN firing rate is secondary to an initial increased LC firing rate from VNS. ..
- Frigon A, Rossignol S. Plasticity of reflexes from the foot during locomotion after denervating ankle extensors in intact cats. J Neurophysiol. 2007;98:2122-32 pubmed..g., nonstimulated bursts during reflex trials). The functional significance of these changes in muscle activity and reflex pathways on the recovery of locomotion after denervating ankle extensors is discussed. ..
- Pribiag H, Stellwagen D. TNF-? downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors. J Neurosci. 2013;33:15879-93 pubmed publisher..Together, these findings demonstrate a distinct mechanism of regulated GABA(A)R endocytosis that may contribute to the disruption of circuit homeostasis under neuroinflammatory conditions. ..
- Birks R, Isacoff E. Burst-patterned stimulation promotes nicotinic transmission in isolated perfused rat sympathetic ganglia. J Physiol. 1988;402:515-32 pubmed..Both burst-patterned potentiation and the post-burst-patterned potentiation were abolished.(ABSTRACT TRUNCATED AT 400 WORDS) ..
- Zhao Y, Klein M. Modulation of the readily releasable pool of transmitter and of excitation-secretion coupling by activity and by serotonin at Aplysia sensorimotor synapses in culture. J Neurosci. 2002;22:10671-9 pubmed
- St Gelais F, Jomphe C, Trudeau L. The role of neurotensin in central nervous system pathophysiology: what is the evidence?. J Psychiatry Neurosci. 2006;31:229-45 pubmed
- Panatier A. Glial cells: indispensable partners of hypothalamic magnocellular neurones. J Neuroendocrinol. 2009;21:665-72 pubmed publisher..As reviewed here, numerous observations show that astrocytes must be considered as key elements in the functioning of the hypothalamo-neurohypophysial system. ..
- Glasgow S, Glovaci I, Karpowicz L, Chapman C. Cholinergic suppression of excitatory synaptic transmission in layers II/III of the parasubiculum. Neuroscience. 2012;201:1-11 pubmed publisher..Therefore, cholinergic receptor activation suppresses excitatory synaptic input to layer II/III neurons of the PaS, and this suppression is mediated in part by M(1) receptor activation...
- Osswald I, Galan A, Bowie D. Light triggers expression of philanthotoxin-insensitive Ca2+-permeable AMPA receptors in the developing rat retina. J Physiol. 2007;582:95-111 pubmed..Eye-opening coincides with the consolidation of inhibitory cell connections suggesting that the developmental switch to a Ca2+-permeable AMPAR with novel pharmacology may be critical to synapse maturation in the mammalian retina. ..
- Richard A, Girard F, Girard D, Boudreault D, Chouinard P, Moumdjian R, et al. Cisatracurium-induced neuromuscular blockade is affected by chronic phenytoin or carbamazepine treatment in neurosurgical patients. Anesth Analg. 2005;100:538-44 pubmed..Also, patients under CAT had a 20% increase in their Cp(ss)95, indicating an increased resistance to the effect of cisatracurium. ..
- St Gelais F, Menard C, Congar P, Trudeau L, Massicotte G. Postsynaptic injection of calcium-independent phospholipase A2 inhibitors selectively increases AMPA receptor-mediated synaptic transmission. Hippocampus. 2004;14:319-25 pubmed..Collectively, these results provide the first experimental evidence that constitutive iPLA2 and/or its metabolites play an important role in the postsynaptic modulation of neurotransmission in CA1 pyramidal cells of the hippocampus. ..
- Cervero F, Laird J. Understanding the signaling and transmission of visceral nociceptive events. J Neurobiol. 2004;61:45-54 pubmed..This article reviews current evidence on the mechanisms of activation and sensitization of visceral nociceptive afferents and on their role in the triggering and maintenance of clinically relevant visceral pain states. ..
- Caruana D, Sorge R, Stewart J, Chapman C. Dopamine has bidirectional effects on synaptic responses to cortical inputs in layer II of the lateral entorhinal cortex. J Neurophysiol. 2006;96:3006-15 pubmed..We propose here that dopamine release in the lateral entorhinal cortex, acting through D(1) receptors, can lead to an enhancement of the salience of sensory representations carried to this region from adjacent sensory cortices. ..
- Croce A, Pelletier J, Tartas M, Lacaille J. Afferent-specific properties of interneuron synapses underlie selective long-term regulation of feedback inhibitory circuits in CA1 hippocampus. J Physiol. 2010;588:2091-107 pubmed publisher..Thus, cell type- and afferent-specific rules of transmission and plasticity underlie distinct OA-IN input-output functions, providing selective long-term regulation in feedback inhibitory networks. ..
- Antri M, Auclair F, Albrecht J, Djeudjang N, Dubuc R. Serotoninergic modulation of sensory transmission to brainstem reticulospinal cells. Eur J Neurosci. 2008;28:655-67 pubmed publisher..Our results indicate that 5-HT modulates sensory transmission to lamprey brainstem RS cells. ..
- Hassani O, Henny P, Lee M, Jones B. GABAergic neurons intermingled with orexin and MCH neurons in the lateral hypothalamus discharge maximally during sleep. Eur J Neurosci. 2010;32:448-57 pubmed publisher..They could accordingly dampen arousal with muscle tone and promote sleep, including PS with muscle atonia. ..
- Dominguez Lopez S, Mahar I, Bambico F, Labonte B, Ochoa Sanchez R, Leyton M, et al. Short-term effects of melatonin and pinealectomy on serotonergic neuronal activity across the light-dark cycle. J Psychopharmacol. 2012;26:830-44 pubmed publisher..This MLT-induced decrease in 5-HT neurotransmission may represent a biological mechanism underlying mood disorders characterized by increased MLT secretion, such as seasonal affective disorder. ..
- Topolnik L, Azzi M, Morin F, Kougioumoutzakis A, Lacaille J. mGluR1/5 subtype-specific calcium signalling and induction of long-term potentiation in rat hippocampal oriens/alveus interneurones. J Physiol. 2006;575:115-31 pubmed..Thus, our findings uncover a novel molecular mechanism of interneurone-specific Ca2+ signalling, critical in regulating synaptic excitability in hippocampal networks. ..
- Araque A, Carmignoto G, Haydon P, Oliet S, Robitaille R, Volterra A. Gliotransmitters travel in time and space. Neuron. 2014;81:728-39 pubmed publisher..We propose that astrocytes mainly signal through high-affinity slowly desensitizing receptors to modulate neurons and perform integration in spatiotemporal domains complementary to those of neurons. ..
- You Z, Chen Y, Wise R. Dopamine and glutamate release in the nucleus accumbens and ventral tegmental area of rat following lateral hypothalamic self-stimulation. Neuroscience. 2001;107:629-39 pubmed
- Hakyemez H, Dagher A, Smith S, Zald D. Striatal dopamine transmission in healthy humans during a passive monetary reward task. Neuroimage. 2008;39:2058-65 pubmed..These data suggest that active behavioral engagement may be necessary to observe robust statewise increases in DA release in the striatum. ..
- Armstrong G, Drapeau P. Loss and gain of FUS function impair neuromuscular synaptic transmission in a genetic model of ALS. Hum Mol Genet. 2013;22:4282-92 pubmed publisher..These results show that both a loss and gain of FUS function result in defective presynaptic function at the NMJ. ..
- Vaccaro A, Tauffenberger A, Aggad D, Rouleau G, Drapeau P, Parker J. Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans. PLoS ONE. 2012;7:e31321 pubmed publisher..We introduce C. elegans transgenics for mutant TDP-43 and FUS motor neuron toxicity that may be used for rapid genetic and pharmacological suppressor screening...
- Low S, Woods I, Lachance M, Ryan J, Schier A, Saint Amant L. Touch responsiveness in zebrafish requires voltage-gated calcium channel 2.1b. J Neurophysiol. 2012;108:148-59 pubmed publisher..These results, coupled with the expression of CACNA1Ab by sensory neurons, suggest that CaV2.1b channel activity is necessary for touch-evoked activation of the locomotor network in zebrafish. ..
- Parent M, Descarries L. Acetylcholine innervation of the adult rat thalamus: distribution and ultrastructural features in dorsolateral geniculate, parafascicular, and reticular thalamic nuclei. J Comp Neurol. 2008;511:678-91 pubmed publisher..In contrast, the entirely synaptic ACh input to PF should allow for a direct relaying of the information from brainstem, affecting basal ganglia function as well as perceptual awareness, including attention and pain perception. ..
- Ran I, Gkogkas C, Vasuta C, Tartas M, Khoutorsky A, Laplante I, et al. Selective regulation of GluA subunit synthesis and AMPA receptor-mediated synaptic function and plasticity by the translation repressor 4E-BP2 in hippocampal pyramidal cells. J Neurosci. 2013;33:1872-86 pubmed publisher..Thus, translational control through 4E-BP2 represents a unique mechanism for selective regulation of AMPAR synthesis, synaptic function, and long-term plasticity, important for hippocampal-dependent memory processes. ..
- Yi J, Hoover R, McIntosh T, Hazell A. Early, transient increase in complexin I and complexin II in the cerebral cortex following traumatic brain injury is attenuated by N-acetylcysteine. J Neurotrauma. 2006;23:86-96 pubmed..These alterations in complexin levels may also play an important role in neuronal cell loss following TBI, and thus contribute to the pathophysiology of cerebral damage following brain injury. ..
- Deemyad T, Metzen M, Pan Y, Chacron M. Serotonin selectively enhances perception and sensory neural responses to stimuli generated by same-sex conspecifics. Proc Natl Acad Sci U S A. 2013;110:19609-14 pubmed publisher..This function is likely to be conserved across systems and species. ..
- Bambico F, Nguyen N, Katz N, Gobbi G. Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission. Neurobiol Dis. 2010;37:641-55 pubmed publisher..These suggest that long-term exposure to cannabinoids during adolescence induces anxiety-like and depression-like behaviours in adulthood and that this may be instigated by serotonergic hypoactivity and noradrenergic hyperactivity. ..
- Toporikova N, Chacron M. SK channels gate information processing in vivo by regulating an intrinsic bursting mechanism seen in vitro. J Neurophysiol. 2009;102:2273-87 pubmed publisher..Our results show that ion channels located in dendrites can have a profound influence on the processing of sensory input by neurons in vivo through the modulation of an intrinsic bursting mechanism. ..
- Drapeau P, Buss R, Ali D, Legendre P, Rotundo R. Limits to the development of fast neuromuscular transmission in zebrafish. J Neurophysiol. 2001;86:2951-6 pubmed
- Darabid H, Arbour D, Robitaille R. Glial cells decipher synaptic competition at the mammalian neuromuscular junction. J Neurosci. 2013;33:1297-313 pubmed publisher..Our results indicate that glial cells decode ongoing synaptic competition and, hence, are poised to influence its outcome. ..
- Jones E, Bernardinelli Y, Tse Y, Chierzi S, Wong T, Murai K. Astrocytes control glutamate receptor levels at developing synapses through SPARC-beta-integrin interactions. J Neurosci. 2011;31:4154-65 pubmed publisher..Thus neuron-glial signals control glutamate receptor levels at developing synapses to enable activity-driven modifications of synaptic strength. ..
- Manseau F, Goutagny R, Danik M, Williams S. The hippocamposeptal pathway generates rhythmic firing of GABAergic neurons in the medial septum and diagonal bands: an investigation using a complete septohippocampal preparation in vitro. J Neurosci. 2008;28:4096-107 pubmed publisher..Our data demonstrate that hippocamposeptal inhibition facilitates theta rhythmic discharges in MS/DB GABAergic neurons while favoring the inhibition of most ACh and glutamate neurons. ..
- Knogler L, Liao M, Drapeau P. Synaptic scaling and the development of a motor network. J Neurosci. 2010;30:8871-81 pubmed publisher..Our results show, for the first time, that scaling of glutamatergic synapses can be induced in vivo in the zebrafish and that synaptic patterning is less plastic than synaptic strength during development. ..
- Liggins J, Pihl R, Benkelfat C, Leyton M. The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers. PLoS ONE. 2012;7:e28370 pubmed publisher..Neither dose altered positive mood. The results suggest that dopamine neurotransmission does not directly influence positive mood in humans. ..
- Bidinosti M, Ran I, Sanchez Carbente M, Martineau Y, Gingras A, Gkogkas C, et al. Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. Mol Cell. 2010;37:797-808 pubmed publisher..4E-BP2 deamidation may represent a compensatory mechanism for the developmental reduction of PI3K-Akt-mTOR signaling. ..
- de Guzman P, Inaba Y, Biagini G, Baldelli E, Mollinari C, Merlo D, et al. Subiculum network excitability is increased in a rodent model of temporal lobe epilepsy. Hippocampus. 2006;16:843-60 pubmed..These findings identify an increase in network excitability within the subiculum of pilocarpine-treated, epileptic rats and point at a reduction in inhibition as an underlying mechanism. ..
- Morissette N, Carbonetto S. Laminin alpha 2 chain (M chain) is found within the pathway of avian and murine retinal projections. J Neurosci. 1995;15:8067-82 pubmed
- Naef L, Moquin L, Dal Bo G, Giros B, Gratton A, Walker C. Maternal high-fat intake alters presynaptic regulation of dopamine in the nucleus accumbens and increases motivation for fat rewards in the offspring. Neuroscience. 2011;176:225-36 pubmed publisher..These findings add to mounting evidence that early life exposure to elevated dietary maternal fat can lead to long lasting changes in DA-mediated behavioral responses to stimulant drugs and fat-enriched foods. ..
- Tsurudome K, Tsang K, Liao E, Ball R, Penney J, Yang J, et al. The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction. Neuron. 2010;68:879-93 pubmed publisher..Finally, we show that repression of Khc-73 by miR-310-313 cluster influences the establishment of normal synaptic homeostasis. Our findings establish a role for miRNAs in the regulation of neurotransmitter release. ..
- Naqib F, Farah C, Pack C, Sossin W. The rates of protein synthesis and degradation account for the differential response of neurons to spaced and massed training protocols. PLoS Comput Biol. 2011;7:e1002324 pubmed publisher..This prediction suggests a powerful mechanism by which information about time is incorporated into neuronal processing. ..
- Martel B, Guimond J, Gariépy J, Gravel J, Auclair F, Kolta A, et al. Respiratory rhythms generated in the lamprey rhombencephalon. Neuroscience. 2007;148:279-93 pubmed..Our results support the hypothesis that normal breathing depends on the activity of neurons located in the rostral rhombencephalon in lampreys, whereas the caudal rhombencephalon generates the slow pattern...
- Murai K, Pasquale E. Eph receptors, ephrins, and synaptic function. Neuroscientist. 2004;10:304-14 pubmed..In this review, we discuss how Eph receptors and ephrins are integrated into the molecular machinery that supports synaptic function. ..
- Zhou Y, Cameron S, Chang W, Rao Y. Control of directional change after mechanical stimulation in Drosophila. Mol Brain. 2012;5:39 pubmed publisher..This study presents an excellent starting point for further dissection of molecular and cellular mechanisms controlling directional adjustment after mechanical stimulation. ..
- Altimimi H, Stellwagen D. Persistent synaptic scaling independent of AMPA receptor subunit composition. J Neurosci. 2013;33:11763-7 pubmed publisher..We observed HSP in cultures from GluA1?/?, GluA2?/?, and GluA2?/? GluA3?/? mice, and conclude that, as with LTP, there is no subunit requirement for HSP. ..
- Kahle K, Schmouth J, Lavastre V, Latremoliere A, Zhang J, Andrews N, et al. Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. Sci Signal. 2016;9:ra32 pubmed publisher..These data provide mechanistic insight into, and a compelling therapeutic target for treating, neuropathic pain after nerve injury. ..
- Migues P, Hardt O, Wu D, Gamache K, Sacktor T, Wang Y, et al. PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor trafficking. Nat Neurosci. 2010;13:630-4 pubmed publisher..Together, these findings indicate that PKMzeta maintains long-term memory by regulating the trafficking of GluR2-containing AMPA receptors, the postsynaptic expression of which directly predicts memory retention. ..
- Debonnel G, de Montigny C. Modulation of NMDA and dopaminergic neurotransmissions by sigma ligands: possible implications for the treatment of psychiatric disorders. Life Sci. 1996;58:721-34 pubmed..More selective ligands and fundamental studies on the respective role of the different subtypes of sigma receptors are needed before clear concepts can be formulated. p3 ..
- Panuccio G, Curia G, Colosimo A, Cruccu G, Avoli M. Epileptiform synchronization in the cingulate cortex. Epilepsia. 2009;50:521-36 pubmed publisher..In addition, mu-opioid receptors appear to modulate both excitatory and inhibitory mechanisms, thus influencing epileptiform synchronization in the ACC. ..
- Tremblay M, Riad M, Bouvier D, Murai K, Pasquale E, Descarries L, et al. Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus. J Comp Neurol. 2007;501:691-702 pubmed..The dual preferential labeling of EphA4 on pre- or postsynaptic specializations of excitatory synapses in adult rat hippocampus is consistent with roles for this receptor in synaptic plasticity and LTP. ..
- Huh C, Goutagny R, Williams S. Glutamatergic neurons of the mouse medial septum and diagonal band of Broca synaptically drive hippocampal pyramidal cells: relevance for hippocampal theta rhythm. J Neurosci. 2010;30:15951-61 pubmed publisher..Our findings suggest that the glutamatergic septohippocampal pathway may play an important role in hippocampal theta oscillations and relevant cognitive functions. ..
- Trempe J, Chen C, Grenier K, Camacho E, Kozlov G, McPherson P, et al. SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination. Mol Cell. 2009;36:1034-47 pubmed publisher..The findings identify a pathway for the recruitment of synaptic substrates to parkin with the potential to explain the defects in synaptic transmission observed in recessive forms of PD. ..
- Krishnaswamy A, Cooper E. An activity-dependent retrograde signal induces the expression of the high-affinity choline transporter in cholinergic neurons. Neuron. 2009;61:272-86 pubmed publisher..Importantly, postsynaptic neurons must be continually active to maintain CHT in presynaptic terminals. ..
- Perucca P, Mula M. Antiepileptic drug effects on mood and behavior: molecular targets. Epilepsy Behav. 2013;26:440-9 pubmed publisher..In this article, we review positive and negative effects of AEDs on mood and behavior, discuss putative underlying mechanisms, and highlight knowledge gaps which should be addressed in future studies. ..
- Bachoo M, Yip R, Polosa C. Effect of naloxone and prolonged preganglionic stimulation on noncholinergic transmission in the superior cervical ganglion of the cat. Can J Physiol Pharmacol. 1990;68:1093-9 pubmed..This suggests that the process underlying the fade involves only the conditioned axons. Recovery from the fade was slow, the response approaching control by 24 h post-stimulus.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Clarke P. Nicotinic modulation of thalamocortical neurotransmission. Prog Brain Res. 2004;145:253-60 pubmed
- Campanucci V, Krishnaswamy A, Cooper E. Diabetes depresses synaptic transmission in sympathetic ganglia by inactivating nAChRs through a conserved intracellular cysteine residue. Neuron. 2010;66:827-34 pubmed publisher..Our work suggests a new model for diabetic-induced dysautonomias and identifies ganglionic nAChRs as targets of hyperglycemia-induced downstream signals. ..
- Hong Y, Henry J. Intrathecal administration of non-NMDA receptor agonists increases arterial pressure and heart rate in the rat. Brain Res. 1992;591:62-8 pubmed..Intrathecal administration of kynurenate (125 nmol; n = 6; 500 nmol; n = 7) decreased arterial pressure and/or heart rate.(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Nakhost A, Houeland G, Castellucci V, Sossin W. Differential regulation of transmitter release by alternatively spliced forms of synaptotagmin I. J Neurosci. 2003;23:6238-44 pubmed..Our results demonstrate a physiological role for splicing in the juxtamembrane domain of Syt I...
- Huh C, Danik M, Manseau F, Trudeau L, Williams S. Chronic exposure to nerve growth factor increases acetylcholine and glutamate release from cholinergic neurons of the rat medial septum and diagonal band of Broca via mechanisms mediated by p75NTR. J Neurosci. 2008;28:1404-9 pubmed publisher..These results demonstrate a previously unidentified role of NGF and its receptor p75(NTR); their interactions are crucial for cholinergic and glutamatergic transmission in the septohippocampal pathway. ..
- Nishi K, Kanemaru K, Diksic M. A genetic rat model of depression, Flinders sensitive line, has a lower density of 5-HT(1A) receptors, but a higher density of 5-HT(1B) receptors, compared to control rats. Neurochem Int. 2009;54:299-307 pubmed publisher..The data also suggest that there could be a different fraction of 5-HT(1A) receptors in high and low affinity states in these strains, as well as the possibility of different intracellular signalling. ..
- Scott P, Cowan A, Stricker C. Quantifying impacts of short-term plasticity on neuronal information transfer. Phys Rev E Stat Nonlin Soft Matter Phys. 2012;85:041921 pubmed..Our results suggest that to efficiently transmit information, the brain must match synaptic type, coding strategy, and network connectivity during development and behavior. ..
- Lacoste B, Riad M, Ratté M, Boye S, Levesque D, Descarries L. Trafficking of neurokinin-1 receptors in serotonin neurons is controlled by substance P within the rat dorsal raphe nucleus. Eur J Neurosci. 2009;29:2303-14 pubmed publisher..These results suggest that the trafficking of NK1rs represents a cellular mechanism in control of the modulation of serotonin neuron activity by SP in DRN. ..
- Gingras J, Rassadi S, Cooper E, Ferns M. Synaptic transmission is impaired at neuronal autonomic synapses in agrin-null mice. Dev Neurobiol. 2007;67:521-34 pubmed..Moreover, they suggest a novel role for agrin, in stabilizing the postsynaptic density of nAChR at nascent neuronal synapses. ..
- Robichaud M, Debonnel G. Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids. J Endocrinol. 2004;182:11-21 pubmed..In conclusion, our results offer a cellular basis for potential antidepressant effects of neurosteroids, which may prove important particularly for women with affective disorders. ..
- Penney J, Tsurudome K, Liao E, Elazzouzi F, Livingstone M, González M, et al. TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction. Neuron. 2012;74:166-78 pubmed publisher..Our findings suggest that cap-dependent translation under the control of TOR plays a critical role in establishing the activity dependent homeostatic response at the NMJ. ..
- Normandin L, Hazell A. Manganese neurotoxicity: an update of pathophysiologic mechanisms. Metab Brain Dis. 2002;17:375-87 pubmed..These consequences may result in impaired astrocytic-neuronal interactions and play a major role in the pathophysiology of manganese neurotoxicity...
- Fallon L, Moreau F, Croft B, Labib N, Gu W, Fon E. Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. J Biol Chem. 2002;277:486-91 pubmed..These data implicate for the first time a PDZ-mediated interaction between parkin and CASK in neurodegeneration and possibly in ubiquitination of proteins involved in synaptic transmission and plasticity. ..
- Jadavji N, Bahous R, Deng L, Malysheva O, Grand Maison M, Bedell B, et al. Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism. Biochem J. 2014;461:205-12 pubmed publisher..This disturbance affects the levels of acetylcholine, a critical neurotransmitter in learning and memory. ..
- Clarke P, Chaudieu I, el Bizri H, Boksa P, Quik M, Esplin B, et al. The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglion. Br J Pharmacol. 1994;111:397-405 pubmed
- ..These difficulties were gradually overcome by the application of powerful techniques, such as single channel recording, cloning receptors, as well as new pharmacological tools. ..
- Hu J, Adler K, Farah C, Hastings M, Sossin W, Schacher S. Cell-Specific PKM Isoforms Contribute to the Maintenance of Different Forms of Persistent Long-Term Synaptic Plasticity. J Neurosci. 2017;37:2746-2763 pubmed publisher..Given the recent controversy over the role of PKM? maintaining memory, these findings are significant in identifying roles of multiple PKMs in the retention of memory. ..
- Tremblay E, Martineau E, Robitaille R. Opposite Synaptic Alterations at the Neuromuscular Junction in an ALS Mouse Model: When Motor Units Matter. J Neurosci. 2017;37:8901-8918 pubmed publisher..These data provide a novel framework of analysis and comparison of synaptic transmission alterations in neurodegenerative disorders. ..
- Rousse I, St Amour A, Darabid H, Robitaille R. Synapse-glia interactions are governed by synaptic and intrinsic glial properties. Neuroscience. 2010;167:621-32 pubmed publisher..As a whole, these results indicate that PSC responsiveness at NMJs of slow- and fast-twitch muscles differ not only according to the level of activity of their synaptic partner but also in accordance with inherent glial properties...