Experts and Doctors on stromal cells in Montréal, Quebec, Canada

Summary

Locale: Montréal, Quebec, Canada
Topic: stromal cells

Top Publications

  1. Liu H, Dowdle J, Khurshid S, Sullivan N, Bertos N, Rambani K, et al. Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation. Dev Cell. 2017;41:392-407.e6 pubmed publisher
    ..This cross-species approach identified unanticipated regulatory networks in mesodermal cells with growth-suppressive function, exposing the conserved and selective nature of mesodermal-epithelial communication in development and cancer. ..
  2. Valverde Franco G, Liu H, Davidson D, Chai S, Valderrama Carvajal H, Goltzman D, et al. Defective bone mineralization and osteopenia in young adult FGFR3-/- mice. Hum Mol Genet. 2004;13:271-84 pubmed
    ..Our observations reveal a role for FGFR3 in post-natal bone growth and remodelling, which identifies it as a potential therapeutic target for osteopenic disorders and those associated with defective bone mineralization. ..
  3. Tormo A, Beaupré L, Elson G, Crabé S, Gauchat J. A polyglutamic acid motif confers IL-27 hydroxyapatite and bone-binding properties. J Immunol. 2013;190:2931-7 pubmed publisher
    ..Furthermore, these observations suggest that polyglutamic motifs could be grafted onto other type I cytokine inter-? helix loops to modify their pharmacological properties. ..
  4. Allard B, Turcotte M, Stagg J. CD73-generated adenosine: orchestrating the tumor-stroma interplay to promote cancer growth. J Biomed Biotechnol. 2012;2012:485156 pubmed publisher
    ..We describe the role of extracellular adenosine in promoting tumor growth through paracrine and autocrine action on tumor cells, endothelial cells, and immune cells. ..
  5. Romieu Mourez R, Francois M, Abate A, Boivin M, Birman E, Bailey D, et al. Mesenchymal stromal cells expressing ErbB-2/neu elicit protective antibreast tumor immunity in vivo, which is paradoxically suppressed by IFN-gamma and tumor necrosis factor-alpha priming. Cancer Res. 2010;70:7742-7 pubmed publisher
    ..These data suggest that whereas MSC could effectively serve as antigen-presenting cells to induce immune responses aimed at tumor autoantigens, these functions are critically regulated by IFN-? and TNF-?...
  6. LeBedis C, Chen K, Fallavollita L, Boutros T, Brodt P. Peripheral lymph node stromal cells can promote growth and tumorigenicity of breast carcinoma cells through the release of IGF-I and EGF. Int J Cancer. 2002;100:2-8 pubmed
    ..The identification of these cells raises the possibility that the lymph node microenvironment may contribute actively to the process of cancer cell dissemination. ..
  7. Rochette A, Boufaied N, Scarlata E, Hamel L, Brimo F, Whitaker H, et al. Asporin is a stromally expressed marker associated with prostate cancer progression. Br J Cancer. 2017;116:775-784 pubmed publisher
    ..Our results suggest that ASPN is a stromally expressed biomarker that correlates with disease progression, and is observed in reactive stroma. ASPN expression in stroma may be part of a stromal response to aggressive tumour subtypes. ..
  8. Papapietro O, Teatero S, Thanabalasuriar A, Yuki K, Diez E, Zhu L, et al. R-spondin 2 signalling mediates susceptibility to fatal infectious diarrhoea. Nat Commun. 2013;4:1898 pubmed publisher
    ..Our data demonstrate a previously unknown role of R-spondins and Wnt signalling in susceptibility to infectious diarrhoea and identify R-spondin2 as a key molecular link between infection and intestinal homoeostasis. ..
  9. Liu X, Nugoli M, Laferriere J, Saleh S, Rodrigue Gervais I, Saleh M, et al. Stromal retinoic acid receptor beta promotes mammary gland tumorigenesis. Proc Natl Acad Sci U S A. 2011;108:774-9 pubmed publisher
    ..Our study thus implicates RAR? in promoting tumorigenesis and suggests that retinoid-based approaches for the prevention and treatment of breast cancer should be redesigned. ..
  10. Landry Y, Le O, Mace K, Restivo T, Beausejour C. Secretion of SDF-1alpha by bone marrow-derived stromal cells enhances skin wound healing of C57BL/6 mice exposed to ionizing radiation. J Cell Mol Med. 2010;14:1594-604 pubmed publisher

Detail Information

Publications25

  1. Liu H, Dowdle J, Khurshid S, Sullivan N, Bertos N, Rambani K, et al. Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation. Dev Cell. 2017;41:392-407.e6 pubmed publisher
    ..This cross-species approach identified unanticipated regulatory networks in mesodermal cells with growth-suppressive function, exposing the conserved and selective nature of mesodermal-epithelial communication in development and cancer. ..
  2. Valverde Franco G, Liu H, Davidson D, Chai S, Valderrama Carvajal H, Goltzman D, et al. Defective bone mineralization and osteopenia in young adult FGFR3-/- mice. Hum Mol Genet. 2004;13:271-84 pubmed
    ..Our observations reveal a role for FGFR3 in post-natal bone growth and remodelling, which identifies it as a potential therapeutic target for osteopenic disorders and those associated with defective bone mineralization. ..
  3. Tormo A, Beaupré L, Elson G, Crabé S, Gauchat J. A polyglutamic acid motif confers IL-27 hydroxyapatite and bone-binding properties. J Immunol. 2013;190:2931-7 pubmed publisher
    ..Furthermore, these observations suggest that polyglutamic motifs could be grafted onto other type I cytokine inter-? helix loops to modify their pharmacological properties. ..
  4. Allard B, Turcotte M, Stagg J. CD73-generated adenosine: orchestrating the tumor-stroma interplay to promote cancer growth. J Biomed Biotechnol. 2012;2012:485156 pubmed publisher
    ..We describe the role of extracellular adenosine in promoting tumor growth through paracrine and autocrine action on tumor cells, endothelial cells, and immune cells. ..
  5. Romieu Mourez R, Francois M, Abate A, Boivin M, Birman E, Bailey D, et al. Mesenchymal stromal cells expressing ErbB-2/neu elicit protective antibreast tumor immunity in vivo, which is paradoxically suppressed by IFN-gamma and tumor necrosis factor-alpha priming. Cancer Res. 2010;70:7742-7 pubmed publisher
    ..These data suggest that whereas MSC could effectively serve as antigen-presenting cells to induce immune responses aimed at tumor autoantigens, these functions are critically regulated by IFN-? and TNF-?...
  6. LeBedis C, Chen K, Fallavollita L, Boutros T, Brodt P. Peripheral lymph node stromal cells can promote growth and tumorigenicity of breast carcinoma cells through the release of IGF-I and EGF. Int J Cancer. 2002;100:2-8 pubmed
    ..The identification of these cells raises the possibility that the lymph node microenvironment may contribute actively to the process of cancer cell dissemination. ..
  7. Rochette A, Boufaied N, Scarlata E, Hamel L, Brimo F, Whitaker H, et al. Asporin is a stromally expressed marker associated with prostate cancer progression. Br J Cancer. 2017;116:775-784 pubmed publisher
    ..Our results suggest that ASPN is a stromally expressed biomarker that correlates with disease progression, and is observed in reactive stroma. ASPN expression in stroma may be part of a stromal response to aggressive tumour subtypes. ..
  8. Papapietro O, Teatero S, Thanabalasuriar A, Yuki K, Diez E, Zhu L, et al. R-spondin 2 signalling mediates susceptibility to fatal infectious diarrhoea. Nat Commun. 2013;4:1898 pubmed publisher
    ..Our data demonstrate a previously unknown role of R-spondins and Wnt signalling in susceptibility to infectious diarrhoea and identify R-spondin2 as a key molecular link between infection and intestinal homoeostasis. ..
  9. Liu X, Nugoli M, Laferriere J, Saleh S, Rodrigue Gervais I, Saleh M, et al. Stromal retinoic acid receptor beta promotes mammary gland tumorigenesis. Proc Natl Acad Sci U S A. 2011;108:774-9 pubmed publisher
    ..Our study thus implicates RAR? in promoting tumorigenesis and suggests that retinoid-based approaches for the prevention and treatment of breast cancer should be redesigned. ..
  10. Landry Y, Le O, Mace K, Restivo T, Beausejour C. Secretion of SDF-1alpha by bone marrow-derived stromal cells enhances skin wound healing of C57BL/6 mice exposed to ionizing radiation. J Cell Mol Med. 2010;14:1594-604 pubmed publisher
  11. Francois M, Romieu Mourez R, Stock Martineau S, Boivin M, Bramson J, Galipeau J. Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties. Blood. 2009;114:2632-8 pubmed publisher
  12. Romieu Mourez R, Francois M, Boivin M, Bouchentouf M, Spaner D, Galipeau J. Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype. J Immunol. 2009;182:7963-73 pubmed publisher
    ..In addition, IFN priming combined with TLR activation may increase immune responses induced by Ag-presenting MSC through presentation of Ag in an inflammatory context, a mechanism that could be applied in a cell-based vaccine. ..
  13. Romieu Mourez R, Francois M, Boivin M, Stagg J, Galipeau J. Regulation of MHC class II expression and antigen processing in murine and human mesenchymal stromal cells by IFN-gamma, TGF-beta, and cell density. J Immunol. 2007;179:1549-58 pubmed
    ..This suggests that the IFN-gamma-induced APC features of MSC can be modulated by TGF-beta, serum factors, and cell density in vitro, although not in the same way in mouse and human MSC, via their convergent effects on CIITA expression. ..
  14. Eliopoulos N, Lejeune L, Martineau D, Galipeau J. Human-compatible collagen matrix for prolonged and reversible systemic delivery of erythropoietin in mice from gene-modified marrow stromal cells. Mol Ther. 2004;10:741-8 pubmed
    ..In conclusion, this investigation demonstrates that mEpo(+) MSCs embedded in a human-compatible viscous collagen matrix offers a potent, durable, and reversible approach for delivery of plasma-soluble therapeutic proteins. ..
  15. You Ten K, Muise E, Itie A, Michaliszyn E, Wagner J, Jothy S, et al. Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice. J Exp Med. 1997;186:683-93 pubmed
    ..This study demonstrates that TC-PTP plays a significant role in both hematopoiesis and immune function. ..
  16. Rafei M, Hsieh J, Fortier S, Li M, Yuan S, Birman E, et al. Mesenchymal stromal cell-derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction. Blood. 2008;112:4991-8 pubmed publisher
    ..Thus, MSCs may play a role in modulating Ig production by PCs via MMP processing of CCL2 and may represent an appealing cell therapy approach for pathologic humoral responses. ..
  17. Rafei M, Campeau P, Aguilar Mahecha A, Buchanan M, Williams P, Birman E, et al. Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner. J Immunol. 2009;182:5994-6002 pubmed publisher
    ..In summary, this is the first report of MSCs modulating EAE biology via the paracrine conversion of CCL2 from agonist to antagonist of CD4 Th17 cell function. ..
  18. Aravindakshan J, Chen X, Sairam M. Age-dependent bimodal GDNF regulation during ovarian tumorigenesis in follitropin receptor mutant mice. Biochem Biophys Res Commun. 2006;351:507-13 pubmed
    ..The peripheral expression pattern and functions of this powerful neurotropic factor suggest mediation of processes involved in pathology of ovarian compartments. ..
  19. Stagg J, Pommey S, Eliopoulos N, Galipeau J. Interferon-gamma-stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell. Blood. 2006;107:2570-7 pubmed
    ..Taken together, our data strongly suggest that MSCs behave as conditional APCs in syngeneic immune responses. ..
  20. Eliopoulos N, Francois M, Boivin M, Martineau D, Galipeau J. Neo-organoid of marrow mesenchymal stromal cells secreting interleukin-12 for breast cancer therapy. Cancer Res. 2008;68:4810-8 pubmed publisher
    ..This study therefore establishes the feasibility of using gene-enhanced MSCs in a cell-based neo-organoid approach for cancer treatment. ..
  21. Campeau P, Rafei M, Boivin M, Sun Y, Grabowski G, Galipeau J. Characterization of Gaucher disease bone marrow mesenchymal stromal cells reveals an altered inflammatory secretome. Blood. 2009;114:3181-90 pubmed publisher
    ..In conclusion, Gaucher disease MSCs display an altered secretome that could contribute to skeletal disease and immune disease manifestations in a manner distinct and additive to Gaucher macrophages themselves. ..
  22. Coutu D, Wu J, Monette A, Rivard G, Blostein M, Galipeau J. Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells. J Biol Chem. 2008;283:17991-8001 pubmed publisher
    ..Furthermore, carboxylated periostin is produced by bone-derived cells of mesenchymal lineage and is abundantly found in mineralized bone nodules in vitro. ..
  23. Louis I, Dulude G, Corneau S, Brochu S, Boileau C, Meunier C, et al. Changes in the lymph node microenvironment induced by oncostatin M. Blood. 2003;102:1397-404 pubmed
    ..These findings identify potential targets for the creation of thymic substitutes (LN HEVs) and for expansion of the CD4 memory T-cell compartment (CCL20). ..
  24. Copland I, Jolicoeur E, Gillis M, Cuerquis J, Eliopoulos N, Annabi B, et al. Coupling erythropoietin secretion to mesenchymal stromal cells enhances their regenerative properties. Cardiovasc Res. 2008;79:405-15 pubmed publisher
    ..Epo overexpression enhances the cellular regenerative properties of MSCs by both autocrine and paracrine pathways. ..
  25. Bourdeau A, Dubé N, Heinonen K, Theberge J, Doody K, Tremblay M. TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}. Blood. 2007;109:4220-8 pubmed
    ..Our results unraveled a new role for TC-PTP in normal B lymphopoiesis and suggest that modulation of bone marrow microenvironment is a potential therapeutic approach for selected B-cell leukemia. ..